Towards an Architecture Operating as a Bio-Cyber-Physical System

Today’s physical-digital continuum challenges designers and architects to envision architecture as a Bio-Cyber-Physical System that is operating as part of a larger ecosystem while addressing societal challenges with a broader understanding of sustainability in mind.  This paper identifies current conditions, challenges and opportunities, while proposing an intercultural dialog toward achieving a better future. The purpose is to enlighten and explore the threshold where the physical interlaces the domain of immaterial flows of information as well as identify some of the digital and material design aspects shaping the multiple facets of bio-cyber-physical-systems in order to propose some possible solutions for current design challenges. &nbsp

Tagungsbericht „Barocke Figuren. Zeit – Gestalt – Medien“

Typologisches Denken gerät im 17. Jahrhundert in Unordnung, wenn die Figuren des Barock, wie der Simplicissimus, nicht (länger) das erfüllen, was sie versprechen und zugleich andere Aspekte des Figurenbegriffs an Bedeutung gewinnen. An diesem Punkt setzte die Tagung „Barocke Figuren. Zeit – Gestalt – Medien“ (27.-29. Oktober 2010, Universität Konstanz) an. Sie untersuchte eben jene (atypischen) Figuren, die sich gegen eine strenge Typologisierung sperren, deren Umwege, Metamorphosen, Begegnungen und Konflikte es aber erlauben, die Frage, was im Barock eine Figur ausmacht, in begrifflich-analytischer Perspektive neu zu stellen

Actuated and Performative Architecture: Emerging Forms of Human-Machine Interaction

This Spool [CpA] #3 issue poses and attempts to answer questions on the nature of this intimate human-machine bond, encouraging the discussion of its potentials also in terms of individual and social resilience. This issue of Spool, moreover, attempts to explore the design of bio-cyber-physical systems, which requires integration of natural, physical, and virtual architectures with digital systems and social organizations. In designing interactions between the (augmented) human and cyber-physical environments, the collection and use of personal data, the management of a multi-layered design approach, and the ethics of such design activity require attention from experts in architectural design, interaction and UX design, civil and architectural engineering, mechanical and electrical engineering, computer and information science, sociology, psychology, education, ethics, philosophy, media arts, and science and technology studies. &nbsp

Actuated and Performative Architecture: Emerging Forms of Human-Machine Interaction

This Spool [CpA] #3 issue poses and attempts to answer questions on the nature of this intimate human-machine bond, encouraging the discussion of its potentials also in terms of individual and social resilience. This issue of Spool, moreover, attempts to explore the design of bio-cyber-physical systems, which requires integration of natural, physical, and virtual architectures with digital systems and social organizations. In designing interactions between the (augmented) human and cyber-physical environments, the collection and use of personal data, the management of a multi-layered design approach, and the ethics of such design activity require attention from experts in architectural design, interaction and UX design, civil and architectural engineering, mechanical and electrical engineering, computer and information science, sociology, psychology, education, ethics, philosophy, media arts, and science and technology studies. &nbsp

Factors Influencing Dental Fear in Students of Biomedicine

Background: Dental fear is a reaction of an individual to actual or potential painful/harmful procedures in dental practice. There is large variation in reports of dental fear prevalence among university students, implying existence of different factors that influence occurrence of dental fear in various populations. Objective: The aim of the study was to investigate putative factors that may influence extent of dental fear among university students of biomedicine. Methods: This study was designed as cross-sectional investigation. In total, 113 students on study courses on the 3rd, 4th, 5th year of dentistry, and on the 4th, 5th and 6th year of medicine undergraduate program were surveyed at the Faculty of Medical Sciences, University of Kragujevac, Serbia. Fear of dentist was measured by the Dental Fear Survey and other variables were generated by questionnaire with questions about socio-demographic characteristics of the participants. Results: Students of biomedicine surveyed in this study did not suffer from dental fear in great extent (median value on the scale was close to the lower limit: 29.5. The only factor that increased risk for developing dental fear in our study was previous traumatic experience with a dentist. Conclusion: Dental fear is not very prevalent among biomedical students. However, main risk factor for dental fear in general population, previous traumatic experience with a dental intervention, also remains primary risk factor in population of biomedical students

Impact of COVID pandemic on attitude and prevalence of plant-based food products consumption in Serbia

