Natural History of MYH7-Related Dilated Cardiomyopathy

BACKGROUND Variants in myosin heavy chain 7 (MYH7) are responsible for disease in 1% to 5% of patients with dilated cardiomyopathy (DCM); however, the clinical characteristics and natural history of MYH7-related DCM are poorly described. OBJECTIVES We sought to determine the phenotype and prognosis of MYH7-related DCM. We also evaluated the influence of variant location on phenotypic expression. METHODS We studied clinical data from 147 individuals with DCM-causing MYH7 variants (47.6% female; 35.6 +/- 19.2 years) recruited from 29 international centers. RESULTS At initial evaluation, 106 (72.1%) patients had DCM (left ventricular ejection fraction: 34.5% +/- 11.7%). Median follow-up was 4.5 years (IQR: 1.7-8.0 years), and 23.7% of carriers who were initially phenotype-negative developed DCM. Phenotypic expression by 40 and 60 years was 46% and 88%, respectively, with 18 patients (16%) first diagnosed at <18 years of age. Thirty-six percent of patients with DCM met imaging criteria for LV noncompaction. During follow-up, 28% showed left ventricular reverse remodeling. Incidence of adverse cardiac events among patients with DCM at 5 years was 11.6%, with 5 (4.6%) deaths caused by end-stage heart failure (ESHF) and 5 patients (4.6%) requiring heart transplantation. The major ventricular arrhythmia rate was low (1.0% and 2.1% at 5 years in patients with DCM and in those with LVEF of <= 35%, respectively). ESHF and major ventricular arrhythmia were significantly lower compared with LMNA-related DCM and similar to DCM caused by TTN truncating variants. CONCLUSIONS MYH7-related DCM is characterized by early age of onset, high phenotypic expression, low left ventricular reverse remodeling, and frequent progression to ESHF. Heart failure complications predominate over ventricular arrhythmias, which are rare. (C) 2022 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation

Outcomes from elective colorectal cancer surgery during the SARS-CoV-2 pandemic

This study aimed to describe the change in surgical practice and the impact of SARS-CoV-2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS-CoV-2 pandemic

Características de planta y rendimiento de sorgo y su interacción con hongos micorrízicos en condiciones de riego y secano

Sorghum response ('DK- 345') to six native strains of experimental arbuscular mycorrhizal fungi (AMF) [3 (Funneliformis mossae), 20 (Gigaspora albida), 32 (F. mossae), 35 (F. mossae), 39 (F. mossae), 55 (Gigaspora sp.)] was compared to mycorrhizal INIFAP (Rhizophagus intraradices) and non-inoculated check under irrigated and rainfed conditions. The chlorophyll index (SPAD) was measured in three stages (flag leaf, flowering and end of flowering), in addition to plant height, biomass and grain yield. In flag leaf, chlorophyll index variations among AMF strains and humidity conditions were observed. AMF did not influence the chlorophyll index during flowering. Although at the end of flowering, outstanding strains were 55 and mycorrhizal INIFAP. Plant height was similar among AMF, but 16.5 cm higher in irrigation. Biomass was similar among the AMF but higher than control. The highest grain yield in the two humidity conditions was obtained with strain 55 and mycorrhizal INIFAP. This study showed the comparative potential of native AMF strains in sorghum.Se evaluó la respuesta del sorgo ('DK-345') a seis cepas nativas de hongos micorrízicos arbusculares (HMA) experimentales [3 (Funneliformis mossae), 20 (Gigaspora albida), 32 (F. mossae), 35 (F. mossae), 39 (F. mossae), 55 (Gigaspora sp.)], comparadas con micorriza INIFAP (Rhizophagus intraradices) y testigo sin inoculación, en riego y secano. El índice de clorofila (SPAD) se midió en tres estados de desarrollo (hoja bandera, floración y final de f loración), además de la altura de planta, biomasa y rendimiento de grano. En hoja bandera, se observaron variaciones de índice de clorofila entre las cepas de HMA y las condiciones de humedad. Los HMA no influyeron en el índice de clorofila durante la floración. Aunque al final de la floración, las cepas sobresalientes fueron 55 y micorriza INIFAP. La altura de planta fue semejante entre los HMA, pero 16.5 cm mayores en riego. La biomasa entre los HMA fue similar pero superior a la del testigo. El mayor rendimiento de grano en las dos condiciones de humedad se obtuvo con la cepa 55 y micorriza INIFAP. El estudio demostró el potencial comparativo de las cepas nativas de HMA en sorgo

Productividad de tomate mediante micorriza arbuscular en agricultura protegida

The effectiveness of arbuscular mycorrhizal fungi in crops under protected agriculture is poorly understood. The obj ective was to study the response oftomato (cv. 'El Cid') to mycorrhizal inoculation in a shade house structure. The seedlings were transplanted into soil, inoculated or not with Rhizophagus intraradices. The inoculated plants significantly increased chlorophyll content, plant height and root colonization compared with non-inoculated plants. Similarly, significant increases were observed in the length, diameter and fruit weight also increased fruit yield by cutting and accumulated in 30% yield. The beneficial effect of R. intraradices as promoter of tomato yield in protected agriculture may represent an efficient production management.La efectividad de los hongos micorrízicos arbusculares en cultivos bajo agricultura protegida es poco conocida. El objetivo del estudio fue conocer la respuesta de tomate (cv. 'El Cid') a la inoculación micorrízica en una estructura casa-sombra. Las plántulas se trasplantaron en suelo, inoculadas o no con Rhizophagus intraradices. Las plantas inoculadas incrementaron significativamente el contenido de clorofila, altura de planta y la colonización micorrízica, comparado con plantas no inoculadas. Igualmente, se observaron incrementos significativos en el largo, diámetro y peso de fruto, además, aumentó el rendimiento de fruto por corte y el rendimiento acumulado en 30%. El efecto benéfico de R. intraradices como promotor del rendimiento de tomate en agricultura protegida puede representar un manejo eficiente de producción

