199 research outputs found
Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity.
- Author
- Aanensen David M
- Abudahab Khalil
- Acheson Erwan
- Adams Alexander
- Adams Helen
- Adriaenssens Evelien M
- Afifi Safiah
- Aggarwal Dinesh
- Ahmad Shazaad SY
- Alam Mohammad T
- Alcolea-Medina Adela
- Alderton Alex
- Alikhan Nabil-Fareed
- Allan John
- Allara Elias
- Amato Roberto
- Andersson Monique
- Angyal Adrienn
- Aranday-Cortes Elihu
- Ariani Cristina
- Asad Hibo
- Asamaphan Patawee
- Ashworth Jordan
- Atkinson Laura
- Attwood Stephen
- Auckland Cressida
- Awan Ali R
- Aydin Alp
- Baker David J
- Baker Paul
- Balcazar Carlos E
- Ball Jonathan
- Barton Edward
- Bashton Matthew
- Batra Rahul
- Baxter Laura
- Beale Mathew A
- Beaver Charlotte
- Beckett Angela
- Beer Robert
- Beggs Andrew
- Bell Andrew
- Bellis Katherine L
- Berger Duncan J
- Berriman Matt
- Berry Lisa
- Berry Louise
- Betancor Gilberto
- Betteridge Emma
- Bewshea Claire M
- Bibby David
- Bicknell Kelly
- Birchley Alec
- Bird Paul
- Bishop Chloe
- Blane Beth
- Bolt Frances
- Bonsall David
- Boswell Tim
- Bosworth Andrew
- Bourgeois Yann
- Boyd Olivia
- Boyes John
- Bradley Declan T
- Bradshaw Daniel
- Breen Cassie
- Bresner Catherine
- Breuer Judith
- Bridgewater Hannah E
- Brooks Tony T
- Broos Alice
- Brown Julianne Rose
- Brown Paul E
- Brown Rebecca
- Brunker Kirstyn
- Bucca Giselda
- Buck David
- Buddenborg Sarah K
- Bull Matthew
- Bull Matthew
- Burton-Fanning Shirelle
- Butcher Ethan
- Caddy Sarah L
- Caller Laura G
- Campbell Sharon
- Carlile Matthew
- Carmichael Stephen N
- Casey Anna
- Castellano Sergi
- Chalker Vicki
- Chand Meera
- Chapman Michael R
- Chappell Joseph G
- Charalampous Themoula
- Charles Ian G
- Chaudhry Yasmin
- Chauhan Anoop J
- Cheng Jeffrey KJ
- Churcher Carol M
- Clark Gemma
- Coll Francesc
- Collins Jennifer
- Colquhoun Rachel
- Colquhoun Rachel M
- Connor Thomas R
- Connor Thomas R
- Constantinidou Chrystala
- Coombes Jason
- Corden Sally
- Cormie Claire
- Cortes Nicholas
- Cortes Nick
- Cottrell Simon
- Coupland Lindsay J
- Cowell Angela
- Cox Alison
- Craine Noel
- Cronin Michelle
- Crooke Derrick
- Curran Martin D
- Curran Tanya
- da Silva Filipe Ana
- da Silva Filipe Ana
- Dabrera Gavin
- Danesh John
- Darby Alistair C
- Davidson Rose K
- Davies Alisha
- Davis Thomas
- de Cesare Mariateresa
- De Lacy Elen
- de Oliveira Martins Leonardo
- de Silva Thushan I
- Debebe Johnny
- Dervisevic Samir
- Dewar Rebecca
- Dias Joana
- Diaz Maria
- Dibling Thomas
- Dorman Matthew J
- Downing Fatima
- Drury Eleanor
- du Plessis Louis
- Duckworth Nichola
- Dyal Patricia L
- Eccles Richard
- Edgeworth Jonathan
- Edwards Sue
- Eldirdiri Sahar
- Ellaby Nicholas
- Ellard Sian
- Elliott Scott
- Eltringham Gary
- Elumogo Ngozi
- Essex Sarah
- Evans Cariad
- Evans Johnathan M
- Eyre David
- Fairley Derek J
- Fallon Karlie
- Farbos Audrey
- Farr Ben
- Feltwell Theresa
- Fina Laia
- Findlay Jacqueline
- Fisher Chloe L
- Fleming Vicki M
- Forrest Leysa M
- Forrest Sally
- Foulser Luke
- Francois Sarah
- Fraser Christophe
- Freeman Timothy M
- Frost Lucy R
- Fuller William
- Gallagher Eileen
- Gallagher Michael D
- Garcia-Casado Maria V
- Gaskin Amy
- Gatica-Wilcox Bree
- Gavriil Artemis
- Geidelberg Lily
- Geidelberg Lily
- Gemmell Matthew
- Georgana Iliana
- George Ryan P
- Gifford Laura
- Gilbert Lauren
- Gill Harmeet K
- Gilroy Rachel AJ
- Girgis Sophia T
- Glaysher Sharon
- Golubchik Tanya
- Goncalves Sonia
- Goodfellow Ian
- Goodfellow Ian G
- Goodwin Scott
- Graham Clive
- Graham Lee
- Grammatopoulos Dimitris
- Green Angie
- Green Luke R
- Greenaway Jane
- Gregory Richard
- Griffith Luke
- Groves Danielle C
- Groves Natalie
- Guest Martyn
- Gulliver Huw
- Gutierrez Ana Victoria
