Experiencing Poverty in an Online Simulation: Effects on Players’ Beliefs, Attitudes and Behaviors about Poverty

Digital simulations are increasingly used to educate about the causes and effects of poverty, and inspire action to alleviate it. Drawing on research about attributions of poverty, subjective well-being, and relative income, this experimental study assesses the effects of an online poverty simulation (entitled Spent) on participants’ beliefs, attitudes, and actions. Results show that, compared with a control group, Spent players donated marginally more money to a charity serving the poor and expressed higher support for policies benefitting the poor, but were less likely to take immediate political action by signing an online petition to support a higher minimum wage. Spent players also expressed greater subjective well-being than the control group, but this was not associated with increased policy support or donations. Spent players who experienced greater presence (perceived realism of the simulation) had higher levels of empathy, which contributed to attributing poverty to structural causes and support for anti-poverty policies. We draw conclusions for theory about the psychological experience of playing online poverty simulations, and for how they could be designed to stimulate charity and support for anti-poverty policies

Termination of Parental Rights for Parents With Substance Use Disorder: For Whom and Then What?

The purpose of this study is to investigate the correlates of termination of parental rights (TPR) for parents with substance use disorder (SUD) and to determine what happens with regard to permanency once a TPR decision is made. Bivariate techniques and hierarchical non-linear modeling are used. Parents of older youth, boys, and Hispanics were less likely, while parents who failed to make progress in substance use treatment and parenting skills are more likely to experience TPR. At follow up, 85% of the children were adopted, 7% remained in a substitute care settings, and 7% were reunified with their parents. Concerns remain for children without a permanent home setting

On the seasonal variability of the Canary Current and the Atlantic Meridional Overturning Circulation

Author Posting. © American Geophysical Union, 2017. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research: Oceans 122 (2017): 4518–4538, doi:10.1002/2017JC012774.The Atlantic Meridional Overturning Circulation (AMOC) is continually monitored along 26°N by the RAPID-MOCHA array. Measurements from this array show a 6.7 Sv seasonal cycle for the AMOC, with a 5.9 Sv contribution from the upper mid-ocean. Recent studies argue that the dynamics of the eastern Atlantic is the main driver for this seasonal cycle; specifically, Rossby waves excited south of the Canary Islands. Using inverse modeling, hydrographic, mooring, and altimetry data, we describe the seasonal cycle of the ocean mass transport around the Canary Islands and at the eastern boundary, under the influence of the African slope, where eastern component of the RAPID-MOCHA array is situated. We find a seasonal cycle of −4.1 ± 0.5 Sv for the oceanic region of the Canary Current, and +3.7 ± 0.4 Sv at the eastern boundary. This seasonal cycle along the eastern boundary is in agreement with the seasonal cycle of the AMOC that requires the lowest contribution to the transport in the upper mid-ocean to occur in fall. However, we demonstrate that the linear Rossby wave model used previously to explain the seasonal cycle of the AMOC is not robust, since it is extremely sensitive to the choice of the zonal range of the wind stress curl and produces the same results with a Rossby wave speed of zero. We demonstrate that the seasonal cycle of the eastern boundary is due to the recirculation of the Canary Current and to the seasonal cycle of the poleward flow that characterizes the eastern boundaries of the oceans.RAPROCAN Project ; Instituto Español de Oceanografía; and as part of the SeVaCan project Grant Number: CTM2013-48695; Ministerio de Economía y Competividad; Apoyo al Personal Investigador en Formación2017-12-0

Spitzer Infrared Spectrograph Observations of Magellanic Cloud Planetary Nebulae: the nature of dust in low metallicity circumstellar ejecta

We present 5 - 40 micron spectroscopy of 41 planetary nebulae (PNe) in the Magellanic Clouds, observed with the Infrared Spectrograph on board the Spitzer Space Telescope. The spectra show the presence of a combination of nebular emission lines and solid-state features from dust, superimposed on the thermal IR continuum. By analyzing the 25 LMC and 16 SMC PNe in our sample we found that the IR spectra of 14 LMC and 4 SMC PNe are dominated by nebular emission lines, while the other spectra show solid-state features. We observed that the solid-state features are compatible with carbon-rich dust grains (SiC, polycyclic aromatic hydrocarbons (PAHs), etc.) in most cases, except in three PNe showing oxygen-rich dust features. The frequency of carbonaceous dust features is generally higher in LMC than in SMC PNe. The spectral analysis allowed the correlations of the dust characteristics with the gas composition and morphology, and the properties of the central stars. We found that: 1) all PNe with carbonaceous dust features have C/O>1, none of these being bipolar or otherwise highly asymmetric; 2) all PNe with oxygen-rich dust features have C/O<1, with probable high mass progenitors if derived from single-star evolution (these PNe are either bipolar or highly asymmetric); 3) the dust temperature tracks the nebular and stellar evolution; and 4) the dust production efficiency depends on metallicity, with low metallicity environments not favoring dust production.Comment: The Astrophysical Journal, in pres

