3,182 research outputs found

    Non-Abelian Braiding of Lattice Bosons

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    We report on a numerical experiment in which we use time-dependent potentials to braid non-abelian quasiparticles. We consider lattice bosons in a uniform magnetic field within the fractional quantum Hall regime, where ν\nu, the ratio of particles to flux quanta, is near 1/2, 1 or 3/2. We introduce time-dependent potentials which move quasiparticle excitations around one another, explicitly simulating a braiding operation which could implement part of a gate in a quantum computation. We find that different braids do not commute for ν\nu near 11 and 3/23/2, with Berry matrices respectively consistent with Ising and Fibonacci anyons. Near ν=1/2\nu=1/2, the braids commute.Comment: 5 pages, 1 figur

    Ethical and Legal Concerns Associated With Withdrawing Mechanical Circulatory Support: A U.S. Perspective

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    Hundreds of thousands of Americans have advanced heart failure and experience severe symptoms (e. g., dyspnea) with minimal exertion or at rest despite optimal management. Although heart transplant is an effective treatment for advanced heart failure, the demand for organs far exceeds the supply. Another option for these patients is mechanical circulatory support (MCS) provided by devices such as the ventricular assist device and total artificial heart. MCS alleviates symptoms, prolongs life, and provides a “bridge to transplant” or a decision regarding future management such as “destination therapy,” in which the patient receives lifelong MCS. However, a patient receiving MCS, or his/her surrogate decision-maker, may conclude ongoing MCS is burdensome and no longer consistent with the patient's healthcare-related values, goals, and preferences and, as a result, request withdrawal of MCS. Likewise, the patient's clinician and care team may conclude ongoing MCS is medically ineffective and recommend its withdrawal. These scenarios raise ethical and legal concerns. In the U.S., it is ethically and legally permissible to carry out an informed patient's or surrogate's request to withdraw any treatment including life-sustaining treatment (LST) if the intent is to remove a treatment perceived by the patient as burdensome and not to terminate intentionally the patient's life. Under these circumstances, death that follows withdrawal of the LST is due to the underlying disease and not a form of physician-assisted suicide or euthanasia. In this article, frequently encountered ethical and legal concerns regarding requests to withdraw MCS are reviewed: the ethical and legal permissibility of withholding or withdrawing LSTs from patients who no longer want such treatments; what to do if the clinician concludes ongoing LST will not result in achieving clinical goals (i.e., medically ineffective); responding to requests to withdraw LST; the features of patients who undergo withdrawal of MCS; the rationale for advance care planning in patients being considered for, or receiving, MCS; and other related topics. Notably, this article reflects a U.S. perspective

    Strontium isotope stratigraphy and age estimates for the Leisey Shell Pit faunas, Hillsborough County, Florida

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    The vertebrate fauna of the Leisey Shell Pit near Tampa Bay, Florida, represents one of the more significant lrvingtonian mammalian faunas of North America. The fossil vertebrates occur in thin bone beds bounded above and below by massive shell beds containing a rich invertebrate ( chiefly molluscan) fauna. Debate has arisen concerning the precise age of the faunas at Leisey. Although generally agreed to be Pleistocene, estimates based upon vertebrate biostratigraphy suggest a somewhat older age than do estimates based upon molluscan biostratigraphy. To help resolve this controvefliy, 87Sr/86Sr ratios were determined on molluscan shells throughout the section. These ratios were then correlated to the global sea water 87Sr/86Sr curve for age detennination. The Sr isotopes support an early Pleistocene age for the vertebrate fauna and suggest a complex history for the shell accumulations

    Troponin Elevations After Electroconvulsive Therapy: The Need for Caution

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    BACKGROUND: Electroconvulsive therapy is used to treat patients with severe or resistant depression. Troponin elevations are associated with an adverse prognosis, and it is well known that central nervous system insults can cause biochemical evidence of cardiac injury. No study previously has studied this with electroconvulsive therapy. METHODS: Patients scheduled for electroconvulsive therapy were enrolled. Clinical information, an electrocardiogram, and a baseline sample for cardiac troponin I and T (cTnI and cTnT) were obtained. Electroconvulsive therapy was done with standard techniques. Subsequently, electrocardiograms and additional samples were obtained. cTnT was measured with the Roche assay and cTnI with the Dade Stratus equipment. Values above the 99th percentile were considered abnormal. RESULTS: Seventy patients completed the study. Four patients had elevated levels of cTn before treatment. In 3 patients, the elevations persisted. Four additional patients developed elevated cTn levels during electroconvulsive therapy. Two of the patients with cTn elevations died. No other events occurred during follow-up. CONCLUSIONS: Elevations of cTn occurred in 11.5% of patients treated with electroconvulsive therapy. Some of the elevations preceded therapy and some occurred during treatment. Given the adverse prognostic importance of cTn elevations in general, in addition to additional studies, an increased degree of medical scrutiny may be appropriate for this group of patients and for those receiving electroconvulsive therapy

