Eficiencia neuromuscular del cuádriceps en mujeres con y sin dolor patelofemoral

El dolor patelofemoral (DPF) puede producir unamenor activación del músculo cuádriceps, lo que lleva a una mayorsobrecarga y dolor en esta articulación. La eficiencia neuromuscular(ENM) es una variable que evalúa la relación entre la cantidad deestímulos neurales y la capacidad de determinado músculo degenerar fuerza, con más eficiencia para el que produce mayorfuerza muscular, con menor activación de las fibras musculares.Así el objetivo del estudio fue evaluar la fuerza y la ENM de losextensores de rodilla en mujeres con y sin dolor patelofemoral.En este estudio participaron 24 mujeres, con edades entre 18 y30 años, con y sin dolor patelofemoral, que han sido reclutadaspor medio de un cuestionario. Se aplicaron la anamnesis,la escala de dolor anterior de rodilla y la escala visual numérica.Posteriormente, se realizaron evaluaciones de la fuerza extensorade la rodilla con dinamómetro manual y de la ENM del vastomedial (VM), vasto lateral (VL) y recto femoral (RF). Para el análisisestadístico, se adoptaron pruebas apropiadas para compararvariables entre grupos y correlacionarlas. En todas las pruebasestadísticas, el nivel de significación fue de α<0,05. Los resultadosmostraron que las mujeres con DPF tenían el 61% menor ENMen el VM y el 52% en el VL en comparación con el grupo sindolor. No hubo diferencias significativas para la fuerza extensorade la rodilla entre los grupos. Se concluye que el dolor influyenegativamente en el reclutamiento de VM y VL, pero no cambia lacapacidad de generar fuerza del cuádriceps| Patellofemoral pain (PFP) may contributeto less activation of the quadriceps muscle, favoringjoint overload and pain. Neuromuscular efficiency (NME)is a variable that evaluates the relationship betweenthe amount of neural stimuli and the ability to generateforce of in a given muscle, with the most efficient beingthe one that produces greater muscle force, with lessactivation of muscle fibers. In this sense, this study aimedto evaluate the strength and NME of knee extensors inwomen with and without patellofemoral pain. A totalof 24 adult women, recruited via a questionnaire, agedfrom 18 to 30 years, with and without patellofemoral pain,participated in this study. Anamnesis, anterior knee painscale, and numerical visual scale were applied. Subsequently,the knee extensor strength, with a hand-held dynamometer,and the NME of vastus medialis (VM), vastus lateralis (VL),and rectus femoris (RF) were assessed. For statisticalanalysis, appropriate tests were adopted to comparevariables between groups and correlate them. In allstatistical tests, a α<0.05 was adopted. Results showedthat women with PFP had 61% lower NME in the VMand 52% in the VL, compared to the group without pain.No significant difference was found for knee extensorstrength between groups. We conclude that pain negativelyinfluences VM and VL recruitment but does not changequadriceps ability to generate strengthA dor patelofemoral (DPF) pode contribuir para menor ativação do músculo quadríceps, favorecendo maior sobrecarga e dor nesta articulação. A eficiência neuromuscular (ENM) é uma variável que avalia a relação entre a quantidade de estímulos neurais e a capacidade de geração de força de um determinado músculo, sendo mais eficiente aquele que produz maior força muscular, com menor ativação das fibras musculares. Nesse sentido, o objetivo do estudo foi avaliar a força e a ENM dos extensores de joelho em mulheres com e sem dor patelofemoral. Participaram deste estudo 24 mulheres, recrutadas por meio de um questionário, com idades entre 18 e 30 anos, com e sem dor patelofemoral. Foram realizadas a anamnese, a escala de dor anterior no joelho e a escala visual numérica e, posteriormente, a avaliação da força extensora de joelho, com dinamômetro manual, e a avaliação da ENM de vasto medial (VM), vasto lateral (VL) e reto femoral (RF). Para análise estatística, foram adotados os testes apropriados para comparação das variáveis entre os grupos e para correlação entre elas. Em todos os testes estatísticos foi adotado o nível de significância de α<0,05. Os resultados mostraram que mulheres com DPF apresentaram 61% menor ENM do VM e 52% do VL, em comparação ao grupo sem dor. Não se encontrou diferença significativa para força extensora de joelho entre os grupos. Concluímos que a dor influencia  negativamente o recrutamento de VM e VL, mas não altera a capacidade do quadríceps de gerar força

