P- and S- wave velocities of consolidated sediments from a seafloor seismic survey in the North Celtic Sea Basin, offshore Ireland

A geophysical survey was conducted over a hydrocarbon prospect in the North Celtic Sea Basin using a small array of ocean-bottom seismographs (OBSs). The purpose of this study was to determine the ratio of (P) compressional- to (S) shear-wave velocity of consolidated sedimentary rocks in order to constrain possible subsurface variations in pore-fluid content. The ratio of VP and VS- is known to be particularly sensitive to lithology, porosity and pore-fluid content, making it a useful parameter for evaluating hydrocarbon prospects. OBSs offer a relatively cheap and time-effective means of acquiring multi-component data compared with ocean-bottom cables. In this contribution, we demonstrate the ability of an OBS survey comprising three pairs of two OBSs spaced at 1.6 km to recover lateral variations in the VP/VS ratio. A key requirement of this type of study is that S-waves will be generated by mode conversions in the subsurface, since they cannot be generated in nor travel through fluids. In this survey, the contrast in physical properties of the hard seabed of the North Celtic Sea Basin provided a means of generating converted S-waves. Two-dimensional ray-tracing and forward modeling was used to create both VP and VS models along a profile crossing the Blackrock prospect in the North Celtic Sea Basin. These models comprise four layers and extend to a maximum depth of 1.1 km. The observed northward decrease in the VP/VS ratio at depths of 500-1000 m below the seafloor in the study area is interpreted to represent lateral variation in the amount of gas present in the pore space of Upper Cretaceous chalks and shales overlying the prospective reservoir

CAYSEIS - magma-starved oceanic crustal accretion and transform margin formation in the Cayman Trough revealed by seismic and seismological data - Cruise No. M115, April 1 - April 28, 2015 - Kingston (Jamaica) - Pointe-à-Pitre (Guadeloupe)

About 57% of the Earth’s outer surface is oceanic crust and new ocean floor is continuously created along the 55,000-60,000 km long mid-ocean ridge (MOR) system. About 25% of MORs spread at an ultra-slow spreading rate of < 20 mm/yr. Most ultra-slow spreading ridges occur in areas of the world that are difficult to reach, like the Gakkel Ridge in the Arctic Ocean and the Southwest Indian Ridge in the Indian Ocean. It has long been recognized that crustal accretion at ultra-slow spreading rates is fundamentally different from crust generated at faster spreading rates. However, due to the remoteness of ultra-slow ridges, the formation of crust at these magma-starved centres is yet not well understood. During the CAYSEIS cruise we surveyed lithospheric formation at ultra-slow spreading rates at the Mid-Cayman spreading centre (MCSC) in the Caribbean Sea, where oceanic crust is formed at a full rate of ~17 mm/yr. To the northeast and southwest, the MCSC is bound by two major transform faults. Using active-source wide-angle seismic imaging and passive local earthquake monitoring we, studied the balance between magmatic accretion and tectonic stretching (and hence oceanic core complex formation) and the relationship between faulting and hydrothermal activity at ultra-slow spreading rates. In addition, we explored transform margin formation at a unique setting, occurring at the southern terminus of the MCSC. In total, six seismic lines surveyed crust formed at the MCSC, two of these profiles also crossed the Swan Island transform fault. The project was a collaboration between German, British and American scientists

Application of a seismic network to baleen whale call detection and localization in the Panama basin – a Bryde’s whale example

Baleen whales use sounds of various characteristics for different tasks and interactions. This study focuses on recordings from the Costa Rica Rift, in the Eastern Tropical Pacific Ocean, made by 25 ocean-bottom seismographs and a vertical array of 12 hydrophones between January and February 2015. The whale calls observed are of two kinds: more commonly, repetitive 4–5 s–long signals separated into two frequency bands centered at ∼20 and ∼36 Hz; less commonly, a series of ∼0.5 to 1.0 s–long, lower amplitude signals with frequencies between 80 and 160 Hz. These characteristics are similar to calls attributed to Bryde's whales which are occasionally sighted in this region. In this study, the repetitive calls are detected using both the short-term average/long-term average approach and a network empirical subspace detector. In total, 188 and 1891 calls are obtained for each method, demonstrating the value of the subspace detector for highly similar signals. These signals are first localized using a non-linear grid search algorithm and then further relocalized using the double-difference technique. The high-resolution localizations reveal the presence of at least seven whales during the recording period, often crossing the instrument network from southwest to northeast

Bone geometry according to menstrual function in female endurance athletes

Athletes have higher bone mineral density (BMD) relative to nonathletes. In amenorrheic athletes BMD may be compromised by estrogen deficiency, but it is unknown whether this is accompanied by structural differences. We compared femoral neck bone geometry and density of a-/oligomenorrheic athletes (AAs), eumenorrheic athletes (EAs), and eumenorrheic controls (ECs). We recruited 156 women: (68 endurance athletes and 88 controls). Femoral neck BMD, section modulus (Z), and width were measured using dual-energy X-ray absorptiometry. Menstrual function was assessed by questionnaire and classified as EA(C10 periods/year) or AA(B9periods/year): 24 athletes were AA and 44 EA. Femoral neck BMD was significantly higher in EA than AA (8 %, difference) and EC (11 % difference): mean [SE] 1.118 [0.015], 1.023 [0.020] and 0.999 [0.014] g cm-2, respectively; p\0.001. Z was significantly higher in EA than EC (11 % difference): EA 667 [19], AA 625 [21], and EC 592 [10] cm3; p\0.001. Femoral neck width did not differ between groups. All differences persisted after adjustment for height, age, and body mass. The higher femoral neck Z and BMD in athletes, despite similar width, may indicate that exercise-related bone gains are endosteal rather than periosteal. Athletes with amenorrhea had smaller increments in bone mass rather than structural adaptation. The maintained femoral neck width in controls may be an adaptive mechanism to conserve bone strength in bending despite inactivity-related bone decrement

