Patient Safety in Primary Health Care, Case Study of Cartaxo PrimaryCare Health Center

Worldwide we should achieve more efficient, clinically more effective and safer health care organizations, specially those in Primary Care (PC), where knowledge is less. For greater Patient Safety (PS) in PC Organizations, professionals are the key to ensure safety, with the involvement from Patient & Family. The goal is understand what Professionals Health Center Cartaxo Know and consequently incorporate PS in professional activity.What the PS know and consequently incorporate SD is little, it is carried out informally, not systematic, there is not enough information / training, much less routine routine of SD. Discrepancies in knowledge highlight crucial training vs information. The Cartaxo Health Center challenges are educational, structural and physical. Who integrates SD health care training (base / postgraduate, service) or Health Accreditation The knowledge about nature/impact and of adverse events is scarce (greater local reality than Primary Care) The Safety & Notification are not uniform, and used mainly in accredited units. The Safety Cultural is non-uniform in Functional Units (do not know differences). Is more difficult to notify about vacines at home. It is very important home context, family, informal caregivers.info:eu-repo/semantics/acceptedVersio

Learning Motion Primitives Automata for Autonomous Driving Applications

Motion planning methods often rely on libraries of primitives. The selection of primitives is then crucial for assuring feasible solutions and good performance within the motion planner. In the literature, the library is usually designed by either learning from demonstration, relying entirely on data, or by model-based approaches, with the advantage of exploiting the dynamical system’s property, e.g., symmetries. In this work, we propose a method combining data with a dynamical model to optimally select primitives. The library is designed based on primitives with highest occurrences within the data set, while Lie group symmetries from a model are analysed in the available data to allow for structure-exploiting primitives. We illustrate our technique in an autonomous driving application. Primitives are identified based on data from human driving, with the freedom to build libraries of different sizes as a parameter of choice. We also compare the extracted library with a custom selection of primitives regarding the performance of obtained solutions for a street layout based on a real-world scenario

Intervention of the Occupational Therapist in the Changes of the Occupational Performance of Newborn Pre-Term in Intensive Neonatal Therapy Unit

Poster apresentado no Annual Meeting 2020, Escola de Saúde de Coimbra.A newborn born less than 37 weeks gestational is considered a preterm newborn. In this sense, the occupational therapist who exhibits a holistic view about it, intends to enhance their occupational performance and improve their quality of life. To describe the performance of Occupational Therapy (OT) with the preterm newborn in Neonatal Intensive Care Units (NICUs), responding to the scarcity of information on the subject at the national level, and the need for occupational therapists in this context.The study uses as a method of data collection a semi-structured interview conducted to an occupational therapist that participates in a NICU in mainland Portugal and as a method of data analysis WebQDA software. It has a qualitative approach, it is a descriptive and exploratory study, taking into account the general objective, and it is assumed as a case study, by the technical procedures used. When identifying and analyzing the information related to the research question, we can affirm that during the interview the occupational therapist emphasized the intervention of OT in Sensory Modulation and Guidance to Caregivers of the Preterm Newborn.In order to optimize the whole intervention, and as a main conclusion, the importance of the caregivers participation in the OT intervention process is emphasized, which is done under the guidance of the therapist, making the approach of this professional indirect.info:eu-repo/semantics/acceptedVersio

The CWKB particle production and classical condensate in de Sitter spacetime

The complex time WKB approximation is an effective tool in studying particle production in curved spacetime. We use it in this work to understand the formation of classical condensate in expanding de Sitter spacetime. The CWKB leads to the emergence of thermal spectrum that depends crucially on horizons (as in de Sitter spacetime) or observer dependent horizons (as in Rindler spacetime). A connection is sought between the horizon and the formation of classical condensate. We concentrate on de Sitter spacetime and study the cosmological perturbation of $k=0$ mode with various values of $m/H_0$. We find that for a minimally coupled free scalar field for $m^2/H_0^2<2$, the one-mode occupation number grows more than unity soon after the physical wavelength of the mode crosses the Hubble radius and soon after diverges as $N(t)\sim O(1)[\lambda_{phys}(t)/{H_0^{-1}}]^{2\sqrt{\nu^2-1/4}}$, where $\nu\equiv (9/4 -m^2/{H_0^2})^{1/2}$. The results substantiates the previous works in this direction. We also find the correct oscillation and behaviour of $N(z)$ at small $z$ from a single expression using CWKB approximation for various values of $m/H_0$. We also discuss decoherence in relation to the formation of classical condensate. We also find that the squeezed state formalism and CWKB method give identical results.Comment: 19 pages, revtex, 5 figure

