The Impediment of Impotency and the Condition of Male Impotence: A Canonical-Medical Study: Medical Considerations

To present the problems involved in the matter of male impotence as related to the validity of marriage, the canonical considerations, as prepared by Rev. Paul v. Harrington, J.C.L., were published in the August and November 1958 issues of The Linacre Quarterly. The Medical study as set forth by Dr. Charles J. E. Kickham appears in this issue. Dr. Kickham is a graduate of Holy Cross College and Harvard medical School. He is Associate Professor of Urology at Tufts medical School and is Surgeon-in-Chief, Department of Urology, St. Elizabeth\u27s Hospital, Brighton; Carney Hospital, Boston, and Pondville Cancer Hospital at Norfolk, Mass. He is a diplomate of the American Board of Urology

The Impediment of Impotency and the Condition of Male Impotence: A Canonical-Medical Study: Part II, Medical Considerations

To present the problems involved in the matter of male impotence as related to the validity of marriage, the canonical considerations, as prepared by Rev. Paul v. Harrington, J.C.L., were published in the August and November 1958 issues of The Linacre Quarterly. The Medical study as set forth by Dr. Charles J. E. Kickham appears in this issue. Dr. Kickham is a graduate of Holy Cross College and Harvard medical School. He is Associate Professor of Urology at Tufts medical School and is Surgeon-in-Chief, Department of Urology, St. Elizabeth\u27s Hospital, Brighton; Carney Hospital, Boston, and Pondville Cancer Hospital at Norfolk, Mass. He is a diplomate of the American Board of Urology

A predicted three-dimensional structure for the carcinoembryonic antigen (CEA)

AbstractA three-dimensional model for the carcinoembryonic antigen (CEA) has been constructed by knowledge-based computer modelling. Each of the seven extracellular domains of CEA are expected to have immunoglobulin folds. The N-terminal domain of CEA was modelled using the first domain of the recently solved NMR structure or rat CD2, as well as the first domain of the X-ray crystal structure of human CD4 and an immunoglobulin variable domain REI as templates. The remaining domains were modelled from the first and second domains or CD4 and REI. Link conformations between the domains were taken from the elbow region of antibodies. A possible packing model between each of the seven domains is proposed. Each residue of the model is labelled as to its suitability for site-directed mutagenesis

Mental and physical health problems before and after detention:A matched cohort study

BACKGROUND: Individuals with poor health are largely overrepresented in prison populations. However, it remains unclear whether their poor health status already exists prior to their detention or reflects an effect of detention. We examined the health of detainees in the year before and after their detention and compared this with the health of matched non-detainees. METHODS: In this matched cohort study, we linked national data on all persons detained in the Netherlands in 2014/2015 to electronic health records (EHR's) of a representative sample of general practitioners in the Netherlands. Participants include 952 detained persons and 4760 matched non-detained persons (matched on age, sex and general practice). Prevalence rates of health problems in the year before and after detention and odds ratios with 95% confidence intervals were calculated. Rates for a variety of physical and mental health problems are presented. FINDINGS: Detainees and matched controls differed statistically significant in their pre-detention health status. Compared with controls, male detainees were more likely to report psychological (odds ratio [OR] 3·64 [95% CI 3·11–4·26]), social (1·96 [1·46–2·64]), neurological (1·34 [1·02–1·76]), digestive (1·23 [1·02–1·49]), genital system-related (1·36 [1·07–1·72]), and unspecified health problems (1·32 [1·10–1·59]) in the year before their detention. For example, 43·7% of detainees and 17·6% of controls reported psychological problems in this pre-detention year. To some extent these pre-detention health differences were related to socioeconomic differences. Nevertheless, after taking these characteristics into account, a number of pre-detention health differences between detainees and controls remained statistically significant. No statistically significant changes in prevalence rates from pre- to post-detention and no differences in the levels of change across detainees and controls were observed. For female detainees a similar pattern was found. INTERPRETATION: People who experience detention have high and complex health needs both pre- and post-detention. While this study did not show a health deteriorating effect of detention, it also did not show a health improving effect. This latter finding may indicate a missed opportunity for health care services to address detainees’ health, especially since persons entering detention have elevated health problems. Knowledge on detainees’ specific health problems may help health care providers in prisons and in the community to adequately address the health care needs of this vulnerable group. FUNDING: None