Inner-Hair Cells Parameterized-Hardware Implementation for Personalized Auditory Nerve Stimulation

In this paper the hardware implementation of an inner hair cell model is presented. Main features of the design are the use of Meddis’ transduction structure and the methodology for Design with Reusability. Which allows future migration to new hardware and design refinements for speech processing and custom-made hearing aid

Clinical and molecular characterization of a cardiac ryanodine receptor founder mutation causing catecholaminergic polymorphic ventricular tachycardia

Background Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a difficult-to-diagnose cause of sudden cardiac death (SCD). We identified a family of 1400 individuals with multiple cases of CPVT, including 36 SCDs during youth. Objectives We sought to identify the genetic cause of CPVT in this family, to preventively treat and clinically characterize the mutation-positive individuals, and to functionally characterize the pathogenic mechanisms of the mutation. Methods Genetic testing was performed for 1404 relatives. Mutation-positive individuals were preventively treated with β-blockers and clinically characterized with a serial exercise treadmill test (ETT) and Holter monitoring. In vitro functional studies included caffeine sensitivity and store overload–induced calcium release activity of the mutant channel in HEK293 cells. Results We identified the p.G357S_RyR2 mutation, in the cardiac ryanodine receptor, in 179 family members and in 6 SCD cases. No SCD was observed among treated mutation-positive individuals over a median follow-up of 37 months; however, 3 relatives who had refused genetic testing (confirmed mutation-positive individuals) experienced SCD. Holter monitoring did not provide relevant information for CPVT diagnosis. One single ETT was unable to detect complex cardiac arrhythmias in 72% of mutation-positive individuals, though the serial ETT improved the accuracy. Functional studies showed that the G357S mutation increased caffeine sensitivity and store overload–induced calcium release activity under conditions that mimic catecholaminergic stress. Conclusion Our study supports the use of genetic testing to identify individuals at risk of SCD to undertake prophylactic interventions. We also show that the pathogenic mechanisms of p.G357S_RyR2 appear to depend on β-adrenergic stimulation

RNAi-based Glyconanoparticles Trigger Apoptotic Pathways for In Vitro and In Vivo Enhanced Cancer-Cell Killing

biotechnology and material science due to their amazing physical, chemical and biological properties. Here, siRNA GlycoNPs (AuNP@PEG@Glucose@siRNA) in comparison to PEGylated GlycoNPs (AuNP@PEG@Glucose) were applied in vitro to a luciferase-CMT/167 adenocarcinoma cancer cell line and in vivo via intratracheal instillation directly into the lung of B6 albino mice grafted with luciferase-CMT/167 adenocarcinoma cells. siRNA GlycoNPs but not PEGylated GlycoNPs induced the expression of pro-apoptotic proteins such as Fas/CD95 and caspases 3 and 9 in CMT/167 adenocarcinoma cells in a dose dependent manner, independent from the inflammatory response, evaluated by bronchoalveolar lavage cell counting. Moreover, in vivo pulmonary delivered siRNA GlycoNPs were capable of targeting c-Myc gene expression (a crucial regulator of cell proliferation and apoptosis) via in vivo RNAi in tumour tissue, leading to a ~80% reduction in tumour size without inflammation associated

Tailoring Three-Point Functions and Integrability III. Classical Tunneling

We compute three-point functions between one large classical operator and two large BPS operators at weak coupling. We consider operators made out of the scalars of N=4 SYM, dual to strings moving in the sphere. The three-point function exponentiates and can be thought of as a classical tunneling process in which the classical string-like operator decays into two classical BPS states. From an Integrability/Condensed Matter point of view, we simplified inner products of spin chain Bethe states in a classical limit corresponding to long wavelength excitations above the ferromagnetic vacuum. As a by-product we solved a new long-range Ising model in the thermodynamic limit.Comment: 37 pages, 10 figure