NEOTROPICAL ALIEN MAMMALS: a data set of occurrence and abundance of alien mammals in the Neotropics

Biological invasion is one of the main threats to native biodiversity. For a species to become invasive, it must be voluntarily or involuntarily introduced by humans into a nonnative habitat. Mammals were among first taxa to be introduced worldwide for game, meat, and labor, yet the number of species introduced in the Neotropics remains unknown. In this data set, we make available occurrence and abundance data on mammal species that (1) transposed a geographical barrier and (2) were voluntarily or involuntarily introduced by humans into the Neotropics. Our data set is composed of 73,738 historical and current georeferenced records on alien mammal species of which around 96% correspond to occurrence data on 77 species belonging to eight orders and 26 families. Data cover 26 continental countries in the Neotropics, ranging from Mexico and its frontier regions (southern Florida and coastal-central Florida in the southeast United States) to Argentina, Paraguay, Chile, and Uruguay, and the 13 countries of Caribbean islands. Our data set also includes neotropical species (e.g., Callithrix sp., Myocastor coypus, Nasua nasua) considered alien in particular areas of Neotropics. The most numerous species in terms of records are from Bos sp. (n = 37,782), Sus scrofa (n = 6,730), and Canis familiaris (n = 10,084); 17 species were represented by only one record (e.g., Syncerus caffer, Cervus timorensis, Cervus unicolor, Canis latrans). Primates have the highest number of species in the data set (n = 20 species), partly because of uncertainties regarding taxonomic identification of the genera Callithrix, which includes the species Callithrix aurita, Callithrix flaviceps, Callithrix geoffroyi, Callithrix jacchus, Callithrix kuhlii, Callithrix penicillata, and their hybrids. This unique data set will be a valuable source of information on invasion risk assessments, biodiversity redistribution and conservation-related research. There are no copyright restrictions. Please cite this data paper when using the data in publications. We also request that researchers and teachers inform us on how they are using the data

Global variation in postoperative mortality and complications after cancer surgery: a multicentre, prospective cohort study in 82 countries

© 2021 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 licenseBackground: 80% of individuals with cancer will require a surgical procedure, yet little comparative data exist on early outcomes in low-income and middle-income countries (LMICs). We compared postoperative outcomes in breast, colorectal, and gastric cancer surgery in hospitals worldwide, focusing on the effect of disease stage and complications on postoperative mortality. Methods: This was a multicentre, international prospective cohort study of consecutive adult patients undergoing surgery for primary breast, colorectal, or gastric cancer requiring a skin incision done under general or neuraxial anaesthesia. The primary outcome was death or major complication within 30 days of surgery. Multilevel logistic regression determined relationships within three-level nested models of patients within hospitals and countries. Hospital-level infrastructure effects were explored with three-way mediation analyses. This study was registered with ClinicalTrials.gov, NCT03471494. Findings: Between April 1, 2018, and Jan 31, 2019, we enrolled 15 958 patients from 428 hospitals in 82 countries (high income 9106 patients, 31 countries; upper-middle income 2721 patients, 23 countries; or lower-middle income 4131 patients, 28 countries). Patients in LMICs presented with more advanced disease compared with patients in high-income countries. 30-day mortality was higher for gastric cancer in low-income or lower-middle-income countries (adjusted odds ratio 3·72, 95% CI 1·70–8·16) and for colorectal cancer in low-income or lower-middle-income countries (4·59, 2·39–8·80) and upper-middle-income countries (2·06, 1·11–3·83). No difference in 30-day mortality was seen in breast cancer. The proportion of patients who died after a major complication was greatest in low-income or lower-middle-income countries (6·15, 3·26–11·59) and upper-middle-income countries (3·89, 2·08–7·29). Postoperative death after complications was partly explained by patient factors (60%) and partly by hospital or country (40%). The absence of consistently available postoperative care facilities was associated with seven to 10 more deaths per 100 major complications in LMICs. Cancer stage alone explained little of the early variation in mortality or postoperative complications. Interpretation: Higher levels of mortality after cancer surgery in LMICs was not fully explained by later presentation of disease. The capacity to rescue patients from surgical complications is a tangible opportunity for meaningful intervention. Early death after cancer surgery might be reduced by policies focusing on strengthening perioperative care systems to detect and intervene in common complications. Funding: National Institute for Health Research Global Health Research Unit

