Identidad y tipografía

Las sociedades de cada país poseen folklore que pone de manifiesto la idiosincrasia del pueblo y por consiguiente su historia. En ese sentido la creación de fuentes tipográficas orientadas a la identidad cultural en este caso con la región norte de nuestro país, supone, desde el punto de vista de diseño, nuevas oportunidades en el mercado de tipografía latinoamericana y, a su vez significa un aporte histórico-cultural importante y un compromiso para con la región y el país. Para entender lo que significa nación o país, es necesario conocer lo más cercano que tenemos; eso implica hablar de la región norte de Perú. En esta región nos vemos rodeados de un pasado cultural del cual solo conocemos por historia. No solo un escudo y un himno son los símbolos de identidad creados para representar una nación, dejando de lado lo que significaron siglos de evolución cultural que las sociedades de ese entonces nos transmitieron sabiamente, y que es todo lo que en la actualidad conocemos como patrimonio dentro de un museo. La región norte, donde se concentraron culturas que dieron increíbles aportes a nuestro país debería poseer no solo una bandera, un escudo y un himno;por el contrario debería poseer una fuente tipográfica que exprese y le de valor a tantos años de desarrollo cultural vividos por nuestros antepasados, y que por ahora,si hablamos netamente de diseño tipográfico nos lo expresa la marca Perú

Chiral extrapolation of the sigma and rho mesons from dispersion relations and Chiral Perturbation Theory

We review our recent study of the pion mass dependence of the rho and sigma resonances, generated from one-loop SU(2) Chiral Perturbation Theory (ChPT) with the Inverse Amplitude Method (IAM). In order to properly account for the Adler zero region, we also review the recently obtained modified version of the IAM; which is based on analyticity, elastic unitarity and ChPT at low energies, thus yielding the correct pion mass dependence of the resonance pole positions up to next-to-leading order in ChPT. As main results we find that the rho-pi-pi coupling constant is almost pion mass independent and that the rho mass shows a smooth pion mass dependence while that of the sigma shows a strong non-analyticity. These findings are important for studies of the meson spectrum on the lattice.Comment: 5 pages, 4 figures, to appear in the proceedings of the "Scalar Mesons and Related Topics" workshop. Lisbon, February 11-16, 200

Long-term temperature prediction with hybrid autoencoder algorithms

This paper proposes two hybrid approaches based on Autoencoders (AEs) for long-term temperature prediction. The first algorithm comprises an AE trained to learn temperature patterns, which is then linked to a second AE, used to detect possible anomalies and provide a final temperature prediction. The second proposed approach involves training an AE and then using the resulting latent space as input of a neural network, which will provide the final prediction output. Both approaches are tested in long-term air temperature prediction in European cities: seven European locations where major heat waves occurred have been considered. The long- term temperature prediction for the entire year of the heatwave events has been analysed. Results show that the proposed approaches can obtain accurate long-term (up to 4 weeks) temperature prediction, improving Persistence and Climatology in the benchmark models compared. In heatwave periods, where the persistence of the temperature is extremely high, our approach beat the persistence operator in three locations and works similarly in the rest of the cases, showing the potential of this AE-based method for long-term temperature prediction

Guidance on the scientific requirements for an application for authorisation of a novel food in the context of Regulation (EU) 2015/2283

The European Commission requested EFSA to update the scientific guidance for the preparation of applications for authorisation of novel foods, previously developed following the adoption of Regulation (EU) 2015/2283 on novel foods. This guidance document provides advice on the scientific information needed to be submitted by the applicant towards demonstrating the safety of the novel food. Requirements pertain to the description of the novel food, production process, compositional data, specifications, proposed uses and use levels and anticipated intake of the novel food. Furthermore, information needed in sections on the history of use of the novel food and/or its source, absorption, distribution, metabolism, excretion, toxicological information, nutritional information and allergenicity is also described. The applicant should integrate and interpret the data presented in the different sections to provide their overall considerations on how the information supports the safety of the novel food under the proposed conditions of use. Where potential health hazards have been identified, they are to be discussed in relation to the anticipated intake of the novel food and the proposed target populations. On the basis of the information provided, EFSA will assess the safety of the novel food under the proposed conditions of use

Endowing Indole-Based Tubulin Inhibitors with an Anchor for Derivatization: Highly Potent 3‑Substituted Indolephenstatins and Indoleisocombretastatins

Colchicine site ligands with indole B rings are potent tubulin polymerization inhibitors. Structural modifications at the indole 3-position of 1-methyl-5-indolyl-based isocombretastatins (1,1-diarylethenes) and phenstatins endowed them with anchors for further derivatization and resulted in highly potent compounds. The substituted derivatives displayed potent cytotoxicity against several human cancer cell lines due to tubulin inhibition, as shown by cell cycle analysis, confocal microscopy, and tubulin polymerization inhibitory activity studies and promoted cell killing mediated by caspase-3 activation. Binding at the colchicine site was confirmed by means of fluorescence measurements of MTC displacement. Molecular modeling suggests that the tropolone-binding region of the colchicine site of tubulin can adapt to hosting small polar substituents. Isocombretastatins accepted substitutions better than phenstatins, and the highest potencies were achieved for the cyano and hydroxyiminomethyl substituents, with TPI values in the submicromolar range and cytotoxicities in the subnanomolar range. A 3,4,5-trimethoxyphenyl ring usually afforded more potent derivatives than a 2,3,4-trimethoxyphenyl ring