Time-dependent transport through a T-coupled quantum dot

We are considering the time-dependent transport through a discrete system, consiting of a quantum dot T-coupled to an infinite tight-binding chain. The periodic driving that is induced on the coupling between the dot and the chain, leads to the emergence of a characteristic multiple Fano resonant profile in the transmission spectrum. We focus on investigating the underlying physical mechanisms that give rise to the quantum resonances. To this end, we use Floquet theory for calculating the transmission spectrum and in addition employ the Geometric Phase Propagator (GPP) approach [Ann. Phys. 375, 351 (2016)] to calculate the transition amplitudes of the time-resolved virtual processes, in terms of which we describe the resonant behavior. This two fold approach, allows us to give a rigorous definition of a quantum resonance in the context of driven systems and explains the emergence of the characteristic Fano profile in the transmission spectrum.Comment: 9 pages, 4 figure

Managing the Future Internet through Intelligent In-Network Substrates

The current Internet has been founded on the architectural premise of a simple network service used to interconnect relatively intelligent end systems. While this simplicity allowed it to reach an impressive scale, the predictive manner in which ISP networks are currently planned and configured through external management systems and the uniform treatment of all traffic are hampering its use as a unifying multi-service network. The future Internet will need to be more intelligent and adaptive, optimizing continuously the use of its resources and recovering from transient problems, faults and attacks without any impact on the demanding services and applications running over it. This article describes an architecture that allows intelligence to be introduced within the network to support sophisticated self-management functionality in a coordinated and controllable manner. The presented approach, based on intelligent substrates, can potentially make the Internet more adaptable, agile, sustainable, and dependable given the requirements of emerging services with highly demanding traffic and rapidly changing locations. We discuss how the proposed framework can be applied to three representative emerging scenarios: dynamic traffic engineering (load balancing across multiple paths); energy efficiency in ISP network infrastructures; and cache management in content-centric networks

Osteomimetic matrix components alter cell migration and drug response in a 3D tumour-engineered osteosarcoma model

vulnerable to recurring disease and pulmonary metastases. Developing 3D in vitro disease models to serve as a test bed for personalised treatment is a promising approach to address this issue. This study describes the generation of 3D osteosarcoma models termed “tumouroids”, which are geometrically compartmentalised to reproduce the bone cancer mass and its surrounding. Although the tumour microenvironment impacts osteosarcoma in many ways, this model focussed on interrogating the influence of a biomimetic matrix on tumour cell behaviour. The 3D matrix was supplemented with the bone-marrow proteins laminin, fibronectin and NuOss® bone granules. This led to increased invasion of osteosarcoma cell aggregates from within the bone-like matrix into the surrounding acellular bone marrow-like ECM. The presence of bone granules also yielded an atypical molecular profile of osteosarcoma cells, suggesting malignant metabolic reprogramming. Changes include decreased MMP-9 (p < 0.05) and increased PTEN (p < 0.05), MCP-1 (p < 0.01) and MCT-4 (p < 0.05) gene expression. This complex 3D biomimetic composition also changed cellular responses to doxorubicin, a common chemotherapeutic agent used to treat osteosarcoma, and reproduced key issues of in vivo treatment like drug penetrance and doxorubicin-induced bone toxicity. This work highlights the importance of a biomimetic matrix in 3D osteosarcoma models for both basic and translational research

Damage analysis of pressure pipes under high temperature and variable pressure conditions

The problem of non-linear stress analysis of creeping reinforced pipes under constant pressure has been treated in a recent work [1]. In the present work, a damage accumulation analysis of the above problem is attempted taking into account the non-linear distribution of the stresses as well as non-linear damage accumulation under variable pressure and/or temperature conditions. For the stress analysis a non-linear differential equation is used to derive the stress concentration in critical locations of power pipes reinforced by rigid rings which are distributed along their axis. Due to step-wised temperature and internal pressure of the pipe, the damage accumulation is predicted by using a damage function specified with respect to damage parameter derived by the stress versus Larson-Miller coefficient curve. Advantages of the proposed methodology are: (a) the 2-D creep stress analysis incorporates mechanical behaviours of material derived by uniaxial tests, (b) the predicted damage accumulation due to the variable pressure takes into account the previous damage history as well as the loading order effect

