Book Review

The Ethical Investor is, despite its flaws, as thorough and comprehensive a treatment of the problems of universities and corporate responsibility as might be desired. It should be required reading for university trustees, and it offers many valuable insights to the general reader. Although it may appear that student and faculty interest has diminished somewhat during the past two years, it is nearly a certainty that this has been more the result of an intelligent and sincere response by university administrators and trustees than of any profound change in the climate of opinion. If the universities continue to respond in a thoughtful and reasonable way, they can make an enormous contribution to the cause of social justice, and they need not suffer in the process

Genotypic Differences in Dry Weight Accumulation, N Assimilation and Redistribution, and the Effects on Seed Yield and Protein Content in Faba Beans

This experiment was conducted to study the effects of genotypic differences in dry weight accumulation, N assimilation and redistribution, and N redistribution efficiency of different plant parts on seed yield and protein content among three faba bean cultivars, using a randomized complete block design. The total dry weight accumulated in different growth stages showed significant differences among cultivars during vegetative growth and early flowering, and during flowering and early seed filling, but not during seed filling. N was assimilated throughout growth but a large quantity was assimilated during seed filling ranging from 47.66 to 56.50% of the total plant N. The redistribution ofN from leaves, stems and pod walls to the seeds ranged from 26.66 - 31.42 %, 6.89 - 11.05% and 12.24 - 20.51 % of the seed N content, respectively. The remaining seed N content was assimilated during seed filling which accounted for 40.04 - 52.15 %. High Protein content in seeds seemed to be due to greater N assimilation during seed filling rather than to the N redistribution efficiency from the vegetative plant parts

Two-horn quiescent prominence observed in H-alpha and MgII h&k lines with THEMIS and IRIS

Prominences are large magnetic structures in the corona filled by cool plasma with fast evolving fine structure. We aim to better understand the plasma conditions in the fine structure of a quiescent prominence including two transient horns observed at the bottom of the cavity using the high-resolution spectrograph IRIS and the MulTi-Raies (MTR) spectrograph of the THEMIS in the Canary Islands. We analysed the spectra obtained in H-alpha by THEMIS and MgII by IRIS and compare them with a grid of 23940 1D radiative transfer models which include a prominence-to-corona transition region (PCTR). The full observed profiles of MgII in each pixel are fitted completely by synthesised profiles with xRMS (Cross RMS; an improved version of the rolling root mean square (rRMS) method). When the RMS is below a certain threshold value, we recover the plasma conditions from the parameters of the model best fitting the observed line profile. This criterion is met in two regions (the horns and edge of the prominence) where the line profiles can generally be described as single peaked. The 1D models suggest that two different kinds of model atmospheres correspond to these two regions. The region at the edge is found to be fitted mainly with isothermal and isobaric models, while the other area (the horns) is seen to be fitted with models with a PCTR that have optical thicknesses <5. In the prominence edge, the theoretical relationship between the integrated intensities in H-alpha and MgII is verified and corresponds to low emission measure values. In these regions the electron density is ~10^10 cm^{-3}, while it is one order of magnitude less in the horn regions. In the horns, we find some profiles are best fitted with models with high mean temperatures. This suggests that the hot PCTR found in the horns could be interpreted as prominence plasma in condensation phase at the bottom of the coronal cavity.Comment: 24 pages, 19 figures, manuscript accepted to publication in A&

