Linking design and manufacturing domains via web-based and enterprise integration technologies

The manufacturing industry faces many challenges such as reducing time-to-market and cutting costs. In order to meet these increasing demands, effective methods are need to support the early product development stages by bridging the gap of communicating early design ideas and the evaluation of manufacturing performance. This paper introduces methods of linking design and manufacturing domains using disparate technologies. The combined technologies include knowledge management supporting for product lifecycle management (PLM) systems, enterprise resource planning (ERP) systems, aggregate process planning systems, workflow management and data exchange formats. A case study has been used to demonstrate the use of these technologies, illustrated by adding manufacturing knowledge to generate alternative early process plan which are in turn used by an ERP system to obtain and optimise a rough-cut capacity plan

Estimation of summary protective efficacy using a frailty mixture model for recurrent event time data.

Recurrent event time data are common in experimental and observational studies. The analytic strategy needs to consider three issues: within-subject event dependence, between-subject heterogeneity in event rates, and the possibility of a nonsusceptible fraction. Motivated by the need to estimate the summary protective efficacy from recurrent event time data as seen in many infectious disease clinical trials, we propose a two-part frailty mixture model that simultaneously accommodates all the three issues. In terms of vaccine action models, the proposed model is a combination of the 'all-or-none' and the 'leaky' models, and the summary protective efficacy is a unified measure of the vaccine's twofold effects in completely or partially protecting the vaccinated individuals against the study event. The model parameters of interest are estimated using the expectation-maximization algorithm with their respective variances estimated using Louis's formula for the expectation-maximization algorithm. The summary protective efficacy is estimated by a composite estimand with its variance estimated using the delta method. The performance of the proposed estimation approach is investigated by a simulation study. Data from a trial of malaria prophylaxis conducted in Ghana are reanalyzed

Looking for Stars and Finding the Moon: Effects of Lunar Gamma-ray Emission on Fermi LAT Light Curves

We are conducting a search for new gamma-ray binaries by making high signal-to-noise light curves of all cataloged Fermi LAT sources and searching for periodic variability using appropriately weighted power spectra. The light curves are created using a variant of aperture photometry where photons are weighted by the probability that they came from the source of interest. From this analysis we find that the light curves of a number of sources near the ecliptic plane are contaminated by gamma-ray emission from the Moon. This shows itself as modulation on the Moon's sidereal period in the power spectra. We demonstrate that this contamination can be removed by excluding times when the Moon was too close to a source. We advocate that this data screening should generally be used when analyzing LAT data from a source located close to the path of the Moon.Comment: 2012 Fermi Symposium proceedings - eConf C12102

The mixing of powders in the horizontal rotating drum mixers

The literature published on powder mixing is reviewed and the conclusion drawn that the operation is misunderstood and the situation confused because insufficient attention has been paid to the properties of particles being mixed. As an aid to simplification, powders are classified as free-flowing powders where the particle motion is individual, and non-free-flowing powders where the mixing is more concerned with the shuffling and subsequent breaking down of large agglomerates. This thesis considers the mixing of free-flowing powders only. [Continues.