Systems Analysis to Promote Frames and Mental Models for Sustainable Water Management

In the water sector, there have been numerous failures in projects aiming at sustainable development and there have been some, but less numerous, examples of successes. However, the most striking observation is the near universal failure to learn from these examples. Somehow, scientists and decision makers have allowed the indications of new approaches and opportunities go undetected because they did not fit with their mindsets or perceptual apparatus. This paper discusses some of the mental frames that have hampered the progress towards sustainable development. It analyzes where these frames come from, who is promoting or defending them, and what can be done to change these frames in ways that are more in line with the basic tenets of sustainable development. It is found that there is a lack of consistency in the interpretation of sustainable development. Most sustainability initiatives have failed because the environment and development were never properly brought together. The “environment” is where we live: and “development” is what we all do in attempting to improve our lot within that abode. The two are unseparable (Our Common Future). Thus, there is a need to draw on diverse disciplinary perspectives and to cut across sectoral boundaries to counter the monovalent approaches that have dominated mainstream enquiry and practice. To that end, systems analysis can help produce enabling frameworks for process changes. These frameworks should define general objectives and means of verification of progress without specifying uniform approaches and activities. Systems analysis is also a methodology helping to make sure that problems posed are adequately defined and that helps detecting biases in goal formulation stemming either from dominant actors or from “solution oriented approaches”

Preclinical Pharmacology of [2-(3-Fluoro-5-Methanesulfonyl-phenoxy)Ethyl](Propyl)amine (IRL790), a Novel Dopamine Transmission Modulator for the Treatment of Motor and Psychiatric Complications in Parkinson Disease.

IRL790 ([2-(3-fluoro-5-methanesulfonylphenoxy)ethyl](propyl)amine, mesdopetam) is a novel compound in development for the clinical management of motor and psychiatric disabilities in Parkinson disease. The discovery of IRL790 was made applying a systems pharmacology approach based on in vivo response profiling. The chemical design idea was to develop a new type of DA D3/D2 receptor type antagonist built on agonist rather than antagonist structural motifs. We hypothesized that such a dopamine antagonist with physicochemical properties similar to agonists would exert antidyskinetic and antipsychotic effects in states of dysregulated dopaminergic signaling while having little negative impact on physiologic dopamine transmission and, hence, minimal liability for side effects related to dopamine-dependent functions. At the level of in vivo pharmacology, IRL790 displays balancing effects on aberrant motor phenotypes, reducing l-DOPA-induced dyskinesias in the rodent 6-hydroxydopamine lesion model and reducing psychostimulant-induced locomotor hyperactivity elicited by pretreatment with either d-amphetamine or dizocilpine, without negatively impacting normal motor performance. Thus, IRL790 has the ability to normalize the behavioral phenotype in hyperdopaminergic as well as hypoglutamatergic states. Neurochemical and immediate early gene (IEG) response profiles suggest modulation of DA neurotransmission, with some features, such as increased DA metabolites and extracellular DA, shared by atypical antipsychotics and others, such as increased frontal cortex IEGs, unique to IRL790. IRL790 also increases extracellular levels of acetylcholine in the prefrontal cortex and ventral hippocampus. At the receptor level, IRL790 appears to act as a preferential DA D3 receptor antagonist. Computational docking studies support preferential affinity at D3 receptors with an agonist-like binding mode. SIGNIFICANCE STATEMENT: This paper reports preclinical pharmacology along with molecular modeling results on IRL790, a novel compound in clinical development for the treatment of motor and psychiatric complications in advanced Parkinson disease. IRL790 is active in models of perturbed dopaminergic and glutamatergic signaling, including rodent 6-hydroxydopamine l-DOPA-induced dyskinesias and psychostimulant-induced hyperactivity, in a dose range that does not impair normal behavior. This effect profile is attributed to interactions at dopamine D2/D3 receptors, with a 6- to 8-fold preference for the D3 subtype

Development Assistance and Sustainable Development: A Critical Assessment

Sustainable development is currently said to be an overriding development goal, also for development assistance. It requires new approaches that challenge not only economic rationality but also bureaucracies in ways that encourage political pluralism and the participation by civil society. As the gap between rich and poor increases and as the pressures on already strained systems constantly increase, the legitimacy of the development industry has increasingly been called into question. Development processes are nonlinear `open' systems that are extremely fluid, in which continuous learning is the sine qua non of being able to respond and intervene effectively. But superficial learning is common within the development industry, because real learning implies change and challenge, and many development failures are due to institutional rather than technical problems. Somehow, agencies and managers have largely allowed the indications of new and better approaches or opportunities go undetected. They seem not to understand that building people's capacity to learn and make connections becomes more important than accumulating information about lessons learned in the past, and that it is more important to target interesting (positive or negative) experiences for learning instead of `averaging' experience across the board. A revamping of policies is urgently needed. This paper tries to provoke a more productive discussion about development assistance which goes beyond pervasive blind faith and thoughtless mantras and discusses some ideological and structural foundations that have prevented the development industry from making progress towards sustainable development. It analyzes what can be done and asserts that it is clear that, if sustainable development is to be supported and realized, it has to be built on the consent and support of those whose lives are affected. Promoting sustainability and understanding and tackling the roots of poverty is a challenge that requires unlocking material resources and allowing people to take part in social, economic and environmental decision making. There is a need to draw on more diverse perspectives and to cut across sectoral boundaries to counter the monovalent approaches that have dominated mainstream development assistance practice. To that end, there is a dire need develop frameworks that can help actors understand the real meaning of sustainable development

Towards Sustainable Urban Water and Sanitation Services: Barriers and Bridges

The Mar del Plata International Water Conference provided the first global assessment of the water sector. It was found that in most developing countries the state of water supply and sanitation services were deplorable. Consequently, a call for concerted action to improve coverage and efficiency of the water supply and sanitation sector was launched. This call resulted in the International Water Supply and Sanitation Decade (1981–1990). The Decade provided important lessons concerning effective methodologies to improve the state of the WSS sector. The paper discusses why the poor state of the water supply and sanitation conditions still tend to be the greatest development failure during the 20th century. The recipe for success was there, and the money was there. So, why were governments and big donors like the World Bank refusing to apply the lessons from the Decade? The basic conditions for success are spelled out, and some successful cases are used to illustrate these. The conclusion is that change is possible but that civil society organizations have to be empowered to make governments "feel the heat" and spend more money on water and sanitation, and to spend it more wisely

Knowledge development and management for urban poverty alleviation

This paper assesses the performance of poverty alleviation projects, asks why so many have failed, and why successful projects have been successful. It gives a retrospective. overview of the development of the concept of poverty, and argues that the way towards poverty eradication goes through holistic, participatory, approaches that build on sharing of knowledge and learning by doing. Projects and programmes should build on the full knowledge of all stakeholders. This way we can create dynamic collaborative environments that build knowledge strategically by developing and applying knowledge as it comes available. It is suggested that approaches should be guided by an enabling framework, within which a multiplicity of partnerships can develop and be effective. Common sense and holistic systems thinking are found to be essential starting points for improvements of the quality of decision-making and the learning and innovation in poverty alleviation efforts