Carpal Tunnel Syndrome - treatment

Litak Jakub, Grochowski Cezary, Litak Joanna, Szmygin Paweł, Kulesza Bartłomiej, Kamieniak Piotr. Carpal Tunnel Syndrome – treatment. Journal of Education, Health and Sport. 2017;7(1):141-146. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.238710 http://ojs.ukw.edu.pl/index.php/johs/article/view/4160 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 754 (09.12.2016). 754 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Author (s) 2017; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 05.12.2016. Revised 20.12.2016. Accepted: 11.01.2017. Zespół cieśni nadgarstka – leczenie Jakub Litak [1], Cezary Grochowski [2], Joanna Litak [3], Paweł Szmygin [1], Bartłomiej Kulesza [1], Piotr Kamieniak [1] [1] Klinika Neurochirurgii i Neurochirurgii Dziecięcej SPSK-4 w Lublinie [2] Katedra i Zakład Anatomii Prawidłowej Człowieka Uniwersytetu Medycznego w Lublinie [3] Centrum Onkologii Ziemii Lubelskiej im. Jana z Dukli Carpal Tunnel Syndrome – treatment Jakub Litak [1], Cezary Grochowski [2], Joanna Litak [3], Paweł Szmygin [1], Bartłomiej Kulesza [1], Piotr Kamieniak [1] [1] Department of Neurosurgery and Pediatric Neurosurgery SPSK-4 in Lublin [2] Department of Human Anatomy Medical University of Lublin [3] St. John`s Cancer Center in Lublin Słowa kluczowe: Zespół cieśni nadgarstka Key words: Carpal Tunnel Syndrome Abstrakt Zespół cieśni nadgarstka jest częstym schorzeniem spotykanym w praktyce lekarskiej. Obraz kliniczny i diagnostyka przewodnictwa nerwowego są podstawą rozpoznania. Leczenie dobrane adekwatnie do nasilenia dolegliwosci daje ulgę w bólu . Zaniki mięśniowe w obrębie kłębu kciuka są wskazaniem do zabiegu operacyjnego . Abstract Carpal Tunnel Syndrome is a common disease in General Practice. Clinical symptoms and Nerve Conduction Evaluation are crucial for proper diagnosis. Adequate treatment leads to pain relief. Thenar dystrophy indicates surgical treatment

Analysis of Trace Elements in Human Brain: Its Aim, Methods, and Concentration Levels

Trace elements play a crucial role in many biochemical processes, mainly as components of vitamins and enzymes. Although small amounts of metal ions have protective properties, excess metal levels result in oxidative injury, which is why metal ion homeostasis is crucial for the proper functioning of the brain. The changes of their level in the brain have been proven to be a risk factor for Alzheimer's, Parkinson's, and Huntington's diseases, as well as amyotrophic lateral sclerosis. Therefore, it is currently an important application of various analytical methods. This review covers the most important of them: inductively coupled ground mass spectrometry (ICP-MS), flame-induced atomic absorption spectrometry (FAAS), electrothermal atomic absorption spectrometry (GFAAS), optical emission spectrometry with excitation in inductively coupled plasma (ICP-OES), X-ray fluorescence spectrometry (XRF), and neutron activation analysis (NAA). Additionally, we present a summary of concentration values found by different research groups

The role of hydrogen bonding in the enzymatic reaction catalyzed by HIV-1 protease

The hydrogen-bond network in various stages of the enzymatic reaction catalyzed by HIV-1 protease was studied through quantum-classical molecular dynamics simulations. The approximate valence bond method was applied to the active site atoms participating directly in the rearrangement of chemical bonds. The rest of the protein with explicit solvent was treated with a classical molecular mechanics model. Two possible mechanisms were studied, general-acid/general-base (GA/GB) with Asp 25 protonated at the inner oxygen, and a direct nucleophilic attack by Asp 25. Strong hydrogen bonds leading to spontaneous proton transfers were observed in both reaction paths. A single-well hydrogen bond was formed between the peptide nitrogen and outer oxygen of Asp 125. The proton was diffusely distributed with an average central position and transferred back and forth on a picosecond scale. In both mechanisms, this interaction helped change the peptide-bond hybridization, increased the partial charge on peptidyl carbon, and in the GA/GB mechanism, helped deprotonate the water molecule. The inner oxygens of the aspartic dyad formed a low-barrier, but asymmetric hydrogen bond; the proton was not positioned midway and made a slightly elongated covalent bond, transferring from one to the other aspartate. In the GA/GB mechanism both aspartates may help deprotonate the water molecule. We observed the breakage of the peptide bond and found that the protonation of the peptidyl amine group was essential for the peptide-bond cleavage. In studies of the direct nucleophilic mechanism, the peptide carbon of the substrate and oxygen of Asp 25 approached as close as 2.3 Å

Upper cervical spine giant cell tumour of the vertebra - case report

Giant cell tumour (GCT) is a benign aggressive tumour, which affects the axial and peripheral skeleton. Pathological fractures often occur in cases where epiphyses are affected. GCT located in the cervical spine is rare and poses a serious surgical challenge and as far as approach and range of operation is concerned, is subject of debate. We report a case of GCT involving two vertebral bodies, C2 and C3, treated with posterior occipito-cervical junction stabilization, denosumab chemotherapy and transoral corpectomy