Preexisting fractures and the formation of an iconic American landscape: Tuolumne Meadows, Yosemite National Park, USA

Tuolumne Meadows, in Yosemite National Park (USA), is a large sub-alpine meadow in the Sierra Nevada Mountains. Immediately adjacent to Tuolumne Meadows—and underlain by the same bedrock lithology (Cathedral Peak Granodiorite)—are vertical rock faces that provide exceptional opportunities to climbers. While the presence of a broad meadow suggests bedrock erodibility, the vertical rock walls indicate bedrock durability. We propose that the Tuolumne Meadows’s landscape is the result of variable glacial erosion due to the presence or absence of pre-existing bedrock fractures. The meadows and valleys formed because of concentrated tabular fracture clusters—a distinctive and locally pervasive type of fracturing—that were particularly susceptible to glacial erosion. In contrast, the vertical rock walls consist of sparsely fractured bedrock that was originally bounded by zones of pervasive tabular fracture clusters. Glacial erosion preferentially removed the highly fractured rock, forming prominent ridges in the upland surrounding Tuolumne Meadows. The orientation and spacing of the tabular fracture clusters, relative to ice flow, has exerted a fundamental control on the geomorphology of the area. The erosional variability exhibited by a single lithology indicates that the degree of fracturing can be more important than the host lithology in controlling landscape evolution

Real Time Mission Planning

The different advantageous embodiments provide a system comprising a number of computers, a graphical user interface, first program code stored on the computer, and second program code stored on the computer. The graphical user interface is executed by a computer in the number of computers. The computer is configured to run the first program code to define a mission using a number of mission elements. The computer is configured to run the second program code to generate instructions for a number of assets to execute the mission and monitor the number of assets during execution of the mission

Real Time Mission Planning

The different advantageous embodiments provide a system comprising a number of computers, a graphical user interface, first program code stored on the computer, and second program code stored on the computer. The graphical user interface is executed by a computer in the number of computers. The computer is configured to run the first program code to define a mission using a number of mission elements. The computer is configured to run the second program code to generate instructions for a number of assets to execute the mission and monitor the number of assets during execution of the mission

Incest in the 1990s: reading Anais Nin's 'Father Story'

In the summer of 1933, diarist, author and critic Anaïs Nin joined her father for a short vacation in France. Nin wrote about the trip in her diary afterwards, referring to it as the ‘Father Story.’ In the story, she details how, aged 30, she embarked upon an affair with her father which would last for several months. Rather than displaying the signs of trauma that we have come to expect from the incest narrative such as dissociation, blame and recrimination, the ‘Father Story’ is more ambiguous in its tone. Part-tribute to the father, part-seduction narrative, part-confession, this is a story that resists categorisation – a resistance that has ethical, critical and formal ramifications for our reading of incest narratives. Upon its publication in the early 1990s, critics responded to the ‘Father Story’ as fantastical, excessive and vulgar. These responses form part of a wider American father story during this period; a story about memory, therapy culture, family values and the concealed rules of testimony. This article reads Anaïs Nin’s narrative as a text which raises fundamental questions about why certain father (and daughter) stories are culturally acceptable and others are not

Watershed Management on Range and Forest Lands Proceedings of the Fifth Workshop of the United States/Australia Rangelands Panel

Preface: The U.S.-Australia Cooperative Rangeland Science Program In October 1968 the governments of the United States and Australia entered into an agreement for the purpose of facilitating close cooperative activities between the scientific communities of the two countries. The joint communique issued at that time designated the U.S. National Science Foundation and the Australian Commonwealth Department of Education and Science as the coordinating agencies. Both countries were to encourage binational teamwork in research, interchanges of scientists, joint seminars, and exchanges of information. A United States-Australia Rangeland Panel was established in December 1969 to further cooperation between the two countries in the rangeland sciences. The present panel includes the following

2003 Manifesto on the California Electricity Crisis

The authors, an ad-hocgroup of professionals with experience in regulatory and energy economics, share a common concern with the continuing turmoil facing the electricity industry ("the industry") in California. Most ofthe authorsendorsed the first California Electricity Manifesto issued on January 25, 2001. Almost two years have passed since that first Manifesto. While wholesale electric prices have moderated and California no longer faces the risk of blackouts, in many ways the industry is in worse shape now than it was at the start of 2001. As a result, the group of signatories continues to have a deep concern with the conflicting policy directions being pursued for the industry at both the State and Federal levels of government and the impact the uncertainties associated with these conflicting policies will have, long term, on the economy of California. Theauthorshave once again convened under the auspices of the Institute of Management, Innovation and Organization at the University of California, Berkeley, to put forward ourtheir ideas on a basic set of necessary policies to move the industry forward for the benefit of all Californians and the nation. The authors point out that theydo not pretend to be "representative." They do bring, however, a very diverse range of backgrounds and expertise.Technology and Industry, Regulatory Reform

