Money and activity in the U.K. 1961-1983: surprise? surprise!

This is a study of the impact of money growth and money growth surprises on U.K. real activity (GDP and unemployment). We find no support for the 'only surprises have real effects' story except in the 1960s when the fixed exchange rate regime makes exogeneity of money questionable. Some support is found for the older monetarist view that lagged actual money growth has real effects. Our most surprising result is that U.S. M1 growth outperforms both U.K. M1 and sterling M3 as a determinant of U.K. real activity in the floating exchange rate period.

Linear theory and velocity correlations of clusters

Linear theory provides a reasonable description of the velocity correlations of biased tracers both perpendicular and parallel to the line of separation, provided one accounts for the fact that the measurement is almost always made using pair-weighted statistics. This introduces an additional term which, for sufficiently biased tracers, may be large. Previous work suggesting that linear theory was grossly in error for the components parallel to the line of separation ignored this term.Comment: 5 pages, 2 figures, MNRAS accepte

Dark Energy Constraints from Galaxy Cluster Peculiar Velocities

Future multifrequency microwave background experiments with arcminute resolution and micro-Kelvin temperature sensitivity will be able to detect the kinetic Sunyaev-Zeldovich (kSZ) effect, providing a way to measure radial peculiar velocities of massive galaxy clusters. We show that cluster peculiar velocities have the potential to constrain several dark energy parameters. We compare three velocity statistics (the distribution of radial velocities, the mean pairwise streaming velocity, and the velocity correlation function) and analyze the relative merits of these statistics in constraining dark energy parameters. Of the three statistics, mean pairwise streaming velocity provides constraints that are least sensitive to velocity errors: the constraints on parameters degrades only by a factor of two when the random error is increased from 100 to 500 km/s. We also compare cluster velocities with other dark energy probes proposed in the Dark Energy Task Force report. For cluster velocity measurements with realistic priors, the eventual constraints on the dark energy density, the dark energy equation of state and its evolution are comparable to constraints from supernovae measurements, and better than cluster counts and baryon acoustic oscillations; adding velocity to other dark energy probes improves constraints on the figure of merit by more than a factor of two. For upcoming Sunyaev-Zeldovich galaxy cluster surveys, even velocity measurements with errors as large as 1000 km/s will substantially improve the cosmological constraints compared to using the cluster number density alone.Comment: 25 pages, 10 figures. Results and conclusions unchanged. Minor changes to match the accepted version in Physical Review

Three-component U-Pu-Th fuel for plutonium irradiation in heavy water reactors

This paper discusses concepts for three-component fuel bundles containing plutonium, uranium and thorium for use in pressurised heavy water reactors, and cases for and against implementation of such a nuclear energy system in the United Kingdom. Heavy water reactors are used extensively in Canada, and are deploying within India and China, whilst the UK is considering the use of heavy water reactors to manage its plutonium inventory of 140 tonnes. The UK heavy water reactor proposal uses a mixed oxide (MOX) fuel of plutonium in depleted uranium, within the enhanced CANDU-6 (EC-6) reactor. This work proposes an alternative heterogeneous fuel concept based on the same reactor and CANFLEX fuel bundle, with eight large-diameter fuel elements loaded with natural thorium oxide and 35 small-diameter fuel elements loaded with a MOX of plutonium and reprocessed uranium stocks from UK MAGNOX and AGR reactors. Indicative neutronic calculations suggest that such a fuel would be neutronically feasible. A similar MOX may alternatively be fabricated from reprocessed <5% enriched light water reactor fuel, such as the fuel of the AREVA EPR reactor, to consume newly produced plutonium from reprocessing, similar to the DUPIC (direct use of PWR fuel in CANDU) process

Genome-Wide Characterization of the Phosphate Starvation Response in Schizosaccharomyces pombe

