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Current Research into Applications of Tomography for Fusion Diagnostics

Author: Abduallev S.
Abhangi M.
Abreu P.
Afzal M.
Aggarwal K. M.
Agostini F. Degli
Ahlgren T.
Ahn J. H.
Aho-Mantila L.
Aiba N.
Airila M.
Albanese R.
Aldred V.
Alegre D.
Alessi E.
Aleynikov P.
Alfier A.
Alkseev A.
Allinson M.
Alper B.
Alves E.
Ambrosino G.
Ambrosino R.
Amicucci L.
Amosov V.
Angelone M.
Anghel M.
Angioni C.
Appel L.
Appelbee C.
Arena P.
Ariola M.
Arnichand H.
Arshad S.
Asakura N. N.
Ash A.
Ashikawa N.
Aslanyan V.
Asunta O.
Auriemma F.
Austin Y.
Avotina L.
Axton M. D.
Ayres C.
Bacharis M.
Baciero A.
Baiao D.
Bailey S.
Baker A.
Balboa I.
Balden M.
Balshaw N.
Bament R.
Banks J. W.
Baranov Y. F.
Barnard M. A.
Barnes D.
Barnes M.
Barnsley R.
Baruzzo M.
Basiuk V.
Bassan M.
Bastow R.
Batista A.
Batistoni P.
Baughan R.
Bauvir B.
Baylor L.
Bazylev B.
Beal J.
Beaumont P. S.
Beckers M.
Beckett B.
Becoulet A.
Bekris N.
Beldishevski M.
Bell K.
Belli F.
Bellinger M.
Belonohy E.
Ben Ayed N.
Benterman N. A.
Bergsaker H.
Bernardo J.
Bernert M.
Berry M.
Bertalot L.
Besliu C.
Beurskens M.
Bieg B.
Bielecki J.
Biewer T.
Bigi M.
Bilkova P.
Binda F.
Bisoffi A.
Bizarro J. P. S.
Bjorkas C.
Blackburn J.
Blackman K.
Blackman T. R.
Blanchard P.
Blatchford P.
Bobkov V.
Boboc A.
Bodnar G.
Bogar O.
Bolshakova I.
Bolzonella T.
Bonanomi N.
Bonelli F.
Boom J.
Booth J.
Borba D.
Borodin D.
Borodkina I.
Botrugno A.
Bottereau C.
Boulting P.
Bourdelle C.
Bowden M.
Bower C.
Bowman C.
Boyce T.
Boyd C.
Boyer H. J.
Bradshaw J. M. A.
Braic V.
Bravanec R.
Breizman B.
Bremond S.
Brennan P. D.
Breton S.
Brett A.
Brezinsek S.
Bright M. D. J.
Brix M.
Broeckx W.
Brombin M.
Broslawski A.
Brown D. P. D.
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Bruno E.
Bucalossi J.
Buch J.
Buchanan J.
Buckley M. A.
Budny R.
Bufferand H.
Bulman M.
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Bunting P.
Buratti P.
Burckhart A.
Buscarino A.
Busse A.
Butler N. K.
Bykov I.
Byrne J.
Cahyna P.
Cal E. de la
Calabro G.
Calvo I.
Camenen Y.
Camp P.
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Cane J.
Cannas B.
Capel A. J.
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Dabirikhah H.
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Dankowski J.
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De Bock M.
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Viezzer E.
Villari S.
Villone F.
Vincenzi P.
Vinyar I.
Viola B.
Vitins A.
Vizvary Z.
Vlad M.
Voitsekhovitch I.
Vondracek P.
Vora N.
Vries P. de
Vu T.
Wakeling B.
Waldon C. W. F.
Walkden N.
Walker M.
Walker R.
Walsh M.
Wang E.
Wang N.
Warder S.
Warren R. J.
Waterhouse J.
Watkins N. W.
Watts C.
Wauters T.
Weckmann A.
Weiland J.
Weisen H.
Weiszflog M.
Wellstood C.
West A. T.
Wheatley M. R.
Whetham S.
Whitehead A. M.
Whitehead B. D.
Widdowson A. M.
Wiechec A. Baron
Wiesen S.
Wilkinson J.
Williams J.
Williams M.
Wilson A. R.
Wilson D. J.
Wilson H. R.
Wilson J.
Wischmeier M.
Withenshaw G.
Withycombe A.
Witts D. M.
Wood D.
Wood R.
Woodley C.
Wray S.
Wright J.
Wright J. C.
Wu J.
Wukitch S.
Wynn A.
Xu T.
Yadikin D.
Yanling W.
Yao L.
Yavorskij V.
Yoo M. G.
Young C.
Young D.
Young I. D.
Young R.
Zacks J.
Zagorski R.
Zaitsev F. S.
Zanino R.
Zarins A.
Zastrow K. D.
Zerbini M.
Zhang W.
Zhou Y.
Zilli E.
Zoita V.
Zoletnik S.
Zychor I.
Publication venue: Springer
Publication date: 22/05/2020
Field of study

Retrieving spatial distribution of plasma emissivity from line integrated measurements on tokamaks presents a challenging task due to ill-posedness of the tomography problem and limited number of the lines of sight. Modern methods of plasma tomography therefore implement a-priori information as well as constraints, in particular some form of penalisation of complexity. In this contribution, the current tomography methods under development (Tikhonov regularisation, Bayesian methods and neural networks) are briefly explained taking into account their potential for integration into the fusion reactor diagnostics. In particular, current development of the Minimum Fisher Regularisation method is exemplified with respect to real-time reconstruction capability, combination with spectral unfolding and other prospective tasks

