New Directions for Transcendental Claims

This article aims to provide an account of the relationship between transcendental claims and the project of using transcendental argumentation that differs from the mainstream literature. In much of the literature, such claims are said to have as their primary value the overcoming of various sceptical positions. The author argues that, whilst transcendental arguments may be narrowly characterised as anti-sceptical, transcendental claims do not have to be used in only this way, and in fact can be useful in several areas of philosophy outside the issue of scepticism, and so can be used by transcendental arguments more broadly conceived. The author offers four examples of transcendental claims that are not used in narrow, anti-sceptical transcendental arguments. The author argues that these broader arguments use transcendental claims but not in an anti-sceptical way. From this, the author concludes that given the well-known difficulties transcendental arguments in this narrow sense seem to have had in defeating scepticism, distinguishing narrow transcendental arguments clearly from transcendental claims as such in this manner can provide a way for the latter to still serve an important role in philosophy, by showing how such claims can be used more broadly, regardless of any doubts one may have about the anti-sceptical value of such claims

A Foucauldian Critique of Scientific Naturalism: ‘Docile Minds’

My aim in this paper is to articulate and challenge a Foucauldian critique of scientific naturalism, and, in particular, a Foucauldian critique of the nomothetic framework underlying the Placement Problem. What I hope to achieve is to bring Foucauldian post-structuralist theory into the conversation concerning scientific naturalism and the Placement Problem. My Foucauldian post-structuralist critique of scientific naturalism questions the relations between our society’s imbrication of economic-political power structures and knowledge in such a way that also effects some constructive critical alignment between Foucault and Habermas, helping to undermine the traditional view of their respective social critiques as incompatible. First, I will outline a brief genealogical backstory for the rise of scientific naturalism, and I will then reconstruct the Placement Problem. In the second part of the paper, I introduce Foucault’s notion of pouvoir-savoir (‘power-knowledge’), namely his account of the interconnection between power and knowledge. I then go on to articulate the Foucauldian critique of scientific naturalism by arguing that the levelling nature of nomothetic rationality and its conservative naturalistic vocabulary involves regulative discourse: anything that resists placeability/locatability is labelled ‘odd’. By being thus visibly marked, ‘odd’ phenomena become ‘queer’ phenomena, which then become ‘problematic’ phenomena. They are, thereby, construed in need of discipline (and even punishment). Understood in this Foucauldian way, the most pressing problem with the disciplinary framework of scientific naturalism is that the erasure of the sui generis features of the normative space of reasons amounts to a debilitating variety of alienation in which humanity is estranged from its pluralist matrix of sense-making practices. Thus, scientific naturalist disciplinarity produces subjected and practised minds, ‘docile’ minds

Does contemporary recognition theory rest on a mistake?

My aim in this paper is to argue, contra Axel Honneth, that ‘the summons’ (Aufforderung), the central pillar of Fichte’s transcendentalist account of recognition, is best made sense of not as an ‘invitation’, but rather as a second-personal demand, whose illocutionary content draws attention to the demandingness of responsibilities towards vulnerable agents. Because of this, the summons has good explanatory force in terms of disclosing the phenomenological dynamics of psychosocially and politically significant reactive attitudes. Under my reading, then, Fichte’s position, contra Honneth’s ‘negative’ treatment of it, is anything but an empty formalism that “fails to refer to subjects of flesh and blood”

Towards the 'Overthrow of Platonism' : Processist Critical Social Ontology and Ameliorative Discourse

In this article, I argue that, for the purpose of developing an effective critical social ontology about gender groups, it is not simply sufficient to carve gender groups at their joints: one must have in view whether the metaphysical categories we use to make sense of gender groups are prone to ideological distortion and vitiation. The norms underpinning a gender group's constitution as a type of social class and the norms involved in gender identity attributions, I propose, provide compelling reason to think critical social ontological discourse is more processist-orientated, rather than substantival-orientated. The advantages of a processist critical social ontology of gender groups are that, unlike substance-discourse, process-discourse recognizes how gender group talk and gender identity talk are often messy and therefore require a conceptual scheme that can transform vocabulary for the emancipatory purpose of ending oppression, domination, and marginalization

Ethical Life, Growth, and Relational Institutions: Intersubjectivity, Freedom, and Critique

