Premiers résultats des plongées Nautile de la campagne SUBPSO 1 sur la zone de collision "ride des Loyauté arc des Nouvelles-Hébrides" (Sud-Ouest Pacifique)

International audienceFour dives were conducted over the collision zone "Loyalty ridge/New Hebrides arc". On the Loyalty ridge, basaltic and rhyolitic breccias overlain by reef limestones were observed. An andesitic volcaniclastic sequence outcrops on the western flank of the New Hebrides arc. Near the trench, the Loyalty ridge has been sliced by normal faults along which the reef limestones collapsed of at least 4,000m. The unusual existence ofSW verging anticlines on the outer wall, 1,000m above the trench, was confirmed. These folds affect rocks ofthe lowerpartofthe ridge flank.Quatre plongées, réalisées sur la zone de collision «ride des Loyauté/arc des NouvellesHébrides », ont permis d'observer: (1) sur la ride des Loyauté, en mur externe de la fosse, des formations volcano-détritiques basaltiques et rhyolitiques, coiffées par des calcaires récifaux, le toutintensément fracturé; (2) sur le flanc occidental de l'arc néo-hébridais, en mur interne de la fosse, une série volcano-détritique andésitique. A l'approche de la fosse, des failles normales ont découpé la ride des Loyauté, amenant les calcaires récifaux jusqu'à des profondeurs de plus de 4000m. Enfin, la présence inhabituelle de plis déjetés vers le SW sur le mur externe, 1000 m au-dessus de la fosse, a été confirmée; ils semblent s'être développés aux dépens de matériel de la partie inférieure du flanc de la ride

Changes in the 5-HT2(A )receptor system in the pre-mammillary hypothalamus of the ewe are related to regulation of LH pulsatile secretion by an endogenous circannual rhythm

BACKGROUND: We wanted to determine if changes in the expression of serotonin 2A receptor (5HT2(A )receptor) gene in the premammillary hypothalamus are associated with changes in reproductive neuroendocrine status. Thus, we compared 2 groups of ovariectomized-estradiol-treated ewes that expressed high vs low LH pulsatility in two different paradigms (2 groups per paradigm): (a) refractoriness (low LH secretion) or not (high LH secretion) to short days in pineal-intact Ile-de-France ewes (RSD) and (b) endogenous circannual rhythm (ECR) in free-running pinealectomized Suffolk ewes in the active or inactive stage of their reproductive rhythm. RESULTS: In RSD ewes, density of 5HT2(A )receptor mRNA (by in situ hybridization) was significantly higher in the high LH group (25.3 ± 1.4 vs 21.4 ± 1.5 grains/neuron, P < 0.05) and (3)H-Ketanserin binding (a specific radioligand) of the median part of the premammillary hypothalamus tended to be higher in the high group (29.1 ± 4.0 vs 24.6 ± 4.2 fmol/mg tissu-equivalent; P < 0.10). In ECR ewes, density of 5HT2(A )receptor mRNA and (3)H-Ketanserin binding were both significantly higher in the high LH group (20.8 ± 1.6 vs 17.0 ± 1.5 grains/neuron, P < 0.01, and 19.7 ± 5.0 vs 7.4 ± 3.4 fmol/mg tissu-equivalent; P < 0.05, respectively). CONCLUSIONS: We conclude that these higher 5HT2(A )receptor gene expression and binding activity of 5HT2(A )receptor in the premammillary hypothalamus are associated with stimulation of LH pulsatility expressed before the development of refractoriness to short days and prior to the decline of reproductive neuroendocrine activity during expression of the endogenous circannual rhythm

Premiers résultats des plongées de la campagne SUBPSO 1 dans la zone de collision des rides d'Entrecasteaux et de l'arc des Nouvelles-Hébrides

