Live Demonstration: neuromorphic robotics, from audio to locomotion through spiking CPG on SpiNNaker.

This live demonstration presents an audio-guided neuromorphic robot: from a Neuromorphic Auditory Sensor (NAS) to locomotion using Spiking Central Pattern Generators (sCPGs). Several gaits are generated by sCPGs implemented on a SpiNNaker board. The output of these sCPGs is sent in a real-time manner to an Field Programmable Gate Array (FPGA) board using an AER-to-SpiNN interface. The control of the hexapod robot joints is performed by the FPGA board. The robot behavior can be changed in real-time by means of the NAS. The audio information is sent to the SpiNNaker board which classifies it using a Spiking Neural Network (SNN). Thus, the input sound will activate a specific gait pattern which will eventually modify the behavior of the robot.Ministerio de Economía y Competitividad TEC2016-77785-

Preferential Solvation of the Antioxidant Agent Daidzein in some Aqueous Co-Solvent Mixtures according to IKBI and QLQC Methods

The preferential solvation parameters by ethanol (EtOH) or propylene glycol (PG) of daidzein were derived from their solution thermodynamic properties by means of the inverse Kirkwood-Buff integrals and the quasi-lattice-quasi-chemical (QLQC) methods. According to IKBI method, the preferential solvation parameter by the co-solvent, δx1,3, is negative in water-rich mixtures but positive in co-solvent-rich mixtures in both kinds of systems. This could demonstrate the relevant role of hydrophobic hydration around the aromatic rings in the drug solvation in water-rich mixtures. Furthermore, the more solvation by co-solvent in co-solvent-rich mixtures could be due mainly to polarity effects and acidic behavior of the hydroxyl groups of the compound in front to the more basic solvents present in the mixtures, i.e. EtOH or PG. Otherwise, according to QLQC method, this drug is preferentially solvated by the co-solvents in all the mixtures in both kind of systems

Bioinspired Spike-Based Hippocampus and Posterior Parietal Cortex Models for Robot Navigation and Environment Pseudomapping

The brain has great capacity for computation and efficient resolution of complex problems, far surpassing modern computers. Neuromorphic engineering seeks to mimic the basic principles of the brain to develop systems capable of achieving such capabilities. In the neuromorphic field, navigation systems are of great interest due to their potential applicability to robotics, although these systems are still a challenge to be solved. This work proposes a spike-based robotic navigation and environment pseudomapping system formed by a bioinspired hippocampal memory model connected to a posterior parietal cortex (PPC) model. The hippocampus is in charge of maintaining a representation of an environment state map, and the PPC is in charge of local decision-making. This system is implemented on the SpiNNaker hardware platform using spiking neural networks. A set of real-time experiments are applied to demonstrate the correct functioning of the system in virtual and physical environments on a robotic platform. The system is able to navigate through the environment to reach a goal position starting from an initial position, avoiding obstacles and mapping the environment. To the best of the authors’ knowledge, this is the first implementation of an environment pseudomapping system with dynamic learning based on a bioinspired hippocampal memory. © 2023 The Authors. Advanced Intelligent Systems published by Wiley-VCH GmbH.Ministerio de Educación, Cultura y Deporte (MECD). España PID2019‐105556GB‐C33Horizonte 2020 (Unión Europea) CHIST‐ERA‐18‐ACAI‐004Horizonte 2020 (Unión Europea) PCI2019‐111841‐2/AEI/10.13039/501100011033Ministerio de Ciencia e Innovación (MCIN) España AEI/10.13039/50110001103

Antimicrobial activity of Argemone ochroleuca Sweet (Chicalote).