Rotation and activity of pre-main-sequence stars

We present a study of rotation (vsini) and chromospheric activity (Halpha EW) based on an extensive set of high-resolution optical spectra obtained with MIKE on the 6.5m Magellan Clay telescope. Our targets are 74 F-M dwarfs in the young stellar associations Eta Cha, TW Hydrae, Beta Pic, and Tuc-Hor, spanning ages from 6 to 30 Myr. While the Halpha EW for most F and G stars are consistent with pure photospheric absorption, most K and M stars show chromospheric emission. By comparing Halpha EW in our sample to results in the literature, we see a clear evolutionary sequence: Chromospheric activity declines steadily from the T Tauri phase to the main sequence. Using activity as an age indicator, we find a plausible age range for the Tuc-Hor association of 10-40 Myr. Between 5 and 30 Myr, we do not see evidence for rotational braking in the total sample, thus angular momentum is conserved, in contrast to younger stars. This difference indicates a change in the rotational regulation at 5-10 Myr, possibly because disk braking cannot operate longer than typical disk lifetimes, allowing the objects to spin up. The rotation-activity relation is flat in our sample; in contrast to main-sequence stars, there is no linear correlation for slow rotators. We argue that this is because young stars generate their magnetic fields in a fundamentally different way from main-sequence stars, and not just the result of a saturated solar-type dynamo. By comparing our rotational velocities with published rotation periods for a subset of stars, we determine ages of 13 (7-20) Myr and 9 (7-17} Myr for the Eta Cha and TWA associations, respectively, consistent with previous estimates. Thus we conclude that stellar radii from evolutionary models by Baraffe et al. (1998) are in agreement with the observed radii within +-15%. (abridged)Comment: 40 pages, 8 figures, ApJ, in pres

Comparison of clinical burden between patients with erosive hand osteoarthritis and inflammatory arthritis in symptomatic community-dwelling adults: the Keele clinical assessment studies.

OBJECTIVE: To investigate in the general population the clinical impact of erosive OA in interphalangeal joints (IPJs) compared with symptomatic radiographic hand OA and inflammatory arthritis. METHODS: Standardized assessments with hand radiographs were performed in participants of two population-based cohorts in North Staffordshire with hand symptoms lasting ≥1 day in the past month. Erosive OA was defined as the presence of an eroded or remodelled phase in ≥1 IPJ using the Verbruggen-Veys method. Radiographic hand OA was defined as the presence of ≥1 IPJ/first carpometacarpal joint with a Kellgren-Lawrence score of ≥2. Diagnoses of inflammatory arthritis were based on medical records. Hand pain and disability were assessed with the Australian/Canadian Hand Osteoarthritis Index (AUSCAN). Linear regression analyses were used to compare clinical determinants between groups and calculate mean differences with 95% CIs, adjusted for age and sex. RESULTS: Of 1076 participants with hand symptoms [60% women, mean age 64.8 years (s.d. 8.3 years)]; 80 persons (7.4%) had erosive OA. The population prevalence of erosive OA in ≥1 IPJ was 2.4% (95% CI 1.8, 3.0). Persons with erosive OA reported more pain and disability than persons with symptomatic radiographic hand OA [adjusted mean difference 1.3 (95% CI 0.3, 2.3) and 2.3 (95% CI 0.4, 4.2), respectively]. Individuals with inflammatory arthritis (n = 44) reported more pain and disability than those with erosive OA [adjusted mean difference 1.7 (95% CI 0.05, 3.4) and 6.3 (95% CI 2.8, 9.9), respectively]. CONCLUSION: While erosive OA has a greater impact than symptomatic radiographic hand OA in the general population, it is not as severe in terms of hand pain and disability as inflammatory RA

Erosive osteoarthritis: a more severe form of radiographic hand osteoarthritis rather than a distinct entity?

