Influential parameters for estimating the environmental impacts of geothermal power: A global sensitivity analysis study

The life-cycle environmental impacts of geothermal power generation are highly variable and depend on many site-specific conditions. The objective of this work is the identification of the most influential parameters for estimating the environmental impacts of geothermal electricity production. First, we developed a general model for computing the impacts of both conventional and enhanced geothermal technologies. The model is validated against selected literature studies for the climate change category. We then use Global Sensitivity Analysis (GSA) to evaluate the contribution of each parameter to the overall variance of the model's output. The results of the GSA suggest that i) the uncertainty of environmental impact estimates can be significantly reduced by obtaining more accurate values for a small number of key parameters, such as the installed capacity of the plant, operational emissions of CO2 and the depth and capacity of wells; and ii) the majority of parameters do not affect significantly the environmental impact estimates and therefore can be fixed anywhere within their range of variability. Finally, we discuss some of the limitations of the present study and propose approaches that could be implemented to overcome such limitations

The environmental performance of protecting seedlings with plastic tree shelters for afforestation in temperate oceanic regions: A UK case study

Restoration of forested land represents an effective strategy to achieve net-zero target emissions by enhancing the removal of greenhouse gases from the atmosphere. The most common afforestation strategy envisages planting seedlings, which are germinated and grown to the desired age at tree nurseries, with plastic shelters to increase growth and survival of trees. This article presents a comprehensive Life Cycle Assessment (LCA) study that compares the environmental performance of current and prospective scenarios for shelter-aided seedling planting compared with a base case where shelters are not employed. The study focuses on the UK, but results and conclusions are valid for other temperate oceanic regions. The scenarios investigated are a combination of different shelters materials and end-of-life (EoL) strategies. Our analysis demonstrates that (i) planting seedling without shelters is the most preferable option across most environmental impact categories (including Climate Change), and in terms of weighted results, (ii) polypropylene shelters are preferable to bio-based alternatives, including polylactic acid-starch blends and bio-polypropylene, (iii) recycling is the most environmentally advantageous EoL treatment. Our study also showed that that the carbon emissions of the scenarios investigated are negligible when compared to the amount of carbon sequestered by a tree in 25 years

The environmental impacts of different mask options for healthcare settings in the UK

During the COVID-19 pandemic, different strategies emerged to combat shortages of certified face masks used in the healthcare sector. These strategies included increasing production from the original manufacturing sites, commissioning new production facilities locally, exploring and allowing the reuse of single-use face masks via various decontamination methods, and developing reusable mask alternatives that meet the health and safety requirements set out in European Standards. In this article, we quantify and evaluate the life-cycle environmental impacts of selected mask options available for use by healthcare workers in the UK, with the objective of supporting decision- and policy-making. We investigate alternatives to traditional single-use face masks like surgical masks and respirators (or FFP3 masks), including cloth masks decontaminated in washing machines; FFP3 masks decontaminated via vapour hydrogen peroxide, and rigid half masks cleaned with antibacterial wipes. Our analysis demonstrates that: (1) the reuse options analysed are environmentally preferential to the traditional “use then dispose” of masks; (2) the environmental benefits increase with the number of reuses; and (3) the manufacturing location and the material composition of the masks have great influence over the life-cycle environmental impacts of each mask use option, in particular for single-use options

Room temperature strong light-matter coupling in three dimensional terahertz meta-atoms

We demonstrate strong light-matter coupling in three dimensional terahertz meta-atoms at room temperature. The intersubband transition of semiconductor quantum wells with a parabolic energy potential is strongly coupled to the confined circuital mode of three-dimensional split-ring metal-semiconductor-metal resonators that have an extreme sub-wavelength volume (λ/10). The frequency of these lumped-element resonators is controlled by the size and shape of the external antenna, while the interaction volume remains constant. This allows the resonance frequency to be swept across the intersubband transition and the anti-crossing characteristic of the strong light-matter coupling regime to be observed. The Rabi splitting, which is twice the Rabi frequency (2ΩRabi), amounts to 20% of the bare transition at room temperature, and it increases to 28% at low-temperatur