- Hadjirin Nazreen F
- Haldenby Sam T
- Hale Antony D
- Hall Grant
- Halstead Fenella
- Hamilton William L
- Haque Tanzina
- Harper Katherine L
- Harris Kathryn Ann
- Harrison Ewan M
- Harrison Ian
- Harrison James W
- Hartman Hassan
- Hattersley Andrew
- Heaney Judith
- Helmer Thomas
- Hesketh Andrew R
- Heyburn David
- Higginson Ellen E
- Hill Verity
- Hill Verity
- Hilvers Ember
- Hiscox Julian A
- Holden Matthew TG
- Holmes Alison
- Holmes Christopher
- Holmes Nadine
- Hoosdally Sarah
- Hopes Richard
- Hosmillo Myra
- Houldcroft Charlotte J
- Howe Robin
- Howson-Wells Hannah C
- Hubb Jonathan
- Hughes Joseph
- Hughes Margaret
- Hunter Adam D
- Hutchings Stephanie
- Impey Robert
- Irish-Tavares Dianne
- Iturriza-Gomara Miren
- Jackson Ben
- Jackson Ben
- Jackson David A
- Jackson David K
- Jackson Kathryn A
- Jahun Aminu S
- James Keith
- Jamrozy Dorota
- Jarrett Ruth
- Jeffries Aaron R
- Jesudason Natasha
- Jesudason Natasha G
- John Michaela
- Johnson Kate
- Johnson Natasha
- Johnson Rob
- Johnson Robert
- Johnston Ian
- Jones Hannah
- Jones Katie
- Jones Rachel
- Jones Sophie
- Jorgensen David
- Jorgensen David
- Joseph Amelia
- Justice Anita
- Kane Leanne
- Kay Gemma L
- Kay Sally
- Keatley Jon-Paul
- Keeley Alexander J
- Kenyon Anita
- Kermack Leanne M
- Khakh Manjinder
- Khokhar Fahad A
- Kidd Stephen
- Kingsley Robert A
- Kitchen Christine
- Knight Bridget A
- Kolyva Anastasia
- Koshy Cherian
- Kraemer Moritz
- Kristiansen Mark
- Kumziene-Summerhayes Sara
- Kwiatkowski Dominic
- Lackenby Angie
- Langford Cordelia
- Lawniczak Mara
- Le-Viet Thanh
- Lee David
- Lee Jack CD
- Letchford Laura
- Levene Nick
- Levett Lisa J
- Li Kathy
- Li Kathy K
- Liggett Steven
- Lindsey Benjamin B
- Lister Michelle M
- Livett Rich
- Lloyd Allyson
- Lo Stephanie
- Loh Joshua
- Loman Nicholas J
- Loman Nicholas J
- Loose Matthew W
- Loveson Katie F
- Lowe Hannah
- Lucaci Anita O
- Ludden Catherine
- Lynch Jessica
- Lyons Ronan A
- Macfarlane-Smith Louissa R
- Machin Nicholas W
- MacIntyre-Cockett George
- Madona Pinglawathee
- Maes Mailis
- Mahungu Tabitha W
- Mair Daniel
- Maksimovic Joshua
- Manesis Nikos
- Manley Robin
- Manso Carmen
- Marchbank Angela
- Martincorena Inigo
- Martinez-Nunez Rocio T
- Masoli Jane AH
- Mason Jenifer
- Mather Alison E
- Mbisa Tamyo
- McCluggage Kathryn
- McClure Patrick C
- McCrone John T
- McCrone JT
- McGuigan Samantha
- McHugh Martin P
- McKenna James P
- McKerr Caoimhe
- McMinn Liz
- McMurray Claire
- Meader Emma J
- Meadows Lizzie
- Menegazzo Mirko
- Meredith Luke W
- Merrick Ian
- Mestek-Boukhibar Lamia
- Miah Shahjahan
- Michell Stephen L
- Michelsen Michelle L
- Molnar Zoltan
- Monaghan Lynn
- Mookerjee Siddharth
- Moore Catherine
- Moore Catrin
- Moore Christopher
- Moore Nathan
- Morgan Mari
- Morgan Sian
- Mori Matilde
- Moses Samuel
- Muir Peter
- Munn Robert
- Myers Richard
- Nascimento Fabricia F
- Nascimento Fabricia F
- Naydenova Plamena
- Neaverson Alexandra S
- Nebbia Gaia
- Nelson Andrew
- Nelson Charlotte
- Nelson Rachel
- Nicholls Sam
- Nicholls Samuel M
- Nichols Jenna
- Niebel Marc O
- Niola Paola
- Nomikou Kyriaki
- O'Toole Elaine
- O'Toole Ăine
- Orton Richard J
- Osman Husam
- Ott Sascha
- OâGrady Justin
- OâToole Ăine
- Pacchiarini Nicole
- Pacchiarini Nicole
- Padgett Debra
- Page Andrew J
- Palmer Sophie
- Palmer Steve
- Panchbhaya Yasmin N
- Pandey Sarojini
- Park Naomi
- Parker Matthew D
- Parmar Surendra
- Parr Yasmin A
- Parsons Paul J
- Partridge David G
- Pascall David J
- Patel Gaurang
- Patel Minal
- Patel Vineet
- Paterson Steve
- Payne Brendan AI
- Peacock Sharon J
- Pearson Clare
- Perry Malorie
- Peto Timothy
- Pinckert Malte L
- Platt Steven
- Plimmer Amy
- Poplawski Radoslaw
- Potter Will
