16,746 research outputs found
Inflammation and changes in cytokine levels in neurological feline infectious peritonitis.
Feline infectious peritonitis (FIP) is a progressive, fatal, predominantly Arthus-type immune-mediated disease that is triggered when cats are infected with a mutant enteric coronavirus. The disease presents variably with multiple organ failure, seizures, generalized effusion, or shock. Neurological FIP is clinically and pathologically more homogeneous than systemic 'wet' or 'dry' FIP; thus, comparison of cytokine profiles from cats with neurological FIP, wet FIP, and non-FIP neurological disease may provide insight into some baseline characteristics relating to the immunopathogenesis of neurological FIP. This study characterizes inflammation and changes in cytokines in the brain tissue of FIP-affected cats. Cellular infiltrates in cats with FIP included lymphocytes, plasma cells, neutrophils, macrophages, and eosinophils. IL-1 beta, IL-6, IL-12, IL-18, TNF-alpha, macrophage inhibitory protein (MIP)-1 alpha, and RANTES showed no upregulation in the brains of control cats, moderate upregulation in neurological FIP cats, and very high upregulation in generalized FIP cats. Transcription of IFN-gamma appeared upregulated in cats with systemic FIP and slightly downregulated in neurological FIP. In most cytokines tested, variance was extremely high in generalized FIP and much less in neurological FIP. Principal components analysis was performed in order to find the least number of 'components' that would summarize the cytokine profiles in cats with neurological FIP. A large component of the variance (91.7%) was accounted for by levels of IL-6, MIP-1 alpha, and RANTES. These findings provide new insight into the immunopathogenesis of FIP and suggest targets for immune therapy of this disease
Ptychographic X-ray computed tomography of extended colloidal networks in food emulsions
As a main structural level in colloidal food materials, extended colloidal
networks are important for texture and rheology. By obtaining the 3D
microstructure of the network, macroscopic mechanical properties of the
material can be inferred. However, this approach is hampered by the lack of
suitable non-destructive 3D imaging techniques with submicron resolution.
We present results of quantitative ptychographic X-ray computed tomography
applied to a palm kernel oil based oil-in-water emulsion. The measurements were
carried out at ambient pressure and temperature. The 3D structure of the
extended colloidal network of fat globules was obtained with a resolution of
around 300 nm. Through image analysis of the network structure, the fat globule
size distribution was computed and compared to previous findings. In further
support, the reconstructed electron density values were within 4% of reference
values.Comment: 19 pages, 4 figures, to be published in Food Structur
Inducing spin-dependent tunneling to probe magnetic correlations in optical lattices
We suggest a simple experimental method for probing antiferromagnetic spin
correlations of two-component Fermi gases in optical lattices. The method
relies on a spin selective Raman transition to excite atoms of one spin species
to their first excited vibrational mode where the tunneling is large. The
resulting difference in the tunneling dynamics of the two spin species can then
be exploited, to reveal the spin correlations by measuring the number of doubly
occupied lattice sites at a later time. We perform quantum Monte Carlo
simulations of the spin system and solve the optical lattice dynamics
numerically to show how the timed probe can be used to identify
antiferromagnetic spin correlations in optical lattices.Comment: 5 pages, 5 figure
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Elevated fetal steroidogenic activity in autism
Autism affects males more than females, giving rise to the idea that the influence of steroid hormones on early fetal brain development may be one important early biological risk factor. Utilizing the Danish Historic Birth Cohort and Danish Psychiatric Central Register, we identified all amniotic fluid samples of males born between 1993 and 1999 who later received ICD-10 (International Classification of Diseases, 10th Revision) diagnoses of autism, Asperger syndrome or PDD-NOS (pervasive developmental disorder not otherwise specified) (n=128) compared with matched typically developing controls. Concentration levels of Δ4 sex steroids (progesterone, 17α-hydroxy-progesterone, androstenedione and testosterone) and cortisol were measured with liquid chromatography tandem mass spectrometry. All hormones were positively associated with each other and principal component analysis confirmed that one generalized latent steroidogenic factor was driving much of the variation in the data. The autism group showed elevations across all hormones on this latent generalized steroidogenic factor (Cohen's d=0.37, P=0.0009) and this elevation was uniform across ICD-10 diagnostic label. These results provide the first direct evidence of elevated fetal steroidogenic activity in autism. Such elevations may be important as epigenetic fetal programming mechanisms and may interact with other important pathophysiological factors in autism