Background: Inorganic phosphate is an essential nutrient required by organisms for growth. During phosphate starvation, Saccharomyces cerevisiae activates the phosphate signal transduction (PHO) pathway, leading to expression of the secreted acid phosphatase, PHO5. The fission yeast, Schizosaccharomyces pombe, regulates expression of the ScPHO5 homolog (pho1+) via a non-orthologous PHO pathway involving genetically identified positive (pho7+) and negative (csk1+) regulators. The genes induced by phosphate limitation and the molecular mechanism by which pho7+ and csk1+ function are unknown. Here we use a combination of molecular biology, expression microarrays, and chromatin immunoprecipitation coupled with high-throughput sequencing (ChIP-Seq) to characterize the role of pho7+ and csk1+ in the PHO response. Results: We define the set of genes that comprise the initial response to phosphate starvation in S. pombe. We identify a conserved PHO response that contains the ScPHO5 (pho1+), ScPHO84 (SPBC8E4.01c), and ScGIT1 (SPBC1271.09) orthologs. We identify members of the Pho7 regulon and characterize Pho7 binding in response to phosphate-limitation and Csk1 activity. We demonstrate that activation of pho1+ requires Pho7 binding to a UAS in the pho1+ promoter and that Csk1 repression does not regulate Pho7 enrichment. Further, we find that Pho7-dependent activation is not limited to phosphate-starvation, as additional environmental stress response pathways require pho7+ for maximal induction. Conclusions: We provide a global analysis of the transcriptional response to phosphate limitation in S. pombe. Our results elucidate the conserved core regulon induced in response to phosphate starvation in this ascomycete distantly related to S. cerevisiae and provide a better understanding of flexibility in environmental stress response networks.Chemistry and Chemical BiologyMolecular and Cellular Biolog

Lessons learnt from the Tasmanian devil facial tumour regarding immune function in cancer

Genetic and genomic technologies have facilitated a greater understanding of the Tasmanian devil immune system and the origins, evolution and spread of devil facial tumour disease (DFTD). DFTD is a contagious cancer that has caused significant declines in devil populations across Tasmania. Immune responses to DFTD are rarely detected, allowing the cancer to pass between individuals and proliferate unimpeded. Early immunosenscence in devils appears to decrease anti-tumour immunity in older animals compared to younger animals, which may increase susceptibility to DFTD and explain high DFTD prevalence in this age group. Devils also have extremely low major histocompatibility complex (MHC) diversity, and multiple alleles are shared with the tumour, lowering histocompatibility barriers which may have contributed to DFTD evolution. DFTD actively evades immune attack by downregulating cell-surface MHC I molecules, making it effectively invisible to the immune system. Altered MHC I profiles should activate natural killer (NK) cell anti-tumour responses, but these are absent in DFTD infection. Recent immunization and immunotherapy using modified DFTD cells has induced an anti-DFTD immune response and regression of DFTD in some devils. Knowledge gained from immune responses to a transmissible cancer in devils will ultimately reveal useful insights into immunity to cancer in humans and other species

Diagnostic Communication in the Memory Clinic: a Conversation Analytic Perspective

Objectives: Whether and how patients should be told their dementia diagnosis, has been an area of much debate. While there is now recognition that early diagnosis is important for dementia care little research has looked at how dementia-related diagnostic information is actually verbally communicated. The limited previous research suggests that the absence of explicit terminology (e.g., use of the term Alzheimer's) is problematic. This paper interrogates this assumption through a conversation analysis of British naturalistic memory clinic interaction. Method: This paper is based on video-recordings of communication within a UK memory clinic. Appointments with 29 patients and accompanying persons were recorded, and the corpus was repeatedly listened to, in conjunction with the transcripts in order to identify the segments of talk where there was an action hearable as diagnostic delivery, that is where the clinician is evaluating the patient's condition. Results: Using a conversation analytic approach this analysis suggests that diagnostic communication, which is sensitive and responsive to the patient and their carers, is not predicated on the presence or absence of particular lexical choices. There is inherent complexity regarding dementia diagnosis, especially in the ‘early stages’, which is produced through and reflected in diagnostic talk in clinical encounters. Conclusion: In the context of continuity of dementia care, diagnostic information is communicated in a way that conforms to intersubjective norms of minimizing catastrophic reactions in medical communication, and is sensitive to problems associated with ‘insight’ in terms of delivery and receipt or non-receipt of diagnosis