Immigration and Human Development: Evidence from Lebanon

This paper takes Lebanon as a case study to examine the relationship between human development and immigration. It examines this issue from both ends: the sending and the receiving countries. The author suggests that by developing the concept of a diasporic civil society and a diasporic public sphere, a significant aspect of the relationship between human development and immigration is illuminated especially at the level of political, social and cultural capitals. The paper also argues that the double impact of the home country and that of destination has a lot to say about the influence of immigration on human development in Lebanon. In examining Australia as a destination country, the paper shows the particular impact that globalisation and September 11 have lately had on the capacity of the Lebanese migrants for human development. Finally, the paper concludes by showing the extent to which the diasporic civil society compensates for the ‘negligent’ character of the Lebanese state in the context of human development.Lebanese diaspora, human development, diasporic civil society, diasporic public sphere, economic and social capitals

Immigration and Human Development: Evidence from Lebanon

This paper takes Lebanon as a case study to examine the relationship between human development and immigration. It examines this issue from both ends: the sending and the receiving countries. The author suggests that by developing the concept of a diasporic civil society and a diasporic public sphere, a significant aspect of the relationship between human development and immigration is illuminated especially at the level of political, social and cultural capitals. The paper also argues that the double impact of the home country and that of destination has a lot to say about the influence of immigration on human development in Lebanon. In examining Australia as a destination country, the paper shows the particular impact that globalisation and September 11 have lately had on the capacity of the Lebanese migrants for human development. Finally, the paper concludes by showing the extent to which the diasporic civil society compensates for the ‘negligent’ character of the Lebanese state in the context of human development.Lebanese diaspora, human development, diasporic civil society, diasporic public sphere, economic and social capitals

Immigration and Human Development: Evidence from Lebanon

This paper takes Lebanon as a case study to examine the relationship between human development and immigration. It examines this issue from both ends: the sending and the receiving countries. The author suggests that by developing the concept of a diasporic civil society and a diasporic public sphere, a significant aspect of the relationship between human development and immigration is illuminated especially at the level of political, social and cultural capitals. The paper also argues that the double impact of the home country and that of destination has a lot to say about the influence of immigration on human development in Lebanon. In examining Australia as a destination country, the paper shows the particular impact that globalisation and September 11 have lately had on the capacity of the Lebanese migrants for human development. Finally, the paper concludes by showing the extent to which the diasporic civil society compensates for the ‘negligent’ character of the Lebanese state in the context of human development

Immigration and Human Development: Evidence from Lebanon

This paper takes Lebanon as a case study to examine the relationship between human development and immigration. It examines this issue from both ends: the sending and the receiving countries. The author suggests that by developing the concept of a diasporic civil society and a diasporic public sphere, a significant aspect of the relationship between human development and immigration is illuminated especially at the level of political, social and cultural capitals. The paper also argues that the double impact of the home country and that of destination has a lot to say about the influence of immigration on human development in Lebanon. In examining Australia as a destination country, the paper shows the particular impact that globalisation and September 11 have lately had on the capacity of the Lebanese migrants for human development. Finally, the paper concludes by showing the extent to which the diasporic civil society compensates for the ‘negligent’ character of the Lebanese state in the context of human development

Ibrutinib Unmasks Critical Role of Bruton Tyrosine Kinase in Primary CNS Lymphoma.

Bruton tyrosine kinase (BTK) links the B-cell antigen receptor (BCR) and Toll-like receptors with NF-κB. The role of BTK in primary central nervous system (CNS) lymphoma (PCNSL) is unknown. We performed a phase I clinical trial with ibrutinib, the first-in-class BTK inhibitor, for patients with relapsed or refractory CNS lymphoma. Clinical responses to ibrutinib occurred in 10 of 13 (77%) patients with PCNSL, including five complete responses. The only PCNSL with complete ibrutinib resistance harbored a mutation within the coiled-coil domain of CARD11, a known ibrutinib resistance mechanism. Incomplete tumor responses were associated with mutations in the B-cell antigen receptor-associated protein CD79B

Chemically specifi C multiscale modeling of clay-polymer nanocomposites reveals intercalation dynamics, tactoid self-assembly and emergent materials properties

A quantitative description is presented of the dynamical process of polymer intercalation into clay tactoids and the ensuing aggregation of polymerentangled tactoids into larger structures, obtaining various characteristics of these nanocomposites, including clay-layer spacings, out-of-plane clay-sheet bending energies, X-ray diffractograms, and materials properties. This model of clay-polymer interactions is based on a three-level approach, which uses quantum mechanical and atomistic descriptions to derive a coarse-grained yet chemically specifi c representation that can resolve processes on hitherto inaccessible length and time scales. The approach is applied to study collections of clay mineral tactoids interacting with two synthetic polymers, poly(ethylene glycol) and poly(vinyl alcohol). The controlled behavior of layered materials in a polymer matrix is centrally important for many engineering and manufacturing applications. This approach opens up a route to computing the properties of complex soft materials based on knowledge of their chemical composition, molecular structure, and processing conditions.This work was funded in part by the EU FP7 MAPPER project (grant number RI-261507) and the Qatar National Research Fund (grant number 09–260–1–048). Supercomputing time was provided by PRACE on JUGENE (project PRA044), the Hartree Centre (Daresbury Laboratory) on BlueJoule and BlueWonder via the CGCLAY project, and on HECToR and ARCHER, the UK national supercomputing facility at the University of Edinburgh, via EPSRC through grants EP/F00521/1, EP/E045111/1, EP/I017763/1 and the UK Consortium on Mesoscopic Engineering Sciences (EP/L00030X/1). The authors are grateful to Professor Julian Evans for stimulating discussions during the course of this project. Data-storage and management services were provided by EUDAT (grant number 283304)