- Prakash Reenesh
- Prestwood Liam
- Price Anna
- Price Anna
- Price James
- Puethe Christoph
- Pybus Oliver
- Pybus Oliver G
- Pymont Hannah M
- Quail Mike
- Quick Joshua
- Raghwani Jayna
- Ragonnet-Cronin Manon
- Rainbow Lucille
- Rajatileka Shavanthi
- Rambaut Andrew
- Rambaut Andrew
- Ramsay Mary
- Randell Paul A
- Raviprakash Veena
- Raza Mohammad
- Resende Silva Paola C
- Rey Sara
- Rey Sara M
- Reynolds Nicola
- Richter Alex
- Robertson David L
- Robertson David L
- Robinson Esther
- Robinson Trevor I
- Robson Samuel C
- Rogers Hazel A
- Rooke Stefan
- Rowan Aileen
- Rowe Will
- Roy Sunando
- Rudder Steven
- Ruis Chris
- Ryan Felicity
- Sambles Christine M
- Sang Fei
- Scarlett Garry P
- Schaefer Ulf
- Scher Emily
- Scott Carol
- Scott Garren
- Sethi Dheeraj K
- Shaaban Sharif
- Shah Divya
- Shah Rajiv
- Shah Rajiv N
- Shankar Giri
- Shaw Robert
- Shepherd James
- Shepherd James G
- Sheriff Nicola
- Shirley Lesley
- Signell Adrian W
- Sillitoe John
- Simpson David A
- Singer Joshua B
- Sivaprakasam Venkat
- Siveroni Igor
- Siveroni Igor
- Sloan Tim J
- Sluga Graciela
- Smith Christen
- Smith Colin P
- Smith Darren L
- Smith Nikki
- Smith Wendy
- Smollett Katherine L
- Snell Luke B
- Souster Emily
- Southgate Joel
- Southgate Joel
- Spellman Karla
- Spencer-Chapman Michael
- Sridhar Sushmita
- Stanley Rachael
- Stanton Thomas D
- Starinskij Igor
- Stark Richard
- Stockton Joanne
- Stuart Claire
- Studholme David J
- Swindells Emma
- Swingler Tracey
- Taha Yusri
- Tang Julian
- Taylor Ben EW
- Taylor Graham P
- Taylor Sarah
- Taylor-Joyce Grace
- Tedim Ana P
- Temperton Ben
- Templeton Kate E
- Thompson Thomas
- Thomson Emma C
- Thomson Emma C
- Thomson Nicholas M
- Thornton Alicia
- Thurston Scott
- Todd John A
- Tong Lily
- Tonkin-Hill Gerry
- Torok M Estee
- Trebes Amy
- Trotter Alexander J
- Tsoleridis Theocharis
- Tucker Rachel M
- Turtle Lance
- Tutill Helena J
- Underwood Anthony P
- Unnikrishnan Meera
- Vamos Edith E
- Vasylyeva Tetyana
- Vattipally Sreenu
- Vipond Ian B
- Volz Erik
- Volz Erik M
- Wain John
- Walsh Sarah
- Wang Dennis
- Wantoch Michelle
- Warne Ben
- Warwick-Dugdale Joanna
- Wastenge Elizabeth
- Watkins Joanne
- Watts Joanne
- Waugh Sheila
- Webber Mark A
- Weeks Sam
- Weldon Danni
- Whitehead Mark
- Williams Charlotte A
- Williams Chris
- Williams David
- Williams Rachel J
- Williams Rebecca
- Williams Thomas
- Williamson Kathleen A
- Willingham Iona
- Wilson Harry D
- Wise Emma
- Workman Trudy
- Wright Victoria
- Wyles Matthew
- Wyllie Sarah
- Yakovleva Anna
- Yasir Muhammad
- Yeats Corin A
- Yew Wen C
- Young Gregory R
- Young Jamie
- Yu Xiaoyu
- Zarebski Alex
- Publication venue
- Cell
- Publication date
- 01/09/2020
- Field of study
Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G are suggestive of a selective advantage but may also be due to a random founder effect. We investigate the hypothesis for positive selection of spike D614G in the United Kingdom using more than 25,000 whole genome SARS-CoV-2 sequences. Despite the availability of a large dataset, well represented by both spike 614 variants, not all approaches showed a conclusive signal of positive selection. Population genetic analysis indicates that 614G increases in frequency relative to 614D in a manner consistent with a selective advantage. We do not find any indication that patients infected with the spike 614G variant have higher COVID-19 mortality or clinical severity, but 614G is associated with higher viral load and younger age of patients. Significant differences in growth and size of 614G phylogenetic clusters indicate a need for continued study of this variant
Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity
- Author
- Aanensen David M.
