Sentinel-1 azimuth subbanding for multiple aperture interferometry - Test case over the Roi Baudoin ice shelf, east Antartica

peer reviewedAs an extension of Synthetic Aperture Radar Interferom- etry, Multiple Aperture Interferometry (MAI) is a spectral diversity technique that allows the determination of azimuth displace- ments from phase shift measurements. This is made possi- ble through the creation of backward- and forward-looking Single-Look-Complex (SLC) data. Then, the phase differ- ence between the backward and forward-looking interfero- gram is translated into a displacement. Using SLC data, MAI requires a proper azimuth splitband operator. Different tech- niques exist to split the azimuth band, but they are often too briefly described in the MAI literature. In this conference pa- per, we analyze the signal properties of the Sentinel-1 TOPS acquisition mode and define an azimuth subbanding proto- col. In particular, we look at the role of de-apodization and apodization in the band filtering operation. We focus our anal- ysis on Sentinel-1 data in Interferometric Wideswath mode over the Roi Baudouin Ice Shelf, East Antarctica.MIMO (Monitoring melt where Ice Meets Ocean); SMAIAD (Sentinel-1 Multiple Aperture Interferometry for Azimuth Displacement Retrieval

Methylation-associated PHOX2B gene silencing is a rare event in human neuroblastoma.

International audienceNeuroblastoma (NB), an embryonic tumour originating from neural crest cells, is one of the most common solid tumours in childhood. Although NB is characterised by numerous recurrent, large-scale chromosome rearrangements, the genes targeted by these imbalances have remained elusive. We recently identified the paired-like homeobox 2B (PHOX2B, MIM 603851) gene as disease-causing in dysautonomic disorders including Congenital Central Hypoventilation Syndrome (CCHS), Hirschsprung disease (HSCR) and NB in various combinations. Most patients with NB due to a germline heterozygous PHOX2B gene mutation are familial and/or syndromic. PHOX2B, at chromosome 4p12, does not lie in a commonly rearranged locus in NB. To evaluate the role of PHOX2B in sporadic, isolated NB, we analysed 13 NB cell lines and 45 tumours for expression, mutations of coding and promoter sequences, loss of heterozygosity (LOH), or aberrant hypermethylation of PHOX2B (13 cell lines and 18 tumours). We didn't identify any mutation but LOH in about 10% of the cases and aberrant CpG dinucleotide methylation of the 500 bp PHOX2B promoter region in 4/31 tumours and cell lines (12.9%). Altogether, both germinal and somatic anomalies at the PHOX2B locus are found in NB

За кадры. 1979. № 46 (2196)

Самый торжественный день / Ю. СтруковаСпасибо, институт! / А. ЧалаяГруппа 5440: семь красных дипломов / Е. ШмидтС точки зрения директора / В. С. ГетманцевПо комплексной теме / Ю. ИгореваВоенные университеты / Л. ИвановаДоброй дороги, выпускники! / А. Д. Чесалин [и др.]Через всю жизнь / Т. Кондрацкая20 лет спустяСессию сдают активисты / Т. ЕвгеньеваНужно сделать правильные выводы / Л. ШикановПервый декан физико-техников / В. И. Горбунов, В. И. КарначукМоя подруга Ингрид / [беседа с] Н. КарнатоваБезмерна жизнь у каждого поэта… / Л. ЩербининаПоленица / В. ГолиненкоШуршутки / И. ПавельеваВ нашей памяти навсегда / О. АртюшинаЗвени, пионерское лето! / С. Козьмин