МИТОХОНДРИАЛЬНЫЙ БЕЛКОВЫЙ ПРОФИЛЬ И ЕГО РОЛЬ В ПАТОЛОГИЧЕСКИХ ПРОЦЕССАХ

Mitochondria import hundreds of different precursor proteins from the cytosol, and only 13 proteins are encoded by mtDNA itself. Recent investigations demonstrated real size of mitochondrial proteome and complexity of their functions There are many methods using for mitochondrial proteome profiling, that help to understand a molecular mechanisms of mitochondrial functions and identify the causes of disruptions that lead to different disorders. In this review we discuss a recent data in the field of mitochondrial proteomics.Собственная ДНК митохондрий кодирует лишь 13 полипептидов – субъединиц электронтранспортной цепи. Большинство же белков импортируются в митохондрии посредством различных механизмов. Последние исследования митохондриального протеома продемонстрировали истинные размеры и сложную функциональную организацию митохондриальных белковых профилей. Для протеомного профилирования митохондрий применяются различные технологии, которые в сумме представляют результаты, помогающие понять молекулярные механизмы функционирования органелл и выявить нарушения, приводящие к различным заболеваниям. В данном обзоре рассмотрены и проанализированны последние данные в области протеомики митохондрий и затронуты некоторые аспекты молекулярного патогенеза заболеваний дыхательной цепи

Automation system of intellectual activity on creating programs in the language of logical programming

The article presents a developed software package that implements the training system that automates intellectual activity in creating programs in the language of logical programming. The choice of semantic networks as a way of the representation of knowledge in the process of modeling subject domains in the learning system during the formulation of educational logical problems is substantiated. The typology of the learning tasks used to master the logical programming language Prolog is grounded, including the following types of tasks: logical, arithmetic, value analysis tasks with subsequent selection or ordering and creation of knowledge bases on the subject domain. In this case, for each type of problem, the possibility of applying analysis of formal concepts to solve them has been investigated and a set of examples has been compiled. The technique of analysis of formal concepts and their grouping depending on the parameters of objects of the domain is developed, the essence of which is to identify an invariant set of descriptors suitable for representing different subject areas, which allows the generation of rules. The technique for generating domain representation rules based on the declaration of predicates with one or more parameters, which are correlated with the peculiarities of formulations of typical learning tasks, is developed. © 2019, Springer International Publishing AG, part of Springer Nature

Formation of the Individual Learning Path in the Information and Educational School Environment

The article shows that if an individual path in the process of teaching high school students an academic subject, firstly, will be formed from the teaching modules focused on an individual content on a subject matter in accordance with the student-significant learning objectives, Second, teaching modules will be presented as a set of recommended electronic educational resources (EER), the mastering of which is carried out after hours on the basis of Smart-technologies, and thirdly, the basis for the development of content for the EER will be based on academic discipline: the principle of correspondence between the content of student-significant learning objectives, correction of dynamic random content and teaching methods principle, the principle of adaptability and customization, it provides in-depth knowledge achievements of students on the subject, high level of motivation to succeed, high level of readiness to use information and educational environment for self-learning

Formation of the Individual Learning Path in the Information and Educational School Environment

The article shows that if an individual path in the process of teaching high school students an academic subject, firstly, will be formed from the teaching modules focused on an individual content on a subject matter in accordance with the student-significant learning objectives, Second, teaching modules will be presented as a set of recommended electronic educational resources (EER), the mastering of which is carried out after hours on the basis of Smart-technologies, and thirdly, the basis for the development of content for the EER will be based on academic discipline: the principle of correspondence between the content of student-significant learning objectives, correction of dynamic random content and teaching methods principle, the principle of adaptability and customization, it provides in-depth knowledge achievements of students on the subject, high level of motivation to succeed, high level of readiness to use information and educational environment for self-learning

Forming Porous Structures on Silicon with a Ferroelectric for Capacitive Microelectronic and Microsystems Engineering Elements

Текст статьи не публикуется в открытом доступе в соответствии с политикой журнала.The formation of heterostructures based on porous silicon with barium titanate for application in capacitive electronic and microsystem engineering elements has been experimentally investigated. The dependences of the capacitance and permittivity on the porous matrix dimensions, number of deposited barium titanate layers, and material of capacitor structure plates has been analyzed

MITOCHONDRIAL PROTEIN PROFILE AND ITS ROLE IN PATHOLOGIC PROCESSES

Mitochondria import hundreds of different precursor proteins from the cytosol, and only 13 proteins are encoded by mtDNA itself. Recent investigations demonstrated real size of mitochondrial proteome and complexity of their functions There are many methods using for mitochondrial proteome profiling, that help to understand a molecular mechanisms of mitochondrial functions and identify the causes of disruptions that lead to different disorders. In this review we discuss a recent data in the field of mitochondrial proteomics