Metacognition as a predictor of improvements in personality disorders

Personality Disorders (PDs) are particularly hard to treat and treatment drop-out rates are high. Several authors have agreed that psychotherapy is more successful when it focuses on the core of personality pathology. For this reason, therapists dealing with PDs need to understand the psychopathological variables that characterize this pathology and exactly what contributes to maintaining psychopathological processes. Moreover, several authors have noted that one key problem that characterizes all PDs is an impairment in understanding mental states - here termed metacognition - which could also be responsible for therapy failures. Unfortunately, a limited number of studies have investigated the role of mentalization in the process of change during psychotherapy. In this paper, we assume that poor metacognition corresponds to a core element of the general pathology of personality, impacts a series of clinical variables, generates symptoms and interpersonal problems, and causes treatment to be slower and less effective. We explored whether changes in metacognition predicted an improvement among different psychopathological variables characterizing PDs; 193 outpatients were treated at the Third Center of Cognitive Psychotherapy in Rome, Italy, and followed a structured path tailored for the different psychopathological variables that emerged from a comprehensive psychodiagnostic assessment that considered patients' symptoms, metacognitive abilities, interpersonal relationships, personality psychopathology, and global functioning. The measurements were repeated after a year of treatment. The results showed that changes in metacognitive abilities predicted improvements in the analyzed variable

Studio botanico finalizzato al recupero del paesaggio vegetale dell’Area archeologica di Lilibeo presso Marsala (Sicilia occidentale)

Viene presentato uno studio botanico volto al recupero del paesaggio vegetale dell’Area Archeologica di Capo Lilibeo (Marsala). Il progetto prevede l’eradicazione delle specie esotiche ad alto grado di invasività quali Ailanthus altissima e Vachellia karroo, il risanamento fitosanitario dei viali di Palme delle Canarie e la sostituzione degli individui malformati con specie ornamentali altamente decorative e a basso grado di invasività. E’ previsto l’impiego di specie afferenti agli stadi più evoluti dei sigmataxa Chamaeropo humilis- Querceto calliprini sigmetum ed al Pistacio lentisci- Chamaeropo humilis sigmetum al fine di assicurare i migliori risultati contro l’espansione della componente esotica ad alto grado di invasività.A plan based on a previous botanical investigation is presented here in order of recovering the plant landscape of the archaeological area o fthe Lilibeo Cape near Marsala. It includes the uprooting of highly invasive exotics such as Ailanthus altissima and Vachellia karroo, the recovery of the Canary date palms the replacement of disfigured tree specimens using less invasive ornamental trees. In addition, species belonging to the final stages of the sigmataxa Chamaeropo humilis- Querceto calliprini sigmetum and of the Pistacio lentisci- Chamaeropo humilis sigmetum in order to oppose successful barriers against the most invasive aliens

Examination on total ozone column retrievals by Brewer spectrophotometry using different processing software

The availability of long-term records of the total ozone content (TOC) represents a valuable source of information for studies on the assessment of short-and long-term atmospheric changes and their impact on the terrestrial ecosystem. In particular, ground-based observations represent a valuable tool for validating satellite-derived products. To our knowledge, details about software packages for processing Brewer spectrophotometer measurements and for retrieving the TOC are seldom specified in studies using such datasets. The sources of the differences among retrieved TOCs from the Brewer instruments located at the Italian stations of Rome and Aosta, using three freely available codes (Brewer Processing Software, BPS; O3Brewer software; and European Brewer Network (EUBREWNET) level 1.5 products) are investigated here. Ground-based TOCs are also compared with Ozone Monitoring Instrument (OMI) TOC retrievals used as an independent dataset since no other instruments near the Brewer sites are available. The overall agreement of the BPS and O3Brewer TOC data with EUBREWNET data is within the estimated total uncertainty in the retrieval of total ozone from a Brewer spectrophotometer (1%). However, differences can be found depending on the software in use. Such differences become larger when the instrumental sensitivity exhibits a fast and dramatic drift which can affect the ozone retrievals significantly. Moreover, if daily mean values are directly generated by the software, differences can be observed due to the configuration set by the users to process single ozone measurement and the rejection rules applied to data to calculate the daily value. This work aims to provide useful information both for scientists engaged in ozone measurements with Brewer spectrophotometers and for stakeholders of the Brewer data products available on Web-based platforms

Profilometer Comparison of the Surface Roughness of Four Denture Base Resins: An In Vitro Study

Background: The roughness of denture base materials is mainly affected by inherent material features, the polishing technique, and the operator’s manual skills. The surface irregularities of the denture base resin’s roughness profile is one of the components characterizing the superficial topography of dental prostheses, and it is a critical parameter for describing surface morphology. Generally, the increment of the surface roughness minimizes cleanability and promotes the rate of bacterial adherence, affecting the expression of bacterial adhesins. The purpose of this in vitro study was to investigate the roughness of four commercially available denture base resins employed for removable prosthodontics. Methods: Twenty-five specimens were realized and submitted to observation for three dimensions (vertically, horizontally, 45 ). Average surface roughness (Ra), Rv, Rp, and Rq were measured with a calibrated mechanical roughness tester (Taylor Hobson Surtronic 25; Taylor Hobson, Leicester, UK). Data were analyzed through a Kruskal–Wallis test. Results: Significant differences in Ra between the groups were assessed. Baltic Denture System™ (Merz Dental GmbH; Lütjenburg, Germania) showed a lower surface roughness coefficient and a more homogeneous surface. Conclusions: The functional importance of surface roughness parameters for denture base materials must be explored, not only considering recognized surface features

