Proof of Presence: Novel Vehicle Detection System

The detection of vehicle presence in parking slots is a fundamental part of smart parking systems. The problem is commonly approached with devices composed of specific sensors, which usually are either magnetic or infrared. The sensor is continuously sampled by an onboard microcontroller capable of determining the slot status (available or occupied) and sending the information to a central collection and gathering system by means of a wireless technology. Nevertheless, cost and power consumption are still an issue. Based on the consideration that the vehicle slot status is only a single bit of information, in this article an alternative low-power and cost-effective approach is proposed. Specifically, two novel vehicle presence detectors, one battery-powered and based on 868 MHz LoRa technology and one solar-cell-powered and adopting BAP 866 MHz UHF RFID technology, are presented, designed, realized, and tested. The obtained results demonstrate the appropriateness of the proposed approach since the same functionalities of conventional devices at lower cost and lower consumption are reached

An innovative AAL system based on neural networks and IoT-aware technologies to improve the quality of life in elderly people

Nowadays more and more elderly people need support in daily activities. This is due to the increase of cognitive diseases and other conditions which lead the elderly to not being self-sufficient. Considering this, providing an Ambient Assisted Living system could improve significantly people life quality and could support caregivers' tasks. The combination of Ambient Assisted Living systems and information and communication technologies achieve this purpose perfectly. They exploit internet of things and artificial intelligence paradigms to make daily challenges easier for people with neurodegenerative diseases. This work melds technologies mentioned above providing a smart system for elderly to manage goods and fill in shopping lists. It was possible using software, hardware, and cloud systems combined with a neural network aimed to recognise products. The proposed system has been validated both from a functional point of view through a proof-of-concept and quantitatively by a performance analysis of its components

GIS based Integration and Analysis of multiple source Information for Non-Proliferation Studies

In recent years the volume and variety of information that needs to be analysed in the context of non-proliferation have been increasing continuously Therefore, an integrated, all-source information analysis is paramount for an efficient and effective monitoring of the Non-Proliferation Treaty (NPT). The ¿Treaty Monitoring¿ workpackage of the LIMES research project addressed this issue by developing an integrated platform supporting the non-proliferation image analyst in verifying treaty compliance. The main benefits of the platform are (i) integrating information from multiple sources and time-frames, including satellite imagery, site models, open source information, reports, etc; (ii) improved information management using a GIS-based platform and (iii) enhanced methodologies for satellite image analysis. The platform components facilitate the analysis by highlighting changes and anomalies, which are potentially safeguards-relevant and by providing quantitative measurements which are not readily available from the images. It improves the efficiency and effectiveness of the information assessment by providing all-source integration capabilities, which allow to easily access supporting collateral information (e.g. Open Source information) from an image analysis task, an vice versa. The paper presents the components of the integration platform and the results of the demonstration which monitored the construction of a nuclear reactor in Olkiluoto, Finland.JRC.E.9-Nuclear security (Ispra

An IoT-Aware Smart System Exploiting the Electromagnetic Behavior of UHF-RFID Tags to Improve Worker Safety in Outdoor Environments

Recently, different solutions leveraging Internet of Things (IoT) technologies have been adopted to avoid accidents in agricultural working environments. As an example, heavy vehicles, e.g., tractors or excavators, have been upgraded with remote controls. Nonetheless, the community continues to encourage discussions on safety issues. In this framework, a localization system installed on remote-controlled farm machines (RCFM) can help in preventing fatal accidents and reduce collision risks. This paper presents an innovative system that exploits passive UHF-RFID technology supported by commercial BLE Beacons for monitoring and preventing accidents that may occur when ground-workers in RCFM collaborate in outdoor agricultural working areas. To this aim, a modular architecture is proposed to locate workers, obstacles and machines and guarantees the security of RCFM movements by using specific notifications for ground-workers prompt interventions. Its main characteristics are presented with its main positioning features based on passive UHF-RFID technology. An experimental campaign discusses its performance and determines the best configuration of the UHF-RFID tags installed on workers and obstacles. Finally, system validation demonstrates the reliability of the main components and the usefulness of the proposed architecture for worker safety