Effects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study

© 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 licenseBackground: Early death after cancer surgery is higher in low-income and middle-income countries (LMICs) compared with in high-income countries, yet the impact of facility characteristics on early postoperative outcomes is unknown. The aim of this study was to examine the association between hospital infrastructure, resource availability, and processes on early outcomes after cancer surgery worldwide. Methods: A multimethods analysis was performed as part of the GlobalSurg 3 study—a multicentre, international, prospective cohort study of patients who had surgery for breast, colorectal, or gastric cancer. The primary outcomes were 30-day mortality and 30-day major complication rates. Potentially beneficial hospital facilities were identified by variable selection to select those associated with 30-day mortality. Adjusted outcomes were determined using generalised estimating equations to account for patient characteristics and country-income group, with population stratification by hospital. Findings: Between April 1, 2018, and April 23, 2019, facility-level data were collected for 9685 patients across 238 hospitals in 66 countries (91 hospitals in 20 high-income countries; 57 hospitals in 19 upper-middle-income countries; and 90 hospitals in 27 low-income to lower-middle-income countries). The availability of five hospital facilities was inversely associated with mortality: ultrasound, CT scanner, critical care unit, opioid analgesia, and oncologist. After adjustment for case-mix and country income group, hospitals with three or fewer of these facilities (62 hospitals, 1294 patients) had higher mortality compared with those with four or five (adjusted odds ratio [OR] 3·85 [95% CI 2·58–5·75]; p<0·0001), with excess mortality predominantly explained by a limited capacity to rescue following the development of major complications (63·0% vs 82·7%; OR 0·35 [0·23–0·53]; p<0·0001). Across LMICs, improvements in hospital facilities would prevent one to three deaths for every 100 patients undergoing surgery for cancer. Interpretation: Hospitals with higher levels of infrastructure and resources have better outcomes after cancer surgery, independent of country income. Without urgent strengthening of hospital infrastructure and resources, the reductions in cancer-associated mortality associated with improved access will not be realised. Funding: National Institute for Health and Care Research

Brazilian Flora 2020: Leveraging the power of a collaborative scientific network

International audienceThe shortage of reliable primary taxonomic data limits the description of biological taxa and the understanding of biodiversity patterns and processes, complicating biogeographical, ecological, and evolutionary studies. This deficit creates a significant taxonomic impediment to biodiversity research and conservation planning. The taxonomic impediment and the biodiversity crisis are widely recognized, highlighting the urgent need for reliable taxonomic data. Over the past decade, numerous countries worldwide have devoted considerable effort to Target 1 of the Global Strategy for Plant Conservation (GSPC), which called for the preparation of a working list of all known plant species by 2010 and an online world Flora by 2020. Brazil is a megadiverse country, home to more of the world's known plant species than any other country. Despite that, Flora Brasiliensis, concluded in 1906, was the last comprehensive treatment of the Brazilian flora. The lack of accurate estimates of the number of species of algae, fungi, and plants occurring in Brazil contributes to the prevailing taxonomic impediment and delays progress towards the GSPC targets. Over the past 12 years, a legion of taxonomists motivated to meet Target 1 of the GSPC, worked together to gather and integrate knowledge on the algal, plant, and fungal diversity of Brazil. Overall, a team of about 980 taxonomists joined efforts in a highly collaborative project that used cybertaxonomy to prepare an updated Flora of Brazil, showing the power of scientific collaboration to reach ambitious goals. This paper presents an overview of the Brazilian Flora 2020 and provides taxonomic and spatial updates on the algae, fungi, and plants found in one of the world's most biodiverse countries. We further identify collection gaps and summarize future goals that extend beyond 2020. Our results show that Brazil is home to 46,975 native species of algae, fungi, and plants, of which 19,669 are endemic to the country. The data compiled to date suggests that the Atlantic Rainforest might be the most diverse Brazilian domain for all plant groups except gymnosperms, which are most diverse in the Amazon. However, scientific knowledge of Brazilian diversity is still unequally distributed, with the Atlantic Rainforest and the Cerrado being the most intensively sampled and studied biomes in the country. In times of “scientific reductionism”, with botanical and mycological sciences suffering pervasive depreciation in recent decades, the first online Flora of Brazil 2020 significantly enhanced the quality and quantity of taxonomic data available for algae, fungi, and plants from Brazil. This project also made all the information freely available online, providing a firm foundation for future research and for the management, conservation, and sustainable use of the Brazilian funga and flora