Magmatic accretion versus serpentinized mantle exhumation at ultraslow spreading rates: constraints from seismic data and Vp/Vs ratios, Mid-Cayman Spreading Centre, Caribbean Sea

About 57% of the Earth’s surface is covered by oceanic crust and new ocean floor is continuously created along the ~60.000 km long mid-ocean ridge (MOR) system. About 25% of the MOR spread at an ultra-slow spreading rate of 1.9. Here, we report results from a seismic refraction survey from the ultra-slow spreading Cayman Spreading Centre in the Caribbean Sea, sampling mature crust along a flowline from both conjugated ridge flanks. The ocean-bottom-seismometer and hydrophones provide both P-wave and S-wave refracted arrivals. Travel time data were inverted using seismic tomography. Resulting Vp/Vs ratios suggest that up to 25% of the lithosphere have high ratios of >1.9, supporting serpentinization and exposure of hydrated mantle at the seafloor. Further, the mode of accretion has changed over time, supporting both areas of mantle exposure and magmatic crust. Magmatic crust has a typical layer 2 and layer 3 velocity structure and a thin crust of 3 to 5 km thickness. However, a well-defined Moho boundary was not observed. Thus, crustal rocks are characterized by typical crustal-velocities (7.6 km/s. Domains of un-roofed mantle have high Vp/Vs ratios and velocities gradually increasing to 7.4-7.6 km/s. In addition, we will use our results to re-assess the depth distribution of local earthquakes at ultra-slow spreading ridges, including the Cayman Trough and the Southwest Indian Ridge. Most importantly, the high Vp/Vs ratio of >1.9 characterizing serpentinized mantle causes earthquakes to focus at much shallower depth when compared to location procedures using a global average for Vp/Vs of 1.73; the bias in depth might be in the order of 10 km

Geometric morphometrics defines shape differences in the cortical area map of C57BL/6J and DBA/2J inbred mice

BACKGROUND: We previously described planar areal differences in adult mouse visual, somatosensory, and neocortex that collectively discriminated C57BL/6J and DBA/2J inbred strain identity. Here we use a novel application of established methods of two-dimensional geometric morphometrics to examine shape differences in the cortical area maps of these inbred strains. RESULTS: We used Procrustes superimposition to align a reliable set of landmarks in the plane of the cortical sheet from tangential sections stained for the cytochrome oxidase enzyme. Procrustes superimposition translates landmark configurations to a common origin, scales them to a common size, and rotates them to minimize an estimate of error. Remaining variation represents shape differences. We compared the variation in shape between C57BL/6J and DBA/2J relative to that within each strain using a permutation test of Goodall's F statistic. Significant differences in shape in the posterior medial barrel subfield (PMBSF), as well as differences in shape across primary sensory areas, characterize the cortical area maps of these common inbred, isogenic strains. CONCLUSION: C57BL/6J and DBA/2J have markedly different cortical area maps, in both size and shape. These differences suggest polymorphism in genetic factors underlying cortical specification, even between common isogenic strains. Comparing cortical phenotypes between normally varying inbred mice or between genetically modified mice can identify genetic contributions to cortical specification. Geometric morphometric analysis of shape represents an additional quantitative tool for the study of cortical development, regardless of whether it is studied from phenotype to gene or gene to phenotype

Expanding the diversity of mycobacteriophages: insights into genome architecture and evolution.

Mycobacteriophages are viruses that infect mycobacterial hosts such as Mycobacterium smegmatis and Mycobacterium tuberculosis. All mycobacteriophages characterized to date are dsDNA tailed phages, and have either siphoviral or myoviral morphotypes. However, their genetic diversity is considerable, and although sixty-two genomes have been sequenced and comparatively analyzed, these likely represent only a small portion of the diversity of the mycobacteriophage population at large. Here we report the isolation, sequencing and comparative genomic analysis of 18 new mycobacteriophages isolated from geographically distinct locations within the United States. Although no clear correlation between location and genome type can be discerned, these genomes expand our knowledge of mycobacteriophage diversity and enhance our understanding of the roles of mobile elements in viral evolution. Expansion of the number of mycobacteriophages grouped within Cluster A provides insights into the basis of immune specificity in these temperate phages, and we also describe a novel example of apparent immunity theft. The isolation and genomic analysis of bacteriophages by freshman college students provides an example of an authentic research experience for novice scientists

Research design considerations for clinical studies of abuse-deterrent opioid analgesics: IMMPACT recommendations

Opioids are essential to the management of pain in many patients, but they also are associated with potential risks for abuse, overdose, and diversion. A number of efforts have been devoted to the development of abuse-deterrent formulations of opioids to reduce these risks. This article summarizes a consensus meeting that was organized to propose recommendations for the types of clinical studies that can be used to assess the abuse deterrence of different opioid formulations. Due to the many types of individuals who may be exposed to opioids, an opioid formulation will need to be studied in several populations using various study designs in order to determine its abuse-deterrent capabilities. It is recommended that the research conducted to evaluate abuse deterrence should include studies assessing: (1) abuse liability; (2) the likelihood that opioid abusers will find methods to circumvent the deterrent properties of the formulation; (3) measures of misuse and abuse in randomized clinical trials involving pain patients with both low risk and high risk of abuse; and (4) post-marketing epidemiological studies