OBJECTIVES: To determine whether erosive osteoarthritis shares the same pattern of joint involvement and risk profile as increasing grades of non-erosive hand osteoarthritis. METHODS: Participants were from two population-based cohorts, aged ≥50 years, reporting hand symptoms in the previous month. Interphalangeal joints were assessed for erosive osteoarthritis (Verbruggen-Veys erosive or remodelled phase) and radiographic osteoarthritis (sliding cut-offs of K&L≥2, K&L≥3 and K&L=4). At the joint level, similarities in the frequency and pattern of erosive and non-erosive osteoarthritis were assessed by Spearman's rank correlation coefficients and generalised estimating equations. At the person level, individuals with erosive osteoarthritis were compared to those with non-erosive osteoarthritis using logistic regression, adjusted for age and gender (aOR), for the following exposures: family history, previous injury, overuse and metabolic factors (BMI, dyslipidaemia, hypertension, diabetes). RESULTS: In 1076 symptomatic participants the ranked frequency of involvement for erosive joints was comparable to joints with K&L≥3 and K&L=4 (r>0.95). Patterns of joint involvement in erosive osteoarthritis were strongest for symmetry (aOR=6.5; 95% CI 3.0 to 14.1), followed by row (2.0; 0.8 to 5.0) and ray (0.3; 0.0 to 2.5), which was similar to joints with K&L≥3 and K&L=4. Individuals with erosive osteoarthritis (n=80) had an increased risk of metabolic syndrome (2.7; 1.0 to 7.1), notably dyslipidaemia (4.7; 2.1 to 10.6) compared with non-erosive osteoarthritis classed K&L≥3 (n=193). CONCLUSIONS: The similar frequency of radiographic joint involvement and patterning in erosive osteoarthritis and more severe non-erosive osteoarthritis is consistent with prevalent erosive osteoarthritis being a severe form of hand osteoarthritis rather than a distinct entity. Metabolic exposures, dyslipidaemia in particular, may be implicated in erosive osteoarthritis

Two-horn quiescent prominence observed in Hα and Mg II h&k lines with THEMIS and IRIS

Context. Prominences are large magnetic structures in the corona filled by cool plasma with fast evolving fine structure. Aims. We aim to better understand the plasma conditions in the fine structure of a quiescent prominence including two transient horns observed at the bottom of the cavity using the high resolution Interface Region Imaging Spectrograph (IRIS) and the MulTi-Raies (MTR) spectrograph of the Télescope Heliographique pour l’Etude du Magnétisme et des Instabilités Solaires (THEMIS) in the Canary Islands. Methods. We analysed the spectra obtained in Hα by THEMIS and Mg II by IRIS and compare them with a grid of 23 940 1D radiative transfer models which include a prominence-to-corona transition region (PCTR). The full observed profiles of Mg II in each pixel are fitted completely by synthesised profiles with ×RMS (Cross RMS; an improved version of the rolling root mean square (rRMS) method). When the RMS is below a certain threshold value, we recover the plasma conditions from the parameters of the model best fitting the observed line profile. This criterion is met in two regions (the horns and edge of the prominence) where the line profiles can generally be described as single peaked. Results. The 1D models suggest that two different kinds of model atmospheres correspond to these two regions. The region at the edge is found to be fitted mainly with isothermal and isobaric models, while the other area (the horns) is seen to be fitted with models with a PCTR that have optical thicknesses of less than 5. In the prominence edge, the theoretical relationship between the integrated intensities in Hα and Mg II is verified and corresponds to low emission measure values. In these regions the electron density is around 1010 cm−3, while it is one order of magnitude less in the horn regions around 109 cm−3. Conclusions. In the horns, we find some profiles are best fitted with models with high mean temperatures. This suggests that the hot PCTR found in the horns could be interpreted as prominence plasma in condensation phase at the bottom of the coronal cavity

Prognosis research strategy (PROGRESS) 1: a framework for researching clinical outcomes.

The PROGRESS series (www.progress-partnership.org) sets out a framework of four interlinked prognosis research themes and provides examples from several disease fields to show why evidence from prognosis research is crucial to inform all points in the translation of biomedical and health related research into better patient outcomes. Recommendations are made in each of the four papers to improve current research standards What is prognosis research? Prognosis research seeks to understand and improve future outcomes in people with a given disease or health condition. However, there is increasing evidence that prognosis research standards need to be improved Why is prognosis research important? More people now live with disease and conditions that impair health than at any other time in history; prognosis research provides crucial evidence for translating findings from the laboratory to humans, and from clinical research to clinical practice This first article introduces the framework of four interlinked prognosis research themes and then focuses on the first of the themes - fundamental prognosis research, studies that aim to describe and explain future outcomes in relation to current diagnostic and treatment practices, often in relation to quality of care Fundamental prognosis research provides evidence informing healthcare and public health policy, the design and interpretation of randomised trials, and the impact of diagnostic tests on future outcome. It can inform new definitions of disease, may identify unanticipated benefits or harms of interventions, and clarify where new interventions are required to improve prognosis