KITopen

Canagliflozin and renal outcomes in type 2 diabetes and nephropathy

Author: A Kaldun Nossuli
Aamir Jamal
Adalbert Schiller
Adam Cheifetz
Adarsh Daswani
Adeera Levin
Adline Ghazi
Adrian Guinsburg
Adriana Cif
Adriana Gabriela Onaca
Adriana Ilavska
Adriana Villarino
Agarwal R.
Agnieszka Starzec
Ahmed Arif
Ahmed Awad
Aiping Yin
Akimichi Asano
Alan Jackson
Alan McMahon
Alan Perlman
Alberto Di Carlo
Alberto Esquenazi
Alejandra Oviedo
Alejandro Valdes Depeda
Aleksandra Kendereski
Alex Valenzuela
Alexander Dreval
Alexander Gonzalez
Alexander Shinkov
Alexander Turchin
Alexandre Klein
Alfonso Soto Gonzalez
Alfred Penfornis
Alfredo Chew Wong
Alfredo Wassermann
Ali Torshizi
Alicia Chilito
Alina Agafyina
Alison Dawson
Alva Hansraj
Amer Al-Karadsheh
Amorin Remus Popa
Amrendra Kumar
Amy Sprague
Ana Limos
Ana Maria Cusumano
Ana Maria Elosegui
Anabella Amigo
Anatoliy Kazmirchuk
Andrea Phillips
Andrea Stella
Andreas Maddux
Andrej Dzupina
Andres Alvarisqueta
Andrew Johnson
Andrew O'Shaughnessy
Andrew Steele
Andrian Yakov
Andrzej Januszewicz
Andrzej Madej
Angelina Angelova
Anibal Gastaldi
Anil Gupta
Anita Bhajan Manocha
Anjanette Tan
Anna Kaminska
Anna Maria Veronelli
Anna Strzelecka
Anna Zateyshchikova
Anselmo Bordonava
Antanas Navickas
Anthony Gunstone
Anthony Roberts
Antonio Ceriello
Antonio Galan Serrano
Antonio Scafuto Scotton
Antonio Terrelonge
Antônio Roberto Chacra
Anupama Gowda
Arjun D Sinha
Armando Perez
Ashot Mkrtumyan
Atanas Koundurdjiev
Augusto Vallejos
Aurelian-Emil Ranetti
Ayim Akyea-Djamson
Aysha Badat
Bakris G.
Baldev Singh
Barbara Greco
Barbara Kaczmarek
Barbara Rewerska
Barry M Brenner
Belia Martin Del Camp Blanco
Bernard Zinman
Bertrand Cariou
Bertrand Dussol
Bhasker Mehta
Bhimavarapu Sudhakar
Björn Paschen
Bompoint S.
Borys Mankovskyy
Botond Csiky
Boyan Nonchev
Brenner B. M.
Brett Kissela
Brian Nichol
Bruce Neal
Bruce Trippe
Bruno Geloneze Neto
Bull S.
Byung-Wan Lee
C B Keshavamurthy
Cannon C. P.
Capuano G.
Carlo Giorda
Carlos Alberto Cuneo
Carlos Arauz-Pacheco
Carlos Barrera
Carlos Perez
Carmel Hawley
Carmen Crisan
Carol Pollock
Carolyn Droste
Caroucel Chuateco
Caryl David
Cecilia Garcia Ballesteros
Cecilia Jimeno
Celso Amodeo
Cesar Javier Zaidman
Cesar Yoiti Hayashida
Chamberlain Obialo
Chang-Hsun Hsieh
Charles Cook
Charles Kaupke
Charytan D. M.
Chek Loong Loh
Chen Leia
Cheol-Young Park
Chih-Ching Lin
Christopher P Cannon
Christy Yao
Chu P. -L.
Chwen-Tzuei Chang
Chye Lee Gan
Clara Barrios
Claude Galphin
Claudia Goycoa
Claudia Moreira de Brito
Clodoaido Caringal
Cristian Serafinceanu
Cristina Toarba
Cristobal Morales Portillo
Csaba Kovesdy
Cynthia Bowman-Stroud
Cynthia Christiano
Cynthia Mustieles Rocha
Cyrus Desouza
Cássio Slompo Ramos
Dagmar Bartaskova
Dale Crawford Allison
Dalia Kozloviene
Dan Scharfstein
Dana Cosma
Daniel Coyne
Daniel Hiser
Daniel Kolansky
Daniel Panarotto
Daniel Pella
Daniel Weiner
Daniil Chizhov
Dariusz Sowinski
Darren K McGuire
Davesh Sennik
David C Wheeler
David Cherney 3rd
David Gorson
David Johnson
David M Charytan
David Packham
David Scott
David Wheeler
De Zeeuw D.
Debbie Cohen-Stein
Debbie Mascaro
Deepak Koppolu
Dennis Levinson
Derek Lewis
Detian Li
Devasmita Dev
Devesh Patel
Dewan Deepak
Dick de Zeeuw
Diego Aizenberg
Dinesh Jain
Dinesh Khullar
Diogo Belo
Dmitry Zateyshshikov
Domenico Santoro
Domingos d'Avila
Donald Brandon
Donald Fraser
Dong-Wan Chae
Dora Inés Molina de Salazar
Dorota Mlodawska-Choluj
Doru Negru
Edgar Arcos
Edoardo Mannucci
Eduardo Farias
Edward Watson
Edwards R.
Egle Gaupsiene
Egle Urbanaviciene
Ekaterina Velichkova
Elena Christofides
Elena Grineva
Elena Kolmakova
Elena Shutemova
Eleonora Harcsa
Elizabeth Barranco
Elizabeth Gelersztein
Elizabeth Kern
Elizete Keitel
Eloisa Tellez Chavez
Emanuela Orsi
Emil Martinka
Emyr Davies
Enrique Gonzalez
Eric Alamartine
Eric Hernandez Triana
Eric Thervet
Erick Turcios Juarez
Esteban Cercos
Eugenia Galindo-Ramos
Eva Peterfai
Evaly Chen
Evandro de Souza Portes
Evgueniy Vazelov
Fabian Otreras
Fabiana Loss de Carvalho Contieri
Fabio Malberti
Fadi Saba
Fadlo Fraige Filho
Favio Edmundo Enriquez Sosa
Fayzal Ahmed
Ferdinando Carlo Sasso
Fernanco Augusto Alves da Costa
Fernanda Cristina Camelo Sanches
Fernando Cereto Castro
Fernando Flores Lozano
Fernando Jimenez Florez
Fernando Krynski
Fernando M Edwin
Fernando Thomé
Fernando Trespalacios
Florence Santos
Florencia Kraft
Fracisco Javier Gonzalez Martinez
Fran Morren
Franciso Jose Tinahones Madueno
Frank Eder
Franklin Joseph
Franklin Paul Haase
Frantisek Saudek
François Dubé
François Madore
Freemu Varghese
Gabriela Cecilia Coloma
Gabriela Genova-Hristova
Gabriele von Ingersleben
Gaetano Serviddio
Galina Nagibovich
Gary Meininger
Gema Fernandez Fresnedo
Georg Plassmann
George Bakris
George Hon
George Newman
Gerald DaRoza
Gerald Keightley
Gerry Tan
Giacomo Garibotto
Giorgio Fuiano
Giovanni Frascà
Giovanni Gambaro
Giuseppe Derosa
Gizella Petro
Glenn Chertow
Gnyandev Patel
Godwin Simon
Goga Vukotic
Gopal Krishna
Grace Aquitania
Grace Lin
Graham Hillis
Graziano Di Cianni
Grazyna Orlowska-Kowalik
Grazyna Popenda
Greene T.
Greg Fulcher
Gregorio Obrador
Gregorio Obrador Vera
Grit Faulmann
Guadalupe Morales Franco
Guillermo Fragale
Guixia Wang
Gulam Latiff
Gustavo Cristian Greloni
Guy Chouinard
Gyongyi Csecsei
Gyorgy Paragh
Halyna Tomashkevych
Hans Prozesky
Harpreet Bajaj
Hasnain Khandwala
Hector Rodriguez
Heerspink H. J. L.
Helena Oosthuizen
Hendrik Nortje
Henry Watson
Hermann Haller
Hernan Finkelstein
Hernan Yupanqui
Hiddo J L Heerspink
Hiralal Maheshwari
Hiroko Oishi
Hiromi Aoki
Hiromi Rodriguez Pattzi
Hiroshi Kono
Hitoshi Akiyama
Holly Wang
Hong Mao
Hong Zhang
Hongguang Zheng
Hongli Lin
Horacio Sessa
Hugo Colombo
Hugo Laviada Molina
Hugo Roberto Kurtz Lisboa
Humberto Pavon
Hyuk-Sang Kwon
Iain MacDougall
Ian Fraser
Idalia Acosta
Ildiko Halmagyi
In-Kyung Jeong
Ines Bartolacci
Ingrid Abrahamsen
Ingrid Buganova
Inna Kolesnyk
Ioana Emilia Ferariu
Irene Noronha
Irina Glinkina
Irina Osipova
Iryna Dudar
Isabel Erika Rucker Joerg
Isabel Garcia
Isam Marar
Israel Hartman
Iuliia Komisarenko
Ivan Fushtey
Ivan Ory
Ivan Rychlik
Ivan Rychlík
Ivan Smirnov
Ivan Topchii
Ivan Villegas
Iveta Smatanova
Jaco Jurgens
Jakkidi Reddy
Jamal Hammoud
James Conway
James Januzzi
James Welker
Jan Culak
Jana Babikova
Jana Belobradkova
Jana Dzuponova
Janos Mucsi
Jardine M. J.
Jason Gaglia
Javier Narvarte
Javier Nieto Iglesias
Jayameena Peringat
Jayant Kumar
Jean Carlo Tibes Hachmann
Jean Welsh
Jean-Pierre Fauvel
Jeevren Reddy
Jeffrey Kropp
Jeffrey Stephens
Jeimeen Agra
Jelena Ignjatovic
Jesus Cuadrado
Jesus Egido de Los Rios
Jian Liu
Jiao Sun
Jinkui Yang
Jiri Lastuvka
Jiri Pumprla
Joaquin Pablo Gonzalez
Johannes Breedt
John Amerena
John Baker
John Ervin
John Evans
John Lentz
John Middleton
John Padron
John Sensenbrenner
John Updegrove
John Wakeling
Jonay Pantoja Perez
Jorge Archibaldo Glenny
Jorge Avendano
Jorge Ernesto Andres Diaz Ruiz
Jorge Hector Resk
Jorge Kusnir
Jorge Mordujovich
Jorgelina Sala
Jose Antonio Sánchez Arenales
Jose Chevaile Ramos
Jose David Gomez Rangel
Jose Esteban Jodar Gimeno
Jose Francisco Kerr Saraiva
Jose Hector Sanchez Mijangos
Jose L Górriz
Jose Luis Accini Mendoza
Jose Ma Portoles Perez
Jose Osvaldo Fretes
Jose Ricardo Correa Rotter
Joseph Abdallah
Joseph Aiello
Joseph Feuerstein
Joseph O'Hare
Joseph Proietto
Josier Nisnisan
José Vicente Sanchez Polo
João Lindolfo Cunha Borges
João Soares Felício
Juan Alfredo Tamayo Y Orozco
Juan Baas Cruz
Juan Carlos Santos
Juan Diego Higuera
Juan Frias
Juan Gonzalo Godoy Jorquera
Juan Pablo Albisu
Juan Pablo Moreira Diaz
Juan Peralta Calcaneo
Juan Rosas Guzman
Juan Villagordoa Mesa
JungEun Lee
Kamal Abouglila
Karel Peterka
Karina Hufert
Karlton Pettis
Katalin Keltai
Katalin Revesz
Katarina Halciakova
Katarina Lalic
Kathy Nicholls
Kati De Brouwer
Kazuhiro Yanagida
Kazunori Koyama
Kazuyuki Mizuyama
Kee Sing Ng
Kenneth Cohen
Kenneth Deck
Kenneth Hershon
Kenneth Liss
Kenneth W Mahaffey
Khalid Abdul Kadir
Khurram Wadud
Kim Travis
Kiril Hristozov
Kook-Hwan Oh
Krisztian Kiss
Kun Ho Yoon
Lachezar Lozanov
Lajos Major
Lalaine Delos Santos
Landman Lombard
Larisha Pillay-Ramaya
Larry Distiller
Larysa Pererva
Laszlo Deak
Laszlo Konyves
Laura Akright
Laura Coffee
Lawrence Distiller
Lawrence Lehrner
Lawrence Leiter
Lech Lazuka
Lee-Ming Chuang
Lenka Dohnalova
Leslie Spry
Levin A.
Li Yuan Lee
Lidia Bermudez
Ligia Petrica
Lilia Beatriz Schiavi
Liliana Monica Angelescu
Liliia Zub
Liliya Martynyuk
Lin Sun
Lincoln Chapin
Linong Ji
Lisa Rich
Liudmila Kvitkova
Lori Yost
Luca Chiovato
Luca De Nicola
Luca Zanoli
Lucas Rista
Luciane Mônica Deboni
Lucyna Hotlos
Ludger Rose
Luigi Gnudi
Luis Alberto Ramirez Roca
Luis Asmarats Mercadal
Luis David Abraira Munoz
Luis Enrique Herrera Jimenez
Luis Fernando Flota Cervera
Luis Henrique Canani
Luis Hernando Garcia Ortiz
Luis Isaias Juncos
Luis Quesada-Suarez
Luis Rodolfo Cartasegna
Luis Valderrama Cometa
Luis Venegas Carrillo
Luiz Alberto Andreotti Turatti
Luiza Despina Demian
László Rosivall
Ma Dovie Lallaine Ygpuara
Mahaffey K. W.
Manel Terns Riera
Manish Saxena
Manthi Hettiarachchi
Manuel Muñoz Lopez Mendoza
Manuel Muñoz Torres
Manuela Schmidt
Marc Rendell
Marcel Twahirwa
Marcelo Medina Fariña
Marcora Mandreoli
Marcus Gomes
Margarita Temelkova
Margarita Vejar
Margit Mileder
Margo Hudson
Maria Antonia Munar Vila
Maria Barnard
Maria Cecilia Cantero
Maria Florencia Fernandez
Maria Isabel Klyver
Maria Jaime
Maria Rosa Ulla
Maria Teresa Zanella
Maria Valdez
Marializa Bernardo
Marianna Zsom
Mario Alberto Berli
Mario Burgos Soto
Mark Davies
Mark Vannorsdall
Mark Warren
Markus Faghih
Marsha Tolentino
Marta Dominquez Lopez
Marta Molnar
Martin Lukac
Martin Valis
Martine Destree
Mary Anne Lim-Abrahan
Mary Lawrence
Mary Seeber
Maryna Vlasenko
María Alicia Fernández Montenegro
María Angustias Quesada Simón
Masahiko Takai
Masahiro Koizumi
Masakiyo Wakasugi
Masayo Yamada
Mastura Ismail
Matthew Abramowitz
Matthew Beacom
Meg J Jardine
Meg Jardine
Meininger G.
Melchor Alpizar Salazar
Melemadathil Sreelatha
Merce Perez Vera
Mercedes Velo Plaza
Michael Oliver
Michael Robinson
Michael Shanik
Michael Thompson
Michael Williams
Michal Nowicki
Michał Nowicki
Michelle Zaniewski-Singh
Mick Kumwenda
Miguel Nazzer Hissa
Migues Angel Reyes Rosano
Mihaela Biscoveanu
Mihaela-Magdalena Busegeanu
Mihaly Dudas
Milan Gupta
Min Jeong Kwon
Minara Shamkhalova
Minghui Zhao
Miodrag Djordjevic
Mircea Munteanu
Mitsuru Tsujimoto
Mohamed El-Shahawy
Mohamed Mookadam
Mohamed Railey
Mohamed Sekkarie
Mohanram Narayanan
Mohd Daud Che Yusof
Mohsen El Kossi
Mona Wahba
Monica Alexandra Terront Lozano
Monika Dhillon
Moogali Arvind
Moon-Kyu Lee
Moon-Suk Nam
Moustafa Moustafa
Muhammad Shakeel
Mukesh Joshi
Mykola Kolesnyk
Márcio Antônio Pereira
Nadia Zalunardo
Nadiya Tryshchuk
Nan Chen
Narayan Prasad
Naresh Aggarwal
Natalia Malaver
Nataliia Pashkovska
Natarajan Gopalakrishnan
Navdeep Tangri
Naveen Atray
Neal B.
Nebojsa Lalic
Neil Kumar
Nelson Kopyt
Nelson Rodriguez Papini
Nestor Horacio Garcia
Ngai Wah Cheung
Nicolae Hancu
Nicole Li
Nik Nur Fatnoon Nik Ahmad
Nina Patel
Nizar Daboul
Noble Gracious
Nomangesi Ngcakani
Nonna Kravchun
Nora Marchetta
Norman Muirhead
Norsiah Ali
Oleg Legun
Oleg Nagibovich
Oleg Uriasyev
Oleksandr Golovchenko
Oleksandr Samoylov
Oleksii Korzh
Olga Barbarash
Olga Barna
Olga Barysheva
Olga Benusova
Olga Godlevska
Olga Gyrina
Olga Sazonova
Olivert Gomez
Oomman Abraham
Osamu Tomonaga
Oscar Tarsicio Moreno Loza
Osvaldo Brusco
Pablo Antonio Novoa
Pablo Mele
Pablo Raffaele
Pablo Serrano Sanson
Paranthaman Vengadasalam
Patricia Del Carmen Gonzalez Colaso
Patrick English
Patrick Parfrey
Paul Ainsworth
Paul Frenk Baron
Paul Nixon
Paul Noonan
Paul Rheeder
Paulina Virginia Lanchiotti
Pavel Weiner
Peak Mann Mah
Pedro Calella
Pedro de Souza
Pedro Velasquez-Mieyer
Peggy Barnhill
Peggy Lin
Pere Alvarez Garcia
Perkovic V.
Peter Danos
Peter Fulop
Peter Van Buren
Peter Winocour
Petr Barton
Philip Gorelick
Philip Home
Philip Nicol
Philippe Zaoui
Phyllis August
Piermarco Piatti
Pierre Gourdy
Pierre-Jean Saulnier
Pietro Castellino
Pilar Trueba
Ping Tu
Pollock C.
Prasanth Surampudi
Pusadee Suchinda
Qinkai Chen
Rachel Bregman
Radica Alicic
Radu Jacob
Rafael Simo Canonge
Raied Abdullah
Rajendran Alappan
Rajiv Agarwal
Rajiv Ranjan
Raju Sree Bhushan
Rakesh Gulati
Rakhi Khanna
Rallabhandi Sankaram
Raman Purighalla
Ramesh Chandra Vyasam
Ramesh Thimmaiah
Ramon Berenguer
Ramon Moreda
Rangel Rangelov
Rao K Satyanarayana
Ravendran Govender
Ravi Sarin
Reddy Sreedhar
Reginald Parker
Rehan Symonds
Reinhold Jerwan-Keim
Remi Rabasa-Lhoret
Renan Montenegro Junior
Renata Bijata-Bronisz
Rhea Severina Comia
Rhonda Bentley-Lewis
Riad Darwish
Ricardo Alfonso Leon de la Fuente
Ricardo Dario Dran
Ricardo Rosero
Riccardo Bonadonna
Richard Ferkl
Richard Kovar
Richard Lindley
Richard Orozco Castellanos
Richard Solomon
Robert Busch
Robert Cohen
Robert Schreiman
Robert Takacs
Robert Walker
Roberto Abrão Raduan
Roberto Jorge da Silva Franco
Roberto Pecoits Filho
Roberto Pecoits-Filho
Roberto Simões de Almeida
Roberto Trevisan
Rodica-Ioana Avram
Rodolfo Andres Ahuad Guerrero
Rohana Abdul Ghani
Rohit Pankhaniya
Rolando Zamarripa Escobedo
Ronald Goldenberg
Ronald Harris
Ronald Watts
Ronaldo Arturo Gonzalez Orellana
Ronan Roussel
Ronnie Aronson
Rosa Isela Luna Ceballos
Rosângela Milagres
Ruben Dario Vargas Alonso
Rury Holman
Russell Scott
Sacha De Serres
Sahay Manisha
Saiful Shahrizal Bin Shudim
Sailaja Ventrapragada
Salah Abusnana
Salvatore De Cosmo
Sam Henein
Sam Philip
Samuel Cohen
Samuel Mujica Trenche
Samy Hadjadj
Sandor Keresztesi
Sandor Vangel
Sandra Berenice Saaveddra Sanchez
Sanjeev Rastogi
Sara Jaffer
Sarah Olelewe
Satoshi Ota
Satu Pesickova
Scott Kasner
Secundino Cigarran Guldris
Senan Sultan
Serge Cournoyer
Sergei Nedogoda
Sergey Vorobyev
Sergio Saul Irizar Santana
Shahabul Arfeen
Shahnaz Shahinfar
Shang-Jyh Hwang
Shelley Williams
Shenaz Ramtoola
Shenglian Gan
Sherry Sussman
Shizuo Kajiyama
Shozo Miyauchi
Silvia Ines Orio
Silvia Nicolai
Simon Davies
Simon Roger
Simon Young
Sin Gon Kim
Singhan Krishnan
Sini George
Slobodan Antic
Sohan Dua
Sonia Hermida
Soo Kun Lim
Sophie Borot
Souhila Ounadjela
Sreedhar Mandayam
Srikanth Bellary
Stanislav Zemek
Stanislaw Mazur
Stefan Dimitrov
Stephan Maxeiner
Stephen Grubb
Stephen Smith
Steven Fishbane
Stuart Handelsman
Suely Keiko Kohara
Sun Kim
Sun-Hee Park
Sunil Sheth
Susumu Kashine
Svetlana Goykhman
Svitlana D Bilyk
Swee Win Lam
Sylvia Rosas
Sylvia Shaw
Szilard Vasas
Sérgio Alberto Cunha Vêncio
Sérgio Yamada
Tadashi Iitsuka
Takamoto Kodera
Takashi Wada
Takayuki Watanabe
Tamara Malek Marin
Tamas Oroszlan
Tara Chang
Tareq Nassar
Tarissa Beatrice Zanata Petry
Tatiana Koroleva
Tatiana Morugova
Tatiana Raskina
Tatyana Zykova
Te-Lin Hsia
Terue Sakakibara
Tetiana Zlova
Tetsuji Niiya
Tetyana Pertseva
Tiago Schuch
Timothy Hall
Tom Christensen
Tom Greene
Tomas Drasnar
Tomas Smith Casabella
Tonatiu Diaz Escalante
Toshihiko Yanase
Toshio Kawada
Vadym Vizir
Vanassa Ratnasingam
Venessa Tsang
Venkata Behara
Vera Klokocnikova
Vera Krane
Veronica Anghel
Veselka Genadieva
Vesna Popovic-Radinovic
Viacheslav Marasaev
Victor Commendatore
Victor Saavedra Gajardo
Vijayaraman Arutchelvam
Viktor Margaritov
Viktor Zaviriukha
Viktoria Andreeva
Vimladhevi Govender
Vincent Pichette
Vincent Woo
Vira Tseluyko
Virginia Esther Visco
Vivek Sood
Vivekan Jha
Vladimir Dobronravov
Vladimir Khirmanov
Vladimir Tesar
Vlado Perkovic
Volker Burst
Volodymyr Botsyurko
Walter Guillermo Douthat
Walter Pharr
Wasim Hanif
Wataru Yumita
Wayne H-H Sheu
Wayne Turner
Wei Yen Kong
Weihong Song
Weiping Lu
Wendy Lane
Wenge Li
Wheeler D. C.
Wladmir Saporito
Xuemei Li
Xueqing Yu
Yamil Canaan
Yan Ren
Yannick Le Meur
Yaozhong Kong
Yasuro Kumeda
Yasushi Wakida
Yavin Y.
Yeong Hoon Kim
Yevgeniya Svyshchenko
Young Min Cho
Yulia Samoylova
Yung-Chuan Lu
Yuriy Mostovoy
Yuriy Shwartz
Yvette Ethel Yap
Zaynab Abejuela
Zdravko Kamenov
Zeid Khitan
Zhang H.
Zinman B.
Zishan Ali
Zuzana Ochodnicka
Ângela Regina Nazario Sabbag
Publication venue: 'Massachusetts Medical Society'
Publication date: 01/01/2019
Field of study

BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to <90 ml per minute per 1.73 m2 of body-surface area and albuminuria (ratio of albumin [mg] to creatinine [g], >300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of <15 ml per minute per 1.73 m2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P<0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P<0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years

Archivio Istituzionale della Ricerca- Università degli Studi di Foggia

Efeitos da inclusão de forragem de leucena (Leucaena leucocephala (Lam.) DeWit) na qualidade da silagem de milho (Zea mays L.)