Infusiones de la parte aérea de Argemone ochroleuca Sweet (Papaveraceae) son utilizadas por los pobladores de Tepotzotlán, Estado de México, para el tratamiento de infecciones en los ojos, enfermedades respiratorias y dermatológicas. El objetivo de este trabajo fue investigar la actividad antimicrobiana de los extractos hexánicos, acetato de etilo y metanólico de la parte aérea de A. ochroleuca. La actividad antimicrobiana fue evaluada frente a trece cepas bacterianas y nueve cepas fúngicas. Solo el extracto metanólico presentó actividad antimicrobiana. S. aureus (MIC= 125 µg/mL) y C. neoformans (MIC= 500 µg/mL) fueron las cepas que presentaron mayor sensibilidad. La purificación biodirigida del extracto metanólico dio como resultado el aislamiento e identificación del alcaloide isoquinolínico berberina. El presente estudio confirma la actividad antimicrobiana del extracto metanólico de A. ochroleuca.Abstract Argemone ochroleuca Sweet (Papaveraceae) is used to treat eye infection, respiratory and dermatological disorders in Tepotzotlán, State of México (México). The aim of this work was to investigate antimicrobial activity of hexane, ethyl acetate and methanol extracts from aerial parts of A. ochroleuca. The antimicrobial activity was evaluated against thirteen bacteria and nine fungal strains. Only methanol extract showed antimicrobial activity. S. aureus (MIC= 125 µg/mL) and C. neoformans (MIC= 500 µg/mL) were the most sensitive strains. The bioassay-guide purification of the methanolic extract resulted in the isolation and identification of the isoquinoline alkaloid berberine. The present study confirms the antimicrobial activity of methanolic extract of A. ochroleuca. Keywords: Antibacterial activity, Antifungal activity, Argemone ochroleuca, Berberine, Papaveraceae, Tepotzotlán, México

Evaluación de la vulnerabilidad estructural para el sector educativo en el municipio de Dosquebradas

CD-T 693.85 G165e;144 p.El proyecto de investigación pretende, a partir del apoyo de planos existentes proporcionados por la oficina de planeación de Dosquebradas y ,en otros casos, mediante el levantamiento de las plantas estructurales y el reconocimiento en campo de elementos como la tipología constructiva, la cimentación, la geometría de las construcciones, la estructura del techo y las características del entorno circundante, valorar de manera cualitativa y cuantitativa la vulnerabilidad física de tales edificaciones, con un relativo énfasis en aquellos aspectos funcionales que posibilitan una adecuada y eficiente prestación del servicio, todo en el marco de la NSR-10.Universidad Libre Seccional Pereir

Impacto de la enfermedad de Kawasaki en la población pediátrica

Kawasaki disease it’s an acute vasculitis of unknown etiology that is characterized by an immune response in patients that are genetically predispose to develop the disease. It affects children below the age of 5 predominantly. The diagnosis is made based on the clinical characteristics, laboratory data and demonstration of coronary aneurisms with an echocardiography. This disease is the primary cause of acquired cardiac disease in children, since the vasculitis affects medium sized vessels, primarily the coronary arteries, which provoke the formation of coronary aneurisms that can trigger a thrombosis. It is essential to make an early diagnosis, so that the treatment can be established to prevent the fatal consequences of the disease product of the formation of aneurisms, which develop in 25% of patients that do no receive and adequate treatment.La enfermedad de Kawasaki es una vasculitis aguda, autolimitada, actualmente de etiología desconocida caracterizada por una respuesta inflamatoria en pacientes genéticamente predispuestos a padecer la enfermedad. Afecta principalmente a niños menores de 5 años y su diagnóstico se realiza basado principalmente en las características clínicas y con apoyo de estudios de laboratorio o con la demostración de aneurismas coronarios. Esta patología es la principal causa de enfermedad cardiaca adquirida en la niñez, debido a que la vasculitis afecta a vasos de mediano calibre, principalmente las arterias coronarias, lo cual desencadena formación de aneurismas coronarios con posterior trombosis. Se debe de realizar un diagnóstico temprano para poder dar el tratamiento adecuado y evitar consecuencias fatales por el desarrollo de aneurismas coronarios, los cuales se desarrollan en un 25% de los pacientes que no reciben tratamiento