The aim of this paper is to argue that there are two important positive connections between Hegel and Dewey, and that these important positive connections form the basis of a critical theory in a broad sense: (i) social processes and modern institutions are structured for the purposes of fostering the development of subjectivities that help individuals achieve self-realization; and (ii) social processes and modern institutions are assessed in terms of how well (if at all) they enable the development of unique subjectivities that help individuals achieve self-realization. Following Axel Honneth, I argue that there is compelling reason to suppose Hegel’s notion of Sittlichkeit and Dewey’s notion of democracy have significant critical dimensions

‘Here be revisionary metaphysics!’ A critique of a concern about process philosophy

In this paper, I argue that John Dupré and Daniel Nicholson's ‘process manifesto’ is ironically more sympathetic to descriptive metaphysics than to revisionary metaphysics. Focusing on their argument that any process philosophy automatically slides into Whiteheadian obscurantism if it does not just rest content with revealing the problematic features of ordinary language, I argue that their position occludes a logical space, one in which revisionary metaphysics is articulated without any Whiteheadian obscurantism and involves no dereliction of critical/revisionary orientation. I argue that key features of the respective critical social ontologies of Judith Butler and Talia Mae Bettcher occupy such a logical space

The Vulnerable Dynamics of Discourse

In this paper, we offer some compelling reasons to think that issues relating to vulnerability play a significant – albeit thus far underacknowledged – role in Jürgen Habermas’s notions of communicative action and discourse. We shall argue that the basic notions of discourse and communicative action presuppose a robust conception of vulnerability and that recognising vulnerability is essential for (i) making sense of the social character of knowledge, on the epistemic side of things, and for (ii) making sense of the possibility of deliberative democracy, on the political side of things. Our paper is divided into four principal sections. In Section 1, we provide a basic outline of Habermas on communicative action and discourse. In Section 2, we develop an account of vulnerability and communication in the context of speaker/hearer relations. We specifically focus on distorted communication, vulnerability and speech. In Section 3, we focus on elaborating epistemic pathologies in the context of epistemic oppression and testimonial injustice. In Section 4, we focus on explaining how Habermasian resources contribute to vulnerability theory, and how introducing vulnerability theory to Habermas broadens or deepens his theory of communication action and his discourse ethics theory

Genomic characterization of murine monocytes reveals C/EBPβ transcription factor dependence of Ly6C(-) cells

Monocytes are circulating, short-lived mononuclear phagocytes, which in mice and man comprise two main subpopulations. Murine Ly6C(+) monocytes display developmental plasticity and are recruited to complement tissue-resident macrophages and dendritic cells on demand. Murine vascular Ly6C(-) monocytes patrol the endothelium, act as scavengers, and support vessel wall repair. Here we characterized population and single cell transcriptomes, as well as enhancer and promoter landscapes of the murine monocyte compartment. Single cell RNA-seq and transplantation experiments confirmed homeostatic default differentiation of Ly6C(+) into Ly6C(-) monocytes. The main two subsets were homogeneous, but linked by a more heterogeneous differentiation intermediate. We show that monocyte differentiation occurred through de novo enhancer establishment and activation of pre-established (poised) enhancers. Generation of Ly6C(-) monocytes involved induction of the transcription factor C/EBP{beta} and C/EBP{beta}-deficient mice lacked Ly6C(-) monocytes. Mechanistically, C/EBP{beta} bound the Nr4a1 promoter and controlled expression of this established monocyte survival factor

Molecular definition of multiple sites of antibody inhibition of malaria transmission-blocking vaccine antigen Pfs25.

The Plasmodium falciparum Pfs25 protein (Pfs25) is a leading malaria transmission-blocking vaccine antigen. Pfs25 vaccination is intended to elicit antibodies that inhibit parasite development when ingested by Anopheles mosquitoes during blood meals. The Pfs25 three-dimensional structure has remained elusive, hampering a molecular understanding of its function and limiting immunogen design. We report six crystal structures of Pfs25 in complex with antibodies elicited by immunization via Pfs25 virus-like particles in human immunoglobulin loci transgenic mice. Our structural findings reveal the fine specificities associated with two distinct immunogenic sites on Pfs25. Importantly, one of these sites broadly overlaps with the epitope of the well-known 4B7 mouse antibody, which can be targeted simultaneously by antibodies that target a non-overlapping site to additively increase parasite inhibition. Our molecular characterization of inhibitory antibodies informs on the natural disposition of Pfs25 on the surface of ookinetes and provides the structural blueprints to design next-generation immunogens