Bivariate random-effects meta-analysis and the estimation of between-study correlation

BACKGROUND: When multiple endpoints are of interest in evidence synthesis, a multivariate meta-analysis can jointly synthesise those endpoints and utilise their correlation. A multivariate random-effects meta-analysis must incorporate and estimate the between-study correlation (ρ(B)). METHODS: In this paper we assess maximum likelihood estimation of a general normal model and a generalised model for bivariate random-effects meta-analysis (BRMA). We consider two applied examples, one involving a diagnostic marker and the other a surrogate outcome. These motivate a simulation study where estimation properties from BRMA are compared with those from two separate univariate random-effects meta-analyses (URMAs), the traditional approach. RESULTS: The normal BRMA model estimates ρ(B )as -1 in both applied examples. Analytically we show this is due to the maximum likelihood estimator sensibly truncating the between-study covariance matrix on the boundary of its parameter space. Our simulations reveal this commonly occurs when the number of studies is small or the within-study variation is relatively large; it also causes upwardly biased between-study variance estimates, which are inflated to compensate for the restriction on [Formula: see text] (B). Importantly, this does not induce any systematic bias in the pooled estimates and produces conservative standard errors and mean-square errors. Furthermore, the normal BRMA is preferable to two normal URMAs; the mean-square error and standard error of pooled estimates is generally smaller in the BRMA, especially given data missing at random. For meta-analysis of proportions we then show that a generalised BRMA model is better still. This correctly uses a binomial rather than normal distribution, and produces better estimates than the normal BRMA and also two generalised URMAs; however the model may sometimes not converge due to difficulties estimating ρ(B). CONCLUSION: A BRMA model offers numerous advantages over separate univariate synthesises; this paper highlights some of these benefits in both a normal and generalised modelling framework, and examines the estimation of between-study correlation to aid practitioners

Using outbreak science to strengthen the use of models during epidemics.

Infectious disease modeling has played a prominent role in recent outbreaks, yet integrating these analyses into public health decision-making has been challenging. We recommend establishing ‘outbreak science’ as an inter-disciplinary field to improve applied epidemic modeling

Access to Sterile Syringes through San Francisco Pharmacies and the Association with HIV Risk Behavior among Injection Drug Users

Increased options for syringe acquisition and disposal have been associated with reductions in high-risk behaviors. This study determined the extent of pharmacy uptake in accessing syringes among injection drug users (IDUs) and estimated associations between pharmacy uptake and safer injection/disposal practices. Two years after the implementation of California’s Disease Prevention Demonstration Project, which removed restrictions to non-prescription syringe sales through pharmacies with local authorization, IDUs were recruited through street outreach in San Francisco and interviewed regarding recent syringe acquisition, use, and disposal. The sample of 105 persons included a high proportion of men (67%), people of color (49%), and homeless persons (71%). The most common syringe source was a syringe exchange program (SEP) (80%), with pharmacies being accessed by 39% of respondents. The most commonly cited source of disposal was a SEP (65%), with very few reports of pharmacy disposal (2%). Adjusted analysis showed that unsuccessful attempts to purchase syringes at a pharmacy increased the odds of both injecting with a used syringe and giving away a used syringe. Using a SEP decreased the odds of unsafe injection and disposal practices. Thus, 2 years after the initiation of the California Disease Prevention Demonstration Project, results from this small study suggest that SEPs still provide the majority of syringe distribution and disposal services to San Francisco IDUs; however, pharmacies now augment syringe access. In addition, unsafe injection behavior is reported more often among those who do not use these syringe sources. These results are consistent with prior studies in suggesting that increasing the availability of syringes through SEPs and pharmacies, and developing bridges between them, may further reduce syringe-related risk

A rapid and sensitive assay for quantification of siRNA efficiency and specificity

RNA Interference has rapidly emerged as an efficient procedure for knocking down gene expression in model systems. However, cross-reactivity, whereby multiple genes may be simultaneously targeted by a single short interfering RNA (siRNA), can potentially jeopardize correct interpretation of gene function. As such, it is essential to test the specificity of a siRNA prior to a full phenotypic analysis. To this end, we have adapted a reporter-based assay harnessing the sensitivity of luciferase activity to provide a quantitative readout of relative RNAi efficacy and specificity. We have tested different siRNAs directed against Thymosin β4 (Tβ4); determined their effectiveness at silencing Tβ4 and have both excluded off-target silencing of the Tβ4 homologue Thymosin β10 (Tβ10) and demonstrated partial knockdown of Tβ10 despite significant (12/23; 52%) sequence mismatch. This assay system is applicable to any RNAi study where there is a risk of targeting homologous genes and to the monitoring of off-target effects at the genome level following microarray expression profiling