Crossref

Measurements of electroweak W±Z boson pair production in association with two jets in pp collisions at √s = 13 TeV with the ATLAS detector

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Aakvaag E.
Abbott B.
Abdelhameed S.
Abeling K.
Abicht N. J.
Abidi S. H.
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Aboulhorma A.
Abramowicz H.
Abreu H.
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Acharya B. S.
Ackermann A.
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Affolder A. A.
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Agheorghiesei C.
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Ahuja S.
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Zhao H.
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Zhemchugov A.
Zheng J.
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Zhong D.
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Zhu Y.
Zhuang X.
Zhukov K.
Zimine N. I.
Zinsser J.
Ziolkowski M.
Zoccoli A.
Zoch K.
Zorbas T. G.
Zormpa O.
Zou W.
Zwalinski L.
Åkesson T. P. A.
Öncel Ö. O.
Ženiš T.
Živković L.
Publication venue: Springer
Publication date: 27/06/2024
Field of study

Measurements of integrated and differential cross-sections for electroweak W±Z production in association with two jets (W±Zjj) in proton-proton collisions are presented. The data collected by the ATLAS detector at the Large Hadron Collider from 2015 to 2018 at a centre-of-mass energy of √ s = 13 TeV are used, corresponding to an integrated luminosity of 140 fb−1 . The W±Zjj candidate events are reconstructed using leptonic decay modes of the gauge bosons. Events containing three identified leptons, either electrons or muons, and two jets are selected. Processes involving pure electroweak W±Zjj production at Born level are separated from W±Zjj production involving a strong coupling. The measured integrated fiducial cross-section of electroweak W±Zjj production per lepton flavour is σW Zjj−EW→ℓ ′ νℓℓjj = 0.368 ± 0.037 (stat.) ± 0.059 (syst.) ± 0.003 (lumi.) fb, where ℓ and ℓ ′ are either an electron or a muon. Respective cross-sections of electroweak and strong W±Zjj production are measured separately for events with exactly two jets or with more than two jets, and in three bins of the invariant mass of the two jets. The inclusive W±Zjj production cross-section, without separating electroweak and strong production, is also measured to be σW Zjj→ℓ ′ νℓℓjj = 1.462 ± 0.063 (stat.) ± 0.118 (syst.) ± 0.012 (lumi.) fb, per lepton flavour. The inclusive W±Zjj production cross-section is measured differentially for several kinematic observables. Finally, the measurements are used to constrain anomalous quartic gauge couplings by extracting 95% confidence level intervals on dimension-8 operators

Enlighten

Measurement of vector boson production cross sections and their ratios using pp collisions at √s = 13.6 TeV with the ATLAS detector

Author: Aad G.
Aakvaag E.
Abbott B.
Abdelhameed S.
Abeling K.
Abicht N.J.
Abidi S.H.
Aboelela M.
Aboulhorma A.
Abramowicz H.
Abreu H.
Abulaiti Y.
Acharya B.S.
Ackermann A.
Adam Bourdarios C.
Adamczyk L.
Addepalli S.V.
Addison M.J.
Adelman J.
Adiguzel A.
Adye T.
Affolder A.A.
Afik Y.
Agaras M.N.
Agarwala J.
Aggarwal A.
Agheorghiesei C.
Ahmad A.
Ahmadov F.
Ahmed W.S.
Ahuja S.
Ai X.
Aielli G.
Aikot A.
Ait Tamlihat M.
Aitbenchikh B.
Akbiyik M.
Akimov A.V.
Akiyama D.
Akolkar N.N.
Aktas S.
Al Khoury K.
Alberghi G.L.
Albert J.
Albicocco P.
Albouy G.L.
Alderweireldt S.
Alegria Z.L.
Aleksa M.
Aleksandrov I.N.
Alexa C.
Alexopoulos T.
Alfonsi F.
Algren M.
Alhroob M.
Ali B.
Ali H.M.J.
Ali S.
Alibocus S.W.
Aliev M.
Alimonti G.
Alkakhi W.
Allaire C.
Allbrooke B.M.M.
Allen J.F.
Allendes Flores C.A.
Allport P.P.
Aloisio A.
Alonso F.
Alpigiani C.
Alsolami Z.M.K.
Alvarez Estevez M.
Alvarez Fernandez A.
Alves Cardoso M.
Alviggi M.G.
Aly M.
Amaral Coutinho Y.
Ambler A.
Amelung C.
Amerl M.
Ames C.G.
Amidei D.
Amirie K.J.
Amor Dos Santos S.P.
Amos K.R.
An S.
Ananiev V.
Anastopoulos C.
Andeen T.
Anders J.K.
Andrean S.Y.
Andreazza A.
Angelidakis S.
Angerami A.
Anisenkov A.V.
Annovi A.
Antel C.
Antipov E.
Antonelli M.
Anulli F.
Aoki M.
Aoki T.
Aparo M.A.
Aperio Bella L.
Appelt C.
Apyan A.
Arbiol Val S.J.
Arcangeletti C.
Arce A.T.H.
Arena E.
Arguin J-F.
Argyropoulos S.
Arling J.-H.
Arnaez O.
Arnold H.
Artoni G.
Asada H.
Asai K.
Asai S.
Asbah N.A.
Assamagan K.
Astalos R.
Astrand K.S.V.
Atashi S.
Atkin R.J.
Atkinson M.
Atmani H.
Atmasiddha P.A.
Augsten K.
Auricchio S.
Auriol A.D.
Austrup V.A.
Avolio G.
Axiotis K.
Azuelos G.
Babal D.
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Backman F.
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Baer T.M.
Bagnaia P.
Bahmani M.
Bahner D.
Bai K.
Baines J.T.
Baines L.
Baker O.K.
Bakos E.
Bakshi Gupta D.
Balakrishnan V.
Balasubramanian R.
Baldin E.M.
Balek P.
Ballabene E.
Balli F.
Baltes L.M.
Balunas W.K.
Balz J.
Bamwidhi I.
Banas E.
Bandieramonte M.
Bandyopadhyay A.
Bansal S.
Barak L.
Barakat M.
Barberio E.L.
Barberis D.
Barbero M.
Barel M.Z.
Barends K.N.
Barillari T.
Barisits M-S.
Barklow T.
Baron Moreno D.A.
Baron P.
Baroncelli A.
Barone G.
Barr A.J.
Barr J.D.
Barreiro Guimarães da Costa J.
Barreiro F.
Barron U.
Barros Teixeira M.G.
Barsov S.
Bartels F.
Bartoldus R.
Barton A.E.
Bartos P.
Basan A.
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Basso M.J.
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Batool B.
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Publication venue: Elsevier
Publication date: 01/07/2024
Field of study

Abstract available from publisher's website

Enlighten

Beam-induced backgrounds measured in the ATLAS detector during local gas injection into the LHC beam vacuum

Author: Aad G.
Aakvaag E.
Abbott B.
Abdelhameed S.
Abeling K.
Abicht N.J.
Abidi S.H.
Aboelela M.
Aboulhorma A.
Abramowicz H.
Abreu H.
Abulaiti Y.
Acharya B.S.
Ackermann A.
Adam Bourdarios C.
Adamczyk L.
Addepalli S.V.
Addison M.J.
Adelman J.
Adiguzel A.
Ady M.
Adye T.
Affolder A.A.
Afik Y.
Agaras M.N.
Agarwala J.
Aggarwal A.
Agheorghiesei C.
Ahmadov F.
Ahmed W.S.
Ahuja S.
Ai X.
Aielli G.
Aikot A.
Ait Tamlihat M.
Aitbenchikh B.
Akbiyik M.
Akimov A.V.
Akiyama D.
Akolkar N.N.
Aktas S.
Al Khoury K.
Alberghi G.L.
Albert J.
Albicocco P.
Albouy G.L.
Alderweireldt S.
Alegria Z.L.
Aleksa M.
Aleksandrov I.N.
Alexa C.
Alexopoulos T.
Alfonsi F.
Algren M.
Alhroob M.
Ali B.
Ali H.M.J.
Ali S.
Alibocus S.W.
Aliev M.
Alimonti G.
Alkakhi W.
Allaire C.
Allbrooke B.M.M.
Allen J.F.
Allendes Flores C.A.
Allport P.P.
Aloisio A.
Alonso F.
Alpigiani C.
Alsolami Z.M.K.
Alvarez Estevez M.
Alvarez Fernandez A.
Alves Cardoso M.
Alviggi M.G.
Aly M.
Amaral Coutinho Y.
Ambler A.
Amelung C.
Amerl M.
Ames C.G.
Amidei D.
Amirie K.J.
Amor Dos Santos S.P.
Amos K.R.
An S.
Ananiev V.
Anastopoulos C.
Andeen T.
Anders J.K.
Anderson A.C.
Andrean S.Y.
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Yan J.
Yan S.
Yan Z.
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Yang H.T.
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Yang X.
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Yao W-M.
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Yeh Y.
Yeletskikh I.
Yeo B.K.
Yexley M.R.
Yildirim T.P.
Yin P.
Yorita K.
Younas S.
Young C.
Young C.J.S.
Yu C.
Yu Y.
Yuan J.
Yuan M.
Yuan R.
Yue L.
Zaazoua M.
Zabinski B.
Zaid E.
Zak Z.K.
Zakareishvili T.
Zambito S.
Zamora Saa J.A.
Zang J.
Zanzi D.
Zaplatilek O.
Zeitnitz C.
Zeng H.
Zeng J.C.
Zenger Jr D.T.
Zenin O.
Zenz S.
Zerradi S.
Zerwas D.
Zhai M.
Zhang D.F.
Zhang J.
Zhang J.
Zhang K.
Zhang L.
Zhang L.
Zhang P.
Zhang R.
Zhang S.
Zhang S.
Zhang T.
Zhang X.
Zhang X.
Zhang Y.
Zhang Y.
Zhang Y.
Zhang Z.
Zhang Z.
Zhang Z.
Zhao H.
Zhao T.
Zhao Y.
Zhao Z.
Zhao Z.
Zhemchugov A.
Zheng J.
Zheng K.
Zheng X.
Zheng Z.
Zhong D.
Zhou B.
Zhou H.
Zhou N.
Zhou Y.
Zhou Y.
Zhou Y.
Zhu C.G.
Zhu J.
Zhu X.
Zhu Y.
Zhu Y.
Zhuang X.
Zhukov K.
Zimine N.I.
Zinsser J.
Ziolkowski M.
Zoccoli A.
Zoch K.
Zorbas T.G.
Zormpa O.
Zou W.
Zwalinski L.
Åkesson T.P.A.
Öncel Ö.O.
Ženiš T.
Živković L.
Publication venue: IOP Publishing
Publication date: 01/06/2024
Field of study

Inelastic beam-gas collisions at the Large Hadron Collider (LHC), within a few hundred metres of the ATLAS experiment, are known to give the dominant contribution to beam backgrounds. These are monitored by ATLAS with a dedicated Beam Conditions Monitor (BCM) and with the rate of fake jets in the calorimeters. These two methods are complementary since the BCM probes backgrounds just around the beam pipe while fake jets are observed at radii of up to several metres. In order to quantify the correlation between the residual gas density in the LHC beam vacuum and the experimental backgrounds recorded by ATLAS, several dedicated tests were performed during LHC Run 2. Local pressure bumps, with a gas density several orders of magnitude higher than during normal operation, were introduced at different locations. The changes of beam-related backgrounds, seen in ATLAS, are correlated with the local pressure variation. In addition the rates of beam-gas events are estimated from the pressure measurements and pressure bump profiles obtained from calculations. Using these rates, the efficiency of the ATLAS beam background monitors to detect beam-gas events is derived as a function of distance from the interaction point. These efficiencies and characteristic distributions of fake jets from the beam backgrounds are found to be in good agreement with results of beam-gas simulations performed with theFluka Monte Carlo programme

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Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK.

