ChlamyCyc - a comprehensive database and web-portal centered on _Chlamydomonas reinhardtii_

*Background* - The unicellular green alga _Chlamydomonas reinhardtii_ is an important eukaryotic model organism for the study of photosynthesis and growth, as well as flagella development and other cellular processes. In the era of high-throughput technologies there is an imperative need to integrate large-scale data sets from high-throughput experimental techniques using computational methods and database resources to provide comprehensive information about the whole cellular system of a single organism.
*Results* - In the framework of the German Systems Biology initiative GoFORSYS a pathway/genome database and web-portal for _Chlamydomonas reinhardtii_ (ChlamyCyc) was established, which currently features about 270 metabolic pathways with related genes, enzymes, and compound information. ChlamyCyc was assembled using an integrative approach combining the recently published genome sequence, bioinformatics methods, and experimental data from metabolomics and proteomics experiments. We analyzed and integrated a combination of primary and secondary database resources, such as existing genome annotations from JGI, EST collections, orthology information, and MapMan classification.
*Conclusion* - Chlamycyc provides a curated and integrated systems biology repository that will enable and assist in systematic studies of fundamental cellular processes in _Chlamydomonas reinhardtii_. The ChlamyCyc database and web-portal is freely available under http://chlamycyc.mpimp-golm.mpg.de

Three issues for mental health nurse educators preparing new preregistration programmes

Universities across the UK must develop and have in place new preregistration programmes by 2020. Unlike in the rest of the world, where initial nurse preparation is generic, preregistration education in the UK allows students to specialize in one of four specific fields of practice - adult, mental health, child or learning disability. To the relief of many , the new standards confirmed the continued survival of the specialist fields at undergraduate level. Educators across the UK now have an opportunity to fully review existing provision and address areas of significance. This paper explores three such issues. These are: •How best to respond to adverse life experiences or trauma.•The ethical tension which we believe is inherent in the use of coercive practice.•The potential to make a difference to the appalling mortality statistics which indicate that people with long standing mental health problems die much younger than their contemporaries In each case we make tentative suggestions for how they might be approached

Comment: Evidence of Other Crimes as Substantive Proof of Guilt in Maryland

The cases dealing with admissibility of prior criminal acts are narrowly decided. Indeed, the results often appear contradictory..

Comment: Evidence of Other Crimes as Substantive Proof of Guilt in Maryland

The cases dealing with admissibility of prior criminal acts are narrowly decided. Indeed, the results often appear contradictory..

Charter School Funding: Inequity in the City

Public charter schools are a growing part of K-12 education. Charter schools are public schools that are granted operational autonomy by their authorizing agency in return for a commitment to achieve specific performance goals. Like traditional public schools, charter schools are free to students and overseen by the state. Unlike traditional public schools, however, most charters are open to all students who wish to apply, regardless of where they live. If a charter school is over-subscribed, usually random lotteries determine which students will be admitted. Most charter schools are independent of the traditional public school district in which they operate

Non-Markovian Quantum Jumps in Excitonic Energy Transfer

We utilize the novel non-Markovian quantum jump (NMQJ) approach to stochastically simulate exciton dynamics derived from a time-convolutionless master equation. For relevant parameters and time scales, the time-dependent, oscillatory decoherence rates can have negative regions, a signature of non-Markovian behavior and of the revival of coherences. This can lead to non-Markovian population beatings for a dimer system at room temperature. We show that strong exciton-phonon coupling to low frequency modes can considerably modify transport properties. We observe increased exciton transport, which can be seen as an extension of recent environment-assisted quantum transport (ENAQT) concepts to the non-Markovian regime. Within the NMQJ method, the Fenna-Matthew-Olson protein is investigated as a prototype for larger photosynthetic complexes.Comment: 9 pages, 4 figures, submitted to Journal of Chemical Physic