Denial of coevalness: charges of dogmatism in the nineteenth-century humanities

Political Culture and National Identit

Two-dimensional shape of sand made by crushing Illinois limestones of different textures

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Nonlocal Effects and Shrinkage of the Vortex Core Radius in YNi2B2C Probed by muSR

The magnetic field distribution in the vortex state of YNi2B2C has been probed by muon spin rotation (muSR). The analysis based on the London model with nonlocal corrections shows that the vortex lattice has changed from hexagonal to square with increasing magnetic field H. At low fields the vortex core radius, rho_v(H), decreases with increasing H much steeper than what is expected from the sqrt(H) behavior of the Sommerfeld constant gamma(H), strongly suggesting that the anomaly in gamma(H) primarily arises from the quasiparticle excitations outside the vortex cores.Comment: 4 pages, 4 figures, submitted to Phys. Rev.

Treatment Patterns and Health Resource Utilization Among Patients Diagnosed With Early Stage Resected Non–Small Cell Lung Cancer at US Community Oncology Practices

AbstractBackgroundPlatin-based adjuvant chemotherapy has extended survival in clinical trials in patients with completely resected non–small cell lung cancer (NSCLC). There are few data on the use of adjuvant therapy in community-based clinical practice in the United States.Materials and MethodsThis was a retrospective observational study using electronic medical record and billing data collected during routine care at US community oncology sites in the Vector Oncology Data Warehouse between January 2007 and January 2014. Patients aged ≥ 18 years with a primary diagnosis of stage IB to IIIA NSCLC were eligible if they had undergone surgical resection. Treatment patterns, health care resource use, and cost were recorded, stratified by stage at diagnosis.ResultsThe study included 609 patients (mean age, 64.8 years, 52.9% male), of whom 215 had stage IB disease, 130 stage IIA/II, 110 stage IIB, and 154 stage IIIA. Adjuvant systemic therapy after resection was provided to 345 (56.7%) of 609 patients, with lower use in patients with stage IB disease (39.1%) than stage II to IIIA disease (64.9-68.2%) (P < .0001). The most common adjuvant regimen at all stages was the combination of carboplatin and paclitaxel. There were no statistically significant differences in office visits or incidence of hospitalization by disease stage. During adjuvant treatment, the total monthly median cost per patient was $17,389.75 (interquartile range,$8,815.61 to $23,360.85).ConclusionAdjuvant systemic therapy was used in some patients with stage IB NSCLC and in the majority of patients with stage IIA to IIIA disease. There were few differences in regimen or health care resource use by disease stage

Employees' perceptions of cycle commuting:A qualitative study

Purpose – This study aims to provide an in-depth individual level understanding of the psychological factors that affect cycle commuting. Design/methodology/approach – A total of 15 participants (eight cycle commuters and seven potential cycle commuters) from a “cycle-friendly” employer based in a Scottish city took part in the study. Semi-structured interviews and interpretative phenomenological analysis (IPA) were used to collect and analyse data. Findings – The present study found that cyclists are more aware of the benefits of cycle commuting than potential cyclists. Those who did not currently cycle to work displayed a heightened awareness of the challenges of cycling to work, whereas cyclists reported more coping strategies for negotiating or overcoming the challenges involved in cycle commuting. These individual cognitions are potentially modifiable through psychological interventions. Research limitations/implications – Future research should be carried out on samples in different contexts to examine whether some of the findings would be supported in other populations. Practical applications – The findings from this paper suggest that psychological interventions based on challenging perceptions of the benefits of and barriers to cycling may have a valuable role to play in enhancing cycle commuting rates. Originality/value – This study uses IPA to explore the complexities of perceptions in relation to cycle commuting. It also brings to light the types of coping strategies used to enable cyclists to overcome some of their challenges associated with cycle commuting.</p