Advances in Wound Healing: A Review of Current Wound Healing Products

Successful wound care involves optimizing patient local and systemic conditions in conjunction with an ideal wound healing environment. Many different products have been developed to influence this wound environment to provide a pathogen-free, protected, and moist area for healing to occur. Newer products are currently being used to replace or augment various substrates in the wound healing cascade. This review of the current state of the art in wound-healing products looks at the latest applications of silver in microbial prophylaxis and treatment, including issues involving resistance and side effects, the latest uses of negative pressure wound devices, advanced dressings and skin substitutes, biologic wound products including growth factor applications, and hyperbaric oxygen as an adjunct in wound healing. With the abundance of available products, the goal is to find the most appropriate modality or combination of modalities to optimize healing

Unsteady Model Estimation for Generic T-Tail Transport Aircraft Using Computational Data

Models including nonlinear and unsteady behaviors are developed for the longitudinal axis of the NASA Generic T-Tail Aircraft over a large range of angle of attack. These models are based on computational simulations of forced-oscillation tests in a wind tunnel. This work continues a recent study and an ongoing effort by NASA to improve aircraft simulations for pilot training in loss-of-control and stalled conditions. The objective of this work is to develop appropriate aerodynamic models that provide representative responses in simulation for a given class of aircraft. In the stall region, nonlinear unsteady responses are often present and may require an extended aerodynamic model compared to that used in the conventional flight envelope. In this study, two objectives are addressed. The first is to obtain representative models for the NASA Generic T-Tail aircraft over a wide range of angle of attack and the second is to continue development of a specialized CFD test technique that uses Schroeder sweeps to create information rich responses for unsteady aerodynamic model identification

Efficient Unsteady Model Estimation Using Computational and Experimental Data

Improving aircraft simulations for pilot training in loss-of-control and stalled conditions is one goal of NASA research in the System Wide Safety Program. One part of this effort is to develop appropriate generic aerodynamic models that provide representative responses in simulation for a given class of aircraft. In this part of the flight envelope nonlinear unsteady responses are often present and may require an extended aerodynamic model compared to that used in the conventional flight envelope. In this preliminary study, two objectives are addressed. First, to obtain a representative model for a NASA generic aircraft at an unsteady condition in the flight envelope and second, to evaluate the techniques involved. To meet these objectives, two different generic aircraft configurations are modeled using both experimental and analytical data. With these results, an initial assessment of the efficiency and quality of the tools and test techniques are evaluated to develop guidance for analytical and experimental approaches to unsteady modeling

Computational Study of a Generic T-tail Transport

This paper presents a computational study on the static and dynamic stability characteristics of a generic transport T-tail configuration under a NASA research program to improve stall models for civil transports. The NASA Tetrahedral Unstructured Software System (TetrUSS) was used to obtain both static and periodic dynamic solutions at low speed conditions for three Reynolds number conditions up to 60 deg angle of attack. The computational results are compared to experimental data. The dominant effects of Reynolds number for the static conditions were found to occur in the stall region. The pitch and roll damping coefficients compared well to experimental results up to up to 40 deg angle of attack whereas yaw damping coefficient agreed only up to 20 deg angle of attack

Reduced duration mismatch negativity in adolescents with psychotic symptoms: further evidence for mismatch negativity as a possible biomarker for vulnerability to psychosis

Background: Deficits in the mismatch negativity (MMN) and P3a components are the most reliable and robust findings in schizophrenia. These abnormalities have also been recently documented in individuals clinically at risk for psychosis, indicating that the MMN may be a potential biomarker for psychosis. However, the at risk samples included in MMN studies are characterised by pre-existing clinical symptomatology and significant functional decline which are related to MMN amplitude. These factors may be potential confounds in determining whether deficient MMN is present prior to clinical manifestation of the disorder. Therefore, investigating the MMN in the extended psychosis phenotype comprising adolescents with psychotic symptoms from the general population may provide important information on whether abnormal MMN is apparent in the earliest stages of risk. Methods: Thirty six adolescents completed a duration deviant MMN task. Fourteen adolescents with psychotic symptoms comprised the at risk group and 22 with no psychotic symptoms comprised the Controls. The task consisted of 85% standard tones (25 ms) and 15% deviant tones (50 ms). The groups were compared on MMN and P3a amplitude and latency across frontocentral and temporal electrodes. Results: Adolescents with psychotic symptoms were characterised by a reduction in MMN amplitude at frontal and temporal regions compared to the controls. Conclusions: This is the first study to demonstrate impaired auditory discrimination for duration deviant tones in nonclinical adolescents with psychotic symptoms. These findings suggest that MMN amplitude may be a possible biomarker for vulnerability to psychosis

SkyMapper Southern Survey: First Data Release (DR1)