COVID pandemic influence on eating behavior and dietary habits with respect to various plant-based foods in Serbia were estimated by an anonymous questionnaire. Most examinees agree that fruits and vegetables contribute to strengthening immunity and that herbal medicines and natural products have beneficial effects on health. Around 55% of examinees consider their diet balanced, and 4% have started to drink herbal teas more often when the pandemic started. Garlic and ginger were the most frequently reported newly included plants in examinees’ diet. The attitudes toward plant-based food products are not strongly dependent on the education level. The age and previous dietary habits of examinees have great influence in the current frequency of consuming fruits, vegetables, herbal teas, spices, and dietary supplements. There was a significant shift toward greater use of herbal teas and dietary supplements, especially among the population that has already consumed them occasionally. Somewhat concerning is the fact that around half of respondents use dietary supplements without the recommendation of an expert. People with good dietary habits and the elderly were most prone to improving their diet. Roughly 15% of all respondents now have the same habits as before the pandemic, although they improved their diets temporarily at the beginning of COVID pandemic

The Economics of the Name Change: Long-term Adjustments towards EU/NATO or Short-term Resolution of Political Uncertainty?

North Macedonia and Greece resolved the 27-year country name dispute and removed the main hurdle for North Macedonia to start the accession processes towards the EU and NATO. The paper analyzes the stock market movements around several events related to the name issue resolution to uncover whether Macedonian companies experienced stock price adjustments according to the long-term benefits/costs of joining the EU/NATO. The dynamics of the market reactions suggest that the investors reacted systematically to the short-term political uncertainty created around the referendum rather than to the long-term perspectives of the EU/NATO integration. We integrate the knowledge from the literature which explores stock market reactions to EU enlargement/exit and political elections and provide contributions for researchers and policymakers

Impact of Selenium Addition to Animal Feeds on Human Selenium Status in Serbia

Research conducted during the 1980s demonstrated Se deficiency in humans. Increased inclusion of selenium in animal feeds started from the year 2000 onwards. The aim of this study was to estimate the effects of selenium inclusion in animal feeds on human selenium status and dietary habits of the Serbian population related to food of animal origin. Plasma selenium concentration in healthy adult volunteers, including residents of one of the regions with the lowest (Eastern Serbia, n = 60) and of one of the regions with the highest Se serum levels reported in the past (Belgrade, n = 82), was determined by hydride generation atomic absorption spectrometry. Multivariate analysis was employed to determine the correlation between Se plasma levels and dietary intake data derived from food frequency questionnaires and laboratory tests. The mean plasma Se level of the participants was 84.3 +/- 15.9 g/L (range: 47.3-132.1 g/L), while 46% of participants had plasma Se levels lower than 80 g/L. Frequency of meat, egg, and fish consumption was significantly correlated with plasma selenium level (r = 0.437, p = 0.000). Selenium addition to animal feed in the quantity of 0.14 mg/kg contributed to the improvement of human plasma selenium levels by approximately 30 mu g/L

“Derived Multiple Allogeneic Protein Paracrine Signaling (d-MAPPS)” Enhances T Cell-Driven Immune Response to Murine Mammary Carcinoma

Breast cancer is considered refractory to immunotherapy. Accordingly, there is an urgent need for the therapeutic use of new immunostimulatory agents which would enhance antitumor immune response against breast cancer cells. “Derived Multiple Allogeneic Protein Paracrine Signaling (d-MAPPS)” is a biological product whose activity is based on chemokines and cytokines that modulate homing and phenotype of immune cells. d-MAPPS contains high concentration of dendritic cell (DC) and T cell-attracting chemokine CXCL16 and potent T cell-activating cytokine IL-27 which enhance DC:T cell cross-talk in inflamed tissues. Herewith, we used 4T1 murine model of breast cancer to analyze d-MAPPS-dependent enhancement of T cell-driven antitumor immunity. 4T1+d-MAPPS-treated mice showed delayed mammary tumor appearance compared to 4T1+saline-treated animals. d-MAPPS significantly reduced tumor weight and volume and improved survival of 4T1-treated mice. Significantly increased concentration of CXCL16, IL-27, IFN-γ, and IL-17 and decreased concentration of immunosuppressive TGF-β and IL-10 were measured in serum samples and tumor tissues of 4T1+d-MAPPS-treated mice. d-MAPPS enhanced production of IL-12 and increased expression of MHC class II and costimulatory molecules on tumor-infiltrated DC, significantly improving their antigen-presenting properties. d-MAPPS in CXCL16-dependent manner promoted recruitment of antitumorigenic IFN-γ/IL-17-producing CD4+Th1/Th17 cells and in IL-27-dependent manner induced expansion of tumoricidal CD178+granzyme B-expressing CD8+CTLs and inhibited generation of tolerogenic DC, IL-10, and TGF-β-producing FoxP3-expressing T regulatory cells. In summing up, d-MAPPS, in CXL16- and IL-27-dependent manner, enhanced T cell-driven antitumor immune response and suppressed breast cancer growth in experimental mice