Discovery of coherent millisecond X-ray pulsations in Aql X-1

We report the discovery of an episode of coherent millisecond X-ray pulsation in the neutron star low-mass X-ray binary Aql X-1. The episode lasts for slightly more than 150 seconds, during which the pulse frequency is consistent with being constant. No X-ray burst or other evidence of thermonuclear burning activity is seen in correspondence with the pulsation, which can thus be identified as occurring in the persistent emission. The pulsation frequency is 550.27 Hz, very close (0.5 Hz higher) to the maximum reported frequency from burst oscillations in this source. Hence we identify this frequency with the neutron star spin frequency. The pulsed fraction is strongly energy dependent, ranging from 10% (16-30 keV). We discuss possible physical interpretations and their consequences for our understanding of the lack of pulsation in most neutron star low-mass X-ray binaries. If interpreted as accretion-powered pulsation, Aql X-1 might play a key role in understanding the differences between pulsating and non-pulsating sources.Comment: 5 pages, 3 figures, accepted by ApJ Letters after minor revisions. Slightly extended discussion. One author added. Uses emulateapj.cl

Local chemotherapy as an adjuvant treatment in unresectable squamous cell carcinoma. what do we know so far?

Background: Squamous cell carcinoma (SCC) is one of the most common cancers involving skin and oral mucosa. Although this condition’s gold-standard treatment is the surgical removal of the lesions, the physician must propose alternative treatments in some cases due to the patient’s ineligibility for surgery. Among the available alternative therapies, local chemotherapy may represent an initial treatment in combination with radiotherapy or systemic chemotherapy due to the low frequency of side-effects and the lack of necessity for expensive devices. Methods: In this paper, we review all available literature in various databases (PubMed, Scopus-Embase, Web of Science), proposing local chemotherapy as a treatment for cutaneous and oral SCC. Exclusion criteria included ocular lesions (where topical treatments are common), non-English language, and non-human studies. Results: We included 14 studies in this review. The majority were case reports and case series describing the treatment of non-resectable localized SCC with either imiquimod or 5-fluorouracil. We also analyzed small studies proposing combination treatments. Almost all studies reported an excellent clinical outcome, with a low risk of relapses in time. Conclusions: Resection of the lesion remains the gold-standard treatment for SCC. When this approach is not feasible, local chemotherapy may represent a treatment alternative, and it may also be associated with radiotherapy or systemic chemotherapy

A multi-transition HCN and HCO+ study of 12 nearby active galaxies: AGN versus SB environments

Recent studies have indicated that the HCN-to-CO(J=1-0) and HCO+-to-HCN(J=1-0) ratios are significantly different between galaxies with AGN (active galactic nucleus) and SB (starburst) signatures. In order to study the molecular gas properties in active galaxies and search for differences between AGN and SB environments, we observed the HCN(J=1-0), (J=2-1), (J=3-2), HCO+(J=1-0) and HCO+(J=3-2), emission with the IRAM 30m in the centre of 12 nearby active galaxies which either exhibit nuclear SB and/or AGN signatures. Consistent with previous results, we find a significant difference of the HCN(J=2-1)-to-HCN(J=1-0), HCN(J=3-2)-to-HCN(J=1-0), HCO+(J=3-2)-to-HCO+(J=3-2), and HCO+-to-HCN intensity ratios between the sources dominated by an AGN and those with an additional or pure central SB: the HCN, HCO+ and HCO+-to-HCN intensity ratios tend to be higher in the galaxies of our sample with a central SB as opposed to the pure AGN cases which show rather low intensity ratios. Based on an LVG analysis of these data, i.e., assuming purely collisional excitation, the (average) molecular gas densities in the SB dominated sources of our sample seem to be systematically higher than in the AGN sources. The LVG analysis seems to further support systematically higher HCN and/or lower HCO+ abundances as well as similar or higher gas temperatures in AGN compared to the SB sources of our sample. Also, we find that the HCN-to-CO ratios decrease with increasing rotational number J for the AGN while they stay mostly constant for the SB sources.Comment: accepted for publication in ApJ; 20 pages, 7 figures; in emulateApJ forma

Accreting Millisecond X-Ray Pulsars

Accreting Millisecond X-Ray Pulsars (AMXPs) are astrophysical laboratories without parallel in the study of extreme physics. In this chapter we review the past fifteen years of discoveries in the field. We summarize the observations of the fifteen known AMXPs, with a particular emphasis on the multi-wavelength observations that have been carried out since the discovery of the first AMXP in 1998. We review accretion torque theory, the pulse formation process, and how AMXP observations have changed our view on the interaction of plasma and magnetic fields in strong gravity. We also explain how the AMXPs have deepened our understanding of the thermonuclear burst process, in particular the phenomenon of burst oscillations. We conclude with a discussion of the open problems that remain to be addressed in the future.Comment: Review to appear in "Timing neutron stars: pulsations, oscillations and explosions", T. Belloni, M. Mendez, C.M. Zhang Eds., ASSL, Springer; [revision with literature updated, several typos removed, 1 new AMXP added