- Abudahab Khalil
- Acheson Erwan
- Adams Alexander
- Adams Helen
- Adriaenssens Evelien M.
- Afifi Safiah
- Aggarwal Dinesh
- Ahmad Shazaad S.Y.
- Alam Mohammad T.
- Alcolea-Medina Adela
- Alderton Alex
- Alikhan Nabil-Fareed
- Allan John
- Allara Elias
- Amato Roberto
- Andersson Monique
- Angyal Adrienn
- Aranday-Cortes Elihu
- Ariani Cristina
- Asad Hibo
- Asamaphan Patawee
- Ashworth Jordan
- Atkinson Laura
- Attwood Stephen
- Auckland Cressida
- Awan Ali R.
- Aydin Alp
- Baker David J.
- Baker Paul
- Balcazar Carlos E.
- Ball Jonathan
- Barton Edward
- Bashton Matthew
- Batra Rahul
- Baxter Laura
- Beale Mathew A.
- Beaver Charlotte
- Beckett Angela
- Beer Robert
- Beggs Andrew
- Bell Andrew
- Bellis Katherine L.
- Berger Duncan J.
- Berriman Matt
- Berry Lisa
- Berry Louise
- Betancor Gilberto
- Betteridge Emma
- Bewshea Claire M.
- Bibby David
- Bicknell Kelly
- Birchley Alec
- Bird Paul
- Bishop Chloe
- Blane Beth
- Bolt Frances
- Bonsall David
- Boswell Tim
- Bosworth Andrew
- Bourgeois Yann
- Boyd Olivia
- Boyes John
- Bradley Declan T.
- Bradshaw Daniel
- Breen Cassie
- Bresner Catherine
- Breuer Judith
- Bridgewater Hannah E.
- Brooks Tony T.
- Broos Alice
- Brown Julianne Rose
- Brown Paul E.
- Brown Rebecca
- Brunker Kirstyn
- Bucca Giselda
- Buck David
- Buddenborg Sarah K.
- Bull Matthew
- Bull Matthew
- Burton-Fanning Shirelle
- Butcher Ethan
- Caddy Sarah L.
- Caller Laura G.
- Campbell Sharon
- Carlile Matthew
- Carmichael Stephen N.
- Casey Anna
- Castellano Sergi
- Chalker Vicki
- Chand Meera
- Chapman Michael R.
- Chappell Joseph G.
- Charalampous Themoula
- Charles Ian G.
- Chaudhry Yasmin
- Chauhan Anoop J.
- Cheng Jeffrey K.J.
- Churcher Carol M.
- Clark Gemma
- Coll Francesc
- Collins Jennifer
- Colquhoun Rachel
- Colquhoun Rachel M.
- Connor Thomas R.
- Connor Thomas R.
- Constantinidou Chrystala
- Coombes Jason
- Corden Sally
- Cormie Claire
- Cortes Nicholas
- Cortes Nick
- Cottrell Simon
- Coupland Lindsay J.
- Cowell Angela
- Cox Alison
- Craine Noel
- Cronin Michelle
- Crooke Derrick
- Curran Martin D.
- Curran Tanya
- da Silva Filipe Ana
- da Silva Filipe Ana
- Dabrera Gavin
- Danesh John
- Darby Alistair C.
- Davidson Rose K.
- Davies Alisha
- Davis Thomas
- de Cesare Mariateresa
- De Lacy Elen
- de Oliveira Martins Leonardo
- de Silva Thushan I.