International audienceGeological cross-sections,constructed from observations and samples collected during seven dives of theFrench submersible Nautile,reveal that the inner wall of the New Hebrides trench, in front of the North d'Entrecasteaux ridge and the Bougainville guyot,is primarily composed of volcanic and volcaniclastic rocks, most likely shed from the arc. Observations indicate that the bedding of thearc-slope rocks,which generally slopes trench ward in this collision zone,dips steeply (40-80°) arcward near the contact of the colliding features. In this particular area, arc-slope rocks are generally highly fractured and sheared, an exception being rocks forming the ridge east of the Bougainville guyot.Arc-slope rocks are deeply incised by erosional channels and show numerous fresh slump scars. These scars confirm the importance of mass wasting along the deformation front. No evidence for fluid venting,such as clams and mud volcanoes,was observed during the dives.Les coupes géologiques réalisées à partir de sept plongées du Nautile ont montré que le mur interne de la fosse des Nouvelles-hébrides,en face de la ride Nord d'Entrecasteaux et du guyot Bougainville,est essentiellement constitué par des formations volcaniques et volcano-détritiques provenant probablement de l'arc. Ces formations, généralement inclinées vers la fosse, ont,au contact de la ride et du guyot,rebroussées vers le haut et pentées de 40 à 80°vers l'arc. A ces niveaux,les roches sont intensément fracturées et cisaillées à l'exception de celles constituant le bourrelet qui surplombe le toit du guyot Bougainville.Le mur interne présente enfin une morphologie remarquable comprenant des loupes d'arrachement gravitaire,des chenaux d'érosion, des canyons et,localement,des marmites de géant.Ces figures confirment l'importance de l'érosion gravitaire le long du front de déformation.Aucune manifestation de sorties de fluides n'a été observée lors de ces plongées

Inflammatory Multiple-Sclerosis Plaques Generate Characteristic Metabolic Profiles in Cerebrospinal Fluid

International audienceBackgroundMultiple sclerosis (MS), an inflammatory disease of the central nervous system, manifests itself in numerous forms and stages. A number of brain metabolic alterations have been reported for MS patients vs. control subjects. However, metabolite profiles of cerebrospinal fluid (CSF) are not consistent among the published MS studies, most probably due to variations in the patient cohorts studied. We undertook the first investigation of highly homogeneous MS patient cohorts to determine characteristic effects of inflammatory MS plaques on the CSF metabolome, including only patients with clinically isolated syndrome (CIS) with or without inflammatory brain plaques, and controls.Methodology/Principal FindingsCSF obtained by lumbar puncture was analyzed by proton magnetic resonance spectroscopy. 27 metabolites were quantified. Differences between groups of control subjects (n = 10), CIS patients with (n = 21) and without (n = 12) inflammatory plaques were evaluated by univariate statistics and principal component analysis (PCA). Seven metabolites showed statistically significant inter-group differences (p<0.05). Interestingly, a significant increase in β-hydroxyisobutyrate (BHIB) was detected in CIS with vs. without active plaques, but not when comparing either CIS group with control subjects. Moreover, a significant correlation was found, for the first time, between CSF lactate concentration and the number of inflammatory MS brain plaques. In contrast, fructose concentrations were equally enhanced in CIS with or without active plaques. PCA based on all 27 metabolites yielded group-specific clusters.Conclusions/SignificanceCSF metabolic profiles suggest a close link between MS plaque activity in CIS patients on the one hand and organic-acid metabolism on the other. Our detection of increased BHIB levels points to a hitherto unsuspected role for this compound in MS with active plaques, and serves as a basis for further investigation. The metabolic effects described in our study are crucial elements in the explanation of biochemical mechanisms involved in specific MS manifestations

Geology of the d'Entrecasteaux - New Hebrides arc collision zone : results from a deep submersible survey

International audienceDuring the SuBPSOl cruise, seven submersible dives were conducted between water depths of 5350 and 900 m over the collision zone between the New Hebrides island arc and the d'Entrecasteaux Zone (DEZ). The DEZ, a topographic high on the Australian plate, encompasses the North d'Entrecasteaux Ridge (NDR) and the Bougainville guyot, both of which collide with the island-arc slope. In this report we use diving observations and samples, as well as dredging results, to analyse the geology of the Bougainville guyot and the outer arc slope in the DEZ-arc collision zone, and to decipher the mechanisms of seamount subduction. These data indicate that the Bougainville guyot is a middle Eocene island arc volcanocapped with reef limestones that appear to have been deposited during the Late Oligocene to Early Miocene and in Miocene-Pliocene times. This guyot possibly emerged during the Middle and Late Miocene, and started to sink in the New Hebrides trench after the Pliocene. The rocks of the New Hebrides arc slope, in the collision zone, consist primarily of Pliocene-Recent volcaniclastic rocks derived from the arc, and underlying fractured island-arc volcanic basement, possibly of Late Miocene age. However, highly sheared, Upper Oligocene to Lower Miocene nannofossil ooze and chalk are exposed at the toe of the arc slope against the northern flank of the NDR. Based on a comparison with cores collected at DSDP Site 286, the ooze and chalk can be interpreted as sediments accreted from the downgoing plate. East of the Bougainville guyot an antifonn that developed in the arc slope as a consequence of the collision reveals a 500-m-thick wedge of strongly tectonized rocks, possibly accreted from the guyot or an already subducted seamount. The wedge that is overlain by less deformed volcaniclastic island-arc rocks and sediments includes imbricated layers of Late Oligocene to Early Miocene reef and micritic limestones. This wedge, which develops against the leading flank of the guyot, tends to smooth its high-drag shape. A comparison between the 500-m-thick wedge of limestones that outcrops southeast of the guyot and the absence of such a wedge over the flat top of the guyot, although the top is overthrust by island-arc rocks and sediments, can be interpreted to suggest that the wedge moves in the subduction zone with the guyot and facilitates its subduction by streamlining

