Biomarkers for personalised prevention of chronic diseases: a common protocol for three rapid scoping reviews

Dataset disponible en: http://hdl.handle.net/20.500.12105/19630Introduction: Personalised prevention aims to delay or avoid disease occurrence, progression, and recurrence of disease through the adoption of targeted interventions that consider the individual biological, including genetic data, environmental and behavioural characteristics, as well as the socio-cultural context. This protocol summarises the main features of a rapid scoping review to show the research landscape on biomarkers or a combination of biomarkers that may help to better identify subgroups of individuals with different risks of developing specific diseases in which specific preventive strategies could have an impact on clinical outcomes. This review is part of the "Personalised Prevention Roadmap for the future HEalThcare" (PROPHET) project, which seeks to highlight the gaps in current personalised preventive approaches, in order to develop a Strategic Research and Innovation Agenda for the European Union. Objective: To systematically map and review the evidence of biomarkers that are available or under development in cancer, cardiovascular and neurodegenerative diseases that are or can be used for personalised prevention in the general population, in clinical or public health settings. Methods: Three rapid scoping reviews are being conducted in parallel (February-June 2023), based on a common framework with some adjustments to suit each specific condition (cancer, cardiovascular or neurodegenerative diseases). Medline and Embase will be searched to identify publications between 2020 and 2023. To shorten the time frames, 10% of the papers will undergo screening by two reviewers and only English-language papers will be considered. The following information will be extracted by two reviewers from all the publications selected for inclusion: source type, citation details, country, inclusion/exclusion criteria (population, concept, context, type of evidence source), study methods, and key findings relevant to the review question/s. The selection criteria and the extraction sheet will be pre-tested. Relevant biomarkers for risk prediction and stratification will be recorded. Results will be presented graphically using an evidence map. Inclusion criteria: Population: general adult populations or adults from specific pre-defined high-risk subgroups; concept: all studies focusing on molecular, cellular, physiological, or imaging biomarkers used for individualised primary or secondary prevention of the diseases of interest; context: clinical or public health settings. Systematic review registration: https://doi.org/10.17605/OSF.IO/7JRWD (OSF registration DOI).The PROPHET project has received funding from the European Union’s Horizon Europe research and innovation program under grant agreement no. 101057721. UK participation in Horizon Europe Project PROPHET is supported by UKRI grant number 10040946 (Foundation for Genomics & Population Health).S

Biomarkers for personalized prevention of chronic diseases

The “PeRsOnalized Prevention roadmap for the future HEalThcare” (PROPHET) project, funded by the European Union’s Horizon Europe research and innovation program and linked to ICPerMed, seeks to develop a Strategy Research and Innovation Agenda (SRIA) for the European Union. Find attached the protocol that corresponds to one of the first steps in the PROPHET, namely a review that aims to map the evidence and highlight the evidence gaps in research or use of biomarkers in personalized prevention in the general population, as well as their integration with digital technologies

Interactive Gap Maps on Available Biomarkers for Risk Prediction and Stratification in Cancer, Cardiovascular, and Neurodegenerative Diseases (PROPHET Project)

Web del proyecto: https://biodama.isciii.es/prophet/ | Material: “Biomarkers for personalized prevention of chronic diseases”: https://osf.io/wg62b/ - "Interactive Evidence Gap Maps": https://osf.io/48g5p/Artículo disponible en: http://hdl.handle.net/20.500.12105/19654[EN] The PROPHET project (“PeRsOnalized Prevention roadmap for the future HEalThcare”), funded by the European Union's Horizon Europe research and innovation program, aims to assess the effectiveness, clinical utility, key success factors, and gaps in personalised preventive approaches for healthcare settings. One of the main task focuses on biomarkers for personalised prevention in the general adult population and their integration with digital technologies. The objective of the task is to highlight gaps in biomarkers research for primary and secondary prevention for cancer, cardiovascular, and neurodegenerative diseases. Three rapid scoping reviews were conducted in parallel by three research teams, one for each group of diseases: cancer, cardiovascular and neurodegenerative diseases. The reviews used a common protocol and framework for searching, data extraction and the representation of results, with disease specific corresponding information and specifications. The following evidence and gap map is a product of these scoping reviews. [ES] El proyecto PROPHET (“PeRsOnalized Prevention roadmap for the future HEalThcare”), financiado por el programa de investigación e innovación Horizonte Europa de la Unión Europea, tiene como objetivo evaluar la eficacia, la utilidad clínica, los factores clave de éxito y las lagunas en los enfoques preventivos personalizados para entornos sanitarios. Una de las principales tareas se centra en los biomarcadores para la prevención personalizada en la población adulta general y su integración con las tecnologías digitales. El objetivo de la tarea es resaltar las lagunas en la investigación de biomarcadores para la prevención primaria y secundaria del cáncer, enfermedades cardiovasculares y neurodegenerativas. Tres equipos de investigación llevaron a cabo en paralelo tres revisiones rápidas de alcance, una para cada grupo de enfermedades: cáncer, enfermedades cardiovasculares y neurodegenerativas. Las revisiones utilizaron un protocolo y un marco común para la búsqueda, la extracción de datos y la representación de los resultados, con la información y especificaciones correspondientes específicas de la enfermedad. La siguiente evidencia y mapa de brechas es producto de estas revisiones de alcance.Co-funded by the European Union. UK participant in Horizon Europe Project PROPHET is supported by UKRI grant number 10040946 (Foundation for Genomics & Population Health)

Interactive gap maps on available biomarkers for risk prediction and stratification in cancer, cardiovascular and neurodegenerative diseases

The "PROPHET" project aims to develop a Strategy Research and Innovation Agenda for personalized prevention in healthcare, focusing on mapping biomarkers for primary and secondary prevention in cancer, cardiovascular, and neurodegenerative diseases. The study conducted rapid three scoping reviews, one for each disease group, respectively, resulting in interactive evidence gap maps that offer valuable insights into current research