52 research outputs found

    Finite-Bandwidth Calculations for Charge Carrier Mobility in Organic Crystals

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    Finite-bandwidth effects on the temperature dependence of the mobility of injected carriers in pure organic crystals are explored for a simplifed case of impurity scattering. Temperature-dependent bandwidth effects are discussed briefly through a simplified combination of band and polaronic concepts

    TRPV1: A Target for Next Generation Analgesics

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    Transient Receptor Potential Vanilloid 1 (TRPV1) is a Ca2+ permeant non-selective cation channel expressed in a subpopulation of primary afferent neurons. TRPV1 is activated by physical and chemical stimuli. It is critical for the detection of nociceptive and thermal inflammatory pain as revealed by the deletion of the TRPV1 gene. TRPV1 is distributed in the peripheral and central terminals of the sensory neurons and plays a role in initiating action potentials at the nerve terminals and modulating neurotransmitter release at the first sensory synapse, respectively. Distribution of TRPV1 in the nerve terminals innervating blood vessels and in parts of the CNS that are not subjected to temperature range that is required to activate TRPV1 suggests a role beyond a noxious thermal sensor. Presently, TRPV1 is being considered as a target for analgesics through evaluation of different antagonists. Here, we will discuss the distribution and the functions of TRPV1, potential use of its agonists and antagonists as analgesics and highlight the functions that are not related to nociceptive transmission that might lead to adverse effects

    Ladungstraegertransport in polymeren Photoleitern Ein mikroskopisches auf Unordnung basierendes Modell

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    Polymere Photoleiter, insbesondere mit organischen Molekuelen dotierte Polymere, gewinnen immer mehr an Bedeutung als grossflaechige Transportschichten in Fotokopierern und Laserdruckern. Von technischer Bedeutung ist dabei der Transportprozess der durch Licht induzierten Ladungen und die Transitzeit des Ladungstraegerpakets. Diese Arbeit praesentiert ein Modell fuer den Ladungstransport, das die in den Polymeren inhaerente geometrische und energetische Unordnung beruecksichtigt. Flugzeitexperimente zeigen, dass die Beweglichkeit #mu# der Ladungstraeger einer exponentiellen #sq root#E-Abhaengigkeit folgt, wobei die Steigung #beta# mit zunehmender Temperatur abnimmt. (orig./MM)Photoconducting polymers especially molecularly doped polymers are becoming more and more important as large area films in photocopy machines and laser printers because of their better chemical and mechanical properties. A question of technical interest is the transport process of the photoinduced charges and the average transit-time of the charge carrier packet. This thesis presents a model of charge transport taking into account the positional and energetic disorder inherent in the polymeric material. Time-of-flight experiments show that mobilities of charge carriers follow an 1 n#mu# vs #sq root#E relationship with the slope #beta# decreasing with increasing temperature. (orig./MM)SIGLEAvailable from TIB Hannover: DW 6455 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman
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