Transportation vehicle energy intensities. A joint DOT/NASA reference paper

A compilation of data on the energy consumption of air and ground vehicles is presented. The ratio BTU/ASM, British Thermal Units/Available Seat Mile, is used to express vehicle energy intensiveness, and related to the energy consumed directly in producing seat-mile or ton-mile productivity. Data is presented on passenger and freight vehicles which are in current use or which are about to enter service, and advanced vehicles which may be operational in the 1980's and beyond. For the advanced vehicles, an estimate is given of the date of initial operational service, and the performance characteristics. Other key considerations in interpreting energy intensiveness for a given mode are discussed, such as: load factors, operations, overhead energy consumption, and energy investments in new structure and equipment

Fair housing in Boston: a role for private organizations.

Massachusetts Institute of Technology. Dept. of City and Regional Planning. Thesis. 1966. M.C.P.Bibliography: leaves [110-116].M.C.P

The New England Cod Fishing Industry and Maritime Dimensions of the American Revolution

THE NEW ENGLAND COD FISHING INDUSTRY AND MARITIME DIMENSIONS OF THE AMERICAN REVOLUTIONChristopher Paul Magra, PhDUniversity of Pittsburgh, 2006 The American Revolution cannot be fully understood without coming to terms with why workers and merchants within the New England cod fishing industry resisted British authority and how their labor and capital contributed to the war effort. The Revolution began in New England with the shot heard around the world in Concord, Massachusetts. New England provided the most manpower for the American military each and every year of the war. And cod represented the most lucrative trade good in all of colonial New England. Between 1768 and 1772, fish represented 35% of New England's total export revenue. The second most valuable export commodity, livestock, represented only 20% of this revenue stream. By 1775, an estimated 10,000 New Englanders, or 8% of the adult male working population, labored in the fishing industry. Yet, to date there has not been a systematic effort to investigate the relationship between this vital colonial industry and the Revolutionary War. In order to get at the linkages between the worlds of commerce and the way of war I triangulated data culled from merchant ledgers, ship's log books, customs records, shipping records, diaries, newspapers, and military service records. Drawing on these sources, the dissertation defends a two-fold argument. First, economic competition between vested interests in the British Empire, principally New England fish merchants, West Country fish merchants, and West Indian sugar planters, resulted in a series of commercial regulations and naval police actions aimed at restricting New England's economic expansion. These regulations and actions culminated in the British state's fateful decision in 1775 to close the New England cod fishing industry, which ultimately motivated colonists to go to war. Second, fishermen and fish merchants played key roles in winning the war. Merchants converted trade routes into military supply lines and transformed their fishing vessels into warships. Fishermen armed and manned the first American navy, served in the first coast guard units, manned privateers, and fought on land. These multi-faceted efforts helped secure American independence

Gene Expression Profiling and the Role of HSF1 in Ovarian Cancer in 3D Spheroid Models

Ovarian cancer is the most lethal gynecological cancer, with over 200,000 women diagnosed each year and over half of those cases leading to death. These poor statistics are related to a lack of early symptoms and inadequate screening techniques. This results in the cancer going undetected until later stages when the tumor has metastasized through a process that requires the epithelial to mesenchymal transition (EMT). In lieu of traditional monolayer cell culture, EMT and cancer progression in general is best characterized through the use of 3D spheroid models. In this study, we examine gene expression changes through microarray analysis in spheroid versus monolayer ovarian cancer cells treated with TGFβ to induce EMT. Transcripts that included Coiled-Coil Domain Containing 80 (CCDC80), Solute Carrier Family 6 (Neutral Amino Acid Transporter), Member 15 (SLC6A15), Semaphorin 3E (SEMA3E) and PIF1 5\u27-To-3\u27 DNA Helicase (PIF1) were downregulated more than 10-fold in the 3D cells while Inhibitor Of DNA Binding 2, HLH Protein (ID2), Regulator Of Cell Cycle (RGCC), Protease, Serine 35 (PRSS35), and Aldo-Keto Reductase Family 1, Member C1 (AKR1C1) were increased more than 50-fold. Interestingly, stress responses and epigenetic processes were significantly affected by 3D growth. The heat shock response and the oxidative stress response were also identified as transcriptome responses that showed significant changes upon 3D growth. Subnetwork enrichment analysis revealed that DNA integrity (e.g. DNA damage, genetic instability, nucleotide excision repair, and the DNA damage checkpoint pathway) were altered in the 3D spheroid model. In addition, two epigenetic processes, DNA methylation and histone acetylation, were increased with 3D growth. These findings support the hypothesis that three dimensional ovarian cell culturing is physiologically different from its monolayer counterpart. The proteotoxic stress-responsive transcription factor HSF1 is frequently overexpressed in a variety of cancers and is vital to cellular proliferation and invasion in some cancers. Upon analysis of various patient data sets, we find that HSF1 is frequently overexpressed in ovarian tumor samples. In order to determine the role of HSF1 in ovarian cancer, inducible HSF1 knockdown cell lines were created. Knockdown of HSF1 in SKOV3 and HEY ovarian cancer cell lines attenuates the epithelial-tomesenchymal transition (EMT) in cells treated with TGFβ, as determined by western blot and quantitative RT-PCR analysis of multiple EMT markers. To further explore the role of HSF1 in ovarian cancer EMT, we cultured multicellular spheroids in a non-adherent environment to simulate early avascular tumors. In the spheroid model, cells more readily undergo EMT; however, EMT inhibition by HSF1 knockdown becomes more pronounced in the spheroid model. These findings suggest that HSF1 is important in the ovarian cancer TGFβ response and in EMT

Durant Weekly News

Weekly newspaper from Durant, Choctaw Nation (in Indian Territory) that includes local, territory, and United States national news along with extensive advertising

Durant Weekly News

Weekly newspaper from Durant, Choctaw Nation (in Indian Territory) that includes local, territory, and United States national news along with extensive advertising

Durant Weekly News

Weekly newspaper from Durant, Choctaw Nation (in Indian Territory) that includes local, territory, and United States national news along with extensive advertising

Durant Weekly News

Weekly newspaper from Durant, Choctaw Nation (in Indian Territory) that includes local, territory, and United States national news along with extensive advertising

Durant Weekly News

Weekly newspaper from Durant, Choctaw Nation (in Indian Territory) that includes local, territory, and United States national news along with extensive advertising