- Debebe Johnny
- Dervisevic Samir
- Dewar Rebecca
- Dias Joana
- Diaz Maria
- Dibling Thomas
- Dorman Matthew J.
- Downing Fatima
- Drury Eleanor
- du Plessis Louis
- Duckworth Nichola
- Dyal Patricia L.
- Eccles Richard
- Edgeworth Jonathan
- Edwards Sue
- Eldirdiri Sahar
- Ellaby Nicholas
- Ellard Sian
- Elliott Scott
- Eltringham Gary
- Elumogo Ngozi
- Essex Sarah
- Evans Cariad
- Evans Johnathan M.
- Eyre David
- Fairley Derek J.
- Fallon Karlie
- Farbos Audrey
- Farr Ben
- Feltwell Theresa
- Fina Laia
- Findlay Jacqueline
- Fisher Chloe L.
- Fleming Vicki M.
- Forrest Leysa M.
- Forrest Sally
- Foulser Luke
- Francois Sarah
- Fraser Christophe
- Freeman Timothy M.
- Frost Lucy R.
- Fuller William
- Gallagher Eileen
- Gallagher Michael D.
- Garcia-Casado Maria V.
- Gaskin Amy
- Gatica-Wilcox Bree
- Gavriil Artemis
- Geidelberg Lily
- Geidelberg Lily
- Gemmell Matthew
- Georgana Iliana
- George Ryan P.
- Gifford Laura
- Gilbert Lauren
- Gill Harmeet K.
- Gilroy Rachel A.J.
- Girgis Sophia T.
- Glaysher Sharon
- Golubchik Tanya
- Goncalves Sonia
- Goodfellow Ian
- Goodfellow Ian G.
- Goodwin Scott
- Graham Clive
- Graham Lee
- Gramatopoulos Dimitris
- Green Angie
- Green Luke R.
- Greenaway Jane
- Gregory Richard
- Griffith Luke
- Groves Danielle C.
- Groves Natalie
- Guest Martyn
- Gulliver Huw
- Gutierrez Ana Victoria
- Hadjirin Nazreen F.
- Haldenby Sam T.
- Hale Antony D.
- Hall Grant
- Halstead Fenella
- Hamilton William L.
- Haque Tanzina
- Harper Katherine L.
- Harris Kathryn Ann
- Harrison Ewan M.
- Harrison Ian
- Harrison James W.
- Hartman Hassan
- Hattersley Andrew
- Heaney Judith
- Helmer Thomas
- Hesketh Andrew R.
- Heyburn David
- Higginson Ellen E.
- Hill Verity
- Hill Verity
- Hilvers Ember
- Hiscox Julian A.
- Holden Matthew T.G.
- Holmes Alison
- Holmes Christopher
- Holmes Nadine
- Hoosdally Sarah
- Hopes Richard
- Hosmillo Myra
- Houldcroft Charlotte J.
- Howe Robin
- Howson-Wells Hannah C.
- Hubb Jonathan
- Hughes Joseph
- Hughes Margaret
- Hunter Adam D.
- Hutchings Stephanie
- Impey Robert
- Irish-Tavares Dianne
- Iturriza-Gomara Miren
- Jackson Ben
- Jackson Ben
- Jackson David A.
- Jackson David K.
- Jackson Kathryn A.
- Jahun Aminu S.
- James Keith
- Jamrozy Dorota
- Jarrett Ruth
- Jeffries Aaron R.
- Jesudason Natasha
- Jesudason Natasha G.
- John Michaela
- Johnson Kate
- Johnson Natasha
- Johnson Rob
- Johnson Robert
- Johnston Ian
- Jones Hannah
- Jones Katie
- Jones Rachel
- Jones Sophie
- Jorgensen David
- Jorgensen David
- Joseph Amelia
- Justice Anita
- Kane Leanne
- Kay Gemma L.
- Kay Sally
- Keatley Jon-Paul
- Keeley Alexander J.
- Kenyon Anita
- Kermack Leanne M.
- Khakh Manjinder
- Khokhar Fahad A.
- Kidd Stephen
- Kingsley Robert A.
- Kitchen Christine
- Knight Bridget A.
- Kolyva Anastasia
- Koshy Cherian
- Kraemer Moritz
- Kristiansen Mark
- Kumziene-Summerhayes Sara
- Kwiatkowski Dominic
- Lackenby Angie
- Langford Cordelia
- Lawniczak Mara
- Le-Viet Thanh
- Lee David
- Lee Jack C.D.
- Letchford Laura
- Levene Nick
- Levett Lisa J.
- Li Kathy
- Li Kathy K.
- Liggett Steven
- Lindsey Benjamin B.
- Lister Michelle M.
- Livett Rich
- Lloyd Allyson
- Lo Stephanie
- Loh Joshua
- Loman Nicholas J.
- Loman Nicholas J.