Oral Contraceptive Use and Clinical Outcomes in Patients with Multiple Sclerosis

Experimental and clinical data suggest a role of sex steroids in the pathogenesis of multiple sclerosis (MS). Scant information is available about the potential effect of oral contraceptive (OC) use on the prognosis of the disease. We aimed to evaluate this. The study population consisted of 132 women with relapsing-remitting MS before receiving disease modifying treatment and a mean disease duration 6.2 (SD 5.1) years. Three groups of patients were distinguished according to their OC behavior: [1] never-users, patients who never used OC [2] past-users, patients who stopped OC use before disease onset, and [3] after-users, those who used these drugs after disease onset. Multiple linear and logistic regression models were used to analyze the association between oral contraceptive use and annualized relapse rates, disability accumulation and severity of the disease. After-user patients had lower Expanded Disability Status Scale (EDSS) and Multiple Sclerosis Severity Score (MSSS) values than never users (p<0.001 and p=0.002, respectively) and past users (p=0.010 and p=0.002, respectively). These patients were also more likely to have a benign disease course (MSSS<2.5) than never and past users together (OR: 4.52, 95%CI: 2.13-9.56, p<0.001). This effect remained significant after adjustment for confounders, including smoking and childbirths (OR: 2.97, 95%CI: 1.24, 6.54, p=0.011 and for MSSS β: -1.04; 95% C.I. -1.78, -0.30, p=0.006). These results suggest that OC use in women with relapsing-remitting MS is possible associated with a milder disabling disease course

Squeezed States of the Generalized Minimum Uncertainty State for the Caldirola-Kanai Hamiltonian

We show that the ground state of the well-known pseudo-stationary states for the Caldirola-Kanai Hamiltonian is a generalized minimum uncertainty state, which has the minimum allowed uncertainty $\Delta q \Delta p = \hbar \sigma_0/2$, where $\sigma_0 (\geq 1)$ is a constant depending on the damping factor and natural frequency. The most general symmetric Gaussian states are obtained as the one-parameter squeezed states of the pseudo-stationary ground state. It is further shown that the coherent states of the pseudo-stationary ground state constitute another class of the generalized minimum uncertainty states.Comment: RevTex4, 9 pages, no fingure; to be published in Journal of Physics

Influence of Apolipoprotein E Plasma Levels and Tobacco Smoking on the Induction of Neutralising Antibodies to Interferon-Beta

Interferon-beta (IFN-beta) therapy for multiple sclerosis (MS) is associated with a potential for induction of neutralizing antibodies (NAbs). Because immune reactivity depends on changes in lipoprotein metabolism, we investigated whether plasma lipoprotein profiles could be associated with the development of NAbs. Thirty-one female MS patients treated with subcutaneously administered IFN-beta were included. Demographic and clinical characteristics were compared between NAbs response groups using t tests for continuous and logistic regression analysis and Fisher's exact tests for categorical data, respectively. Multivariate logistic regression was used to evaluate the effect of potential confounders. Patients who developed NAbs had lower apoE levels before treatment, 67 (47-74) mg/L median (interquartile range), and at the moment of NAb analysis, 53 (50-84) mg/L, in comparison to those who remained NAb-negative, 83 (68-107) mg/L, P = 0.03, and 76 (66-87) mg/L, P = 0.04, respectively. When adjusting for age and smoking for a one-standard deviation decrease in apoE levels, a 5.6-fold increase in the odds of becoming NAb-positive was detected: odds ratios (OR) 0.18 (95% CI 0.04-0.77), P = 0.04. When adjusting for apoE, smoking habit became associated with NAb induction: OR 5.6 (95% CI 1.3-87), P = 0.03. These results suggest that apoE-containing lipoprotein metabolism and, possibly, tobacco smoking may be associated with risk of NAb production in female MS patients treated with IFN-beta

Determinação de paclobutrazol em solo por cromatografia líquida de alta eficiência.

Este trabalho descreve um método para determinação de paclobutrazol em amostras de solo. A extração foi feita em metanol e as análises por cromatografia líquida de alta eficiência (CLAE), usando coluna de fase-reversa, C-18, fase móvel metanol/água 60:40, v/v, detecção e quantificação a 220 nm. Os seguintes parâmetros de validação foram obtidos: limite de detecção do método de 0,010 mg kg-1, limite de quantificação do método de 0,020 mg kg-1, linearidade de 0,100?5,00 mg L-1 (r2 ? 0,999); recuperação de 70 a 99%, precisão intermediária (%RSD) < 13%, para paclobutrazol. O método mostrou ser simples, eficiente e confiável para a determinação de resíduos de paclobutrazol em amostras de solo