Ulcerative colitis: let's talk about extent

Ulcerative colitis (UC) is a chronic inflammatory disease in which clinical course varies substantially between patients. The extent of the disease is usually pointed out as one of the factors responsible for this variation. With this study, we pretended to evaluate the differences in natural history and pharmacological therapy prescription between left-sided and extended UC

A new class of quantum bound states: diprotons in extreme magnetic fields

This paper considers the possibility that two charged particles with an attractive short-ranged potential between them which is not strong enough to form bound states in free space, may bind in uniform magnetic fields. It is shown that in the formal limit where Coulomb repulsion is negligible (q -> 0 and B_0 -> \infty with q B_0 fixed where q is the charge and B_0 the field strength) there always exists a bound state for a system of two identical charged particles in a constant magnetic field, provided that there is a short-range uniformly attractive potential between them. Moreover, it is shown that in this limit {\it any} potential with an attractive s-wave scattering length will posses bound states provided that the range of the potential is much smaller than the characteristic magnetic length, r_0 = (\frac{q B_0}{4})^{-1/2}. For this case, the binding is computed numerically. We estimate the size of the magnetic field needed to approximately reach a regime where the formal limit considered becomes a good approximation to the dynamics. These numerical estimates indicate that two protons in an extremely strong magnetic field such as might be found in a magnetar will bind to form a diproton

Very long baseline astrometry of PSR J1012+5307 and its implications on alternative theories of gravity

PSR J1012+5307, a millisecond pulsar in orbit with a helium white dwarf (WD), has been timed with high precision for about 25 years. One of the main objectives of this long-term timing is to use the large asymmetry in gravitational binding energy between the neutron star and the WD to test gravitational theories. Such tests, however, will be eventually limited by the accuracy of the distance to the pulsar. Here, we present VLBI (very long baseline interferometry) astrometry results spanning approximately 2.5 years for PSR J1012+5307, obtained with the Very Long Baseline Array as part of the MSPSRPI project. These provide the first proper motion and absolute position for PSR J1012+5307 measured in a quasi-inertial reference frame. From the VLBI results, we measure a distance of $0.83^{+0.06}_{-0.02}$kpc (all the estimates presented in the abstract are at 68% confidence) for PSR J1012+5307, which is the most precise obtained to date. Using the new distance, we improve the uncertainty of measurements of the unmodeled contributions to orbital period decay, which, combined with three other pulsars, places new constraints on the coupling constant for dipole gravitational radiation $\kappa_D=(-1.7\pm1.7)\times 10^{-4}$ and the fractional time derivative of Newton's gravitational constant $\dot{G}/G = -1.8^{\,+5.6}_{\,-4.7}\times 10^{-13}\,{\rm yr^{-1}}$ in the local universe. As the uncertainties of the observed decays of orbital period for the four leading pulsar-WD systems become negligible in $\approx10$ years, the uncertainties for $\dot{G}/G$ and $\kappa_D$ will be improved to $\leq1.5\times10^{-13}\,{\rm yr^{-1}}$ and $\leq1.0\times10^{-4}$, respectively, predominantly limited by the distance uncertainties.Comment: published in ApJ (2020ApJ...896...85D

A Massive Neutron Star in the Globular Cluster M5

We report the results of 19 years of Arecibo timing for two pulsars in the globular cluster NGC 5904 (M5), PSR B1516+02A (M5A) and PSR B1516+02B (M5B). This has resulted in the measurement of the proper motions of these pulsars and, by extension, that of the cluster itself. M5B is a 7.95-ms pulsar in a binary system with a > 0.13 solar mass companion and an orbital period of 6.86 days. In deep HST images, no optical counterpart is detected within ~2.5 sigma of the position of the pulsar, implying that the companion is either a white dwarf or a low-mass main-sequence star. The eccentricity of the orbit (e = 0.14) has allowed a measurement of the rate of advance of periastron: (0.0142 +/-0.0007) degrees per year. We argue that it is very likely that this periastron advance is due to the effects of general relativity, the total mass of the binary system then being 2.29 +/-0.17 solar masses. The small measured mass function implies, in a statistical sense, that a very large fraction of this total mass is contained in the pulsar: 2.08 +/- 0.19 solar masses (1 sigma); there is a 5% probability that the mass of this object is < 1.72 solar masses and a 0.77% probability that is is between 1.2 and 1.44 solar masses. Confirmation of the median mass for this neutron star would exclude most ``soft'' equations of state for dense neutron matter. Millisecond pulsars (MSPs) appear to have a much wider mass distribution than is found in double neutron star systems; about half of these objects are significantly more massive than 1.44 solar masses. A possible cause is the much longer episode of mass accretion necessary to recycle a MSP, which in some cases corresponds to a much larger mass transfer.Comment: 10 pages in ApJ emulate format, 2 tables, 6 figures. Added February 2008 data, slightly revised mass limits. Accepted for publication in Ap