Author: Aban Marites
Abayomi Fatola
Abeyskera Kushala
Aboagye Jeremy
Adam Matthew
Adams Kirsty
Adamson James
Adelaja Yemi A.
Adlou Syed
Ahmed Khatija
Akhalwaya Saajida
Akhalwaya Yasmeen
Alcock Andrew
Aley Parvinder K.
Ali Aabidah
Allen Elizabeth R.
Allen Lauren
Almeida Thamires C. D. S. C
Alves Mariana P.S.
Amorim Fabio
Andritsou Foteini
Angus Brian
Anslow Rachel
Appleby Matthew
Arbe-Barnes Edward H.
Ariaans Mark P.
Arns Beatriz
Arruda Laiana
Awedetan Gbadebo
Azi Lorena
Azi Paula
Babbage Gavin
Bailey Catherine
Baillie Vicky L.
Baker Kenneth F.
Baker Megan
Baker Natalie
Baker Philip
Baldwin Lisa
Baleanu Ioana
Bandeira Danieli
Bara Anna
Barbosa Marcella A.S.
Barker Debbie
Barlow Gavin D.
Barnabas Shaun L.
Barnes Eleanor
Barr Andrew S.
Barrett Jessica
Barrett Jordan R.
Bates Louise
Batten Alexander
Beadon Kirsten
Beales Emily
Beckley Rebecca
Belij-Rammerstorfer Sandra
Bell Jonathan
Bellamy Duncan
Bellei Nancy
Belton Sue
Berg Adam
Bermejo Laura
Berrie Eleanor
Berry Lisa
Berzenyi Daniella
Beveridge Amy
Bewley Kevin R.
Bexhell Helen
Bhikha Sutika
Bhorat Asad E.
Bhorat Qasim E.
Bhorat Zaheda E.
Bibi Sagida
Bijker Else
Birch Geeta
Birch Sarah
Bird Adam
Bird Olivia
Bisnauthsing Karen
Bittaye Mustapha
Blackstone Katherine
Blackwell Luke
Bletchly Heather
Blundell Caitlin L.
Blundell Susannah R.
Bodalia Pritesh
Boettger Bruno C.
Bolam Emma
Boland Elena
Bormans Daan
Borthwick Nicola
Bowring Francesca
Boyd Amy
Bradley Penny
Brenner Tanja
Briner Carmen
Brown Claire
Brown Phillip
Brown-O'Sullivan Charlie
Bruce Scott
Brunt Emily
Buchan Ruaridh
Budd William
Bulbulia Yusuf A.
Bull Melanie
Burbage Jamie
Burhan Hassan
Burn Aileen
Buttigieg Karen R.
Byard Nicholas
Cabera Puig Ingrid
Calderon Gloria
Calvert Anna
Camara Susana
Cao Michelangelo
Cappuccini Federica
Cardoso João R.
Carr Melanie
Carroll Miles W.
Carson-Stevens Andrew
Carvalho José A.M.
Carvalho Yasmin de M.
Casey Helen R.
Cashen Paul
Castro Lucia Carratala
Castro Thais
Cathie Katrina
Cavey Ana
Cerbino-Neto José
Chadwick Jim
Chapman David
Charlton Sue
Chelysheva Irina
Chester Oliver
Chita Sunder
Cho Jee-Sun
Cicconi Paola
Cifuentes Liliana
Clark Elizabeth
Clark Matthew
Clarke Andrea
Clemens Sue Ann Costa
Clutterbuck Elizabeth A.
Colin-Jones Rachel
Collins Andrea M.
Collins Sarah L.K.
Conlon Christopher P.
Connarty Sean
Coombes Naomi
Cooper Cushla
Cooper Rachel
Cornelissen Lynne
Corrah Tumena
Cosgrove Catherine
Cox Tony
Crocker Wendy E.M.
Crosbie Sarah
Cullen Dan
Cullen Lorraine
Cunha Debora R.M.F.
Cunningham Christina
Cuthbertson Fiona C.
Cutland Clare L.
Da Guarda Suzete N. Farias
da Silva Moraes Antonio Carlos
da Silva Larissa P.
Damratoski Brad E.
Danos Zsofia
Dantas Maria T.D.C.
Darroch Paula
Darton Thomas C.
Datoo Mehreen S.
Datta Chandrabali
Davids Malika
Davies Hannah
Davies Sarah L.
Davis Elizabeth
Davis John
Davis Judith
De Jager Jeanne
De Nobrega Maristela M.D.
De Oliveira Kalid Lis Moreno
Dearlove David
Demissie Tesfaye
Desai Amisha
Dheda Keertan
Di Marco Stefania
Di Maso Claudio
Dinelli Maria I.S.
Dinesh Tanya
Docksey Claire
Dold Christina
Dong Tao
Donnellan Francesca R.
Dos Santos Erika Pachecho
Dos Santos Tannyth
dos Santos Thainá G.
Douglas Alexander D.
Douglas Naomi
Downing Charlotte
Drake Jonathan
Drake-Brockman Rachael
Driver Kimberley
Drury Ruth
Du Plessis Joan
Dunachie Susanna J.
Duncan Christopher J. A.
Durham Benjamin S.
Dutra Lidiana
Easom Nicholas J.W.
Edwards Mandy
Edwards Nick J.
El Muhanna Omar M.
Elias Sean C.
Elmore Mike
Emary Katherine R. W.
English Marcus
Esmail Alisgair
Essack Yakub Moosa
Ewer Katie J.
Fairlie Lee
Farmer Eoghan
Farooq Mutjaba
Farrar Madi
Farrugia Leonard
Faulkner Beverley
Faust Saul N.
Fedosyuk Sofiya
Felle Sally
Feng Shuo
Feng Shuo
Ferreira Da Silva Carla
Ferreira Daniela M.
Field Samantha
Finn Adam
Fisher Richard
Flaxman Amy
Fletcher James
Fofie Hazel
Fok Henry
Folegatti Pedro M.
Ford Karen J.
Fowler Jamie
Fraiman Pedro H.A.
Francis Emma
Franco Marilia M.
Frater John
Freire Marilúcia S.M.
Fry Samantha H.
Fudge Sabrina
Furze Julie
Fuskova Michelle
Galian-Rubio Pablo
Galiza Eva
Garlant Harriet
Gavrila Madita
Geddes Ailsa
Gibbons Karyna A.
Gilbert Sarah C
Gilbride Ciaran
Gill Hardeep
Glynn Sharon
Godwin Kerry
Gokani Karishma
Goldoni Ursula Carvalho
Goncalves Maria
Gonzalez Isabela G.S.
Goodman Anna L.
Goodwin Jayne
Goondiwala Amina
Gordon-Quayle Katherine
Gorini Giacomo
Grab Janet
Gracie Lara
Green Catherine M.
Green Christopher A.
Greenland Melanie
Greenwood Nicola
Greffrath Johann
Groenewald Marisa M.
Grossi Leonardo
Gupta Gaurav
Hackett Mark
Hallis Bassam
Hamaluba Mainga
Hamilton Elizabeth
Hammersley Daniel
Hanrath Aidan T.
Hanumunthadu Brama
Harris Clair
Harris Stephanie A.
Harris Tara
Harrison Daisy
Harrison Thomas D.
Hart Thomas C.
Hartnell Birgit
Hassan Shadin
Haughney John
Hawkins Sophia
Hay Jodie
Head Ian
Heath Paul T.
Henry John
Hermosin Herrera Macarena
Hettle David B.
Hill Adrian V. S.
Hill Catherine
Hill Helen
Hill Jennifer
Hirsch Ian
Hodges Gina
Hodgson Susanne H. C.
Horne Elizea
Hou Mimi M.
Houlihan Catherine
Howe Elizabeth
Howell Nicola
Humphreys Jonathan
Humphries Holly E.
Hurley Katrina
Huson Claire
Hyamns Catherine
Hyder-Wright Angela
Ikram Sabina
Ishwarbhai Alka
Ivan Monica
Iveson Poppy
Iyer Vidyashankara
Izu Alane
Jackson Frederic
Jackson Susan
Jaumdally Shameem
Jeffers Helen
Jenkin Daniel
Jesudason Natasha
Joe Carina C. D.
Jones Bryony
Jones Christopher
Jones Elizabeth
Jones Kathryn
Jorge Marianna Rocha
Jose Aylin
Joshi Amar
Júnior Eduardo A.M.S.
Kadziola Joanne
Kailath Reshma
Kana Faeeza
Karampatsas Konstantinos
Kasanyinga Mwila
Keen Jade
Kelly Dearbhla M.
Kelly Debbie
Kelly Elizabeth J.
Kelly Sarah
Kerr David
Kerridge Simon
Kfouri Renato de Ávila
Khan Liaquat
Khozoee Baktash
Kidd Sarah
Killen Annabel
Kinch Jasmin
Kinch Patrick
King Lloyd D.W.
King Thomas B.
Kingham Lucy
Klenerman Paul
Knapper Francesca
Knight Julian C.
Knott Daniel
Koen Anthonet
Koleva Stanislava
Kwatra Gaurav
Lambe Teresa
Lang Gail
Lang Matilda
Larkworthy Colin W.
Larwood Jessica P.J.
Law Rebecca
Lawrie Alison M.
Lazarus Erica M.
Lazarus Rajeka
Leach Amanda
Lees Emily A.
Lelliott Alice
Lemm Nana-Marie
Lessa Alvaro
Leung Stephanie
Li Yuanyuan
Lias Amelia M.
Liatsikos Kostas
Libri Vincenzo
Lillie Patrick J.
Linder Aline
Lipworth Samuel
Liu Shuchang
Liu Xinxue
Lloyd Adam
Lloyd Stephanie
Loew Lisa
Lopez Ramon Raquel
Lora Leandro
Lowthorpe Vicki
Luz Kleber
MacDonald Jonathan C.
MacGregor Gordon
Madhavan Meera
Madhi Shabir A.
Mainwaring David O.
Makambwa Edson
Makinson Rebecca
Malahleha Mookho
Malamatsho Ross
Mallett Garry
Mallory Raburn
Mansatta Kushal
Maoko Takalani
Mapetla Katlego
Marchevsky Natalie G.
Marinou Spyridoula
Marlow Emma
Marques Gabriela N.
Marriott Paula
Marshall Julia L.
Marshall Richard P.
Martins Flávia J.
Masenya Masebole
Masilela Mduduzi
Masters Shauna K.
Mathew Moncy
Matlebjane Hosea
Matshidiso Kedidimetse
Mazur Olga
Mazzella Andrea
McCaughan Hugh
McEwan Joanne
McGlashan Joanna
McGregor Alastair
McInroy Lorna
McIntyre Zoe
McLenaghan Daniela
McRobert Nicky
McSwiggan Steve
Megson Clare
Mehdipour Savviz
Meijs Wilma
Mendes Ana V .A.
Mendonça Renata N.Á.
Mentzer Alexander J.
Milan Eveline P.
Minassian Angela M.
Mirtorabi Neginsadat
Mitton Celia
Mnyakeni Sibusiso
Moghaddas Fiona
Molapo Kgaogelo
Moloi Mapule
Moore Maria
Moraes-Pinto M. Isabel
Moran Marni
Morey Ella
Morgans Róisín
Morris Helen C.
Morris Sheila
Morris Susan
Morrison Hazel
Morselli Franca
Morshead Gertraud
Morter Richard
Mottal Lynelle
Moultrie Andrew
Moya Nathifa
Mpelembue Mushiya
Msomi Sibekezelo
Mugodi Yvonne
Mujadidi Yama F.
Mukhopadhyay Ekta
Muller Jilly
Munro Alasdair
Munro Claire
Murphy Sarah
Mweu Philomena
Myasaki Celia Hatsuko
Naik Gurudutt
Naker Kush
Nana Anusha
Nastouli Eleni
Nazir Abida
Ndlovu Bongani
Neffa Fabio
Njenga Cecilia
Noal Helena
Novaes Gabrielle
Noé Andrés
Nugent Fay L.
Nunes Géssika
O'Brien Katie
O'Connor Daniel
O'Reilly Paula
O'Reilly Peter J.
Odam Miranda
Oelofse Suzette
Oguti Blanche
Olchawski Victoria
Oldfield Neil J.
Oliveira Catarina
Oliveira Marianne G.
Oosthuizen Angela
Osborne Piper
Owen David R.J.
Owen Lydia
Owens Daniel
Owino Nelly
Pacurar Mihaela
Padayachee Sherman D.
Paiva Brenda V.B.
Palhares Edna M.F.
Palmer Susan
Parkinson Sivapriyai
Parracho Helena M.R.T.
Parsons Karen
Patel Bhumika
Patel Dipak
Patel Faeezah
Patel Kelly
Patrick-Smith Maia
Payne Ruth O.
Peng Yanchun
Penn Elizabeth J.
Pennington Anna
Peralta Alvarez Marco Polo
Perring James
Perry Nicola
Perumal Rubeshan
Petkar Sahir
Philip Tricia
Phillips Daniel J.
Phillips Jennifer
Phohu Mary Kgomotso
Pickup Lorinda
Pieterse Sonja
Piper Jo
Pipini Dimitra
Pittella Ana
Plank Mary
Plested Emma
Pollard Andrew J
Pollard Samuel
Pollock Katrina M.
Pooley Jennifer
Pooran Anil
Poulton Ian
Powers Claire
Presa Fernando B.
Price David A.
Price Vivien
Primeira Marcelo
Proud Pamela C.
Provstgaard-Morys Samuel
Pueschel Sophie
Pulido David
Quaid Sheena
Rabara Ria
Radford Alexandra
Radia Kajal
Rajapaska Durga
Rajeswaran Thurkka
Ramasamy Maheshi N.
Ramos Lopez Fernando
Ramos Alberto San Francisco
Rampling Tommy
Rand Jade
Ratcliffe Helen
Rawlinson Tom
Rea David
Rees Byron
Reiné Jesús
Resuello-Dauti Mila
Reyes Pabon Emilia
Rhead Sarah
Ribiero Carla M.
Ricamara Marivic
Richter Alex
Ritchie Adam J.
Ritchie Neil
Robbins Alexander J.
Roberts Hannah
Robinson Hannah
Robinson Ryan E.
Rocchetti Talita T.
Rocha Beatriz Pinho
Roche Sophie
Rollier Christine
Rose Louisa
Ross Russell Amy L.
Rossouw Lindie
Royal Simon
Rudiansyah Indra
Ruiz Sarah
Saich Stephen
Sala Claudia
Sale Jessica
Salman Ahmed M.
Salvador Natalia
Salvador Stephannie
Sampaio Milla
Samson Annette D.
Sanchez-Gonzalez Amada
Sanders Helen
Sanders Katherine
Santos Guerra Mayara F.S.
Santos Erika
Satti Iman
Saunders Caroline
Saunders Jack E.
Sayed Aakifah
Schim van der Loeff Ina
Schmid Annina B.
Schofield Ella
Schwarzbold Alexandre V.
Screaton Gavin
Seddiqi Samiullah
Segireddy Rameswara R.
Senger Roberta
Serrano Sonia
Shah Rajiv
Shaik Imam
Sharpe Hannah E.
Sharrocks Katherine
Shaw Robert
Shea Adam
Shepherd Amy
Shepherd James G.
Shiham Farah
Sidhom Emad
Silk Sarah E.
Silva-Junior Gilberto
Silva-Reyes Laura
Silveira Anderson D.
Silveira Mariana B.V.
Singh Nisha
Sinha Jaisi
Skelly Donal T.
Smith Andrew
Smith Catherine C.
Smith Daniel C.
Smith David J.
Smith Holly E.
Smith Nick
Snape Matthew D.
Soares Airanuédida
Soares Tiago
Solórzano Carla
Song Rinn
Sorio Guilherme L.
Sorley Kim
Sosa-Rodriguez Tiffany
Souza Alessandra R.
Souza Bruno S.D.F.
Souza Cinthia M.C.D.L.
Spencer Alexandra J.
Spina Fernanda
Spoors Louise
Sprinz Eduardo
Stafford Lizzie
Stamford Imogen
Starinskij Igor
Stein Ricardo
Steven Jill
Stockdale Lisa
Stockwell Lisa V.
Strickland Louise H.
Stuart Arabella C.
Sturdy Ann
Sutherland Rebecca K.
Sutton Natalina
Szigeti Anna
Tahiri-Alaoui Abdessamad
Tanner Rachel
Taoushanis Carol
Tarr Alexander W.
Tarrant Richard
Taylor Iona Jennifer
Taylor Justin
Taylor Keja
Taylor Ursula
te Water Naude Rebecca
Themistocleous Andreas
Themistocleous Yrene
Thomas Kelly
Thomas Merin
Thomas Tonia M.
Thombrayil Asha
Thompson Amber
Thompson Ameeka
Thompson Fawziyah
Thompson Kevin
Thomson Emma C.
Thomson Julia
Thornton-Jones Viv
Tighe Patrick J.
Tinoco Lygia Accioly
Tiongson Gerlynn
Tladinyane Bonolo
Tomasicchio Michele
Tomic Adriana
Tonks Susan
Toshner Mark
Tran Nguyen
Tree Julia
Trillana Gerry
Trinham Charlotte
Trivett Rose
Truby Adam
Tsheko Betty Lebogang
Turabi Aadil
Turner Cheryl
Turner David P. J.
Turner Richard
Török M Estée
Ulaszewska Marta
Underwood Benjamin R.
van Eck Samual
Varughese Rachel
Vekemans Johan
Verbart Dennis
Verheul Marije
Vichos Iason
Vieira Taiane
Villafana Tonya L.
Voysey Merryn
Waddington Claire S.
Walker Laura
Wallis Erica
Wand Matthew
Warbick Deborah
Wardell Theresa
Warimwe George
Warren Sarah C.
Watkins Bridget
Watson Ekaterina
Watson Marion E. E.
Webb Stewart
Webb-Bridges Alice
Webster Angela
Weckx Lily Y.
Welch Jessica
Wells Jeanette
West Alison
White Caroline
White Rachel
Williams Christopher J.
Williams Paul
Williams Rachel L.
Winslow Rebecca
Woodyer Mark
Worth Andrew T.
Wright Danny
Wroblewska Marzena
Yao Andy
Zimmer Rafael
Zizi Dalila
Zuidewind Peter
Publication venue: 'Elsevier BV'
Publication date: 03/12/2020
Field of study