Barotrauma during Noninvasive Respiratory Support in COVID-19 Pneumonia Outside ICU: The Ancillary COVIMIX-2 Study

Background: Noninvasive respiratory support (NIRS) has been extensively used during the COVID-19 surge for patients with acute respiratory failure. However, little data are available about barotrauma during NIRS in patients treated outside the intensive care unit (ICU) setting. Methods: COVIMIX-2 was an ancillary analysis of the previous COVIMIX study, a large multicenter observational work investigating the frequencies of barotrauma (i.e., pneumothorax and pneumomediastinum) in adult patients with COVID-19 interstitial pneumonia. Only patients treated with NIRS outside the ICU were considered. Baseline characteristics, clinical and radiological disease severity, type of ventilatory support used, blood tests and mortality were recorded. Results: In all, 179 patients were included, 60 of them with barotrauma. They were older and had lower BMI than controls (p < 0.001 and p = 0.045, respectively). Cases had higher respiratory rates and lower PaO2/FiO2 (p = 0.009 and p < 0.001). The frequency of barotrauma was 0.3% [0.1–1.3%], with older age being a risk factor for barotrauma (OR 1.06, p = 0.015). Alveolar-arterial gradient (A-a) DO2 was protective against barotrauma (OR 0.92 [0.87–0.99], p = 0.026). Barotrauma required active treatment, with drainage, in only a minority of cases. The type of NIRS was not explicitly related to the development of barotrauma. Still, an escalation of respiratory support from conventional oxygen therapy, high flow nasal cannula to noninvasive respiratory mask was predictive for in-hospital death (OR 15.51, p = 0.001). Conclusions: COVIMIX-2 showed a low frequency for barotrauma, around 0.3%. The type of NIRS used seems not to increase this risk. Patients with barotrauma were older, with more severe systemic disease, and showed increased mortality

Disc-jet coupling in low-luminosity accreting neutron stars

In outburst, neutron star X-ray binaries produce less powerful jets than black holes at a given X-ray luminosity. This has made them more difficult to study as they fade towards quiescence. To explore whether neutron stars power jets at low accretion rates (L X ? 10 36 erg s -1 ), we investigate the radio and X-ray properties of three accreting millisecond X-ray pulsars (IGR J17511-3057, SAX J1808.4-3658 and IGR J00291+5934) during their outbursts in 2015, and of the non-pulsing neutron starCenX-4 in quiescence (2015) and in outburst (1979). We did not detect the radio counterpart of IGR J17511-3057 in outburst or of Cen X-4 in quiescence, but did detect IGR J00291+5934 and SAX J1808.4-3658, showing that at least some neutron stars launch jets at low accretion rates. While the radio and X-ray emission in IGR J00291+5934 seem to be tightly correlated, the relationship in SAX J1808.4-3658 is more complicated.We find that SAX J1808.4-3658 produces jets during the reflaring tail, and we explore a toy model to ascertain whether the radio emission could be attributed to the onset of a strong propeller. The lack of a universal radio/X-ray correlation, with different behaviours in different neutron star systems (with various radio/X-ray correlations; some being radio faint and others not), points at distinct disc-jet interactions in individual sources, while always being fainter in the radio band than black holes at the same X-ray luminosity

The long-term evolution of the spin, pulse shape, and orbit of the accretion-powered millisecond pulsar SAX J1808.4-3658

We present a 7 yr timing study of the 2.5 ms X-ray pulsar SAX J1808.4-3658, an X-ray transient with a recurrence time of ~2 yr, using data from the Rossi X-ray Timing Explorer covering 4 transient outbursts (1998-2005). We verify that the 401 Hz pulsation traces the spin frequency fundamental and not a harmonic. Substantial pulse shape variability, both stochastic and systematic, was observed during each outburst. Analysis of the systematic pulse shape changes suggests that, as an outburst dims, the X-ray "hot spot" on the pulsar surface drifts longitudinally and a second hot spot may appear. The overall pulse shape variability limits the ability to measure spin frequency evolution within a given X-ray outburst (and calls previous nudot measurements of this source into question), with typical upper limits of |nudot| < 2.5x10^{-14} Hz/s (2 sigma). However, combining data from all the outbursts shows with high (6 sigma) significance that the pulsar is undergoing long-term spin down at a rate nudot = (-5.6+/-2.0)x10^{-16} Hz/s, with most of the spin evolution occurring during X-ray quiescence. We discuss the possible contributions of magnetic propeller torques, magnetic dipole radiation, and gravitational radiation to the measured spin down, setting an upper limit of B < 1.5x10^8 G for the pulsar's surface dipole magnetic field and and Q/I < 5x10^{-9} for the fractional mass quadrupole moment. We also measured an orbital period derivative of Pdot = (3.5+/-0.2)x10^{-12} s/s. This surprising large Pdot is reminiscent of the large and quasi-cyclic orbital period variation observed in the so-called "black widow" millisecond radio pulsars, supporting speculation that SAX J1808.4-3658 may turn on as a radio pulsar during quiescence. In an appendix we derive an improved (0.15 arcsec) source position from optical data.Comment: 22 pages, 10 figures; accepted for publication in Ap