Thermodynamics of Heat Shock Response
Production of heat shock proteins are induced when a living cell is exposed
to a rise in temperature. The heat shock response of protein DnaK synthesis in
E.coli for temperature shifts from temperature T to T plus 7 degrees,
respectively to T minus 7 degrees is measured as function of the initial
temperature T. We observe a reversed heat shock at low T. The magnitude of the
shock increases when one increase the distance to the temperature , thereby mimicking the non monotous stability of proteins at low
temperature. Further we found that the variation of the heat shock with T
quantitatively follows the thermodynamic stability of proteins with
temperature. This suggest that stability related to hot as well as cold
unfolding of proteins is directly implemented in the biological control of
protein folding. We demonstrate that such an implementation is possible in a
minimalistic chemical network.Comment: To be published in Physical Review Letter
Antiferromagnetic noise correlations in optical lattices
We analyze how noise correlations probed by time-of-flight (TOF) experiments
reveal antiferromagnetic (AF) correlations of fermionic atoms in
two-dimensional (2D) and three-dimensional (3D) optical lattices. Combining
analytical and quantum Monte Carlo (QMC) calculations using experimentally
realistic parameters, we show that AF correlations can be detected for
temperatures above and below the critical temperature for AF ordering. It is
demonstrated that spin-resolved noise correlations yield important information
about the spin ordering. Finally, we show how to extract the spin correlation
length and the related critical exponent of the AF transition from the noise.Comment: 4 pages, 4 figure
Canted antiferromagnetism in phase-pure CuMnSb
We report the low-temperature properties of phase-pure single crystals of the
half-Heusler compound CuMnSb grown by means of optical float-zoning. The
magnetization, specific heat, electrical resistivity, and Hall effect of our
single crystals exhibit an antiferromagnetic transition at and a second anomaly at a temperature . Powder and single-crystal neutron diffraction establish an
ordered magnetic moment of ,
consistent with the effective moment inferred from the Curie-Weiss dependence
of the susceptibility. Below , the Mn sublattice displays
commensurate type-II antiferromagnetic order with propagation vectors and
magnetic moments along (magnetic space group ).
Surprisingly, below , the moments tilt away from by
a finite angle , forming a canted antiferromagnetic
structure without uniform magnetization consistent with magnetic space group
. Our results establish that type-II antiferromagnetism is not the
zero-temperature magnetic ground state of CuMnSb as may be expected of the
face-centered cubic Mn sublattice.Comment: 14 pages, 15 figure
Spin-orbit interaction and the 'metal-insulator' transition observed in two-dimensional hole systems
We present calculations of the spin and phase relaxation rates in GaAs/AlGaAs
-type quantum wells. These rates are used to derive the temperature
dependence of the weak-localization correction to the conductivity. In -type
quantum wells both weak localization and weak anti-localization are present due
to the strong spin-orbit interaction. When determining the total conductivity
correction one also have to include the term due to hole-hole interaction. The
magnitude of the latter depends on the ratio between the thermal energy and the
Fermi energy, and whether the system can be considered
as ballistic or diffusive (). We argue that due to the relatively low Fermi energy
and the moderate mobilities, in the -type systems in question, the
conductivity correction arising from hole-hole interactions is negligible at
the highest temperatures accessible in the experiments. Hence the
'metal-insulator' transition observed at these relatively high temperatures
could be caused by interference effects. We compare our calculations of the
weak anti-localization correction with the experimental results from different
independent groups with special emphasis on the experiments by Simmons et al.
We find good agreement between predicted and observed transistion density
.Comment: 6 pages, 4 figures. Accepted to PRB (15 June, 2002
Einstein-Weyl structures corresponding to diagonal K\"ahler Bianchi IX metrics
We analyse in a systematic way the four dimensionnal Einstein-Weyl spaces
equipped with a diagonal K\"ahler Bianchi IX metric. In particular, we show
that the subclass of Einstein-Weyl structures with a constant conformal scalar
curvature is the one with a conformally scalar flat - but not necessarily
scalar flat - metric ; we exhibit its 3-parameter distance and Weyl one-form.
This extends previous analysis of Pedersen, Swann and Madsen , limited to the
scalar flat, antiself-dual case. We also check that, in agreement with a
theorem of Derdzinski, the most general conformally Einstein metric in the
family of biaxial K\"ahler Bianchi IX metrics is an extremal metric of Calabi,
conformal to Carter's metric, thanks to Chave and Valent's results.Comment: 15 pages, Latex file, minor modifications, to be published in Class.
Quant. Gra
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