BACKGROUND: A safe and efficacious vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), if deployed with high coverage, could contribute to the control of the COVID-19 pandemic. We evaluated the safety and efficacy of the ChAdOx1 nCoV-19 vaccine in a pooled interim analysis of four trials. METHODS: This analysis includes data from four ongoing blinded, randomised, controlled trials done across the UK, Brazil, and South Africa. Participants aged 18 years and older were randomly assigned (1:1) to ChAdOx1 nCoV-19 vaccine or control (meningococcal group A, C, W, and Y conjugate vaccine or saline). Participants in the ChAdOx1 nCoV-19 group received two doses containing 5 × 1010 viral particles (standard dose; SD/SD cohort); a subset in the UK trial received a half dose as their first dose (low dose) and a standard dose as their second dose (LD/SD cohort). The primary efficacy analysis included symptomatic COVID-19 in seronegative participants with a nucleic acid amplification test-positive swab more than 14 days after a second dose of vaccine. Participants were analysed according to treatment received, with data cutoff on Nov 4, 2020. Vaccine efficacy was calculated as 1 - relative risk derived from a robust Poisson regression model adjusted for age. Studies are registered at ISRCTN89951424 and ClinicalTrials.gov, NCT04324606, NCT04400838, and NCT04444674. FINDINGS: Between April 23 and Nov 4, 2020, 23 848 participants were enrolled and 11 636 participants (7548 in the UK, 4088 in Brazil) were included in the interim primary efficacy analysis. In participants who received two standard doses, vaccine efficacy was 62·1% (95% CI 41·0-75·7; 27 [0·6%] of 4440 in the ChAdOx1 nCoV-19 group vs71 [1·6%] of 4455 in the control group) and in participants who received a low dose followed by a standard dose, efficacy was 90·0% (67·4-97·0; three [0·2%] of 1367 vs 30 [2·2%] of 1374; pinteraction=0·010). Overall vaccine efficacy across both groups was 70·4% (95·8% CI 54·8-80·6; 30 [0·5%] of 5807 vs 101 [1·7%] of 5829). From 21 days after the first dose, there were ten cases hospitalised for COVID-19, all in the control arm; two were classified as severe COVID-19, including one death. There were 74 341 person-months of safety follow-up (median 3·4 months, IQR 1·3-4·8): 175 severe adverse events occurred in 168 participants, 84 events in the ChAdOx1 nCoV-19 group and 91 in the control group. Three events were classified as possibly related to a vaccine: one in the ChAdOx1 nCoV-19 group, one in the control group, and one in a participant who remains masked to group allocation. INTERPRETATION: ChAdOx1 nCoV-19 has an acceptable safety profile and has been found to be efficacious against symptomatic COVID-19 in this interim analysis of ongoing clinical trials. FUNDING: UK Research and Innovation, National Institutes for Health Research (NIHR), Coalition for Epidemic Preparedness Innovations, Bill & Melinda Gates Foundation, Lemann Foundation, Rede D'Or, Brava and Telles Foundation, NIHR Oxford Biomedical Research Centre, Thames Valley and South Midland's NIHR Clinical Research Network, and AstraZeneca

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Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK

Author: Aban Marites
Abayomi Fatola
Abeyskera Kushala
Aboagye Jeremy
Adam Matthew
Adams Kirsty
Adamson James
Adelaja Yemi A.
Adlou Syed
Ahmed Khatija
Akhalwaya Saajida
Akhalwaya Yasmeen
Alcock Andrew
Aley Parvinder K.
Ali Aabidah
Allen Elizabeth R.
Allen Lauren
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Zuidewind Peter
Publication venue: 'Elsevier BV'
Publication date: 09/01/2021
Field of study

Background A safe and efficacious vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), if deployed with high coverage, could contribute to the control of the COVID-19 pandemic. We evaluated the safety and efficacy of the ChAdOx1 nCoV-19 vaccine in a pooled interim analysis of four trials. Methods This analysis includes data from four ongoing blinded, randomised, controlled trials done across the UK, Brazil, and South Africa. Participants aged 18 years and older were randomly assigned (1:1) to ChAdOx1 nCoV-19 vaccine or control (meningococcal group A, C, W, and Y conjugate vaccine or saline). Participants in the ChAdOx1 nCoV-19 group received two doses containing 5 × 1010 viral particles (standard dose; SD/SD cohort); a subset in the UK trial received a half dose as their first dose (low dose) and a standard dose as their second dose (LD/SD cohort). The primary efficacy analysis included symptomatic COVID-19 in seronegative participants with a nucleic acid amplification test-positive swab more than 14 days after a second dose of vaccine. Participants were analysed according to treatment received, with data cutoff on Nov 4, 2020. Vaccine efficacy was calculated as 1 - relative risk derived from a robust Poisson regression model adjusted for age. Studies are registered at ISRCTN89951424 and ClinicalTrials.gov, NCT04324606, NCT04400838, and NCT04444674. Findings Between April 23 and Nov 4, 2020, 23 848 participants were enrolled and 11 636 participants (7548 in the UK, 4088 in Brazil) were included in the interim primary efficacy analysis. In participants who received two standard doses, vaccine efficacy was 62·1% (95% CI 41·0–75·7; 27 [0·6%] of 4440 in the ChAdOx1 nCoV-19 group vs71 [1·6%] of 4455 in the control group) and in participants who received a low dose followed by a standard dose, efficacy was 90·0% (67·4–97·0; three [0·2%] of 1367 vs 30 [2·2%] of 1374; pinteraction=0·010). Overall vaccine efficacy across both groups was 70·4% (95·8% CI 54·8–80·6; 30 [0·5%] of 5807 vs 101 [1·7%] of 5829). From 21 days after the first dose, there were ten cases hospitalised for COVID-19, all in the control arm; two were classified as severe COVID-19, including one death. There were 74 341 person-months of safety follow-up (median 3·4 months, IQR 1·3–4·8): 175 severe adverse events occurred in 168 participants, 84 events in the ChAdOx1 nCoV-19 group and 91 in the control group. Three events were classified as possibly related to a vaccine: one in the ChAdOx1 nCoV-19 group, one in the control group, and one in a participant who remains masked to group allocation. Interpretation ChAdOx1 nCoV-19 has an acceptable safety profile and has been found to be efficacious against symptomatic COVID-19 in this interim analysis of ongoing clinical trials

