The Role of Advanced Glycation End-Product Levels Measured by Skin Autofluorescence in the Development of Mitral Annular Calcification

As a person ages, mitral annular calcification develops in the mitral annulus with increasing frequency. Lipid deposition, inflammation, and aging-related degeneration have been cited as potential causes of this pathophysiology, though there is currently no conclusive evidence to support this. AGEs accumulate in tissues due to the glycation of proteins and lipids, increasing the release of proinflammatory cytokines secondary to oxidative stress through the AGE receptor. The AGE levels increase in diabetic microvascular complications and degenerative aortic valve disease. Our study was planned prospectively as a case–control study involving 94 MAC-positive patients and 94 MAC-negative patients. The demographics, echocardiographic data and AGE levels of the patients were measured and recorded using the skin autofluorescence method. AGE levels were significantly higher in the MAC-positive patient group (3.2 vs. 2.7; p p < 0.001). In a ROC-curve analysis, the AUC was 0.79 (95% CI: 0.72–0.85). At a cut-off value of 2.7, 79.7% sensitivity and 69.1% specificity were observed. AGE levels can be used to cheaply, easily and non-invasively identify patients at risk of developing MAC

GPU accelerated 3DES encryption

Triple DES (3DES) is a NIST and ISO/IEC standard block cipher that is also used in some web browsers and several electronic payment applications. We propose an optimized bit-level parallelization of 3DES for GPU accelerated encryption to allow processing high volumes of data. Since the block size of 3DES is 64 bits, our approach considers a kernel block as a 64-bit 3DES block. Each kernel block performs XOR, permutation, and S-box operations of this cipher in parallel and memory accesses are optimized by the use of constant and shared memory. Although table based and bitsliced implementations of block ciphers on GPUs outperform naive implementations, their performance vary significantly on different GPU models and architectures. Lack of publicly available source codes prohibit a fair comparison of the performance results for different implementations. In this work, we provide performance results on various GPU models and make our implementation publicly available for reproducibility and further comparisons. When compared against the baseline multi-threaded CPU implementation, our optimization achieves an average of 15.95urn:x-wiley:cpe:media:cpe6507:cpe6507-math-0001 speed-up when encrypting large files using an RTX 2070 Super GPU. Moreover, when modified into a key search attack, more than 94.4 million 3DES key searches per second can be conducted on an RTX 2070 Super GPU

Biküspit aort kapaklı hastada geçici kalp bloğu: Olgu sunumu

Bicuspid aortic valve is a common congenital cardiovascular malformation. We present a case with bicuspid aorta and ascending aortic aneurysm developing transient complete heart block. This case is the first in literature to report the concurrence of bicuspid aortic valve and ascending aortic dilatation with transient complete heart block.Biküspit aort kapak sık görülen doğumsal kardiyovasküler bozukluktur. Sunduğumuz vaka biküspit aort kapak ve çıkan aort anevrizmasında gelişen geçici tam kalp bloğudur. Bu vaka biküspit aort ve çıkan aort genişlemesine geçici kalp bloğunun eşlik ettiği literatürdeki ilk vakadı

Two Cases of Dyke-Davidoff Masson Syndrome

Dyke-Davidoff Masson Syndrome (DDMS) is a rare syndrome characterized by seizures, facial asymmetry, and contralateral hemiplegia or hemiparesis. The typical radiological features of DDMS include cerebral hemiatrophy with ipsilateral hypertrophy of the skull and sinuses. It is usually diagnosed in childhood. Presently described are 2 rare cases of DDMS that were diagnosed in adults based on magnetic resonance imaging of the brain

Prevalence of Coronary Artery Anomalies in 12,457 Adult Patients Who Underwent Coronary Angiography

Background: Coronary artery anomalies are found in 0.2% to1.3% of patients undergoing coronary angiography and 0.3% of an autopsy series. We aimed to estimate the frequency of coronary artery anomalies in our patient population

Successful coil embolization of LIMA side branch that is suspected to cause recurrent angina

Koroner arter baypas cerrahisinde greft amacıyla sık kullanı- lan sol internal mamaryan arterde (LIMA) yan dalların anastomoz öncesi kapatılması, cerrahi sonrası çalmaya bağlı miyokard iskemisini engellemek için son derece önemlidir. Bu vakada koroner arter baypas cerrahisinden 2 yıl sonra özellikle kol egzersizi sırasında belirginleşen göğüs ağrısı yakınması bulunan bir hastada koroner çalma sendromuna neden olduğunu düşündüğümüz LIMA yan dalı başarılı koil embolizasyon ile kapatılmasını gösterdik.The left internal mammarian artery (LIMA) is the most commonly used arterial graft for coronary artery bypass grafting (CABG). Selective occlusion of LIMA side branches during surgery is important for avoiding myocardial ischemia. We report on a case with limp claudication on exertion due to patent LIMA side branch following CABG operation two years prior to hospital admission. The patent side branch was successfully occluded with coil embolization

Biküspit aort kapaklı hastada geçici kalp bloğu: Olgu sunumu

Bicuspid aortic valve is a common congenital cardiovascular malformation. We present a case with bicuspid aorta and ascending aortic aneurysm developing transient complete heart block. This case is the first in literature to report the concurrence of bicuspid aortic valve and ascending aortic dilatation with transient complete heart block.Biküspit aort kapak sık görülen doğumsal kardiyovasküler bozukluktur. Sunduğumuz vaka biküspit aort kapak ve çıkan aort anevrizmasında gelişen geçici tam kalp bloğudur. Bu vaka biküspit aort ve çıkan aort genişlemesine geçici kalp bloğunun eşlik ettiği literatürdeki ilk vakadı

Neutrophil to lymphocyte ratio is associated with proximal/middle segment of the LAD lesions in patients with ST segment elevation infarction

Introduction: Neutrophil to lymphocyte ratio (NLR) was revaled to have a close relation with atherosclerotic cardiovascular disease. The relationship between NLR and culprit plaque localization has never been studied. Aim of the study : To evaluate the association between NLR and unstable plaque localization of left anterior descending artery (LAD) in anterior miyocardial infarction patients. Material and methods : Patients admitted to our hospital with acute anterior STEMI were included. Fifhy-eight patients who have single-vessel disease at LAD and their hematological parameters were analyzed retrospectively. Proximal segment of LAD lesions were groupped as Group I and mid segment of the LAD lesion groupped as Group II. The groups were compared according to their NLR and other parameters. Results : Between group I (n = 41, mean age 52.5 ±12.7) and group II (n = 17, mean ages 52.0 ±10.8); NLR, were significantly higher in group I compared to the group II (6.9 ±5.6 vs. 3.3 ±2.0, p = 0.01). In group I, left ventricular ejection fraction (LVEF) was significantly lower (p = 0.02). In correlation analyzes, NLR was positively correlated with CK MB (r = 0.32, p = 0.01) and negatively correlated with LVEF (r = –0.28, p = 0.03). Conclusions : The present study demonstrated that anterior myocardial infarction patients with high NLR had a greater possibility having proximal culprit lesion on the LAD. Therefore NLR can be used as a useful tool to culprit plaque localization in patients with acute miyocardial infarction patients