The air-launched autonomous micro observer

Author Posting. © American Meteorological Society, 2022. This article is posted here by permission of American Meteorological Society for personal use, not for redistribution. The definitive version was published in Journal of the Atmospheric and Oceanic Technology 39(4), (2022): 491–502, https://doi.org/10.1175/jtech-d-21-0046.1.The Air-Launched Autonomous Micro Observer (ALAMO) is a versatile profiling float that can be launched from an aircraft to make temperature and salinity observations of the upper ocean for over a year with high temporal sampling. Similar in dimensions and weight to an airborne expendable bathythermograph (AXBT), but with the same capability as Argo profiling floats, ALAMOs can be deployed from an A-sized (sonobuoy) launch tube, the stern ramp of a cargo plane, or the door of a small aircraft. Unlike an AXBT, however, the ALAMO float directly measures pressure, can incorporate additional sensors, and is capable of performing hundreds of ocean profiles compared to the single temperature profile provided by an AXBT. Upon deployment, the float parachutes to the ocean, releases the air-deployment package, and immediately begins profiling. Ocean profile data along with position and engineering information are transmitted via the Iridium satellite network, automatically processed, and then distributed by the Global Telecommunications System for use by the operational forecasting community. The ALAMO profiling mission can be modified using the two-way Iridium communications to change the profiling frequency and depth. Example observations are included to demonstrate the ALAMO’s utility.This work was supported by the National Oceanographic and Atmospheric Administration under Grants NA13OAR4830233 (as part of CINAR Sandy Supplemental funding from the Disaster Relief Appropriations Act of 2013) and NA14OAR4320158 and by Office of Naval Research under Grants N0001416WX01384, N0001416WX01262, and N000141512293. ALAMO floats are commercially available from MRV Systems, LLC (https://www.mrvsys.com)

Characterization of the Theileria parva sporozoite proteome

East Coast fever is a lymphoproliferative disease caused by the tick-borne protozoan parasite Theileria parva. The sporozoite stage of this parasite, harboured and released from the salivary glands of the tick Rhipicephalus appendiculatus during feeding, invades and establishes infection in bovine lymphocytes. Blocking this initial stage of invasion presents a promising vaccine strategy for control of East Coast fever and can in part be achieved by targeting the major sporozoite surface protein p67. To support research on the biology of T. parva and the identification of additional candidate vaccine antigens, we report on the sporozoite proteome as defined by LC–MS/MS analysis. In total, 4780 proteins were identified in an enriched preparation of sporozoites. Of these, 2007 were identified as T. parva proteins, representing close to 50% of the total predicted parasite proteome. The remaining 2773 proteins were derived from the tick vector. The identified sporozoite proteins include a set of known T. parva antigens targeted by antibodies and cytotoxic T cells from cattle that are immune to East Coast fever. We also identified proteins predicted to be orthologs of Plasmodium falciparum sporozoite surface molecules and invasion organelle proteins, and proteins that may contribute to the phenomenon of bovine lymphocyte transformation. Overall, these data establish a protein expression profile of T. parva sporozoites as an important starting point for further study of a parasitic species which has considerable agricultural impact

KEMIRINGAN LERENG DAN GRANULOMETRI SEDIMEN GISIK TANJUNG MERAH, BITUNG SULAWESI UTARA

Beach slope and sediment granulometry  is one of the importat aspect in coastal management.  Beach offers a variety of functions and potential to be utilized. In the interests of phisical use in the beach, coastal structure in the form of groynes has been built. Actually, the groin has been used as a dock. This research was conducted with the aim of revealing the slope and granulometry sediment in Tanjung Merah beach. The results obtained, the beach slope is considered sloping and very sloping, the composition of the sediment consists mainly  of medium sand, fine sand and very fine sand. Sediment distribution analysis obtained results, the main grain size was mainly in the form of medium sand, sorting was mainly classified as poor, skewness was mostly asymmetrie strong to large size, most curtosis was mesokurtic. The results of the study indicate the occurrence of the process of erosion and deposition ia certain spaces on the beach studied.Keywords: Tanjung Merah, beach slope, sediment granulometryKemiringan lereng dan granulometri sedimen gisik merupakan salah satu aspek penting dalam pengelolaan pantai. Gisik menawarkan beragam fungsi dan potensi untuk dimanfaatkan. Dalam kepentingan pemanfaatan lahan gisik, berbagai modifikasi dilakukan oleh manusia. Pada gisik di Tanjung Merah, telah dibangun struktur pantai berupa groin. Secara aktual, groin tersebut telah difunsikan sebagai dermaga. Penelitian ini dilakukan dengan tujuan mengungkapkan kemiringan dan granulometri sedimen di gisik Tanjung Merah. Hasil penelitian yang diperoleh, lereng gisik terkriteria miring dan sangat miring, komposisi sedimen terutama terdiri dari pasir sedang, pasir halus, dan pasir sangat halus. Analisis distribusi memperoleh hasil, rataan empirik terutama berupa pasir sedang, penyortiran terutama terklasifikasi buruk, kemencengan terbanyak berupa asimetris kuat ke ukuran besar, peruncingan terbanyak berupa mesokurtik. Hasil studi mengindikasikan terjadi proses erosi dan deposisi pada ruang-ruang tertentu di gisik yang ditelaah.Kata kunci : Tanjung Merah, kemiringan lereng, granulometri sedime