Infección del virus de la hepatitis E en mujeres embarazadas

The hepatitis E virus is an emergent infectious agent that affects both developing and developed countries. This hepatotropic virus causes a wide spectrum of clinical scenarios; from an acute auto limited viral hepatitis E to a fulminant hepatic failure. Due to hormonal and immunological reasons, pregnant women are at increased risk of adverse outcomes of this disease related to higher maternal and fetal morbimortality. The main treatment for hepatitis E infections in pregnant women is merely supportive, making prevention in this population the main goal. This article will review the epidemiology, clinical scenarios and obstetric complications associated with the hepatitis virus infection during pregnancy. In addition, the progesterone and immunological system role in this disease will be discussed.El virus de la hepatitis E es un agente infeccioso emergente que afecta tanto países en vías de desarrollo como países ya desarrollados. Este virus hepatotropo causa una amplia gama de cuadros clínicos; desde hepatitis viral aguda autolimitada hasta falla hepática fulminante. Las mujeres embarazadas se encuentran en mayor riesgo,  por causas hormonales e inmunológicas, de una evolución tórpida de esta enfermedad aumentando la morbimortalidad materno-fetal. El manejo de la hepatitis E en mujeres gestantes se limita a tratamiento de soporte, por lo que las medidas preventivas son la meta principal para esta población. Este artículo de revisión destaca la epidemiología, los diferentes cuadros clínicos y complicaciones obstétricas asociadas a la infección del virus de la hepatitis E durante el embarazo. Además, se discute el rol de la progesterona y el sistema inmunológico en las pacientes afectadas por esta enfermedad

ED-Scorbot: A Robotic test-bed Framework for FPGA-based Neuromorphic systems

Neuromorphic engineering is a growing and promising discipline nowadays. Neuro-inspiration and brain understanding applied to solve engineering problems is boosting new architectures, solutions and products today. The biological brain and neural systems process information at relatively low speeds through small components, called neurons, and it is impressive how they connect each other to construct complex architectures to solve in a quasi-instantaneous way visual and audio processing tasks, object detection and tracking, target approximation, grasping…, etc., with very low power. Neuromorphs are beginning to be very promising for a new era in the development of new sensors, processors, robots and software systems that mimic these biological systems. The event-driven Scorbot (EDScorbot) is a robotic arm plus a set of FPGA / microcontroller’s boards and a library of FPGA logic joined in a completely event-based framework (spike-based) from the sensors to the actuators. It is located in Seville (University of Seville) and can be used remotely. Spike-based commands, through neuro-inspired motor controllers, can be sent to the robot after visual processing object detection and tracking for grasping or manipulation, after complex visual and audio-visual sensory fusion, or after performing a learning task. Thanks to the cascade FPGA architecture through the Address-Event-Representation (AER) bus, supported by specialized boards, resources for algorithms implementation are not limited.Ministerio de Economía y Competitividad TEC2012-37868-C04-02Junta de Andalucía P12-TIC-130

PanDrugs2: prioritizing cancer therapies using integrated individual multi-omics data

Genomics studies routinely confront researchers with long lists of tumor alterations detected in patients. Such lists are difficult to interpret since only a minority of the alterations are relevant biomarkers for diagnosis and for designing therapeutic strategies. PanDrugs is a methodology that facilitates the interpretation of tumor molecular alterations and guides the selection of personalized treatments. To do so, PanDrugs scores gene actionability and drug feasibility to provide a prioritized evidence-based list of drugs. Here, we introduce PanDrugs2, a major upgrade of PanDrugs that, in addition to somatic variant analysis, supports a new integrated multi-omics analysis which simultaneously combines somatic and germline variants, copy number variation and gene expression data. Moreover, PanDrugs2 now considers cancer genetic dependencies to extend tumor vulnerabilities providing therapeutic options for untargetable genes. Importantly, a novel intuitive report to support clinical decision-making is generated. PanDrugs database has been updated, integrating 23 primary sources that support >74K drug–gene associations obtained from 4642 genes and 14 659 unique compounds. The database has also been reimplemented to allow semi-automatic updates to facilitate maintenance and release of future versions. PanDrugs2 does not require login and is freely available at https://www.pandrugs.org/.Instituto de Salud Carlos III | Ref. IMP/00019Agencia Estatal de Investigacion | Ref. PID2021-124188NB-I00Xunta de Galicia | Ref. | Ref. ED431C2018/55Xunta de Galicia | Ref. | Ref. ED431C2022/0