Micorriza arbuscular en sorgo bajo diferente manejo agrotecnológico y ambiental

The symbiotic relationship between arbuscular mycorrhizal fungi (AMF) and plants induce to improve nutrition and plant health. The biotechnological application of AMF in production systems will depend on the effectiveness of the strain on the agro ecological environment, as well as its adoption with existing practices and equipment. It was determined the effectiveness of Glomus intraradices (strain from INIFAP) inoculated the seed of sorghum (Sorghum bicolor) under different agricultural and environmental management in Tamaulipas during 20072009. 21commercial plots were established, 13 under rainfed and eight under irrigation (0.25-1ha), where the seed was compared with and without the inoculant G. intraradices, the agronomical management was used by the producers. Under rainfed weren't added inorganic fertilizers, while under irrigation was used in different doses ofN and P, only in one site manure was incorporated (2 t ha-1). Measurements made were, length of panicle, radical fresh biomass and grain yield. The cost of production was estimated (cost-benefit) at each site. On average under rainfed and irrigation was found that G. intraradices increased (p= 0.01) root biomass, panicle length and grain yield of 7.6 g, 3.3 cm and 524 kg ha-1, respectively and the profitability of production grew 17%. The results proved a consistent promoting response that the mycorrhizal inoculant had on sorghum, compared with non-inoculated seed, despite the variability of genotypes, soils, agronomical and environmental practices.La relación simbiótica entre los hongos micorrízicos arbusculares (HMAS) y las plantas inducen a mejorar la nutrición y sanidad de los vegetales. La aplicación biotecnológica de los HMAS en los sistemas de producción, dependerá de la efectividad de la cepa en el entorno agroecológico, así como su adopción con las prácticas y maquinaria existentes. Se determinó la efectividad de Glomus intraradices (cepa INIFAP) inoculado a la semilla de sorgo (Sorghum bicolor), bajo diferente manejo agronómico y de ambiente en Tamaulipas durante 2007-2009. Se establecieron 21 parcelas comerciales, 13 en secano y ocho en riego (0.25-1ha), donde se comparó la semilla con y sin el inoculante G. intraradices, el manejo agronómico fue el utilizado por los productores. En secano no se adicionaron fertilizantes inorgánicos, mientras que en riego se utilizaron diferentes dosis de N y P, solamente en un sitio se incorporó gallinaza (2 t ha-1). Se midió la longitud de la panoja, la biomasa fresca radical y el rendimiento de grano. Se estimó la rentabilidad de la producción (costo-beneficio) en cada sitio. En el promedio de secano y riego se observó que G. intraradices incrementó (p= 0.01) la biomasa radical, la longitud de la panoja y el rendimiento de grano en 7.6 g, 3.3 cm y 524 kg ha-1, respectivamente; la rentabilidad de la producción se acrecentó 17%. Los resultados demostraron una consistente respuesta promotora que tuvo el inoculante micorrízico en sorgo, comparada con semilla no inoculada, a pesar de la variabilidad de genotipos, suelos, prácticas agronómicas y ambientes

Características de planta, suelo y productividad entre sorgo fertilizado e inoculado con micorriza arbuscula

Inoculation with mycorrhizal fungi is an alternative to improve the biological balance of the soil and reduce the use of inorganic fertilizer (IF). For five consecutive years (2002-2006), some characteristics of soil and plant sorghum grown with mycorrhizal fungi inoculation Rhizofagus intraradices (RI) and fertilized with 60-2000 control (FI) were determined. Grain yield was similar between treatments during the five years, although the inoculated RI exceeded 17.7 % ($216.00 ha-1) benefit-cost relative to the FI relationship. Chlorophyll content, plant height, biomass, pH, organic matter, electrical conductivity, P and K showed no statistical significance between both treatments. The soil N with FI exceeded 6. 7 mg kg-1 soil inoculation with RI. In contrast, root biomass, the number of spores of arbuscular mycorrhizal fungi in soil and soil CO2 emission increased with mycorrhizae. The impact of R. intraradices showed higher profitability of sorghum production (savings of$ 926.00 ha-1) and biological activity in the soil.La inoculación con hongos formadores de micorrizas es una alternativa para mejorar el balance biológico del suelo y reducir el uso de fertilización inorgánica (FI). Durante cinco años consecutivos (2002-2006), se determinaron algunas características de suelo y planta en sorgo cultivado con inoculación del hongo micorrízico Rhizofagus intraradices (RI) y testigo fertilizado con 60-20-00 (FI). El rendimiento de grano fue similar entre tratamientos durante los cinco años, aunque el inoculado con RI superó en 17.7% ($216.00 ha-1) la relación beneficio-costo con relación a FI. El contenido de clorofila, altura de planta, biomasa pH, materia orgánica, conductividad eléctrica, P y K no presentaron significancia estadística entre los dos tratamientos. El N del suelo en FI superó con 6.7 mg kg-1 al suelo con inoculación de RI. Por el contrario, la biomasa radical, el número de esporas de hongos micorrízicos arbusculares en el suelo y la emisión de CO2 del suelo se incrementaron con la micorrización. El impacto de R. intraradices manifestó mayores rentabilidad de la producción de sorgo (ahorro de$ 926.00ha-1) y actividad biológica en el suelo