Glucagon-like peptide-1 analogs against antipsychotic-induced weight gain: potential physiological benefits

BACKGROUND: Antipsychotic-induced weight gain constitutes a major unresolved clinical problem which may ultimately be associated with reducing life expectancy by 25 years. Overweight is associated with brain deterioration, cognitive decline and poor quality of life, factors which are already compromised in normal weight patients with schizophrenia. Here we outline the current strategies against antipsychotic-induced weight gain, and we describe peripheral and cerebral effects of the gut hormone glucagon-like peptide-1 (GLP-1). Moreover, we account for similarities in brain changes between schizophrenia and overweight patients. DISCUSSION: Current interventions against antipsychotic-induced weight gain do not facilitate a substantial and lasting weight loss. GLP-1 analogs used in the treatment of type 2 diabetes are associated with significant and sustained weight loss in overweight patients. Potential effects of treating schizophrenia patients with antipsychotic-induced weight gain with GLP-1 analogs are discussed. CONCLUSIONS: We propose that adjunctive treatment with GLP-1 analogs may constitute a new avenue to treat and prevent metabolic and cerebral deficiencies in schizophrenia patients with antipsychotic-induced weight gain. Clinical research to support this idea is highly warranted

Bone Status in Obese, Non-diabetic, Antipsychotic-Treated Patients, and Effects of the Glucagon-Like Peptide-1 Receptor Agonist Exenatide on Bone Turnover Markers and Bone Mineral Density

Background: Low bone mineral density (BMD) may constitute an underestimated comorbidity in schizophrenia patients undergoing long-term antipsychotic treatment. Glucagon-like peptide 1 (GLP-1) receptor agonists are antidiabetic drugs, which may also affect bone turnover.Methods: In planned secondary analyses of a 3 months, double-blind, randomized, placebo-controlled trial (n = 45), we explored effects of the GLP-1 receptor agonist exenatide 2 mg once-weekly (n = 23), or placebo (n = 22) on bone turnover markers (BTMs) and BMD in chronic, obese, antipsychotic-treated patients with schizophrenia spectrum disorder. Baseline BTMs were compared to sex- and age-adjusted reference values from a Danish population cohort, and T- and Z-scores were calculated for BMD.Results: In women (n = 24), all baseline BTM measurements of procollagen type I N-terminal propeptide (PINP) and C-terminal cross-linking telopeptide of type I collagen (CTX) were within reference values. In men (n = 21), 5% displayed lower PINP and 14% displayed lower CTX. One patient displayed BMD Z-score Conclusions: Sex- and age-adjusted measures of bone status in chronic, obese, antipsychotic-treated patients appeared comparable to the reference population. Subtle changes in bone markers during 3 months exenatide treatment may suggest beneficial effects of GLP-1 receptor agonists on bone status in antipsychotic-treated patients, and further studies should consider the potential influence of prolactin.</p

Economic and other barriers to adopting recommendations to prevent childhood obesity: results of a focus group study with parents

Abstract Background Parents are integral to the implementation of obesity prevention and management recommendations for children. Exploration of barriers to and facilitators of parental decisions to adopt obesity prevention recommendations will inform future efforts to reduce childhood obesity. Methods We conducted 4 focus groups (2 English, 2 Spanish) among a total of 19 parents of overweight (BMI &#8805; 85th percentile) children aged 5-17 years. The main discussion focused on 7 common obesity prevention recommendations: reducing television (TV) watching, removing TV from child's bedroom, increasing physically active games, participating in community or school-based athletics, walking to school, walking more in general, and eating less fast food. Parents were asked to discuss what factors would make each recommendation more difficult (barriers) or easier (facilitators) to follow. Participants were also asked about the relative importance of economic (time and dollar costs/savings) barriers and facilitators if these were not brought into the discussion unprompted. Results Parents identified many barriers but few facilitators to adopting obesity prevention recommendations for their children. Members of all groups identified economic barriers (time and dollar costs) among a variety of pertinent barriers, although the discussion of dollar costs often required prompting. Parents cited other barriers including child preference, difficulty with changing habits, lack of information, lack of transportation, difficulty with monitoring child behavior, need for assistance from family members, parity with other family members, and neighborhood walking safety. Facilitators identified included access to physical activity programs, availability of alternatives to fast food and TV which are acceptable to the child, enlisting outside support, dietary information, involving the child, setting limits, making behavior changes gradually, and parental change in shopping behaviors and own eating behaviors. Conclusions Parents identify numerous barriers to adopting obesity prevention recommendations, most notably child and family preferences and resistance to change, but also economic barriers. Intervention programs should consider the context of family priorities and how to overcome barriers and make use of relevant facilitators during program development.http://deepblue.lib.umich.edu/bitstream/2027.42/78270/1/1471-2431-9-81.xmlhttp://deepblue.lib.umich.edu/bitstream/2027.42/78270/2/1471-2431-9-81.pdfPeer Reviewe