NSAID Use Selectively Increases the Risk of Non-Fatal Myocardial Infarction: A Systematic Review of Randomised Trials and Observational Studies

Recent clinical trials and observational studies have reported increased coronary events associated with non steroidal anti-inflammatory drugs (NSAIDs). There appeared to be a disproportionate increase in non-fatal versus fatal events, however, numbers of fatal events in individual studies were too small, and event rates too low, to be meaningful.We undertook a pooled analysis to investigate the effect of NSAIDs on myocardial infarction (MI) risk with the specific aim to differentiate non-fatal from fatal events.We searched Pubmed (January, 1990 to March, 2010) for observational studies and randomised controlled trials that assessed the effect of NSAIDs (traditional or selective COX-2 inhibitors [coxibs]) on MI incidence separately for fatal and non-fatal events. Summary estimates of relative risk (RR) for non-fatal and fatal MIs were calculated with a random effects model.NSAID therapy carried a RR of 1.30 (95% CI, 1.20-1.41) for non-fatal MI with no effect on fatal MI (RR 1.02, 95% CI, 0.89-1.17) in six observational studies. Overall, the risk increase for non-fatal MI was 25% higher (95% CI, 11%-42%) than for fatal MI. The two studies that included only individuals with prior cardiovascular disease presented risk estimates for non-fatal MI on average 58% greater (95% CI, 26%-98%) than those for fatal MI. In nine randomised controlled trials, all investigating coxibs, the pooled RR estimate for non-fatal MI was 1.61 (95% CI, 1.04-2.50) and 0.86 (95% CI 0.51-1.47) for fatal MIs.NSAID use increases the risk of non-fatal MI with no substantial effect on fatal events. Such differential effects, with potentially distinct underlying pathology may provide insights into NSAID-induced coronary pathology. We studied the association between the use of nonsteroidal anti-inflammatory drugs (NSAIDs) and the risk of myocardial infarction (MI), separating non-fatal from fatal events, summarizing the evidence from both observational studies and randomised controlled trials. An increased risk of non-fatal MI was clearly found in both types of studies while use of NSAID did not confer an increased risk of fatal MI. Our findings provide support for the concept that thrombi generated under NSAID treatment could be different from spontaneous thrombi

Multicentre evaluation of the Boehringer Mannheim / Hitachi 911 Analysis System

The analytical performance and practicability of the Boehringer Mannheim (BM)/mtaci 91 analysis system have been assessed in a multicentre evaluation, which involved six laboratories from European countries. Analytes commonly used in classical clinical chemistry were tested in a core programme, which mainlyfollowed lhe ECCLS guidelines. In addition, a satellite programme covered other analytes, such as proteins, drugs and urine analytes. In total, the study comprised more than 100 000 data items collected over a three-month period. The evaluation was supported with 'Computer Aided Evaluation' (CAEv) and telecommunications. Acceptance criteria for the results were established at the beginning ofthe study. Nearly all ofthe analytes met the imprecision limits.' within-run imprecision (as CVs) was 2l/ofor enzyme and substrate assays, l%for ISE methods and 5l/o for immunoassays; between-day imprecision was 3l/ofor enzyme and substrate assays, 2o//o for ISE methods and 10% for immunoassays

Potentiation of thrombus instability: a contributory mechanism to the effectiveness of antithrombotic medications

