Siniestralidad vial y subjetivación: el coche en la gestión global de la vida y la muerte

Depto. de Sociología: Metodología y TeoríaFac. de Ciencias Políticas y SociologíaTRUEpu

The prognostic significance of tumor-infiltrating lymphocytes, PD-L1, BRCA mutation status and tumor mutational burden in early-stage high-grade serous ovarian carcinoma. A study by the Spanish Group for Ovarian Cancer Research (GEICO)

Early stages are under-represented in studies on the molecular and immune features of high-grade serous ovarian carcinoma (HGSOC), and specific studies focused on early-stage HGSOC are required for a better prognostic stratification and to personalize chemotherapy. The aim of this study was to determine the prognostic significance of CD8+ and CD4+ tumor-infiltrating lymphocytes (TILs), tumoral cell PD-L1 expression, BRCA mutational status and tumor mutation burden (TMB) in early-stage HGSOC. A retrospective study was performed on stage I and II HGSOC from the Molecular Reclassification of Early Stages of Ovarian Cancer (RECLAMO) cohort from the Spanish Group of Ovarian Cancer Research (GEICO). Centralized histological typing was performed based on morphological and immunohistochemical features. Intraepithelial (i) and stromal (s) CD8+ and CD4+ T cells and PD-L1 were evaluated on tissue microarrays by immunohistochemistry. BRCA1 and BRCA2 mutation status and TMB were analyzed in tumor DNA using next-generation sequencing. The study included 124 tumors. High iCD8+ (>20 TILs/core), low/intermediate CD4+ (35/core) were associated with favorable outcomes. Tumor cell PD-L1 expression (TPS ≥ 1) was present in only 8% of tumors. In total, 11 (16%) and 6 (9%) out of 69 HGSOC tested carried pathogenic or likely pathogenic BRCA1 or BRCA2 mutations, respectively. Median TMB of 40 tumors analyzed was 5.04 mutations/Mb and only 6 tumors had 10 or more mutations/Mb. BRCA status and TMB were not associated with TILs or prognosis. When compared with studies on advanced HGSOC, our results suggested that prognostic variables differed according to stage and that more studies focused on early stages of HGSOC are needed to better stratify these tumors: This work was supported by Instituto de Salud Carlos III (ISCIII) (grants PI19/01331, PI22/01892 and PMP22/00054); CIBERONC (grant CB16/12/00316); European Development Re gional Fund ‘A way to achieve Europe’ (FEDER), Spanish Group of Research in Ovarian Cancer (GEICO group); and by the Spanish Association Against Cancer Scientific Foundation (AECC)

Una perspectiva socio-cultural de los trastornos alimentarios

En este artículo se presenta una propuesta de estudio de trastornos alimentarios (Anorexia Nerviosa, Bulimia Nerviosa) desde la antropología aplicada. Enfatiza la dimensión social de esta problemática y prioriza el análisis del contexto socio-cultural que permitiría una visión holística eintegral y ayudaría en la prevención, detección y tratamiento de este tipo de trastornos.Artikulu honetan jate arazoen (Nerbio Anorexia, Nerbio Bulimia) azterketa proposamen bat aurkezten da antropologia aplikatuaren ikuspegitik. Arazo honen alderdi soziala azpimarratu eta giro sozio-kulturalaren azterketa lehenesten da, modu horretara ikuspegi holistiko eta integrala bideratuko litzatekeelako eta nahaste mota horren prebentzio, detekzio eta tratamenduan lagundukolukeelako.Dans cet article on présente une proposition d'étude de troubles alimentaires (Anorexie Nerveuse, Boulimie Nerveuse) à partir de l'anthropologie appliquée. Elle emphatise la dimension sociale de cette problématique et donne la priorité à l'analyse du contexte socio-culturel qui permettrait une vision holistique et intégrale et aiderait à la prévention, détection et traitement de ce type detrouble.The objective of this work is to ascertain the knowledge of adolescents inthe municipality of Errenteria on nutritional behaviour problems with a view toelaborate a health promotion program for this age group. The knowledge on bulimia and anorexia is scarce in both boys and girls, and knowledge on important aspects like osteoporosis and cardiac alterations is non-existent