The Mobile Generation: Global Transformations at the Cellular Level

Every year we see a new dimension of the ongoing Digital Revolution, which is enabling an abundance of information to move faster, cheaper, in more intelligible forms, in more directions, and across borders of every kind. The exciting new dimension on which the Aspen Institute focused its 2006 Roundtable on Information Technology was mobility, which is making the Digital Revolution ubiquitous. As of this writing, there are over two billion wireless subscribers worldwide and that number is growing rapidly. People are constantly innovating in the use of mobile technologies to allow them to be more interconnected. Almost a half century ago, Ralph Lee Smith conjured up "The Wired Nation," foretelling a world of interactive communication to and from the home that seems commonplace in developed countries today. Now we have a "Wireless World" of communications potentially connecting two billion people to each other with interactive personal communications devices. Widespead adoption of wireless handsets, the increasing use of wireless internet, and the new, on-the-go content that characterizes the new generation of users are changing behaviors in social, political and economic spheres. The devices are easy to use, pervasive and personal. The affordable cell phone has the potential to break down the barriers of poverty and accessibility previously posed by other communications devices. An entire generation that is dependant on ubiquitous mobile technologies is changing the way it works, plays and thinks. Businesses, governments, educational institutions, religious and other organizations in turn are adapting to reach out to this mobile generation via wireless technologies -- from SMS-enabled vending machines in Finland to tech-savvy priests in India willing to conduct prayers transmitted via cell phones. Cellular devices are providing developing economies with opportunities unlike any others previously available. By opening the lines of communication, previously disenfranchised groups can have access to information relating to markets, economic opportunities, jobs, and weather to name just a few. When poor village farmers from Bangladesh can auction their crops on a craigslist-type service over the mobile phone, or government officials gain instantaneous information on contagious diseases via text message, the miracles of mobile connectivity move us from luxury to necessity. And we are only in the early stages of what the mobile electronic communications will mean for mankind. We are now "The Mobile Generation." Aspen Institute Roundtable on Information Technology. To explore the implications of these phenomena, the Aspen Institute Communications and Society Program convened 27 leaders from business, academia, government and the non-profit sector to engage in three days of dialogue on related topics. Some are experts in information and communications technologies, others are leaders in the broader society affected by these innovations. Together, they examined the profound changes ahead as a result of the convergence of wireless technologies and the Internet. In the following report of the Roundtable meeting held August 1-4, 2006, J. D. Lasica, author of Darknet and co-founder of Ourmedia.org, deftly sets up, contextualizes, and captures the dialogue on the impact of the new mobility on economic models for businesses and governments, social services, economic development, and personal identity

Use of an index to reflect the aggregate burden of long-term exposure to criteria air pollutants in the United States.

Air pollution control in the United States for five common pollutants--particulate matter, ground-level ozone, sulfur dioxide, nitrogen dioxide, and carbon monoxide--is based partly on the attainment of ambient air quality standards that represent a level of air pollution regarded as safe. Regulatory and health agencies often focus on whether standards for short periods are attained; the number of days that standards are exceeded is used to track progress. Efforts to explain air pollution to the public often incorporate an air quality index that represents daily concentrations of pollutants. While effects of short-term exposures have been emphasized, research shows that long-term exposures to lower concentrations of air pollutants can also result in adverse health effects. We developed an aggregate index that represents long-term exposure to these pollutants, using 1995 monitoring data for metropolitan areas obtained from the U.S. Environmental Protection Agency's Aerometric Information Retrieval System. We compared the ranking of metropolitan areas under the proposed aggregate index with the ranking of areas by the number of days that short-term standards were exceeded. The geographic areas with the highest burden of long-term exposures are not, in all cases, the same as those with the most days that exceeded a short-term standard. We believe that an aggregate index of long-term air pollution offers an informative addition to the principal approaches currently used to describe air pollution exposures; further work on an aggregate index representing long-term exposure to air pollutants is warranted

A case of atypical disseminated herpes simplex virus 1 with hepatitis in a liver transplant recipient: the need for dermatologic evaluation

Disseminated herpes simplex virus (HSV) is mainly seen in immunocompromised individuals. Atypical lesions can be present in both primary infection and reactivation disease. Compared with the general population, inmunocompromised hosts are at greater risk of increased persistency and severity of clinical manifestations, including severe systemic involvement such as esophagitis, meningitis, and hepatitis. Herein, we report the case of a liver transplant recipient with atypical disseminated herpes simplex virus-1 complicated by HSV-related hepatitis. Dermatological consultation and histological assessment were crucial for a correct diagnosis and treatment

Kinetics of the neutralizing antibody response to respiratory syncytial virus infections in a birth cohort