Crossref

Online Research @ Cardiff

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Abbas Jaffar
Abbasi Madineh Akram
Abbasian Mohammadreza
Abbastabar Hedayat
Abd-Rabu Rami
Abdelmasseh Michael
Abdollahi Mohammad
Abdollahi Mozhan
Abdollahifar Mohammad-Amin
Abdulah Deldar Morad
Abdullahi Auwal
Abedi Aidin
Abedi Vida
Abeldaño Zuñiga Roberto Ariel
Abidi Hassan
Abiodun Olumide
Aboagye Richard Gyan
Abolhassani Hassan
Aboyans Victor
Abrha Woldu Aberhe
Abu-Gharbieh Eman
Abualhasan Ahmed
Aburuz Salahdein
Adamu Lawan Hassan
Addo Isaac Yeboah
Adebayo Oladimeji M
Adekanmbi Victor
Adekiya Tayo Alex
Adikusuma Wirawan
Adnani Qorinah Estiningtyas Sakilah
Adra Saryia
Afework Tsion
Afolabi Aanuoluwapo Adeyimika
Afraz Ali
Afzal Saira
Aghamiri Shahin
Agodi Antonella
Agyemang-Duah Williams
Ahinkorah Bright Opoku
Ahmad Aqeel
Ahmad Danish
Ahmad Sajjad
Ahmadzade Amir Mahmoud
Ahmed Ali
Ahmed Ayman
Ahmed Haroon
Ahmed Jivan Qasim
Ahmed Luai A
Ahmed Muktar Beshir
Ahmed Syed Anees
Ajami Marjan
Aji Budi
Ajumobi Olufemi
Akade Seyed Esma'il
Akbari Morteza
Akbarialiabad Hossein
Akhlaghi Shiva
Akinosoglou Karolina
Akinyemi Rufus Olusola
Akonde Maxwell
Al Hasan Syed Mahfuz
AL-Ahdal Tareq Mohammed Ali
Al-amer Rasmieh Mustafa
Al-Gheethi Adel Ali Saeed
Al-Omari Basem
Al-Shahi Salman Rustam
Al-Tawfiq Jaffar A
Al-Worafi Yaser Mohammed
Alahdab Fares
Albashtawy Mohammed
AlBataineh Mohammad T
Aldawsari Khalifah A
Alemi Hediyeh
Alemi Sharifullah
Algammal Abdelazeem M
Alhalaiqa Fadwa Alhalaiqa Naji
Alhassan Robert Kaba
Ali Abid
Ali Endale Alemayehu
Ali Liaqat
Ali Mohammed Usman
Ali Musa Mohammed
Ali Rafat
Ali Shahid
Ali Syed Shujait Shujait
Ali Zahid
Alif Sheikh Mohammad
Alimohamadi Yousef
Aliyi Ahmednur Adem
Aljofan Mohamad
Aljunid Syed Mohamed
Alladi Suvarna
Almazan Joseph Uy
Almustanyir Sami
Alqahtani Jaber S
Alqasmi Ibrahim
Alqutaibi Ahmed Yaseen
Altaany Zaid
Altirkawi Khalid A
Alvis-Guzman Nelson
Aly Hany
Aly Safwat
Alzoubi Karem H
Amani Reza
Amindarolzarbi Alireza
Amiri Sohrab
Amirzade-Iranaq Mohammad Hosein
Amu Hubert
Amugsi Dickson A
Amusa Ganiyu Adeniyi
Amzat Jimoh
Ancuceanu Robert
Anderlini Deanna
Anderson David B
Andrei Catalina Liliana
Androudi Sofia
Angappan Dhanalakshmi
Angesom Teklit W
Anil Abhishek
Ansari-Moghaddam Alireza
Anwer Razique
Arafat Mosab
Aravkin Aleksandr Y
Areda Demelash
Ariffin Hany
Arifin Hidayat
Arkew Mesay
Arooj Mahwish
Artamonov Anton A
Artanti Kurnia Dwi
Aruleba Raphael Taiwo
Asadi-Pooya Ali A
Asena Tilahun Ferede
Asghari-Jafarabadi Mohammad
Ashraf Muhammad
Ashraf Tahira
Atalell Kendalem Asmare
Athari Seyyed Shamsadin
Atinafu Bantalem Tilaye Tilaye
Atorkey Prince
Atout Maha Moh'd Wahbi
Atreya Alok
Aujayeb Avinash
Avan Abolfazl
Ayala Quintanilla Beatriz Paulina
Ayatollahi Haleh
Ayinde Olatunde O
Ayyoubzadeh Seyed Mohammad
Azadnajafabad Sina
Azizi Zahra
Azizian Khalil
Azzam Ahmed Y
Babaei Mahsa
Badar Muhammad
Badiye Ashish D
Baghdadi Soroush
Bagherieh Sara
Bai Ruhai
Baig Atif Amin
Balakrishnan Senthilkumar
Balalla Shivanthi
Baltatu Ovidiu Constantin
Banach Maciej
Bandyopadhyay Soham
Banerjee Indrajit
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Barboza Miguel A
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Barrow Amadou
Bashash Davood
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Basu Sanjay
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Bhat Vivek
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Bikbov Boris
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Biswas Atanu
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Bitra Veera R
Bjørge Tone
Bodolica Virginia
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Caetano dos Santos Florentino Luciano
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Cao Bochen
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Carabin Hélène
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Castañeda-Orjuela Carlos A
Casulli Adriano
Catalá-López Ferrán
Catapano Alberico L
Cavallera Vanessa
Caye Arthur
Cegolon Luca
Cenderadewi Muthia
Cerin Ester
Chacón-Uscamaita Pamela R Uscamaita
Chan Jeffrey Shi Kai
Chanie Gashaw Sisay
Charan Jaykaran
Chattu Vijay Kumar
Chekol Abebe Endeshaw
Chen Hui
Chen Jianqi
Chi Gerald
Chichagi Fatemeh
Chidambaram Saravana Babu
Chimoriya Ritesh
Ching Patrick R
Chitheer Abdulaal
Chong Yuen Yu
Chopra Hitesh
Choudhari Sonali Gajanan
Chowdhury Enayet Karim
Chowdhury Rajiv
Christensen Hanne
Chu Dinh-Toi
Chukwu Isaac Sunday
Chung Eric
Coberly Kaleb
Columbus Alyssa
Comachio Josielli
Conde Joao
Cortesi Paolo Angelo
Costa Vera Marisa
Cousin Ewerton
Couto Rosa A S
Criqui Michael H
Cruz-Martins Natália
Cárdenas Rosario
D'Amico Emanuele
Dabbagh Ohadi Mohammad Amin
Dadana Sriharsha
Dadras Omid
Dai Xiaochen
Dai Zhaoli
Danawi Hadi A
Dandona Lalit
Dandona Rakhi
Darwish Amira Hamed
Das Saswati
Das Subasish
Dascalu Ana Maria
Dash Nihar Ranjan
Dashti Mohsen
De la Hoz Fernando Pio
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De Leo Diego
Dean Frances E
Dehghan Amin
Dehghan Azizallah
Dejene Hiwot
Demant Daniel
Demetriades Andreas K
Demissie Solomon
Deng Xinlei
Desai Hardik Dineshbhai
Devanbu Vinoth Gnana Chellaiyan
Dhama Kuldeep
Dharmaratne Samath Dhamminda
Dhimal Meghnath
Dias da Silva Diana
Diaz Daniel
Dibas Mahmoud
Ding Delaney D
Dinu Monica
Dirac M Ashworth
Diress Mengistie
Do Thanh Chi
Do Thao Huynh Phuong
Doan Khanh Duy Khanh
Dodangeh Milad
Doheim Mohamed Fahmy
Dokova Klara Georgieva
Dongarwar Deepa
Dsouza Haneil Larson
Dua Tarun
Dube John
Duraisamy Senbagam
Durojaiye Oyewole Christopher
Dutta Sulagna
Dziedzic Arkadiusz Marian
Edinur Hisham Atan
Eissazade Negin
Ekholuenetale Michael
Ekundayo Temitope Cyrus
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El Sayed Iman
Elahi Najafi Mohammad Amin
Elbarazi Iffat
Elemam Noha Mousaad
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Elhabashy Hala Rashad
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Elilo Legesse Tesfaye
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Elsohaby Ibrahim
Emamverdi Mehdi
Emeto Theophilus I
Endres Matthias
Esezobor Christopher Imokhuede
Eskandarieh Sharareh
Fadaei Abdolmajid
Fagbamigbe Adeniyi Francis
Fahim Ayesha
Faramarzi Ali
Fares Jawad
Farjoud Kouhanjani Mohsen
Faro Andre
Farzadfar Farshad
Fatehizadeh Ali
Fathi Mobina
Fathi Saeid
Fatima Syeda Anum Fatima
Feigin Valery L
Feizkhah Alireza
Fereshtehnejad Seyed-Mohammad
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Ferreira Nuno
Fetensa Getahun
Firouraghi Neda
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Fonseca Ana Catarina
Force Lisa M
Fornari Arianna
Foroutan Behzad
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Gadanya Muktar A
Gaidhane Abhay Motiramji
Galali Yaseen
Galehdar Nasrin
Gan Quan
Gandhi Aravind P
Ganesan Balasankar
Gardner William M
Garg Naval
Gau Shuo-Yan
Gautam Rupesh K
Gebre Teshome
Gebrehiwot Mesfin
Gebremeskel Gebreamlak Gebremedhn
Gebreslassie Haftay Gebremedhin
Getacher Lemma
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Ghadirian Fataneh
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Ghasemi MohammadReza
Ghazy Ramy Mohamed
Ghimire Sailaja
Gholami Ali
Gholamrezanezhad Ali
Ghotbi Elena
Ghozy Sherief
Gialluisi Alessandro
Gill Paramjit Singh
Glasstetter Logan M
Gnedovskaya Elena V
Golchin Ali
Golechha Mahaveer
Goleij Pouya
Golinelli Davide
Gomes-Neto Mansueto
Goulart Alessandra C
Goyal Anmol
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Grivna Michal
Guadie Habtamu Alganeh
Guan Bin
Guarducci Giovanni
Guicciardi Stefano
Gunawardane Damitha Asanga
Guo Hanbing
Gupta Bhawna
Gupta Rajeev
Gupta Sapna
Gupta Veer Bala
Gupta Vivek Kumar
Gutiérrez Reyna Alma
Habibzadeh Farrokh
Hachinski Vladimir
Haddadi Rasool
Hadei Mostafa
Hadi Najah R
Haep Nils
Hagins Hailey
Haile Teklehaimanot Gereziher
Haj-Mirzaian Arvin
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Halwani Rabih
Hameed Sajid
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Hammoud Ahmad
Han Hannah
Hanifi Nasrin
Hankey Graeme J
Hannan Md. Abdul
Hao Junwei
Harapan Harapan
Hareru Habtamu Endashaw
Hargono Arief
Harlianto Netanja I.
Haro Josep Maria
Hartman Nicholas Nathaniel
Hasaballah Ahmed I.
Hasan Faizul
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Hasanian Mohammad
Hassan Amr
Hassan Shoaib
Hassanipour Soheil
Hassankhani Hadi
Hassen Mohammed Bheser
Haubold Johannes
Hay Simon I
Hayat Khezar
Hegazy Mohamed I
Heidari Golnaz
Heidari Mohammad
Heidari-Soureshjani Reza
Hesami Hamed
Hezam Kamal
Hiraike Yuta
Hoffman Howard J
Holla Ramesh
Hopf Kathleen Pillsbury
Horita Nobuyuki
Hossain Md Mahbub
Hossain Md. Belal
Hossain Sahadat
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Hosseinzadeh Mehdi
Hostiuc Sorin
Hu Chengxi
Huang Junjie
Huda Md. Nazmul
Hussain Javid
Hussein Nawfal R
Huynh Hong-Han
Hwang Bing-Fang
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Ilaghi Mehran
Ilesanmi Olayinka Stephen
Ilic Irena M
Ilic Milena D
Immurana Mustapha
Iravanpour Farideh
Islam Sheikh Mohammed Shariful
Ismail Faisal
Iso Hiroyasu
Isola Gaetano
Iwagami Masao
Iwu Chidozie C D
Iyer Mahalaxmi
Jaan Ali
Jacob Louis
Jadidi-Niaragh Farhad
Jafari Mahboobeh
Jafarinia Morteza
Jafarzadeh Abdollah
Jahankhani Kasra
Jahanmehr Nader
Jahrami Haitham
Jaiswal Abhishek
Jakovljevic Mihajlo
Jamora Roland Dominic G
Jana Somnath
Javadi Nilofer
Javed Saad
Javeed Saad
Jayapal Sathish Kumar
Jayaram Shubha
Jiang Heng
Johnson Catherine Owens
Johnson Walter D
Jokar Mohammad
Jonas Jost B
Joseph Abel
Joseph Nitin
Joshua Charity Ehimwenma
Jürisson Mikk
Kabir Ali
Kabir Zubair
Kabito Gebisa Guyasa
Kadashetti Vidya
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Kamath Sagarika
Kanchan Tanuj
Kandel Amit
Kandel Himal
Kanmodi Kehinde Kazeem
Karajizadeh Mehrdad
Karami Jafar
Karanth Shama D
Karaye Ibraheem M
Karch André
Karimi Behnagh Arman
Karimi Aliasghar
Karimi Hanie
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Kauppila Joonas H
Kaur Harkiran
Kaur Navjot
Kayode Gbenga A
Kazemi Foad
Keikavoosi-Arani Leila
Keller Cathleen
Keykhaei Mohammad
Khadembashiri Mohammad Amin
Khader Yousef Saleh
Khafaie Morteza Abdullatif
Khajuria Himanshu
Khalaji Amirmohammad
Khamesipour Faham
Khammarnia Mohammad
Khan Suheb Mahammed Ziauddin
Khan Maseer
Khan Moien AB
Khan Yusra H
Khanmohammadi Shaghayegh
Khanna Tripti
Khatab Khaled
Khatatbeh Haitham
Khatatbeh Moawiah Mohammad
Khateri Sorour
Khatib Mahalaqua Nazli
Khayat Kashani Hamid Reza
Khonji Mohammad Saeid
khorashadizadeh Fatemeh
Khormali Moein
Khubchandani Jagdish
Kian Saeid
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Kim Jihee
Kim Min Seo
Kim Yun Jin
Kimokoti Ruth W
Kisa Adnan
Kisa Sezer
Kivimäki Mika
Kochhar Sonali
Kolahi Ali-Asghar
Koly Kamrun Nahar
Kompani Farzad
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Kosen Soewarta
Kourosh Arami Masoumeh
Koyanagi Ai
Kravchenko Michael A
Krishan Kewal
Krishnamoorthy Vijay
Kuate Defo Barthelemy
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Kumar Ashish
Kumar G Anil
Kumar Manasi
Kumar Nithin
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Kurniasari Maria Dyah
Kusuma Dian
Kuttikkattu Ambily
Kyu Hmwe Hmwe
La Vecchia Carlo
Ladan Muhammad Awwal
Lahariya Chandrakant
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Lal Dharmesh Kumar
Lallukka Tea
Lami Faris Hasan
Landires Iván
Langguth Berthold
Lasrado Savita
Latief Kamaluddin
Latifinaibin Kaveh
Lau Kathryn Mei-Ming
Laurens Matthew B
Lawal Basira Kankia
Le Long Khanh Dao
Le Thao Thi Thu
Ledda Caterina
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Lee Wei-Chen
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Leonardi Matilde
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Li Wei
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Liu Wei
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Lobo Stany W
Logroscino Giancarlo
Lopes Graciliana
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Lorenzovici László
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Lubinda Jailos
Lucchetti Giancarlo
Lutzky Saute Ricardo
Lám Judit
Ma Zheng Feei
Mabrok Mahmoud
Machoy Monika
Madadizadeh Farzan
Magdy Abd El Razek Mohammed
Maghazachi Azzam A
Maghbouli Nastaran
Mahjoub Soleiman
Mahmoudi Morteza
Majeed Azeem
Malagón-Rojas Jeadran N.
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Malhotra Kashish
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Malik Iram
Mallhi Tauqeer Hussain
Malta Deborah Carvalho
Manilal Aseer
Mansouri Vahid
Mansournia Mohammad Ali
Marasini Bishnu P
Marateb Hamid Reza
Maroufi Seyed Farzad
Martinez-Raga Jose
Martini Santi
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Martorell Miquel
Marzo Roy Rillera
Massano João
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Mathews Elezebeth
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Maugeri Andrea
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Mayeli Mahsa
Mazaheri Maryam
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Mi Tianyue
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Mihretie Ephrem Tesfaye
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Mirzaei Mehdi
Misganaw Awoke
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Mithra Prasanna
Mizana Biru Abdissa
Moberg Madeline E
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Mohammed Shafiu
Mohan Syam
Mojiri-forushani Hoda
Moka Nagabhishek
Mokdad Ali H
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Morovatdar Negar
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Mosapour Abbas
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Musaigwa Fungai
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Möller Holger
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Naik Ganesh R
Nainu Firzan
Nair Tapas Sadasivan
Najmuldeen Hastyar Hama Rashid
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Natto Zuhair S
Nauman Javaid
Nayak Biswa Prakash
Nazri-Panjaki Athare
Negaresh Mohammad
Negash Hadush
Negoi Ionut
Negoi Ruxandra Irina
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Nejadghaderi Seyed Aria
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Nri-Ezedi Chisom Adaobi
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O'Donnell Martin James
Oancea Bogdan
Odetokun Ismail A
Ogunsakin Ropo Ebenezer
Oguta James Odhiambo
Oh In-Hwan
Okati-Aliabad Hassan
Okeke Sylvester Reuben
Okekunle Akinkunmi Paul
Okonji Osaretin Christabel
Okwute Patrick Godwin
Olagunju Andrew T
Olaiya Muideen Tunbosun
Olana Matifan Dereje
Olatubi Matthew Idowu
Oliveira Gláucia Maria Moraes
Olufadewa Isaac Iyinoluwa
Olusanya Bolajoko Olubukunola
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Ong Kanyin Liane
Ong Sokking
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Ordak Michal
Orji Aislyn U
Ortega-Altamirano Doris V
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Owolabi Mayowa O
P A Mahesh Padukudru
Pacheco-Barrios Kevin
Padubidri Jagadish Rao
Pal Pramod Kumar
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Palladino Raffaele
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Pan Feng
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Pandey Ashok
Pandian Jeyaraj Durai
Pangaribuan Helena Ullyartha
Pantazopoulos Ioannis
Pardhan Shahina
Parija Pragyan Paramita
Parikh Romil R
Park Seoyeon
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Pashaei Ava
Patel Jay
Patil Shankargouda
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Pawar Shrikant
Pedersini Paolo
Pensato Umberto
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Pereira Jeevan
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Peres Mario F P
Perico Norberto
Perna Simone
Petcu Ionela-Roxana
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Plotnikov Evgenii
Poddighe Dimitri
Polat Burcu
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Pourbagher-Shahri Ali Mohammad
Pourfridoni Mohammad
Pourtaheri Naeimeh
Prakash Peralam Yegneswaran
Prakash Sanjay
Prakash V
Prates Elton Junio Sady
Pritchett Natalie
Purnobasuki Hery
Qasim Nameer Hashim
Qattea Ibrahim
Qian Gangzhen
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Raee Pourya
Raeisi Shahraki Hadi
Rafique Ibrar
Raggi Alberto
Raghav Pankaja Raghav
Rahati Meghdad M
Rahim Fakher
Rahimi Zahra
Rahimifard Mahban
Rahman Md Obaidur
Rahman Mohammad Hifz Ur
Rahman Mosiur
Rahman Muhammad Aziz
Rahmani Youshanlouei Hamed
Rahmani Amir Masoud
Rahmani Shayan
Rahmati Masoud
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Rajabpour-Sanati Ali
Ramadan Hazem
Ramasamy Shakthi Kumaran
Ramasubramani Premkumar
Ramazanu Sheena
Rancic Nemanja
Rao Indu Ramachandra
Rao Sowmya J
Rapaka Deepthi
Rashedi Vahid
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Rashidi Alavijeh Mehran
Rashidi Mohammad-Mahdi
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Rawaf Salman
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Rezaei Nazila
Rezaei Negar
Rezaei Nima
Rezaeian Mohsen
Rhee Taeho Gregory
Riad Abanoub
Robinson Stephen R
Rodrigues Mónica
Rodriguez Jefferson Antonio Buendia
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Ronfani Luca
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Saadatian Zahra
Saber Korosh
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Sacco Simona
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Saeed Umar
Saeed Usman
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Sagar Rajesh
Sagoe Dominic
Saheb Sharif-Askari Fatemeh
Saheb Sharif-Askari Narjes
Sahebkar Amirhossein
Sahoo Soumya Swaroop
Sahraian Mohammad Ali
Sajedi Seyed Aidin
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Schwarzinger Michaël
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Selvaraj Siddharthan
Sendekie Ashenafi Kibret
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Serban Dragos
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SeyedAlinaghi SeyedAhmad
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Shahabi Saeed
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Sinaei Ehsan
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Singh Garima
Singh Paramdeep
Singh Surjit
Sirota Sarah Brooke
Sivakumar Shravan
Sohag Abdullah Al Mamun
Solanki Ranjan
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Sunny Angel
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Tabatabai Shima
Tabish Mohammad
Taheri Majid
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Tampa Mircea
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Tang Haosu
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Tarigan Ingan Ukur
Tat Nathan Y
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Tavakoli Oliaee Razieh
Tavangar Seyed Mohammad
Tavasol Arian
Tefera Yibekal Manaye
Tehrani-Banihashemi Arash
Temesgen Worku Animaw
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Teramoto Masayuki
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Tesler Riki
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Thapa Rajshree
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Thrift Amanda G
Ticoalu Jansje Henny Vera
Tillawi Tala
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Tovani-Palone Marcos Roberto
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Tsegay Guesh Mebrahtom
Tsermpini Evangelia Eirini
Tualeka Abdul Rohim
Tufa Derara Girma
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Vos Theo
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Weldemariam Abrha Hailay
Westerman Ronny
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Yamagishi Kazumasa
Yang Lin
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Yao Yao
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Yeshaneh Alex
Yesiltepe Metin
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Yon Dong Keon
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You Yuyi
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Yu Chuanhua
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Zhai Chunxia
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Zhang Haijun
Zhang Yunquan
Zhang Zhi-Jiang
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Zheng Peng
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Zhu Bin
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Zielińska Magdalena
Zikarg Yossef Teshome
Zoladl Mohammad
Ärnlöv Johan
Publication venue: Elsevier
Publication date: 01/04/2024
Field of study