- Loose Matthew W.
- Loveson Katie F.
- Lowe Hannah
- Lucaci Anita O.
- Ludden Catherine
- Lynch Jessica
- Lyons Ronan A.
- Macfarlane-Smith Louissa R.
- Machin Nicholas W.
- MacIntyre-Cockett George
- Madona Pinglawathee
- Maes Mailis
- Mahungu Tabitha W.
- Mair Daniel
- Maksimovic Joshua
- Manesis Nikos
- Manley Robin
- Manso Carmen
- Marchbank Angela
- Martincorena Inigo
- Martinez-Nunez Rocio T.
- Masoli Jane A.H.
- Mason Jenifer
- Mather Alison E.
- Mbisa Tamyo
- McCluggage Kathryn
- McClure Patrick C.
- McCrone J.T.
- McCrone John T.
- McGuigan Samantha
- McHugh Martin P.
- McKenna James P.
- McKerr Caoimhe
- McMinn Liz
- McMurray Claire
- Meader Emma J.
- Meadows Lizzie
- Menegazzo Mirko
- Meredith Luke W.
- Merrick Ian
- Mestek-Boukhibar Lamia
- Miah Shahjahan
- Michell Stephen L.
- Michelsen Michelle L.
- Molnar Zoltan
- Monaghan Lynn
- Mookerjee Siddharth
- Moore Catherine
- Moore Catrin
- Moore Christopher
- Moore Nathan
- Morgan Mari
- Morgan Sian
- Mori Matilde
- Moses Samuel
- Muir Peter
- Munn Robert
- Myers Richard
- Nascimento Fabricia F.
- Nascimento Fabricia F.
- Naydenova Plamena
- Neaverson Alexandra S.
- Nebbia Gaia
- Nelson Andrew
- Nelson Charlotte
- Nelson Rachel
- Nicholls Sam
- Nicholls Samuel M.
- Nichols Jenna
- Niebel Marc O.
- Niola Paola
- Nomikou Kyriaki
- O'Toole Elaine
- O'Toole Ăine
- Orton Richard J.
- Osman Husam
- Ott Sascha
- OâGrady Justin
- OâToole Ăine
- Pacchiarini Nicole
- Pacchiarini Nicole
- Padgett Debra
- Page Andrew J.
- Palmer Sophie
- Palmer Steve
- Panchbhaya Yasmin N.
- Pandey Sarojini
- Park Naomi
- Parker Matthew D.
- Parmar Surendra
- Parr Yasmin A.
- Parsons Paul J.
- Partridge David G.
- Pascall David J.
- Patel Gaurang
- Patel Minal
- Patel Vineet
- Paterson Steve
- Payne Brendan A.I.
- Peacock Sharon J.
- Pearson Clare
- Perry Malorie
- Peto Timothy
- Pinckert Malte L.
- Platt Steven
- Plimmer Amy
- Poplawski Radoslaw
- Potter Will
- Prakash Reenesh
- Prestwood Liam
- Price Anna
- Price Anna
- Price James
- Puethe Christoph
- Pybus Oliver
- Pybus Oliver G.
- Pymont Hannah M.
- Quail Mike
- Quick Joshua
- Raghwani Jayna
- Ragonnet-Cronin Manon
- Rainbow Lucille
- Rajatileka Shavanthi
- Rambaut Andrew
- Rambaut Andrew
- Ramsay Mary
- Randell Paul A.
- Raviprakash Veena
- Raza Mohammad
- Resende Silva Paola C.
- Rey Sara
- Rey Sara M.
- Reynolds Nicola
- Richter Alex
- Robertson David L.
- Robertson David L.
- Robinson Esther
- Robinson Trevor I.
- Robson Samuel C.
- Rogers Hazel A.
- Rooke Stefan
- Rowan Aileen
- Rowe Will
- Roy Sunando
- Rudder Steven
- Ruis Chris
- Ryan Felicity
- Sambles Christine M.
- Sang Fei
- Scarlett Garry P.
- Schaefer Ulf
- Scher Emily
- Scott Carol
- Scott Garren
- Sethi Dheeraj K.
- Shaaban Sharif
- Shah Divya
- Shah Rajiv
- Shah Rajiv N.
- Shankar Giri
- Shaw Robert
- Shepherd James
- Shepherd James G.
- Sheriff Nicola
- Shirley Lesley
- Signell Adrian W.
- Sillitoe John
- Simpson David A.
- Singer Joshua B.
- Sivaprakasam Venkat
- Siveroni Igor
- Siveroni Igor
- Sloan Tim J.
- Sluga Graciela
- Smith Christen
- Smith Colin P.
- Smith Darren
- Smith Nikki
- Smith Wendy
- Smollett Katherine L.
- Snell Luke B.