A Substrate-induced Switch in the Reaction Mechanism of a Thermophilic Esterase KINETIC EVIDENCES AND STRUCTURAL BASIS

The reaction mechanism of the esterase 2 (EST2) from Alicyclobacillus acidocaldarius was studied at the kinetic and structural level to shed light on the mechanism of activity and substrate specificity increase previously observed in its double mutant M211S/R215L. In particular, the values of kinetic constants (k1, k(-1), k2, and k3) along with activation energies (E1, E(-1), E2, and E3) were measured for wild type and mutant enzyme. The previously suggested substrate-induced switch in the reaction mechanism from kcat=k3 with a short acyl chain substrate (p-nitrophenyl hexanoate) to kcat=k2 with a long acyl chain substrate (p-nitrophenyl dodecanoate) was validated. The inhibition afforded by an irreversible inhibitor (1-hexadecanesulfonyl chloride), structurally related to p-nitrophenyl dodecanoate, was studied by kinetic analysis. Moreover the three-dimensional structure of the double mutant bound to this inhibitor was determined, providing essential information on the enzyme mechanism. In fact, structural analysis explained the observed substrate-induced switch because of an inversion in the binding mode of the long acyl chain derivatives with respect to the acyl- and alcohol-binding sites

Apolipoprotein A-I (ApoA-I) Mimetic Peptide P2a by Restoring CholesterolEsterification Unmasks ApoA-I Anti-Inflammatory Endogenous Activity In Vivo. CO-FIRST AUTHOR

The acute-phase protein haptoglobin (Hpt) binds apolipoprotein A-I (ApoA-I) and impairs its action on lecithin-cholesterol acyltransferase, an enzyme that plays a key role in reverse cholesterol transport. We have previously shown that an ApoA-I mimetic peptide, P2a, displaces Hpt from ApoA-I, restoring the enzyme activity in vitro. The aim of this study was to evaluate whether P2a displaces Hpt from ApoA-I in vivo and whether this event leads to anti-inflammatory activity. Mice received subplantar injections of carrageenan. Paw volume was measured before the injection and 2, 4, 6, 24, 48, 72, and 96 h thereafter. At the same time points, concentrations of HDL cholesterol (C) and cholesterol esters (CEs) were measured by high-performance liquid chromatography, and Hpt and ApoA-I plasma levels were evaluated by enzyme-linked immunosorbent assay. Western blotting analysis for nitric-oxide synthase and cyclooxygenase (COX) isoforms was also performed on paw homogenates. CEs significantly decreased in carrageenan-treated mice during edema development and negatively correlated with the Hpt/ApoA-I ratio. P2a administration significantly restored the CE/C ratio. In addition, P2a displayed an anti-inflammatory effect on the late phase of edema with a significant reduction in COX2 expression coupled to an inhibition of prostaglandin E2 synthesis, implying that, in the presence of P2a, CE/C ratio rescue and edema inhibition were strictly related. In conclusion, the P2a effect is due to its binding to Hpt with consequent displacement of ApoA-I that exerts anti-inflammatory activity. Therefore, it is feasible to design drugs that, by enhancing the physiological endogenous protective role of ApoA-I, may be useful in inflammation-based diseases

Numerical modelling of slope–vegetation–atmosphere interaction: an overview

The behaviour of natural and artificial slopes is controlled by their thermo-hydro-mechanical conditions and by soil–vegetation–atmosphere interaction. Porewater pressure changes within a slope related to variable meteorological settings have been shown to be able to induce soil erosion, shrinkage–swelling and cracking, thus leading to an overall decrease of the available soil strength with depth and, ultimately, to a progressive slope collapse. In terms of numerical modelling, the stability analysis of partially saturated slopes is a complex problem and a wide range of approaches from simple limit equilibrium solutions to advanced numerical analyses have been proposed in the literature. The more advanced approaches, although more rigorous, require input data such as the soil water retention curve and the hydraulic conductivity function, which are difficult to obtain in some cases. The quantification of the effects of future climate scenarios represents an additional challenge in forecasting slope–atmosphere interaction processes. This paper presents a review of real and ideal case histories regarding the numerical analysis of natural and artificial slopes subjected to different types of climatic perturbations. The limits and benefits of the different numerical approaches adopted are discussed and some general modelling recommendations are addressed

Le disfunzioni metacognitive nei disturbi di personalit Una review delle ricerche del III Centro di Psicoterapia Cognitiva

Dagli anni '90, il III Centro di Psicoterapia Cognitiva di Roma si è impegnato nell'attività clinica e di ricerca sul trattamento di pazienti gravi e difficili da trattare. In questo lavoro verranno analizzati alcuni tra i più importanti lavori pubblicati dal Gruppo in questo ambito. Si tratta di ricerche sul processo terapeutico condotte a partire dall’osservazione clinica secondo cui la presenza di specifici malfunzionamenti metacognitivi ostacolerebbe la costruzione della rappresentazione degli stati mentali propri e altrui; la regolazione della relazione terapeutica potrebbe migliorare tali malfunzionamenti rendendo così possibili gli interventi sugli aspetti sintomatici del paziente. Sono state portate, quindi, prove sufficienti a sostenere che la metacognizione sia una grandezza composta da sottofunzioni distinte semi-indipendenti. Altri studi del Gruppo hanno mostrato poi come la realtà clinica del paziente grave sia influenzata in modo diverso dalla presenza di specifici malfunzionamenti metacognitivi