BackgroundDisorders affecting the nervous system are diverse and include neurodevelopmental disorders, late-life neurodegeneration, and newly emergent conditions, such as cognitive impairment following COVID-19. Previous publications from the Global Burden of Disease, Injuries, and Risk Factor Study estimated the burden of 15 neurological conditions in 2015 and 2016, but these analyses did not include neurodevelopmental disorders, as defined by the International Classification of Diseases (ICD)-11, or a subset of cases of congenital, neonatal, and infectious conditions that cause neurological damage. Here, we estimate nervous system health loss caused by 37 unique conditions and their associated risk factors globally, regionally, and nationally from 1990 to 2021.MethodsWe estimated mortality, prevalence, years lived with disability (YLDs), years of life lost (YLLs), and disability-adjusted life-years (DALYs), with corresponding 95% uncertainty intervals (UIs), by age and sex in 204 countries and territories, from 1990 to 2021. We included morbidity and deaths due to neurological conditions, for which health loss is directly due to damage to the CNS or peripheral nervous system. We also isolated neurological health loss from conditions for which nervous system morbidity is a consequence, but not the primary feature, including a subset of congenital conditions (ie, chromosomal anomalies and congenital birth defects), neonatal conditions (ie, jaundice, preterm birth, and sepsis), infectious diseases (ie, COVID-19, cystic echinococcosis, malaria, syphilis, and Zika virus disease), and diabetic neuropathy. By conducting a sequela-level analysis of the health outcomes for these conditions, only cases where nervous system damage occurred were included, and YLDs were recalculated to isolate the non-fatal burden directly attributable to nervous system health loss. A comorbidity correction was used to calculate total prevalence of all conditions that affect the nervous system combined.FindingsGlobally, the 37 conditions affecting the nervous system were collectively ranked as the leading group cause of DALYs in 2021 (443 million, 95% UI 378–521), affecting 3·40 billion (3·20–3·62) individuals (43·1%, 40·5–45·9 of the global population); global DALY counts attributed to these conditions increased by 18·2% (8·7–26·7) between 1990 and 2021. Age-standardised rates of deaths per 100 000 people attributed to these conditions decreased from 1990 to 2021 by 33·6% (27·6–38·8), and age-standardised rates of DALYs attributed to these conditions decreased by 27·0% (21·5–32·4). Age-standardised prevalence was almost stable, with a change of 1·5% (0·7–2·4). The ten conditions with the highest age-standardised DALYs in 2021 were stroke, neonatal encephalopathy, migraine, Alzheimer's disease and other dementias, diabetic neuropathy, meningitis, epilepsy, neurological complications due to preterm birth, autism spectrum disorder, and nervous system cancer.InterpretationAs the leading cause of overall disease burden in the world, with increasing global DALY counts, effective prevention, treatment, and rehabilitation strategies for disorders affecting the nervous system are needed