- Souster Emily
- Southgate Joel
- Southgate Joel
- Spellman Karla
- Spencer-Chapman Michael
- Sridhar Sushmita
- Stanley Rachael
- Stanton Thomas D.
- Starinskij Igor
- Stark Richard
- Stockton Joanne
- Stuart Claire
- Studholme David J.
- Swindells Emma
- Swingler Tracey
- Taha Yusri
- Tang Julian
- Taylor Ben E.W.
- Taylor Graham P.
- Taylor Sarah
- Taylor-Joyce Grace
- Tedim Ana P.
- Temperton Ben
- Templeton Kate E.
- Thompson Thomas
- Thomson Emma C.
- Thomson Emma C.
- Thomson Nicholas M.
- Thornton Alicia
- Thurston Scott
- Todd John A.
- Tong Lily
- Tonkin-Hill Gerry
- Torok M. Estee
- Trebes Amy
- Trotter Alexander J.
- Tsoleridis Theocharis
- Tucker Rachel M.
- Turtle Lance
- Tutill Helena J.
- Underwood Anthony P.
- Unnikrishnan Meera
- Vamos Edith E.
- Vasylyeva Tetyana
- Vattipally Sreenu
- Vipond Ian B.
- Volz Erik
- Volz Erik M.
- Wain John
- Walsh Sarah
- Wang Dennis
- Wantoch Michelle
- Warne Ben
- Warwick-Dugdale Joanna
- Wastenge Elizabeth
- Watkins Joanne
- Watts Joanne
- Waugh Sheila
- Webber Mark A.
- Weeks Sam
- Weldon Danni
- Whitehead Mark
- Williams Charlotte A.
- Williams Chris
- Williams David
- Williams Rachel J.
- Williams Rebecca
- Williams Thomas
- Williamson Kathleen A.
- Willingham Iona
- Wilson Harry D.
- Wise Emma
- Workman Trudy
- Wright Victoria
- Wyles Matthew
- Wyllie Sarah
- Yakovleva Anna
- Yasir Muhammad
- Yeats Corin A.
- Yew Wen C.
- Young Gregory R.
- Young Jamie
- Yu Xiaoyu
- Zarebski Alex
- Publication venue
- Elsevier
- Publication date
- 07/01/2021
- Field of study
Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G are suggestive of a selective advantage but may also be due to a random founder effect. We investigate the hypothesis for positive selection of spike D614G in the United Kingdom using more than 25,000 whole genome SARS-CoV-2 sequences. Despite the availability of a large dataset, well represented by both spike 614 variants, not all approaches showed a conclusive signal of positive selection. Population genetic analysis indicates that 614G increases in frequency relative to 614D in a manner consistent with a selective advantage. We do not find any indication that patients infected with the spike 614G variant have higher COVID-19 mortality or clinical severity, but 614G is associated with higher viral load and younger age of patients. Significant differences in growth and size of 614G phylogenetic clusters indicate a need for continued study of this variant
Observation of gravitational waves from the coalescence of a 2.5â4.5 Mâ compact object and a neutron star
- Author
- Abac Adrian
- Abbott R.
- Abouelfettouh I.
- Acernese F.
- Ackley Kendall
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Afif Ismail M.
- Agarwal Deepali
- Agathos Michalis
- Aghaei Abchouyeh Maryam
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akcay Sarp
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Al-Shammari S.
- Albanesi Simone
- Alex iandolo Guido
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Altin Paul
- Alvarez-Lopez Sofia
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Amra C.
- Ananyeva A.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés Vallejo Peña Sergio
- Andrés-Carcasona Marc
- Anglin J.
- Anne Bizouard Marie
- Ansoldi Stefano
- Antelis Javier M.
- Antier Sarah
- Antoni Ramis Vidal Felip
- Antonietta Palaia Maria
- Antonio Font Roda Jose
- Aoumi M.
- Appavuravther E. Z.
- Appert S.
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- Arai Koji
- Araya Akito
- Araya Melody
- Areeda Joseph
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- Arogeti Megan
- Aronson Scott
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- Assiduo M.
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- Astone Pia
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- Yamazaki Ryo
- Yan S.
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- Yasui H.
- Yeh S. -W.
- Yelikar A. B.
- Yin X.
- Yokoyama Jun'ichi
- Yokozawa T.
- Yoo Jooheon
- Yu Hang
- Yuan S.
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- Zhao Yue
- Zhao Yuhang
- Zheng Yanyan
- Zhong Haowen
- Zhou R.
- Zhu Xingjiang
- Zhu Zong-Hong
- Zimmerman Aaron
- Zucker M. E.
- Zweizig John
- ĂrpĂĄd Gergely LĂĄszlĂł
- ć ćæŹœ
- éœäžž éèĄ
- Publication venue
- Publication date
- 23/04/2024
- Field of study
Search for eccentric black hole coalescences during the third observing run of LIGO and Virgo
- Author
- Abac A. G.