The kinetics of respiratory syncytial virus (RSV) neutralizing antibodies following birth, primary and secondary infections are poorly defined. The aims of the study were to measure and compare neutralizing antibody responses at different time points in a birth cohort followed-up over three RSV epidemics. Rural Kenyan children, recruited at birth between 2002 and 2003, were monitored for RSV infection over three epidemic seasons. Cord and 3-monthly sera, and acute and convalescent sera following RSV infection, were assayed in 28 children by plaque reduction neutralization test (PRNT). Relative to the neutralizing antibody titers of pre-exposure control sera (1.8 log10 PRNT), antibody titers following primary infection were (i) no different in sera collected between 0 and 0.4 months post-infection (1.9 log10 PRNT, P = 0.146), (ii) higher in sera collected between 0.5 and 0.9 (2.8 log10 PRNT, P < 0.0001), 1.0–1.9 (2.5 log10 PRNT, P < 0.0001), and 2.0–2.9 (2.3 log10 PRNT, P < 0.001) months post-infection, and (iii) no different in sera collected at between 3.0 and 3.9 months post-infection (2.0 log10 PRNT, P = 0.052). The early serum neutralizing response to secondary infection (3.02 log10 PRNT) was significantly greater than the early primary response (1.9 log10 PRNT, P < 0.0001). Variation in population-level virus transmission corresponded with changes in the mean cohort-level neutralizing titers. It is concluded that following primary RSV infection the neutralizing antibody response declines to pre-infection levels rapidly (∼3 months) which may facilitate repeat infection. The kinetics of the aggregate levels of acquired antibody reflect seasonal RSV occurrence, age, and infection history

Aided by Adderall: Illicit Use of ADHD Medications by College Students

“I don’t know that many kids that have done coke, none that have tried crack, and only a few that have dropped acid. I can’t even count all of the ones who’ve taken Adderall” (Stice). This statement made in an interview by a freshman art history major at the University of Maryland, College Park, in 2007 effectively highlights a still growing problem among undergraduate students in the United States: the nonmedical use of stimulant medications prescribed to treat Attention Deficit Hyperactivity Disorder (ADHD) as “study aids.” Even as early as 2004, up to twenty percent of college students had used Adderall or Ritalin, both drugs used to treat ADHD, according to a report released by the National Center on Addiction and Substance Abuse (Stice). This phenomenon of abusing prescription stimulant medications is well-documented not only in research literature but also in numerous news articles. A 2009 NPR article documented the increasingly prevalent use of ADHD medications by college students to help them study and included commentary from Martha J. Farah, director at the Center for Cognitive Neuroscience at the University of Pennsylvania, who described the behavior as “worrisome” due to the drugs’ serious side effects and the potential for addiction (Trudeau). In 2012 The New York Times published just a small fraction of the submissions they received after inviting students to share personal accounts of taking prescription medications for academic purposes, and almost all of them were written by high school students or recent graduates (Schwartz). In 2016, CBS News published a story titled “Adderall misuse rising among young adults,” making it clear that this problem has not lessened in the decade or so that has passed since publication of the 2007 article describing the growing trend of “young people taking prescription drug abuse to college” (Kraft; Stice)

Aided by Adderall: Illicit Use of ADHD Medications by College Students

“I don’t know that many kids that have done coke, none that have tried crack, and only a few that have dropped acid. I can’t even count all of the ones who’ve taken Adderall” (Stice). This statement made in an interview by a freshman art history major at the University of Maryland, College Park, in 2007 effectively highlights a still growing problem among undergraduate students in the United States: the nonmedical use of stimulant medications prescribed to treat Attention Deficit Hyperactivity Disorder (ADHD) as “study aids.” Even as early as 2004, up to twenty percent of college students had used Adderall or Ritalin, both drugs used to treat ADHD, according to a report released by the National Center on Addiction and Substance Abuse (Stice). This phenomenon of abusing prescription stimulant medications is well-documented not only in research literature but also in numerous news articles. A 2009 NPR article documented the increasingly prevalent use of ADHD medications by college students to help them study and included commentary from Martha J. Farah, director at the Center for Cognitive Neuroscience at the University of Pennsylvania, who described the behavior as “worrisome” due to the drugs’ serious side effects and the potential for addiction (Trudeau). In 2012 The New York Times published just a small fraction of the submissions they received after inviting students to share personal accounts of taking prescription medications for academic purposes, and almost all of them were written by high school students or recent graduates (Schwartz). In 2016, CBS News published a story titled “Adderall misuse rising among young adults,” making it clear that this problem has not lessened in the decade or so that has passed since publication of the 2007 article describing the growing trend of “young people taking prescription drug abuse to college” (Kraft; Stice)