Représentations Systèmes Multi-Machines (SMM) de machines polyphasées

Cet article présente le principe de décomposition de machines polyphasées en machines fictives monophasée et diphasées non couplées magnétiquement. Après la description de la méthodologie de décomposition SMM (Systèmes Multimachines Multiconvertisseurs), deux cas sont étudiés. Une machine synchrone pentaphasée, est d'abord analysée avec son modèle de machines équivalentes. Un second cas plus original est ensuite étudié : deux machines pentaphasées connectées en série et alimentées par un onduleur 5 bras.This paper presents the equivalence of multi-phase machines with a set a of 1-phase and 2-phase machines with no magnetic couplings. Two cases are then studied. First, a 5-phase machine supplied by a Voltage Source Inverter(VSI) is analyzed. Then, a model is established for a single 5-leg VSI supplying two 5-phase machines whose windings are connected in series

Digital and physical spaces in informal settlements: migrants, refugee camps and mapping

Design tools to help understand the migratory journeys and experiences of individuals and communities from countries in crisis heading towards Europe have been well documented and studied in recent years. In particular, the use of new media (social media) and related technologies, like mobile phones, has recently become a useful instrument of connection between individuals with both shared and different cultural, ethnic, and linguistic backgrounds.The existing literature can be divided into two main categories: the studies that focus on using new and traditional media to trace and record both individual and communities’ experiences on their journey, and those that examine and propose new technologies to create maps and log the details of the journey and their connectivity, and a more intersubjective experience.Existing studies are therefore helpful in providing insights into both the physical journey and the individual experience of it. However, they are limited to the data available and to the traditional ways employed to elicit information from individuals in transit, including refugees. A large number of individuals are less represented within these studies, and often their stories are not told in a subjective manner. New ways of eliciting information, mapping individual experiences and gathering and interpreting data are necessary.In this chapter we present an analysis of a case study in which refugees in Calais, northern France have actively contributed to group initiatives involving physical and digital mapping. Using this case study as a starting point, we elaborate on ways in which new and advanced technologies could be used to improve communication between refugees and the charities and volunteers working with them. This chapter explores ways in which such data can be gathered in order to have new insights into the experience of refugees in camps and informal settlements through new technologies. We reflect on new ways in which maps can be drawn and relationships of individuals with the territories that they temporarily inhabit are formed and recorded

Down-regulation of COX-2 activity by 1α,25(OH)2D3 is VDR dependent in endothelial cells transformed by Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor

Our previous reports showed that 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3) has antiproliferative actions in endothelial cells stably expressing viral G protein-coupled receptor (vGPCR) associated with the pathogenesis of Kaposi's sarcoma. It has been reported that COX-2 enzyme, involved in the tumorigenesis of many types of cancers, is induced by vGPCR. Therefore, we investigated whether COX-2 down-regulation is part of the growth inhibitory effects of 1α,25(OH)2D3. Proliferation was measured in presence of COX-2 inhibitor Celecoxib (10–20 μM) revealing a decreased in vGPCR cell number, displaying typically apoptotic features in a dose dependent manner similarly to 1α,25(OH)2D3. In addition, the reduced cell viability observed with 20 μM Celecoxib was enhanced in presence of 1α,25(OH)2D3. Remarkably, although COX-2 mRNA and protein levels were up-regulated after 1α,25(OH)2D3 treatment, COX-2 enzymatic activity was reduced in a VDR-dependent manner. Furthermore, an interaction between COX-2 and VDR was revealed through GST pull-down and computational analysis. Additionally, high-affinity prostanoid receptors (EP3 and EP4) were found down-regulated by 1α,25(OH)2D3. Altogether, these results suggest a down-regulation of COX-2 activity and of prostanoid receptors as part of the antineoplastic mechanism of 1α,25(OH)2D3 in endothelial cells transformed by vGPCR.Fil: Tapia, Cinthya Mariela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; ArgentinaFil: Zamarreño, Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Física del Sur. Universidad Nacional del Sur. Departamento de Física. Instituto de Física del Sur; ArgentinaFil: Salvador, Gabriela Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: Casali, Cecilia Irene. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas; ArgentinaFil: Viso, Juan Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Física del Sur. Universidad Nacional del Sur. Departamento de Física. Instituto de Física del Sur; ArgentinaFil: Fernandez, Maria del Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas; ArgentinaFil: White, John H.. McGill University; CanadáFil: González Pardo, María Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; Argentin