Border parasites: schistosomiasis control among Uganda's fisherfolk

Copyright @ 2012 Taylor & Francis. This article has been made publically available through the Brunel Open Access Publishing Fund.It is recognized that the control of schistosomisais in Uganda requires a focus on fisherfolk. Large numbers suffer from this water-borne parasitic disease; notably along the shores of lakes Albert and Victoria and along the River Nile. Since 2004, a policy has been adopted of providing drugs, free of charge, to all those at risk. The strategy has been reported to be successful, but closer investigation reveals serious problems. This paper draws upon long-term research undertaken at three locations in northwestern and southeastern Uganda. It highlights consequences of not engaging with the day to day realities of fisherfolk livelihoods; attributable, in part, to the fact that so many fisherfolk live and work in places located at the country’s international borders, and to a related tendency to treat them as "feckless" and "ungovernable". Endeavours to roll out treatment end up being haphazard, erratic and location-specific. In some places, concerted efforts have been made to treat fisherfolk; but there is no effective monitoring, and it is difficult to gauge what proportion have actually swallowed the tablets. In other places, fisherfolk are, in practice, largely ignored, or are actively harassed in ways that make treatment almost impossible. At all sites, the current reliance upon resident "community" drug distributors or staff based at static clinics and schools was found to be flawed.The Schistosomiasis Control Initiative, Imperial College, under the auspices of the Bill and Melinda Gates Foundation

Further explorations of Skyrme-Hartree-Fock-Bogoliubov mass formulas. XII: Stiffness and stability of neutron-star matter

We construct three new Hartree-Fock-Bogoliubov (HFB) mass models, labeled HFB-19, HFB-20, and HFB-21, with unconventional Skyrme forces containing $t_4$ and $t_5$ terms, i.e., density-dependent generalizations of the usual $t_1$ and $t_2$ terms, respectively. The new forces underlying these models are fitted respectively to three different realistic equations of state of neutron matter for which the density dependence of the symmetry energy ranges from the very soft to the very stiff, reflecting thereby our present lack of complete knowledge of the high-density behavior of nuclear matter. All unphysical instabilities of nuclear matter, including the transition to a polarized state in neutron-star matter, are eliminated with the new forces. At the same time the new models fit essentially all the available mass data with rms deviations of 0.58 MeV and give the same high quality fits to measured charge radii that we obtained in earlier models with conventional Skyrme forces. Being constrained by neutron matter, these new mass models, which all give similar extrapolations out to the neutron drip line, are highly appropriate for studies of the $r$-process and the outer crust of neutron stars. Moreover, the underlying forces, labeled BSk19, BSk20 and BSk21, respectively, are well adapted to the study of the inner crust and core of neutron stars. The new family of Skyrme forces thus opens the way to a unified description of all regions of neutron stars.Comment: 45 pages, 16 figures, accepted for publication in Physical Review

The "zeroth law" of turbulence: Isotropic turbulence simulations revisited

The dimensionless kinetic energy dissipation rate C_epsilon is estimated from numerical simulations of statistically stationary isotropic box turbulence that is slightly compressible. The Taylor microscale Reynolds number Re_lambda range is 20 < Re_lambda < 220 and the statistical stationarity is achieved with a random phase forcing method. The strong Re_lambda dependence of C_epsilon abates when Re_lambda approx. 100 after which C_epsilon slowly approaches approx 0.5 a value slightly different to previously reported simulations but in good agreement with experimental results. If C_epsilon is estimated at a specific time step from the time series of the quantities involved it is necessary to account for the time lag between energy injection and energy dissipation. Also, the resulting value can differ from the ensemble averaged value by up to +-30%. This may explain the spread in results from previously published estimates of C_epsilon.Comment: 7 pages, 7 figures. Submitted to Phys. Rev.

The Physio-Chemical Properties for the Interior of Enceladus

We have reviewed the current physical and chemical conditions of the Enceladus sub-surface environment, including the composition, temperature, pH and pressure. Here we have defined some of these parameters and, through the aid of modelling, will define and refine the remaining parameters needed for our experimental work. Simulations of the chemical reactions occurring within Enceladus can then be carried out to advance our understanding of the internal environment of Enceladus and help evaluate its potential habitability. Once a better understanding of the chemical reactions occurring at the rock-water interface has been carried out, then potential analogues on Earth can be evaluated and known microbial life can be tested to see if it could survive the conditions of Enceladus

Targeting tumor multicellular aggregation through IGPR-1 inhibits colon cancer growth and improves chemotherapy

Adhesion to extracellular matrix (ECM) is crucially important for survival of normal epithelial cells as detachment from ECM triggers specific apoptosis known as anoikis. As tumor cells lose the requirement for anchorage to ECM, they rely on cell-cell adhesion 'multicellular aggregation' for survival. Multicellular aggregation of tumor cells also significantly determines the sensitivity of tumor cells to the cytotoxic effects of chemotherapeutics. In this report, we demonstrate that expression of immunoglobulin containing and proline-rich receptor-1 (IGPR-1) is upregulated in human primary colon cancer. Our study demonstrates that IGPR-1 promotes tumor multicellular aggregation, and interfering with its adhesive function inhibits multicellular aggregation and, increases cell death. IGPR-1 supports colon carcinoma tumor xenograft growth in mouse, and inhibiting its activity by shRNA or blocking antibody inhibits tumor growth. More importantly, IGPR-1 regulates sensitivity of tumor cells to the chemotherapeutic agent, doxorubicin/adriamycin by a mechanism that involves doxorubicin-induced AKT activation and phosphorylation of IGPR-1 at Ser220. Our findings offer novel insight into IGPR-1's role in colorectal tumor growth, tumor chemosensitivity, and as a possible novel anti-cancer target.Grant support from: R01 CA175382/CA/NCI NIH HHS/United States, R21 CA191970/CA/NCI NIH HHS/United States, and R21 CA193958/CA/NCI NIH HHS/United State