    Bimanual motor coordination in agenesis of the corpus callosum

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    The nature and extent of deficiencies in bimanual motor coordination in individuals with agenesis of the corpus callosum (ACC) was studied using the computerized Bimanual Coordination Test (cBCT). Compared with previous bimanual tasks, the cBCT is more specifically reliant on interhemispheric interactions of lateralized motor control, allows more precise measurement, and permits examination of performance over a wider range of bimanual challenges. The cBCT performance of 13 high-functioning individuals with complete ACC was compared to 21 age- and IQ-matched controls. The groups did not differ in unimanual response speed. On trials involving angled paths that require bimanual coordination, the ACC group performed significantly slower and less accurately across all angles. The largest group differences in speed occurred on trials where the hands must respond symmetrically, while mirror-image (vs. parallel) responding produced the greatest deficits in accuracy. These data confirm previous findings of deficits in bimanual coordination in callosal absence, but using significantly improved measurement technology. Deficits in bimanual coordination in ACC are present across different demands for interhand interactions in the speed and direction of movement

    Preliminary Low Temperature Electron Irradiation of Triple Junction Solar Cells

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    For many years extending solar power missions far from the sun has been a challenge not only due to the rapid falloff in solar intensity (intensity varies as inverse square of solar distance) but also because some of the solar cells in an array may exhibit a LILT (low intensity low temperature) degradation that reduces array performance. Recent LILT tests performed on commercial triple junction solar cells have shown that high performance can be obtained at solar distances as great as approx. 5 AU1. As a result, their use for missions going far from the sun has become very attractive. One additional question that remains is whether the radiation damage experienced by solar cells under low temperature conditions will be more severe than when measured during room temperature radiation tests where thermal annealing may take place. This is especially pertinent to missions such as the New Frontiers mission Juno, which will experience cell irradiation from the trapped electron environment at Jupiter. Recent testing2 has shown that low temperature proton irradiation (10 MeV) produces cell degradation results similar to room temperature irradiations and that thermal annealing does not play a factor. Although it is suggestive to propose the same would be observed for low temperature electron irradiations, this has not been verified. JPL has routinely performed radiation testing on commercial solar cells and has also performed LILT testing to characterize cell performance under far sun operating conditions. This research activity was intended to combine the features of both capabilities to investigate the possibility of any room temperature annealing that might influence the measured radiation damage. Although it was not possible to maintain the test cells at a constant low temperature between irradiation and electrical measurements, it was possible to obtain measurements with the cell temperature kept well below room temperature. A fluence of 1E15 1MeV electrons was selected as representative of a moderately high dose that might be expected for a solar powered mission. Fluences much greater than this would require large increases in array area and mass, compromising the ability of PV to compete with non-solar alternatives

    Using Machine Learning to Generate a Core Set of Echocardiographic Indices for Pediatric Research: A Sub-study in the PCS2 Cohort

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    With a multitude of echocardiographic (echo) parameters at a clinician’s disposal and clinical efficiency paramount, determining the most reliable and relevant pediatric echo parameters remains challenging. Using machine learning (ML), clinical relevance, and inter/intra-rater reliability, we aimed to identify a core set of echo parameters from the PCS2 cohort of childhood cancer survivors and healthy controls to guide pediatric research and clinical care. A standard set of 94 echocardiographic parameters were chosen and screened for missing variation, linear combinations, and high correlations. A hierarchical cluster analysis using Ward’s method was performed on the remaining variables to produce a clustering dendrogram. Thereafter, inter- and intra-rater reliability analyses were conducted using intraclass correlation coefficients (ICC) and Bland-Altman (B-A) plots. Using highly reliable (\u3e0.65 ICC) and available (\u3e80% scored) parameters, five pediatric cardiologists ranked each parameter within cluster for clinical relevance. Of the 61 echo parameters selected for the dendrogram, only 54 were scored due to feasibility of sonographer acquisition. ≥73% of all scored parameters had good (0.60-0.74) or excellent (≥0.75) ICC in the inter- and intra-rater analyses. Mean within cluster ranks were assigned per parameter to identify a core set of 10, and minimal set of 5 parameters: ejection fraction (EF), mitral valve E/E’, tissue doppler interventricular septum valve S-velocity, average global longitudinal strain, and LV end diastolic diameter. Using clustering analysis, clinical relevance rankings, and reliability we have identified 10 core and 5 minimal echo indices to guide further pediatric echocardiographic research and clinical care

    Potential Polygamous Breeding Behavior in Northern Bobwhite

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    Breeding behavior ofradio-tagged northern bobwhite (Colinus uirginianus) was observed at Fort Bragg Military Reservation (n = 19), North Carolina, in 1985-88, and Tall Timbers Research Station (n = 27), Florida, during 1984-86. We observed apparent polygamous breeding behavior in 95% (18 of 19) of the radio-tagged northern bobwhite at Fort Bragg, and 93% (25 of 27) of the birds at Tall Timbers. We documented 5 cases of double-clutching by radio-tagged females. Twenty-seven percent of Fort Bragg clutches (n = 30), and 20% of Tall Timbers clutches (n = 56) were incubated by radio-tagged males. Northern bobwhite exhibited characteristics of both rapid multiclutch and am bisexual polygamous mating systems. Northern bobwhite are capable of uniparental care, have long breeding seasons, live in an environment with fluctuating resources, suffer high predation pressure during the nesting season, and raise precocial young; all traits that are similar to other bird species which have evolved polygamous mating systems
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