Association between meniscal tears and the peak external knee adduction moment and foot rotation during level walking in postmenopausal women without knee osteoarthritis: a cross-sectional study

Introduction Meniscal injury is a risk factor for the development and progression of knee osteoarthritis, yet little is known about risk factors for meniscal pathology. Joint loading mediated via gait parameters may be associated with meniscal tears, and determining whether such an association exists was the aim of this study. Methods Three-dimensional Vicon gait analyses were performed on the dominant knee of 20 non-osteoarthritic women, and the peak external knee adduction moment during early and late stance was determined. The degree of foot rotation was also examined when the knee adductor moment peaked during early and late stance. Magnetic resonance imaging was used to determine the presence and severity of meniscal lesions in the dominant knee. Results The presence (P = 0.04) and severity (P = 0.01) of medial meniscal tears were positively associated with the peak external knee adduction moment during early stance while a trend for late stance was observed (P = 0.07). They were also associated with increasing degrees of internal foot rotation during late stance, independent of the magnitude of the peak external knee adduction moment occurring at that time (P = 0.03). During level walking among healthy women, the presence and severity of medial meniscal tears were positively associated with the peak external knee adduction moment. Moreover, the magnitude of internal foot rotation was associated with the presence and severity of medial meniscal lesions, independent of the peak knee adductor moment during late stance. Conclusion These data may suggest that gait parameters may be associated with meniscal damage, although longitudinal studies will be required to clarify whether gait abnormalities predate meniscal lesions, or vice versa, and therefore whether modification of gait patterns may be helpful

Value of biomarkers in osteoarthritis: Current status and perspectives

Osteoarthritis affects the whole joint structure with progressive changes in cartilage, menisci, ligaments and subchondral bone, and synovial inflammation. Biomarkers are being developed to quantify joint remodelling and disease progression. This article was prepared following a working meeting of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis convened to discuss the value of biochemical markers of matrix metabolism in drug development in osteoarthritis. The best candidates are generally molecules or molecular fragments present in cartilage, bone or synovium and may be specific to one type of joint tissue or common to them all. Many currently investigated biomarkers are associated with collagen metabolism in cartilage or bone, or aggrecan metabolism in cartilage. Other biomarkers are related to non-collagenous proteins, inflammation and/or fibrosis. Biomarkers in osteoarthritis can be categorised using the burden of disease, investigative, prognostic, efficacy of intervention, diagnostic and safety classification. There are a number of promising candidates, notably urinary C-terminal telopeptide of collagen type II and serum cartilage oligomeric protein, although none is sufficiently discriminating to differentiate between individual patients and controls (diagnostic) or between patients with different disease severities (burden of disease), predict prognosis in individuals with or without osteoarthritis (prognostic) or perform so consistently that it could function as a surrogate outcome in clinical trials (efficacy of intervention). Future avenues for research include exploration of underlying mechanisms of disease and development of new biomarkers; technological development; the ‘omics’ (genomics, metabolomics, proteomics and lipidomics); design of aggregate scores combining a panel of biomarkers and/or imaging markers into single diagnostic algorithms; and investigation into the relationship between biomarkers and prognosis. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 3.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial

Signification géodynamique des calcaires de plate-forme en cours de subduction sous l'arc des Nouvelles-Hébrides (Sud-Ouest de l'océan Pacifique)

Note présentée par Jean DercourtInternational audienceThe analysis of carbonates from New Hébrides Trench shows that three main épisodes of shallow water carbonate déposition occurred during Late Eocene,Late Oligocene-Early Miocène,Mio-Pliocene-Quaternary, controlled by eustatism and tectonic.L'analyse de carbonates issus de la fosse des Nouvelles-Hébrides a permis de reconnaître trois périodes favorables au développement de plates-formes(Éocène supérieur,Oligocène supérieur-Miocène inférieur,Mio-Pliocène-Quaternaire)contrôlé par l'eustatisme et la tectonique