We present the first data release (DR1) of the SkyMapper Southern Survey, a hemispheric survey carried out with the SkyMapper Telescope at Siding Spring Observatory in Australia. Here, we present the survey strategy, data processing, catalogue construction and database schema. The DR1 dataset includes over 66,000 images from the Shallow Survey component, covering an area of 17,200 deg$^2$ in all six SkyMapper passbands $uvgriz$, while the full area covered by any passband exceeds 20,000 deg$^2$. The catalogues contain over 285 million unique astrophysical objects, complete to roughly 18 mag in all bands. We compare our $griz$ point-source photometry with PanSTARRS1 DR1 and note an RMS scatter of 2%. The internal reproducibility of SkyMapper photometry is on the order of 1%. Astrometric precision is better than 0.2 arcsec based on comparison with Gaia DR1. We describe the end-user database, through which data are presented to the world community, and provide some illustrative science queries.Comment: 31 pages, 19 figures, 10 tables, PASA, accepte

A Randomized, Double-Blinded, Phase II Trial of Gemcitabine and Nab-Paclitaxel Plus Apatorsen or Placebo in Patients with Metastatic Pancreatic Cancer: The RAINIER Trial.

Lessons learnedThe addition of the heat shock protein 27 (Hsp27)-targeting antisense oligonucleotide, apatorsen, to a standard first-line chemotherapy regimen did not result in improved survival in unselected patients with metastatic pancreatic cancer.Findings from this trial hint at the possible prognostic and predictive value of serum Hsp27 that may warrant further investigation.BackgroundThis randomized, double-blinded, phase II trial evaluated the efficacy of gemcitabine/nab-paclitaxel plus either apatorsen, an antisense oligonucleotide targeting heat shock protein 27 (Hsp27) mRNA, or placebo in patients with metastatic pancreatic cancer.MethodsPatients were randomized 1:1 to Arm A (gemcitabine/nab-paclitaxel plus apatorsen) or Arm B (gemcitabine/nab-paclitaxel plus placebo). Treatment was administered in 28-day cycles, with restaging every 2 cycles, until progression or intolerable toxicity. Serum Hsp27 levels were analyzed at baseline and on treatment. The primary endpoint was overall survival (OS).ResultsOne hundred thirty-two patients were enrolled, 66 per arm. Cytopenias and fatigue were the most frequent grade 3/4 treatment-related adverse events for both arms. Median progression-free survival (PFS) and OS were 2.7 and 5.3 months, respectively, for arm A, and 3.8 and 6.9 months, respectively, for arm B. Objective response rate was 18% for both arms. Patients with high serum level of Hsp27 represented a poor-prognosis subgroup who may have derived modest benefit from addition of apatorsen.ConclusionAddition of apatorsen to chemotherapy does not improve outcomes in unselected patients with metastatic pancreatic cancer in the first-line setting, although a trend toward prolonged PFS and OS in patients with high baseline serum Hsp27 suggests this therapy may warrant further evaluation in this subgroup

Lake Breezes in Southern Ontario and Their Relation to Tornado Climatology

Geostationary Operational Environmental Satellite (GOES) imagery is used to demonstrate the development of lake-breeze boundaries in southern Ontario under different synoptic conditions. The orientation of the gradient wind with respect to the shorelines is important in determining the location of such lines. When moderate winds (5–10 m s21) are parallel to straight sections of coastlines, cloud lines can extend well inland. In the region between Lakes Huron and Erie lake-breeze lines merge frequently, sometimes resulting in long-lasting stationary storms and attendant heavy rain and flooding. The influence of the lakes is apparent in the tornado climatology for the region: tornadoes appear to be suppressed in regions visited by lake-modified air and enhanced in regions favored by lake-breeze convergence lines. The cloud patterns in the case of a cold front interacting with merging lake-breeze boundaries are shown to be similar to those on a major tornado outbreak day. Two of the cases discussed are used as conceptual models to explain many of the features in the patterns of tornado touchdown locations. In general, it appears that the lakes suppress tornadoes in southern Ontario, compared with neighboring states and in particular in areas where southwest winds are onshore, but enhance tornado likelihood locally in areas of frequent lake-breeze activity. 1

Constraining fundamental constants of physics with quasar absorption line systems

We summarize the attempts by our group and others to derive constraints on variations of fundamental constants over cosmic time using quasar absorption lines. Most upper limits reside in the range 0.5-1.5x10-5 at the 3sigma level over a redshift range of approximately 0.5-2.5 for the fine-structure constant, alpha, the proton-to-electron mass ratio, mu, and a combination of the proton gyromagnetic factor and the two previous constants, gp(alpha^2/mu)^nu, for only one claimed variation of alpha. It is therefore very important to perform new measurements to improve the sensitivity of the numerous methods to at least <0.1x10-5 which should be possible in the next few years. Future instrumentations on ELTs in the optical and/or ALMA, EVLA and SKA pathfinders in the radio will undoutedly boost this field by allowing to reach much better signal-to-noise ratios at higher spectral resolution and to perform measurements on molecules in the ISM of high redshift galaxies.Comment: 11 pages, 3 figure