© The Author(s) 2018The stability of an arterial thrombus, determined by its structure and ability to resist endogenous fibrinolysis, is a major determinant of the extent of infarction that results from coronary or cerebrovascular thrombosis. There is ample evidence from both laboratory and clinical studies to suggest that in addition to inhibiting platelet aggregation, antithrombotic medications have shear-dependent effects, potentiating thrombus fragility and/or enhancing endogenous fibrinolysis. Such shear-dependent effects, potentiating the fragility of the growing thrombus and/or enhancing endogenous thrombolytic activity, likely contribute to the clinical effectiveness of such medications. It is not clear how much these effects relate to the measured inhibition of platelet aggregation in response to specific agonists. These effects are observable only with techniques that subject the growing thrombus to arterial flow and shear conditions. The effects of antithrombotic medications on thrombus stability and ways of assessing this are reviewed herein, and it is proposed that thrombus stability could become a new target for pharmacological intervention.Peer reviewedFinal Published versio

Celecoxib exerts protective effects in the vascular endothelium via COX-2-independent activation of AMPK-CREB-Nrf2 signalling

Although concern remains about the athero-thrombotic risk posed by cyclo-oxygenase (COX)-2-selective inhibitors, recent data implicates rofecoxib, while celecoxib appears equivalent to NSAIDs naproxen and ibuprofen. We investigated the hypothesis that celecoxib activates AMP kinase (AMPK) signalling to enhance vascular endothelial protection. In human arterial and venous endothelial cells (EC), and in contrast to ibuprofen and naproxen, celecoxib induced the protective protein heme oxygenase-1 (HO-1). Celecoxib derivative 2,5-dimethyl-celecoxib (DMC) which lacks COX-2 inhibition also upregulated HO-1, implicating a COX-2-independent mechanism. Celecoxib activated AMPKα(Thr172) and CREB-1(Ser133) phosphorylation leading to Nrf2 nuclear translocation. Importantly, these responses were not reproduced by ibuprofen or naproxen, while AMPKα silencing abrogated celecoxib-mediated CREB and Nrf2 activation. Moreover, celecoxib induced H-ferritin via the same pathway, and increased HO-1 and H-ferritin in the aortic endothelium of mice fed celecoxib (1000 ppm) or control chow. Functionally, celecoxib inhibited TNF-α-induced NF-κB p65(Ser536) phosphorylation by activating AMPK. This attenuated VCAM-1 upregulation via induction of HO-1, a response reproduced by DMC but not ibuprofen or naproxen. Similarly, celecoxib prevented IL-1β-mediated induction of IL-6. Celecoxib enhances vascular protection via AMPK-CREB-Nrf2 signalling, a mechanism which may mitigate cardiovascular risk in patients prescribed celecoxib. Understanding NSAID heterogeneity and COX-2-independent signalling will ultimately lead to safer anti-inflammatory drugs

Liver transplantation as last-resort treatment for patients with bile duct injuries following cholecystectomy: A multicenter analysis

Background Liver transplantation (LT) has been used as a last resort in patients with end-stage liver disease due to bile duct injuries (BDI) following cholecystectomy. Our study aimed to identify and evaluate factors that cause or contribute to an extended liver disease that requires LT as ultimate solution, after BDI during cholecystectomy. Methods Data from 8 high-volume LT centers relating to patients who underwent LT after suffering BDI during cholecystectomy were prospectively collected and retrospectively analyzed. Results Thirty-four patients (16 men, 18 women) with a median age of 45 (range 22-69) years were included in this study. Thirty of them (88.2%) underwent LT because of liver failure, most commonly as a result of secondary biliary cirrhosis. The median time interval between BDI and LT was 63 (range 0-336) months. There were 23 cases (67.6%) of postoperative morbidity, 6 cases (17.6%) of post-transplant 30-day mortality, and 10 deaths (29.4%) in total after LT. There was a higher probability that patients with concomitant vascular injury (hazard ratio 10.69, P=0.039) would be referred sooner for LT. Overall survival following LT at 1, 3, 5 and 10 years was 82.4%, 76.5%, 73.5% and 70.6%, respectively. Conclusion LT for selected patients with otherwise unmanageable BDI following cholecystectomy yields acceptable long-term outcomes