Robustness of Majorana Fermion induced Fractional Josephson Effect

It is shown in previous works that the coupling between two Majorana end states in superconducting quantum wires leads to fractional Josephson effect. However, in realistic experimental conditions, multiple bands of the wires are occupied and the Majorana end states are accompanied by other fermionic end states. This raises the question concerning the robustness of fractional Josephson effect in these situations. In this work, we show that the absence of the avoided energy crossing which gives rise to the fractional Josephson effect is robust, even when the Majorana fermions are coupled with arbitrary strengths to other fermions. Moreover, we calculate the temperature dependence of the fractional Josephson current and show that it is suppressed by thermal excitations to the other fermion bound states.Comment: 4+ pages, 3 figure

Mass fluxes and isofluxes of methane (CH4) at a New Hampshire fen measured by a continuous wave quantum cascade laser spectrometer

We have developed a mid‐infrared continuous‐wave quantum cascade laser direct‐absorption spectrometer (QCLS) capable of high frequency (≥1 Hz) measurements of 12CH4 and 13CH4 isotopologues of methane (CH4) with in situ 1‐s RMS image precision of 1.5 ‰ and Allan‐minimum precision of 0.2 ‰. We deployed this QCLS in a well‐studied New Hampshire fen to compare measurements of CH4 isoflux by eddy covariance (EC) to Keeling regressions of data from automated flux chamber sampling. Mean CH4 fluxes of 6.5 ± 0.7 mg CH4 m−2 hr−1 over two days of EC sampling in July, 2009 were indistinguishable from mean autochamber CH4 fluxes (6.6 ± 0.8 mgCH4 m−2 hr−1) over the same period. Mean image composition of emitted CH4 calculated using EC isoflux methods was −71 ± 8 ‰ (95% C.I.) while Keeling regressions of 332 chamber closing events over 8 days yielded a corresponding value of −64.5 ± 0.8 ‰. Ebullitive fluxes, representing ∼10% of total CH4 fluxes at this site, were on average 1.2 ‰ enriched in 13C compared to diffusive fluxes. CH4 isoflux time series have the potential to improve process‐based understanding of methanogenesis, fully characterize source isotopic distributions, and serve as additional constraints for both regional and global CH4 modeling analysis

SU(3) monopoles and their fields

Some aspects of the fields of charge two SU(3) monopoles with minimal symmetry breaking are discussed. A certain class of solutions look like SU(2) monopoles embedded in SU(3) with a transition region or ``cloud'' surrounding the monopoles. For large cloud size the relative moduli space metric splits as a direct product AH\times R^4 where AH is the Atiyah-Hitchin metric for SU(2) monopoles and R^4 has the flat metric. Thus the cloud is parametrised by R^4 which corresponds to its radius and SO(3) orientation. We solve for the long-range fields in this region, and examine the energy density and rotational moments of inertia. The moduli space metric for these monopoles, given by Dancer, is also expressed in a more explicit form.Comment: 17 pages, 3 figures, latex, version appearing in Phys. Rev.

Theory of Quasi-Particles in the Underdoped High Tc Superconducting State

The microscopic theory of superconducting (SC) state in the SU(2) slave-boson model is developed. We show how the pseudogap and Fermi surface (FS) segments in the normal state develop into a d-wave gap in the superconducting state. Even though the superfluid density is of order x (the doping concentration), the physical properties of the low lying quasiparticles are found to resemble those in BCS theory. Thus the microscopic theory lay the foundation for our earlier phenomenological discussion of the unusual SC properties in the underdoped cuprates.Comment: 4 pages in RevTeX, 1 figure in eps, revised versio

Degenerate Bose liquid in a fluctuating gauge field

We study the effect of a strongly fluctuating gauge field on a degenerate Bose liquid, relevant to the charge degrees of freedom in doped Mott insulators. We find that the superfluidity is destroyed. The resulting metallic phase is studied using quantum Monte Carlo methods. Gauge fluctuations cause the boson world lines to retrace themselves. We examine how this world-line geometry affects the physical properties of the system. In particular, we find a transport relaxation rate of the order of 2kT, consistent with the normal state of the cuprate superconductors. We also find that the density excitations of this model resemble that of the full tJ model.Comment: 4 pages. Uses RevTeX, epsf, multicols macros. 5 postscript figure

Prospective Study on Retinal Nerve Fibre Layer Thickness Changes in Isolated Unilateral Retrobulbar Optic Neuritis

Purpose. To investigate the retinal nerve fibre layer (RNFL) thickness after unilateral acute optic neuritis using optical coherence tomography (OCT). Patients and Methods. This prospective cohort study recruited consecutive patients with a first episode of isolated, unilateral acute optic neuritis. RNFL thickness and visual acuity (VA) of the attack and normal fellow eye were measured at presentation and 3 months in both the treatment and nontreatment groups. Results. 11 subjects received systemic steroids and 9 were treated conservatively. The baseline RNFL thickness was similar in the attack and fellow eye (P≥0.4). At 3 months, the attack eye had a thinner temporal (P=0.02) and average (P=0.05) RNFL compared to the fellow eye. At 3 months, the attack eye had significant RNFL thinning in the 4 quadrants and average thickness (P≤0.0002) compared to baseline. The RNFL thickness between the treatment and nontreatment groups was similar at baseline and 3 months (P≥0.1). Treatment offered better VA at 3 months (0.1 ± 0.2 versus 0.3 ± 0.2 LogMAR, P=0.04). Conclusion. Generalized RNFL thinning occurred at 3 months after a first episode of acute optic neuritis most significantly in the temporal quadrant and average thickness. Visual improvement with treatment was independent of RNFL thickness

Restoring Ureagenesis in Hepatocytes by CRISPR/Cas9-mediated Genomic Addition to Arginase-deficient Induced Pluripotent Stem Cells.

Urea cycle disorders are incurable enzymopathies that affect nitrogen metabolism and typically lead to hyperammonemia. Arginase deficiency results from a mutation in Arg1, the enzyme regulating the final step of ureagenesis and typically results in developmental disabilities, seizures, spastic diplegia, and sometimes death. Current medical treatments for urea cycle disorders are only marginally effective, and for proximal disorders, liver transplantation is effective but limited by graft availability. Advances in human induced pluripotent stem cell research has allowed for the genetic modification of stem cells for potential cellular replacement therapies. In this study, we demonstrate a universally-applicable CRISPR/Cas9-based strategy utilizing exon 1 of the hypoxanthine-guanine phosphoribosyltransferase locus to genetically modify and restore arginase activity, and thus ureagenesis, in genetically distinct patient-specific human induced pluripotent stem cells and hepatocyte-like derivatives. Successful strategies restoring gene function in patient-specific human induced pluripotent stem cells may advance applications of genetically modified cell therapy to treat urea cycle and other inborn errors of metabolism

Colossal Positive Magnetoresistance in a Doped Nearly Magnetic Semiconductor

We report on a positive colossal magnetoresistance (MR) induced by metallization of FeSb$_{2}$, a nearly magnetic or "Kondo" semiconductor with 3d ions. We discuss contribution of orbital MR and quantum interference to enhanced magnetic field response of electrical resistivity.Comment: 5 pages, 5 figure