Swings between rotation and accretion power in a millisecond binary pulsar

It is thought that neutron stars in low-mass binary systems can accrete matter and angular momentum from the companion star and be spun-up to millisecond rotational periods. During the accretion stage, the system is called a low-mass X-ray binary, and bright X-ray emission is observed. When the rate of mass transfer decreases in the later evolutionary stages, these binaries host a radio millisecond pulsar whose emission is powered by the neutron star's rotating magnetic field. This evolutionary model is supported by the detection of millisecond X-ray pulsations from several accreting neutron stars and also by the evidence for a past accretion disc in a rotation-powered millisecond pulsar. It has been proposed that a rotation-powered pulsar may temporarily switch on during periods of low mass inflow in some such systems. Only indirect evidence for this transition has hitherto been observed. Here we report observations of accretion-powered, millisecond X-ray pulsations from a neutron star previously seen as a rotation-powered radio pulsar. Within a few days after a month-long X-ray outburst, radio pulses were again detected. This not only shows the evolutionary link between accretion and rotation-powered millisecond pulsars, but also that some systems can swing between the two states on very short timescales.Comment: 43 pages, 9 figures, 4 table. Published by Nature on 26 Sep 2013. Includes Supplementary information. Minor differences with published version may exis

The reflares and outburst evolution in the accreting millisecond pulsar SAX J1808.4-3658: A disk truncated near co-rotation?

© 2016. The American Astronomical Society. All rights reserved. The accreting millisecond X-ray pulsar SAX J1808.43658 shows peculiar low luminosity states known as "reflares" after the end of the main outburst. During this phase the X-ray luminosity of the source varies by up to three orders of magnitude in less than 12 days. The lowest X-ray luminosity observed reaches a value of ~1032 erg s-1, only a factor of a few brighter than its typical quiescent level. We investigate the 2008 and 2005 reflaring state of SAX J1808.43658 to determine whether there is any evidence for a change in the accretion flow with respect to the main outburst. We perform a multiwavelength photometric and spectral study of the 2005 and 2008 reflares with data collected during an observational campaign covering the near-infrared, optical, ultra-violet and X-ray band. We find that the NIR/optical/UV emission, expected to come from the outer accretion disk, shows variations in luminosity over an order of magnitude. The corresponding X-ray luminosity variations are instead much deeper, spanning about 23 orders of magnitude. The X-ray spectral state observed during the reflares does not change substantially with X-ray luminosity, indicating a rather stable configuration of the accretion flow. We investigate the most likely configuration of the innermost regions of the accretion flow and we infer an accretion disk truncated at or near the co-rotation radius. We interpret these findings as due to either a strong outflow (due to a propeller effect) or a trapped disk (with limited/no outflow) in the inner regions of the accretion flow

Allogeneic mesenchymal stem cells improve the wound healing process of sheep skin

Abstract Background Skin wound healing includes a system of biological processes, collectively restoring the integrity of the skin after injury. Healing by second intention refers to repair of large and deep wounds where the tissue edges cannot be approximated and substantial scarring is often observed. The objective of this study was to evaluate the effects of mesenchymal stem cells (MSCs) in second intention healing using a surgical wound model in sheep. MSCs are known to contribute to the inflammatory, proliferative, and remodeling phases of the skin regeneration process in rodent models, but data are lacking for large animal models. This study used three different approaches (clinical, histopathological, and molecular analysis) to assess the putative action of allogeneic MSCs at 15 and 42 days after lesion creation. Results At 15 days post-lesion, the wounds treated with MSCs showed a higher degree of wound closure, a higher percentage of re-epithelialization, proliferation, neovascularization and increased contraction in comparison to a control group. At 42 days, the wounds treated with MSCs had more mature and denser cutaneous adnexa compared to the control group. The MSCs-treated group showed an absence of inflammation and expression of CD3+ and CD20+. Moreover, the mRNA expression of hair-keratine (hKER) was observed in the MSCs-treated group 15 days after wound creation and had increased significantly by 42 days post-wound creation. Collagen1 gene (Col1α1) expression was also greater in the MSCs-treated group compared to the control group at both days 15 and 42. Conclusion Peripheral blood-derived MSCs may improve the quality of wound healing both for superficial injuries and deep lesions. MSCs did not induce an inflammatory response and accelerated the appearance of granulation tissue, neovascularization, structural proteins, and skin adnexa