E-government adoption: A cultural comparison

This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ Springer Science + Business Media, LLC 2008.E-government diffusion is an international phenomenon. This study compares e-government adoption in the U.K. to adoption in the U.S. In particular, this study seeks to determine if the same factors are salient in both countries. Several studies have explored citizen acceptance of e-government services in the U.S. However, few studies have explored this phenomenon in the U.K. To identify the similarities and differences between the U.K. and the U.S. a survey is conducted in the U.K. and the findings are compared to the literature that investigates diffusion in the U.S. This study proposes a model of e-government adoption in the U.K. based on salient factors in the U.S. A survey is administered to 260 citizens in London to assess the importance of relative advantage, trust and the digital divide on intention to use e-government. The results of binary logistic regression indicate that there are cultural differences in e-government adoption in the U.K. and the U.S. The results indicate that of the prevailing adoption constructs, relative advantage and trust are pertinent in both the U.S. and the U.K., while ICT adoption barriers such as access and skill may vary by culture. Implications for research and practice are discussed

An integrated bandwidth allocation and admission control framework for the support of heterogeneous real-time traffic in class-based IP networks

The support of real-time traffic in class-based IP networks requires the reservation of resources in all the links along the end-to-end paths through appropriate queuing and forwarding mechanisms. This resource allocation should be accompanied by appropriate admission control procedures in order to guarantee that newly admitted real-time traffic flows do not cause any violation to the Quality of Service (QoS) experienced by the already established real-time traffic flows. In this paper we initially aim to highlight certain issues with respect to the areas of bandwidth allocation and admission control for the support of real-time traffic in class-based IP networks. We investigate the implications of topological placement of both the bandwidth allocation and admission control schemes. We show that the performance of bandwidth allocation and admission control schemes depends highly on the location of the employed procedures with respect to the end-users requesting the services and the various network boundaries (access, metro, core, etc.). Based on our results we conclude that the strategies for applying these schemes should be location-aware, because the performance of bandwidth allocation and admission control at different points in a class-based IP network, and for the same traffic load, can be quite different and can deviate greatly from the expected performance. Through simulations we also try to provide a quantitative view of the aforementioned deviations. Taking the implications of this “location-awareness” into account, we subsequently present a new Measurement-based Admission Control (MBAC) scheme for real-time traffic that uses measurements of aggregate bandwidth only, without keeping the state of any per-flow information. In this scheme there is no assumption made on the nature of the traffic characteristics of the real-time traffic flows, which can be of heterogeneous nature. Through simulations we show that the admission control scheme is robust with respect to traffic heterogeneity and measurement errors. We also show that our scheme compares favorably against other admission control schemes in the literature

Electronic nose: clinical diagnosis based on soft computing methodologies

Recently, the use of smell in clinical diagnosis has been rediscovered due to major advances in odour sensing technology and artificial intelligence. It was well known in the past that a number of infectious or metabolic diseases could liberate specific odours characteristic of the disease stage and among others, urine volatile compounds have been identified as possible diagnostic markers. A newly developed electronic nose based on chemoresistive sensors has been employed to identify in vitro 13 bacterial clinical isolates, collected from patients diagnosed with urinary tract infections, gastrointestinal and respiratory infections, and in vivo urine samples from patients with suspected uncomplicated UTI who were scheduled for microbiological analysis in a UK health laboratory environment. An intelligent model consisting of an odour generation mechanism, and a classifier system based a neural networks, genetic algorithms, and multivariate techniques such as principle components analysis and discriminant function analysis-cross validation. The experimental results confirm the validility of the presented methods

Policy conflict analysis for diffserv quality of service management

Policy-based management provides the ability to (re-)configure differentiated services networks so that desired Quality of Service (QoS) goals are achieved. This requires implementing network provisioning decisions, performing admission control, and adapting bandwidth allocation to emerging traffic demands. A policy-based approach facilitates flexibility and adaptability as policies can be dynamically changed without modifying the underlying implementation. However, inconsistencies may arise in the policy specification. In this paper we provide a comprehensive set of QoS policies for managing Differentiated Services (DiffServ) networks, and classify the possible conflicts that can arise between them. We demonstrate the use of Event Calculus and formal reasoning for the analysis of both static and dynamic conflicts in a semi-automated fashion. In addition, we present a conflict analysis tool that provides network administrators with a user-friendly environment for determining and resolving potential inconsistencies. The tool has been extensively tested with large numbers of policies over a range of conflict types