Keele Research Repository

Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19

Author: ?ivko Iris
Abbass Hakam
Abdeladim Lilia
Abdelhady Hesham
Abdelkharim Hussam
Abdelrazik Marwa
Abdi Zakee
Abdukahil Sheryl Ann
Abel Lynn
Abraham Jacinta
Abrahamson Gail
Abusamra Yousuf
Aceto Romina
Adams Nick
Adams Peter
Adebambo Olumide
Adhikari Neill
Adhikari Sheetal
Affleck Julia
Agha Gloria
Aghemo Alessio
Agno Ronan
Ahmad Norfaizan
Ain Quratul
Ainscough Kate
Ainsworth James
Aitken Lindianne
Akamp Ceren
Al Enezi Farhan
Al-Bassam Wisam
Al-Beidh Farah
Albert Martin
Albrett Jonathan
Alderman Meera
Aldo Bonizzoni Matteo
Alegria Ana
Alessandro Carà Gianmarco
Alexander Brian
Alexander Peter
Alfonso Jordan
Ali Maryam
Ali Murtaza
Allam Hayat
Allen Barbara
Allen Louise
Allibone Suzanne
Almeshhedani Hasham
AlQahtani Samah
Alswaidan Lolowa
Altomy Mohammed
Al Amri Ali
Al Qasim Eman
Amatya Sameena
Ambrosino Richard
Anderson Thomas
Andreae Mark
Aneman Anders
Angus Derek C.
Anjum Aisha
Ankert Juliane
Annane Djillali
Anne-Laure Fedou
Anstey Matthew
Antcliffe David
Anthony Alpha
Antoine Marchalot
Antoine Pierre
Antoine Studer
Anumakonda Vikram
Aparicio Christelle
Aquino Maia
Arabi Yaseen M.
Arachchige Malka
Aravindan Latha
Arbane Gill
Archambault Patrick
Archer Simon
Aref Noah
Arias Ana-Marie
Arias Sonia
Arishi Hatim
Arnold Donald
Arnold John
Arnott Andrew
Arora Anand
Aryal Diptesh
Asghar Adeeba
Asif Namra
Aspinwall Angelique
Attokaran Antony
Attwood Ben
Au Carly
Audry Mathilde
Austin Karen
Austin Pauline
Auvet Adrien
Avard Bronwyn
Awan Sidra
Ayee Robert
Azaiz Amine
Azzaui Harun
Babu Suresh
Bacon Gina
Badalamenti Salvatore
Badie Julio
Bagavathy Kavitha
Bagot Catherine
Bagshaw Sean
Baig Nadia
Baikady Ravishankar
Bailey Lucy
Baillie Kenneth
Bain William
Baker Alice
Baker Evelyn
Baker Stuart
Bakthavatsalam Dhanalakshmi
Balaie Morteza
Balls-Burgess Sam
Bamford Amy
Bamford Peter
Banach Dorota
Bannard-Smith Jonathan
Barbash Ian
Barber Russell
Barbier François
Barge Deborah
Bariola Ryan
Barker Gareth
Barker Stephanie
Barnes Nicky
Baron Rebecca M.
Barreau Amelie
Barreau Amélie
Bart Robert
Bartholomew Jazz
Bartley Shauna
Barton David
Barton Frances
Bashyal Archana
Basile Kim
Bass Frances
Bassford Christopher
Bastos Joana Margarida Pereira Sousa
Bates Michelle
Bates Samantha
Batista Teresa Margarida Oliveira
Bauchmuller Kris
Bayne Madeleine
Bean Sarah
Beane Abi
Beane Abigail
Beard Gregory
Beasley Richard
Beaudoin Rosalie
Beavis Sarah
Beddows Seonaid
Bedford Caroline
Beer Deborah
Beer Sally
Begin Phillipe
Begum Salma
Bell Gillian
Bellemare David
Belletti Allesandro
Bendjemar Lynda
Benettaib Fatna
Bensen Nicole
Bentley Andrew
Benyon Sarah
Benzekri Dalila
Beqai Besa
Berdaguer Fernando
Beresford Stephanie
Bergin Colin
Berry Lindsay R.
Berry Scott
Berryman Emily
Bertel Melanie
Best-Lane Janis
Besten Henny
Bevan Emily
Bewley Jeremy
Beyerl Ashley
Bhagani Sanjay
Bhandal Khushpreet
Bharaj Kiranjit
Bhattarai Bina
Bhattarai Binita
Bhonagiri Deepak
Biddie Simon
Bigas Judit
Bihari Shailesh
Bin Hasan Mohd Shahnaz
Bindels Manon
Binnie Alexandra
Biradar Vishwanath
Birch Catherine
Birch Janine
Birch Sophie
Birchall Kathrine
Birkinshaw Isobel
Black Ethel
Blackledge Bethany
Blakemore Hayley
Blanck Wendy
Bland Yvonne
Blank Elisabeth
Bleasdale John
Bloomfield Jack
Bloos Frank
Board Jasmin
Boardman Melanie
Boari Gianluca
Bocher Simon
Bociek Aneta
Boivin Anne-Helene
Boivin Anne-Hélène
Bojunga Jörg
Bomken Charlotte
Bonaccorso Allesandra
Bongaerts Katherine
Bonner Stephen
Bonten Marc J. M.
Borgatta Barbara
Borislavova Borislava
Borrill Zoe
Boschert Catherine
Bossard Isabelle
Bothma Pieter
Boudineau Michel
Boulanger Marie-Claude
Boumahni Dounia
Bouman Angela
Bounab Rania
Bourgoin Charlotte
Bourne Michelle
Bourne Richard
Boutin Mireille
Bouvier Elodie
Bouw-Ruiter Marianne
Boué Yvonnick
Bowen James
Bowler Helen
Boyd Craig
Boyles Rebecca
Bracke Stephanie
Bradbury Charlotte A.
Bradley Paul
Brady Kara
Brailsford Jane
Brain Matthew
Brakké Karen
Brant Emily
Brasselet Aurélie
Breen Patrick
Bremmer Pamela
Brend Morwenna
Brennan Aoife
Bretagnol Anne
Brett Stephen
Brewer Chris
Brickell Kathy
Bridges Sarah
Brieger Klaus-Gerd
Brightling Chris
Brimfield Lutece
Brittain Michael
Britton Kate
Brochard Laurent
Brodbeck Andreas
Brohi Farooq
Brooks Nicole
Brown Cynthia
Brown Julia
Brown Louise
Brown Nerissa
Brown Zarah
Brugman Curt
Brunetta Enrico
Brunkhorst Frank M.
Brunskill Nigel
Bryan-Morris Kayla
Bryden Emma
Budd Joanna
Buehner Ulrike
Buhay Megan
Buhr Heidi
Burbee Dylan
Burda Dorota
Burgess Richard
Burke David
Burke Tara
Burkey Jason
Burnish Rachel
Burns Dean
Burns Karen
Burrell Aidan
Burt Karen
Buscher Hergen
Butler Amelia
Butler Magdalena
Butler Susan
Buxton Meredith
Buzgau Adrian
Byrne Kathleen
Byrne Rahim
Cabrelli Louise
Cabreros Leilani
Cairns Tom
Calfee Carolyn
Callahan Jean-Christophe
Cambalova Lenka
Campbell Andrew
Campbell Bridget
Campbell Debbie
Campbell Hilary
Campbell Lewis
Campbell Marion
Campbell Ryan
Campion Alexandra
Campisi Josie
Camsooksai Julie
Caplin Cecile
Carbonneau Elaine
Carmichael Samantha
Carmona Rosario
Carn Vanessa
Carpio Lillian
Carr Zoe
Carr-Wilkinson Joanne
Carrier François
Carrier Marc
Carter Angus
Carter Brittney
Carter David
Carter Jay
Carter Michael
Casali Sherry
Casey Ruth
Casey Siobhan
Castelain Vincent
Castle James
Cathcart Susanne
Catorze Nuno José Teodoro Amaro dos Santos
Cattelan Jessy
Cavayas Alexandros
Cawley Kathryn
Cecconi Maurizio
Centofanti John
Chambers Emma
Champanerkar Shreekant
Chan Carmen
Chan Charles
Chan Peter
Chapman Rachel
Chapman Susan
Charles Bethan
Charles Walton
Charlewood Richard
Charlton Sam
Charron Cyril
Chartier Delphine
Chasse Michael
Chassé Michaël
Chen Jonathan
Chen Lixian
Chen Yan
Cheng Allen C.
Cherian Shiney
Chhablani Manish
Chin Teri
Chudeau Nicolas
Chukkambotla Sri
Ciccarelli Michele
Cirstea Emanuel
Clair Bernard
Clark Amy
Clark Michele
Clark Richard
Clark Sarah
Clarke Frances
Clarke Jennifer
Claxton Andrew
Cleary Joanne
Clement Ian
Clere-Jehl Raphael
Clermont Giles
Clermont Gilles
Clinton Alison
Cloutier Ève
Cockrell Maeve
Codreanu Daniel
Coetzee Samantha
Coghlan Phoebe
Cole Jade
Coles Jennifer
Colin Gwenhael
Collier Dawn
Collins Amy
Collins Daniel
Collins Emma
Collins Joanne
Collins Érin
Collis Matthew
Combaux Daniele
Commons Robert
Comp Susan
Concha Pablo
Connolly Karen
Constantini Elena
Constantino-Occhipinti Claudia
Contou Damien
Convery Karen
Conway Robert
Conzelmann Nadine
Cook Deborah
Cook Tim
Cooke Jill
Cooke Justin
Cooper Jamie
Cooper Josh
Cooper Lauren
Cooper Melanie
Cooper Nichola
Corbett Sarah
Corcoran Ele
Corcoran Kathleen
Cornell Sarah
Cornell Thomas
Cort Jon
Costerousse Olivier
Couillard-Chénard Émilie
Courtin Laura
Coutts Amanda
Couture Lourie
Cove Matthew
Cowdrey Keri-Anne
Cowley Nicholas
Cowton Amanda
Coyne Mark
Craddock Richard
Craner Michelle
Craven Thomas
Crawshaw Sarah
Creagh-Brown Ben
Creange Vanessa
Cremer Olaf
Crisp Nikki
Croft Maria
Csabi Peter
Cudlipp Joanna
Cuesta Jeronimo
Cuffaro Raffaele
Curley Gerard
Currie Andrew
Cusack Rebecca
Cuthbertson Brian
Cutler Sean
Cárcel Sheila
Côté Émilie
D?Amato Fabiola
D?Aragon Frédérick
Daebis Admad
Daher Rana
Dale Katie
Daley Jessica
Dalton James
Daly James
Daly Zoe
Daneman Nick
Dark Paul
Darnell Robert
Darreau Cedric
Daugherty Jason
Davey Miriam
Davidson Neil
Davies Ellie
Davies Gwyneth
Davies Jennifer
Davies Louisa
Davies Michelle
Davies Rhys
Dawson Laura Ann
Dawvda Ashlish
Day Christopher
Da Rocha Joana
De Bus Liesbet
de Courcy-Golder Kim
de Groot Klaas
de Jong Menno
de Jonge Evert
De Keulenaer Bart
de la Torre Cisneros Julian
de Man Angelique
De Neef Mark
De Smeytere Anouska
Deacon Bethan
Dean Steven
Dean Tessa
Dearden Joy
Dechert William
Declercq Pierre-Louis
Degracia Anna
del Sorbo Lorenzo
Dela Rosa Arnold
Delaney Kirsha
Dell Abbie
del Prado Michael
Demetriou Carrie
Dempster Debra
Denham Lynn
Denmade Craig
Dent Martin
Depante Maria
Depuydt Pieter
Dequin Pierre-François
Derde Lennie P. G.
Deshpande Kush
Detry Michelle A.
Deye Nicolas
de la Fuente Carmen
De Waele Jan
Dheke Krishan
Di Lucca Giuseppe
Dias Priya
Dice Julie
Digby Stephen
Diridis Kristina
Distler Michael
Dobell-Brown Kelsey
Doble Patricia
Dobson Jade
Doherty Kaleigh
Doherty Ronan
Doi Yohei
Dolman Rozzie
Domingo-Marco Joana
Donadee Chenell
Donaldson Kate
Dondrop Arjen
Donegan Clare
Donlon Sinead
Donnelly Adrian
Donnelly Kieran
Donnison Phil
Doonan Reece
Doran Peter
Dore Rachael
Dormand Natalie
Dos Santos Filipa
Douillard Thomas
Drake Chelsea
Drapola Debra
Drayss Maria
Drummond Andrew
Drury Kay
Duan Erick
Duberley Stephen
Duffy Eamon
Duffy Oscar
Duke Graeme
Duke Zoe
Duncan Tracy
Dunsavage Janice
Duplaix Mathilde
Duric Natalie
Duroux Maree
Dushianthan Ahilanandan
Dyas Sarah
Eapen Beena
Eastgate Christine
Ebenezer R
Edmunds Natasha
Edwards Alexandra
Efford Georgia
Egreteau Pierre
Ehrmann Stephan
Eichenauer Dennis
Eisenbeis Simone
Ekhérian Jean-Michel
El-Khawas Khaled
Elender Corinna
Elgendy Ahmad
Elhassan Munzir
Ellervee Anneli
Ellis Chiara
Ellis Christine
Ellis Yvette
Elmahi Einas
Elsefi Tarek
Eltayeb Ayaa
Elvira Evangeline
England Jenna
Englert Sarah
English Shane
Epelman¸ Slava
Eroglu Ege
Estcourt Lise J.
Estensen Kristen
Evans Amy
Evans Andrew
Evans Debra
Evans Gabrielle
Everitt Robert
Evers Mirjam
Evetts George
Ewalds Esther
Ezekowitz Justin
Fagan Laura
Fagbodun Elizabeth
Farahi Neda
Fareed Komal
Farnell-Ward Sarah
Fartoukh Muriel
Faulkner Beverley
Faulkner Maria
Fazla Fathima
Featherstone Peter
Felton Tim
Fennessy Gerard
Ferguson Niall
Ferguson Susan
Fergusson Dean
Fernandes Edna
Fernandez Maria
Fernando Gloria
Fernández de Pinedo Artaraz Ziortza
Ferreira Ricardo Manuel Castro
Ferrier Janet
Ferringer Cindy
Fesz Jessica
Fierens Jan
Finch Cheryl
Finn André
Finn Stephanie
Finnis Mackenzie
Fiouni Sofia
Fischer Roy
Fitzgerald Mark
Fitzpatrick Meghan
Fletcher Simon
Flint Neil
Flor Thomas
Florescu Simin
Fluher Jure
Flynn Gordon
Focà Emanuele
Folci Marco
Forbes Andrew
Ford Megan
Forster Elliot
Foster Tracy
Fottrell-Gould Deirdre
Foulds Angela
Fowler Rob
Fowler Robert
Fox Claire
Fox Eleonore
Fragner Gertrud
Frakking Thuy
Franch-LLasat Diego
Francis Olesya
Francoeur François
Francois Bruno
Frankfurter Claudia
Franz Christopher
François Bourgerol
Fraser Catherine
Frater Alasdair
French Craig
Frey Anna
Frey Christian
Frise Matthew
Frost Victoria
Fuchs Ralph
Fujitani Shigeki
Fysh Ed
Gachet Alexandre
Galbiati Carola
Galea James
Ganesan Arunkumar
Ganesan Manisha
Ganguly Saibal
Garcia Sara
Gardiner-Hill Caroline
Garot Denis
Garrard Hywel
Garrard William
Garrett Peter
Garrier Ludivine
Garrod Esther
Garton Mark
Garvey James
Gascoyne Rachel
Gattas David
Gauli Basanta
Gay Alexandra
Gaylard Jane
Gellamucho Minerva
Gemmell Lisa
Gendall Emma
Geng Wenli
Geoghegan Pierce
Geri Guillaume
Geurts Heidi
Ghaffari Mehrdad
Ghamraoui Ali
Ghattaoraya Amardeep
Ghosh Alison
Giardina Giuseppe
Gibbins Alexandra
Gill Mandy
Gilliam Matthew
Gilmour Kate
Girard Timothy
Girijadevi Dinuraj
Gladas Kirsty
Glasby Kathleen
Gledhill Lisa
Glister Georgina
Glynou Loukia
Goddard Wendy
Godement Mathieu
Godoy Lucas C.
Goebeler M.E.
Golden David
Goldman John
Goligher Ewan
Gomez Keith
Gommans Frank
Goodwin Jayne
Goossens Herman
Gopal Shameer
Gopinath Amitha
Goralski Patricia
Gordon Anthony C.
Gosbell Iain
Gould Richard
Grady Bart
Graham Cheryl
Graham Libby
Graniewski Jaroslaw
Grant Caroline
GrauNovellas Neus
Greco Massimiliano
Grecu Irina
Green Cameron
Green Jackie
Greene Emma
Greener Danni
Gregory Jane
Gresham Rebecca
Greven Frances
Grieve Richard
Grimm Patrick
Grimmer Lisa
Groeneveld Erika
Gross Jamie
Grünewaldt Achim
Guanco Mark
Guerineau Elodie
Guitton Christophe
Gummadi Mahitha
Gupta Abhinav
Gurung Anita
Guérin Emmanuelle
Gómez Francisco
Göpel Siri
Habeichi Wadih
Habraken Hannah
Hadebe Bernard
Haffiane Abdelmagid
Hagel Stefan
Haghi Theerata
Haiba Khalid
Haidar Ghady
Haider Nafeesah
Haider Syeda
Hajdu Bence
Hakak Sheeba
Halden Sandra
Haldeos Anne
Hall Alistair S
Hall Amelia
Hall Andrew
Hall Kathryn
Hall Rebecca
Hamilton David
Hamilton-Davies Colin
Hamlyn Vincent
Hammond Naomi
Hammonds Fiona
Hand James
Haniffa Rashan
Hanisch Alexis
Hanley Joanne
Hansen Dan
Hanson Helen
Hanson Jane
Harden Lesley
Harding Daniel
Hardy Chloe
Harford Rachel
Harland Cain
Harper Heather
Harrington Claire
Harrington Kate
Harris Celia
Harris Jade
Harris John
Harrison David A.
Harrison Susan
Harrow Kath
Hartley Melissa
Harvala-Simmonds Heli
Harvey Alice
Harvey Daniel
Harvey James
Harward Meg
Hashmi Madhia
Hashmi Madiha
Hassan Noor
Hausermann Marie-Helene
Hawcutt Daniel
Hawes Joanne
Hawkins Nancy
Hay Sophie
Haydon Tim
Hayes Amber
Hayes Anne
Hayes Kati
Hayes Leanne
HC Ooi
Headdon William
Headlam Evie
Healey Gail
Hegazy Ahmed
Hegazy Mohamed
Heinonen Jonna
Helms Julie
Heming Nicholas
Henderson Kelly
Henderson Steven
Henning Jeremy
Henri-Lagarrigue Matthieu
Henry Joanne
Henry Lavinia
Hensley Joseph
Heritier Stephane
Hernandez Erik
Hewitt Claire
Hey Samuel
Hickey John
Hierons Sarah
Higgins Alisa M.
Hill Claire
Hill Dianne
Hill Helen
Hilldrith Anette
Hills Thomas
Hin Lui Lok
Hindle Grace
Hinrichs Carl
Hird Clare
Hodge Christopher
Hodgson Carol
Hodgson Helen
Hoff Uwe
Hoiting Oscar
Holbrook Catherine
Holland Andrew
Holland Nicky
Holland Susan
Hollos Laszlo
Homes Jennifer
Honda Hitoshi
Hope David
Hopkins Phil
Hormis Anil
Horner Dan
Hornsby James
Horton Michelle
Horvat Christopher M.
Howcroft Clare
Howell Alice
Hower Martin
Howie Lucy
Howle Ryan
Hoxha Elvira
Huang David T.
Hughes Debbie
Hugill Keith
Huijbens Danique
Hullegie Sebastiaan
Hulley Amanda
Hulme Jonathan
Hulse Sarah
Humphrey Charlotte
Hunt Beverley
Hunter Stephanie
Hurford Sally-Anne
Hussain Mahwish
Hussain Sajid
Hutchinson Christina
Hutton Paula
Hüning Vanessa
Ichihara Nao
Ijaz Nazia
Ikhena Ikhuemose
Inskip Deborah
Irving Ben
Isgro Graziella
Isguzar Agah
Ishani Pramodya
Ivatt Helen
Jackson Carolyn
Jackson Shane
Jackson Susan
Jacob Reni
Jacquier Sophie
Jafarzadeh Mina
Jagannathan Vijay
Jain Susan
James Augustian
James Christie
Jan Hassing Robert
Janin Pierre
Jarczak Dominik
Jarman Claire
Jayakumar Deva
Jayakumar Devachandran
Jean-Pierre Eraldi
Jeblaoui Asma
Jenkins Samuel
Jenkins Sarah
Jenkins Steve
Jennings Stacey
Jepson Eleanor
Jerenec Katja
Jesty Robert
Jha Avinash
Jha Rajeev
Jhanji Shaman
Jin Xia
Jindai Kazuaki
John Maya
Johns Magaret
Johnson David
Johnson Paul
Johnson Rebekah
Johnson Toby
Johnston Brian
Jones Andrea
Jones Cathy
Jones Dawn
Jones Emily
Jones Jessica
Jones Samantha
Jongebloed Katherine
Joseph Sibet
Joseph Treesa
Joyce Kirsten
Juffermans Nicole
Juhaz Vera
Kadam Umesh
Kalamar ?iga
Kalchko-Veyssal Selver
Kalchthaler Kyle
Kaliappan Agilan
Kalla Ismail
Kalogirou Michael
Kamata Kazuhiro
Kamel Toufik
Kampschreur Linda
Kamra Maneesha
Kandeepan Revathi
Kannan Santhana
Kannan Thogulava
Kanwal Darakhshan
Karachi Tim
Karim Hina
Karki Rakshya
Karlikowski Michal
Karlsson Sari
Kasipandian Vidya
Kassir Sandy
Katary Amro
Kato Hideaki
Kavanagh Lisa
Kayani Abdul
Kayastha Srijana
Kaye Callum
Kazi Aayesha
KC Shirish
KC Shirsh
Keating Liza
Keatley Claire
Keeler Sheryl
Keen Alexandra
Keen Sherbrina
Keijzer-Timmers Nicole
Kell Kay
Kelly Martin
Kelly Niamh
Kelsall Olivia
Kendrick Sara
Kernan Maeve
Kerslake Ian
Kester Esmee
Khade Reena
Khalid Imrana
Khan Meherunnisa
Khanal Kishor
Khanal Sushil
Khare Divya
Khoso Nasir
Khoud Ahmed
Khwaja Kosar
Kidwai Aneela
Kiiski Heikki
Kilner Mari
Kim Edy Y.
Kimpton Sarah
King Andrew
Kinney Fiona
Kirk Jill
Kirk Rosemary
Kirkby Amy
Kirkham Simon
Kit Barbara
Kitsios Georgios
Kittridge Lauren
Klein Daniela
Klop-Riehl Margreet
Kluge Stefan
Knowles Karen
Kochanek Matthias
Kochert Erik
Koelink Maaike
Koirala Kanchan
Koirala Sabin
Kolanos Steffi
Kolovou Angeliki
Konecny Pam
Kong Jing
Koopmans Matty
Kosa Alma
Kremling Julius
Kreß Gabriele
Krishnamoorthy S
Krishnamurthy Vinodh
Kruger Peter
Kruisdijk-Gerritsen Arriette
Kruisselbrink Rebecca
Kuitunen Anne
Kumar Anand
Kumar Nikhil
Kumar Rohit
Kummerlen Christine
Kunishima Hiroyuki
Kunwar Puja
Kunz Kevin
Kurenda Catherine
Kutsogiannis Demetrios
Kuybida Yuriy
Kwan Yvonne
Kyeremeh Lynsey
Kyle Laura
L?Hotellier Sylvie
Labbe Vincent
Laffan Mike
Laffey John
Laha Shondipon
Lai Vivian
Lambert Bridget
Lamontagne Francois
Lampro Lamprini
Landais Michaël
Landoni Giovanni
Landsiedel-Mechenbier Elke
Lang Eva
Langridge Emma
Latham Victoria
Latino Reece
Laudi Svenja
Laugs Fabian
Lavana Jayshree
Laver Russell D.
Law Daniel
Lawler Patrick R.
Le Basnier Elliot
Le Guen Lenaïg
Le Loup Guillaume
Leaf David E.
Lean Richard
Leaver Susannah
Leavis Helen
Leblond Julie
Leditschke Anne
Lee Kelvin
Lee Stephanie
Lee Stephen
Lefevre Montaine
Leffelaar Evelien
Lehalleur Adrien
Lellouche Francois
Lemaire-Brunel Delphine
Lembo Rosalba
Leparco Cécile
Leroyer Marie-Helene
Lesona Eden
Levett Chris
Lewis Joanne
Lewis Roger J.
Lewis Sarah
LewisProsser Lorraine
Liao Angela
Lim Rosario
Limb James
Lindergard Gabriella
Linnett Vanessa
Linstrum Kelsey M.
Litton Ed
Litton Edward
Liu Theresa
Lizotte Patricia
Lock Stephen
Lockett Teresa
Logan Meg
Lomme Kaatje
Long Matilda
Lopus Alyssa
Lorenzi Elizabeth
Lother Sylvain
Lowe Benjamin
Lowery Maryalyce
Lowrey Julie
Lucas Rachael
Luis David
Luitel Subekshya
Luk Tracy
Lunde Ragnar
Luo Ji
Lye Alison
Lynch Ceri
Lynch Daniella
López Maria
López Rafael
Löbel Madlen
MacKay Callum
Mackay Euan
Mackay Josephine
MacKay Lynn
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Vanjak Christian
Vanmali Piyush
van Opdorp Marjolein
van Vonderen Marit
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Varghese Siby
Vautier Sarah
Vazquez-Grande Gloria
Veenith Tonny
Veillard Marion
Venkatesh Bala
Verlander Mark
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Vignesh C
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Watkins Claire
Watpool Irene
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Watts Angela
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Webb Steve A.
Weber Lisa
Webster Denise
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Weiss Daniel
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Wells Alan
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Wells Karen
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West Lauren
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Whileman Amanda
Whitbread Jennifer
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Whitehead Christina
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Wigbers Jeanette
Wijewardena Gayathri
Wilby Elizabeth
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Wilcox Louise
Wild Helen
Wild Laura
Wilding Laura
Wiles Matt
Wiley Daisy
Wilhelmsen Elva
Wilkinson Dean
Willams Felicity
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Williams Angharad
Williams Anna
Williams Erin
Williams Gemma
Williams Hannah
Williams Karen
Williams Marie
Williams Patricia
Williams Penny
Williams Tony
Williams Virginie
Williamson Dawn
Williamson James D
Willis Joanna
Willson Jayne
Wilson Anna
Wilson Craig
Wilson Jean
Wilson Maggie
Winters James
Winters Lauren
Wise Matt
Wisniewski Mary
Wittekamp Bastiaan
Wittenberg Wendy
Wnuk Chris
Woelke Amy
Wong Jenny
Wong Onyee
Wood Erica
Wood Hannah
Wood Tracy
Woods Jane
Woods Lindsey
Woodward Robert
Woolett Melissa
Worner Ruth
Wren Jess
Wren Lynn
Wrey Brown Caroline
Wright Chris
Wright Kim
Wunderley Renee
Wyatt Rachel
Wylie Katharine
Xavier Kugan
Yamagishi Yoshiaki
Yamashita Chizuru
Yang Yang
Yarad Elizabeth
Yates Bryan
Yates David
Yealy Donald
Young Ian
Young Meredith
Young Paul
Youngstein Taryn
Yu Haili
Yusuff Hakeem
Zaharia Mihaela
Zaidi Abbas
Zaki Ahmed
Zaman Mohsin
Zarychanski Ryan
Zdanavidiene Ausra
Zhao Xiao
Zinzoni Vanessa
Zitter Letizia
Zouita Louisa
Publication venue: 'American Medical Association (AMA)'
Publication date: 11/04/2023
Field of study

IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19. Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19. DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022). INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days. MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes. RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively). CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes. TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570

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