The energy requirement of farming in New Zealand

This report presents the findings of a study of the direct and indirect energy use by the New Zealand farming sector on a 'to-farm-gate' basis. Although detailed statistics are available on this sector in financial terms, little data has been collected on inputs to agriculture in physical terms, and this complicates the application of energy analysis. This report therefore provides complete detail on all working calculations and the assumptions made, so that through wide distribution of these findings and the resulting feedback, the study estimates may be more precisely defined and the resulting energy requirement data improved

Diffusion, peer pressure and tailed distributions

We present a general, physically motivated non-linear and non-local advection equation in which the diffusion of interacting random walkers competes with a local drift arising from a kind of peer pressure. We show, using a mapping to an integrable dynamical system, that on varying a parameter, the steady state behaviour undergoes a transition from the standard diffusive behavior to a localized stationary state characterized by a tailed distribution. Finally, we show that recent empirical laws on economic growth can be explained as a collective phenomenon due to peer pressure interaction.Comment: RevTex: 4 pages + 3 eps-figures. Minor Revision and figure 3 replaced. To appear in Phys. Rev. Letter

CBI limits on 31 GHz excess emission in southern HII regions

We have mapped four regions of the southern Galactic plane at 31 GHz with the Cosmic Background Imager. From the maps, we have extracted the flux densities for six of the brightest \hii regions in the southern sky and compared them with multi-frequency data from the literature. The fitted spectral index for each source was found to be close to the theoretical value expected for optically thin free-free emission, thus confirming that the majority of flux at 31 GHz is due to free-free emission from ionised gas with an electron temperature of $\approx 7000-8000$ K. We also found that, for all six sources, the 31 GHz flux density was slightly higher than the predicted value from data in the literature. This excess emission could be due to spinning dust or another emission mechanism. Comparisons with $100 \mu$m data indicate an average dust emissivity of $3.3\pm1.7 \mu$K (MJy/sr)$^{-1}$, or a 95 per cent confidence limit of $<6.1 \mu$K (MJy/sr)$^{-1}$. This is lower than that found in diffuse clouds at high Galactic latitudes by a factor of $\sim 3-4$. The most significant detection ($3.3\sigma$) was found in $G284.3-0.3$ (RCW49) and may account for up to $\approx 30$ per cent of the total flux density observed at 31 GHz. Here, the dust emissivity of the excess emission is $13.6\pm4.2 \mu$K (MJy/sr)$^{-1}$ and is within the range observed at high Galactic latitudes. Low level polarised emission was observed in all six sources with polarisation fractions in the range $0.3-0.6$ per cent. This is likely to be mainly due to instrumental leakage and is therefore upper an upper limit to the free-free polarisation. It corresponds to an upper limit of $\sim1$ per cent for the polarisation of anomalous emission.Comment: Accepted in MNRAS. 12 pages, 10 figures, 5 table

Granivory of invasive, naturalized, and native plants in communities differentially susceptible to invasion

Seed predation is an important biotic filter that can influence abundance and spatial distributions of native species through differential effects on recruitment. This filter may also influence the relative abundance of nonnative plants within habitats and the communities’ susceptibility to invasion via differences in granivore identity, abundance, and food preference. We evaluated the effect of postdispersal seed predators on the establishment of invasive, naturalized, and native species within and between adjacent forest and steppe communities of eastern Washington, USA that differ in severity of plant invasion. Seed removal from trays placed within guild-specific exclosures revealed that small mammals were the dominant seed predators in both forest and steppe. Seeds of invasive species (Bromus tectorum, Cirsium arvense) were removed significantly less than the seeds of native (Pseudoroegneria spicata, Balsamorhiza sagittata) and naturalized (Secale cereale, Centaurea cyanus) species. Seed predation limited seedling emergence and establishment in both communities in the absence of competition in a pattern reflecting natural plant abundance: S. cereale was most suppressed, B. tectorum was least suppressed, and P. spicata was suppressed at an intermediate level. Furthermore, seed predation reduced the residual seed bank for all species. Seed mass correlated with seed removal rates in the forest and their subsequent effects on plant recruitment; larger seeds were removed at higher rates than smaller seeds. Our vegetation surveys indicate higher densities and canopy cover of nonnative species occur in the steppe compared with the forest understory, suggesting the steppe may be more susceptible to invasion. Seed predation alone, however, did not result in significant differences in establishment for any species between these communities, presumably due to similar total small-mammal abundance between communities. Consequently, preferential seed predation by small mammals predicts plant establishment for our test species within these communities but not between them. Accumulating evidence suggests that seed predation can be an important biotic filter affecting plant establishment via differences in consumer preferences and abundance with important ramifications for plant invasions and in situ community assembly

Learning Incoherent Subspaces: Classification via Incoherent Dictionary Learning

In this article we present the supervised iterative projections and rotations (s-ipr) algorithm, a method for learning discriminative incoherent subspaces from data. We derive s-ipr as a supervised extension of our previously proposed iterative projections and rotations (ipr) algorithm for incoherent dictionary learning, and we employ it to learn incoherent sub-spaces that model signals belonging to different classes. We test our method as a feature transform for supervised classification, first by visualising transformed features from a synthetic dataset and from the ‘iris’ dataset, then by using the resulting features in a classification experiment