186 research outputs found
Quasi-Newtonian dust cosmologies
Exact dynamical equations for a generic dust matter source field in a
cosmological context are formulated with respect to a non-comoving
Newtonian-like timelike reference congruence and investigated for internal
consistency. On the basis of a lapse function (the relativistic
acceleration scalar potential) which evolves along the reference congruence
according to (), we find that
consistency of the quasi-Newtonian dynamical equations is not attained at the
first derivative level. We then proceed to show that a self-consistent set can
be obtained by linearising the dynamical equations about a (non-comoving) FLRW
background. In this case, on properly accounting for the first-order momentum
density relating to the non-relativistic peculiar motion of the matter,
additional source terms arise in the evolution and constraint equations
describing small-amplitude energy density fluctuations that do not appear in
similar gravitational instability scenarios in the standard literature.Comment: 25 pages, LaTeX 2.09 (10pt), to appear in Classical and Quantum
Gravity, Vol. 15 (1998
The dynamics of cosmological perturbations in thermal theory
Using a recent thermal-field-theory approach to cosmological perturbations,
the exact solutions that were found for collisionless ultrarelativistic matter
are generalized to include the effects from weak self-interactions in a
model through order . This includes the effects
of a resummation of thermal masses and associated nonlocal gravitational
vertices, thus going far beyond classical kinetic theory. Explicit solutions
for all the scalar, vector, and tensor modes are obtained for a
radiation-dominated Einstein-de Sitter model containing a weakly interacting
scalar plasma with or without the admixture of an independent component of
perfect radiation fluid.Comment: 32 pages, REVTEX, 13 postscript figures included by epsf.st
Respiratory syncytial virus infection activates IL-13–producing group 2 innate lymphoid cells through thymic stromal lymphopoietin
BACKGROUND:
Respiratory syncytial virus (RSV) is a major health care burden with a particularly high worldwide morbidity and mortality rate among infants. Data suggest that severe RSV-associated illness is in part caused by immunopathology associated with a robust type 2 response.
OBJECTIVE:
We sought to determine the capacity of RSV infection to stimulate group 2 innate lymphoid cells (ILC2s) and the associated mechanism in a murine model.
METHODS:
Wild-type (WT) BALB/c, thymic stromal lymphopoietin receptor (TSLPR) knockout (KO), or WT mice receiving an anti-TSLP neutralizing antibody were infected with the RSV strain 01/2-20. During the first 4 to 6 days of infection, lungs were collected for evaluation of viral load, protein concentration, airway mucus, airway reactivity, or ILC2 numbers. Results were confirmed with 2 additional RSV clinical isolates, 12/11-19 and 12/12-6, with known human pathogenic potential.
RESULTS:
RSV induced a 3-fold increase in the number of IL-13-producing ILC2s at day 4 after infection, with a concurrent increase in total lung IL-13 levels. Both thymic stromal lymphopoietin (TSLP) and IL-33 levels were increased 12 hours after infection. TSLPR KO mice did not mount an IL-13-producing ILC2 response to RSV infection. Additionally, neutralization of TSLP significantly attenuated the RSV-induced IL-13-producing ILC2 response. TSLPR KO mice displayed reduced lung IL-13 protein levels, decreased airway mucus and reactivity, attenuated weight loss, and similar viral loads as WT mice. Both 12/11-19 and 12/12-6 similarly induced IL-13-producing ILC2s through a TSLP-dependent mechanism.
CONCLUSION:
These data demonstrate that multiple pathogenic strains of RSV induce IL-13-producing ILC2 proliferation and activation through a TSLP-dependent mechanism in a murine model and suggest the potential therapeutic targeting of TSLP during severe RSV infection
Clues from nearby galaxies to a better theory of cosmic evolution
The great advances in the network of cosmological tests show that the
relativistic Big Bang theory is a good description of our expanding universe.
But the properties of nearby galaxies that can be observed in greatest detail
suggest a still better theory would more rapidly gather matter into galaxies
and groups of galaxies. This happens in theoretical ideas now under discussion.Comment: published in Natur
Large Scale Structure of the Universe
Galaxies are not uniformly distributed in space. On large scales the Universe
displays coherent structure, with galaxies residing in groups and clusters on
scales of ~1-3 Mpc/h, which lie at the intersections of long filaments of
galaxies that are >10 Mpc/h in length. Vast regions of relatively empty space,
known as voids, contain very few galaxies and span the volume in between these
structures. This observed large scale structure depends both on cosmological
parameters and on the formation and evolution of galaxies. Using the two-point
correlation function, one can trace the dependence of large scale structure on
galaxy properties such as luminosity, color, stellar mass, and track its
evolution with redshift. Comparison of the observed galaxy clustering
signatures with dark matter simulations allows one to model and understand the
clustering of galaxies and their formation and evolution within their parent
dark matter halos. Clustering measurements can determine the parent dark matter
halo mass of a given galaxy population, connect observed galaxy populations at
different epochs, and constrain cosmological parameters and galaxy evolution
models. This chapter describes the methods used to measure the two-point
correlation function in both redshift and real space, presents the current
results of how the clustering amplitude depends on various galaxy properties,
and discusses quantitative measurements of the structures of voids and
filaments. The interpretation of these results with current theoretical models
is also presented.Comment: Invited contribution to be published in Vol. 8 of book "Planets,
Stars, and Stellar Systems", Springer, series editor T. D. Oswalt, volume
editor W. C. Keel, v2 includes additional references, updated to match
published versio
A cosmological constant from degenerate vacua
Under the hypothesis that the cosmological constant vanishes in the true
ground state with lowest possible energy density, we argue that the observed
small but finite vacuum-like energy density can be explained if we consider a
theory with two or more degenerate perturbative vacua, which are unstable due
to quantum tunneling, and if we still live in one of such states. An example is
given making use of the topological vacua in non-Abelian gauge theories.Comment: 8 pages, no figur
Laser-Plasma Interactions Enabled by Emerging Technologies
An overview from the past and an outlook for the future of fundamental
laser-plasma interactions research enabled by emerging laser systems
Adiabatic and entropy perturbations propagation in a bouncing Universe
By studying some bouncing universe models dominated by a specific class of
hydrodynamical fluids, we show that the primordial cosmological perturbations
may propagate smoothly through a general relativistic bounce. We also find that
the purely adiabatic modes, although almost always fruitfully investigated in
all other contexts in cosmology, are meaningless in the bounce or null energy
condition (NEC) violation cases since the entropy modes can never be neglected
in these situations: the adiabatic modes exhibit a fake divergence that is
compensated in the total Bardeen gravitational potential by inclusion of the
entropy perturbations.Comment: 25 pages, no figure, LaTe
Measuring our universe from galaxy redshift surveys
Galaxy redshift surveys have achieved significant progress over the last
couple of decades. Those surveys tell us in the most straightforward way what
our local universe looks like. While the galaxy distribution traces the bright
side of the universe, detailed quantitative analyses of the data have even
revealed the dark side of the universe dominated by non-baryonic dark matter as
well as more mysterious dark energy (or Einstein's cosmological constant). We
describe several methodologies of using galaxy redshift surveys as cosmological
probes, and then summarize the recent results from the existing surveys.
Finally we present our views on the future of redshift surveys in the era of
Precision Cosmology.Comment: 82 pages, 31 figures, invited review article published in Living
Reviews in Relativity, http://www.livingreviews.org/lrr-2004-
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