PATOLOGIA CLÍNICA EM AVES DE PRODUÇÃO – UMA FERRAMENTA PARA MONITORAR A SANIDADE AVÍCOLA – REVISÃO

Clinical pathology has been usedin veterinary medicine for many years to evaluatemetabolic changes that may indicate any sign ofdisease in animals. Even though the use of bloodparameters is routine in companion animals, it isnot commonly used for avian clinical evaluationeither wild or production birds. Among others, thelack of information of avian blood reference valueshas limited the use of this tool in avian medicine.The blood parameters in avian medicine are helpfulto evaluate aspects related to animal health forwild and also production birds. Thus, this reviewpaper presents some ways to use clinical pathologyparameters to evaluate and to monitor the avian health.A patologia clínica é usada na medicinaveterinária há muitos anos para avaliar as alteraçõesmetabólicas que possam indicar algum sinalde doença nos animais. Apesar do uso dos parâmetroslaboratoriais ser rotina em animais de companhia,não são comumente utilizados para avaliaçãoclínica de aves selvagens ou de produção. Aausência de informações sobre valores sanguíneosde referência limitou o uso destas ferramentas namedicina de aves. Os parâmetros laboratoriais namedicina de aves são úteis para avaliar aspectosrelacionados à saúde animal. Desta forma, assimesta revisão apresenta formas de utilização da patologiaclínica (hematologia e bioquímica clínica)para auxílio na avaliação e monitoramento da saúde das aves

The “Personal Health Budget” intervention model in early psychosis: Preliminary findings from the Parma experience

Objectives Personal Health Budget (PHB) has recently been provided to people with severe mental illness, reflecting a policy shift towards a personalized mental health care based on individual unmet needs. However, evidence on effectiveness of PHB initiatives is still limited. Aim of this research was to provide preliminary data about the beneficial effects of adding PHB to a multicomponent EIP intervention in patients with First-Episode Psychosis (FEP) along a 2-year follow-up period. Methods Participants (n = 49) were FEP patients, aged 18-50 years, entered the “Parma Early Psychosis” program and completing the Health of Nation Outcome Scale (HoNOS), the Brief Psychiatric Rating Scale (BPRS) and the Global Assessment of Functioning (GAF). Friedman test for repeated measure (with Wilcoxon test as post-hoc procedure) was performed to evaluate the longitudinal stability of functioning and clinical parameters. A linear regression analysis was also carried out. Results A significant effect of time on all HoNOS, BPRS and GAF scores along the 2 years of follow-up was found. Regression analysis results specifically showed a relevant association between a PHB multiaxial intervention and the longitudinal decrease in BPRS “Negative Symptoms” subscores, as well as in HoNOS “Behavioral Problems” and “Social Problems” scores. Conclusions Our results support the general applicability of a PHB approach within an “Early Intervention in Psychosis” program for help-seeking adults with FEP

The use of a P. falciparum specific coiled-coil domain to construct a self-assembling protein nanoparticle vaccine to prevent malaria.

The parasitic disease malaria remains a major global public health concern and no truly effective vaccine exists. One approach to the development of a malaria vaccine is to target the asexual blood stage that results in clinical symptoms. Most attempts have failed. New antigens such as P27A and P27 have emerged as potential new vaccine candidates. Multiple studies have demonstrated that antigens are more immunogenic and are better correlated with protection when presented on particulate delivery systems. One such particulate delivery system is the self-assembling protein nanoparticle (SAPN) that relies on coiled-coil domains of proteins to form stable nanoparticles. In the past we have used de novo designed amino acid domains to drive the formation of the coiled-coil scaffolds which present the antigenic epitopes on the particle surface. Here we use naturally occurring domains found in the tex1 protein to form the coiled-coil scaffolding of the nanoparticle. Thus, by engineering P27A and a new extended form of the coiled-coil domain P27 onto the N and C terminus of the SAPN protein monomer we have developed a particulate delivery system that effectively displays both antigens on a single particle that uses malaria tex1 sequences to form the nanoparticle scaffold. These particles are immunogenic in a murine model and induce immune responses similar to the ones observed in seropositive individuals in malaria endemic regions. We demonstrate that our P27/P27A-SAPNs induce an immune response akin to the one in seropositive individuals in Burkina Faso. Since P27 is highly conserved among different Plasmodium species, these novel SAPNs may even provide cross-protection between Plasmodium falciparum and Plasmodium vivax the two major human malaria pathogens. As the SAPNs are also easy to manufacture and store they can be delivered to the population in need without complication thus providing a low cost malaria vaccine