- Abbott R.
- Abe H.
- Acernese F.
- Ackley Kendall
- Adamcewicz C.
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Adya V. B.
- Affeldt C.
- Afif Ismail M.
- Agarwal D.
- Agathos Michalis
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Albanesi S.
- Alberto Trani Alessandro
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Almualla M.
- Altin Paul
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Anand S.
- Ananyeva A.
- Andersen R.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés-Carcasona Marc
- Anne Bizouard Marie
- Ansoldi S.
- Antelis Javier M.
- Antier Sarah
- Antonio Font Roda Jose
- Aoumi M.
- Apostolatos T.
- Appavuravther E. Z.
- Appert S.
- Apple S. K.
- Arai Koji
- Araya Akito
- Araya Melody
- Areeda Joseph
- Arif Shaikh Md
- Aritomi Naoki
- Armato F.
- Arnaud Nicolas
- Arogeti Megan
- Aronson Scott
- Arun K. G.
- Ashton Gregory
- Aso Yoichi
- Assiduo M.
- Aston S. M.
- Astone Pia
- Aubin Florian
- Babak Stanislav
- Badalyan A.
- Badaracco Francesca
- Badger C.
- Bae Sangwook
- Bagnasco Stefano
- Bai Y.
- Baier Jeremy
- Bajpai Rishabh
- Baka T.
- Ball M.
- Ballardin G.
- Ballmer S. W.
- Baltus Grégory
- Banagiri Sharan
- Banerjee Biswajit
- Bankar Deepak
- Baral Pratyusava
- Barayoga J. C.
- Barber J.
- Barish B. C.
- Barker D.
- Barneo Pablo
- Barone Fabrizio
- Barr Bryan
- Barsotti Lisa
- Barsuglia Matteo
- Barta DĂĄniel
- Barthelmy S. D.
- Barton Mark Andrew
- Bartos I.
- Basak Soummyadip
- Basalaev Artem
- Bassiri Riccardo
- Basti Andrea
- Bawaj Mateusz
- Baxi P.
- Bayley Joseph
- Baylor Amanda
- Bazzan M.
- Bedakihale V. M.
- Beirnaert Freija
- Bejger MichaĆ
- Bell Angus
- Benedetto V.
- Beniwal D.
- Benoit William
- Bentley Joe
- Bera Sayantani
- Berbel Marina
- Bergamin Fabio
- Berger Beverly
- Bernuzzi Sebastiano
- Beroiz Martin
- Berry Christopher P. L.
- Bersanetti Diego
- Bertolini A.
- Betzwieser Joseph
- Beveridge Damon
- Bevins Nathaniel
- Bhandare R.
- Bhandari A. V.
- Bhardwaj Uddipta
- Bhatt R.
- Bhattacharjee Dripta
- Bhaumik Shubhagata
- Bianchi A.
- Bilenko I. A.
- Bilicki Maciej
- Billingsley GariLynn
- Binetti Alberto
- Bini Sophie
- Birnholtz Ofek
- Biscans S.
- Bischi M.
- Biscoveanu Andrea Sylvia
- Bisht A.
- Bitossi M.
- Blackburn Kent
- Blair C. D.
- Blair D. G.
- Bobba F.
- Bode Nina
- Bogaert G.
- Boileau Guillaume
- Boldrini Mattia
- Bolingbroke Georgia
- Bondarescu Ruxandra
- Bondu François
- Bonilla Carrasquel Edgard
- Bonilla G. S.
- Bonnand Romain
- Booker P.
- Boschi Valerio
- Bose S.
- Bossilkov V.
- Boudart Vincent
- Bozzi A.
- Boër M.
- Bradaschia C.
- Brady Patrick R.
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- LIETO ALBERTO. DI.
- LIGO Collaboration
- Lin Chien-Yu
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- Lin En-Tzu
- Lin F.
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- MORALES ESTER. RUIZ.
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- PACE SIBILLA. DI.
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- Ălvarez-LĂłpez S.
- ĂrpĂĄd Gergely LĂĄszlĂł
- ć ćæŹœ
- æčćšéź
- éœäžž éèĄ
- Publication venue
- Publication date
- 01/08/2023
- Field of study
Despite the growing number of confident binary black hole coalescences observed through gravitational waves so far, the astrophysical origin of these binaries remains uncertain. Orbital eccentricity is one of the clearest tracers of binary formation channels. Identifying binary eccentricity, however, remains challenging due to the limited availability of gravitational waveforms that include effects of eccentricity. Here, we present observational results for a waveform-independent search sensitive to eccentric black hole coalescences, covering the third observing run (O3) of the LIGO and Virgo detectors. We identified no new high-significance candidates beyond those that were already identified with searches focusing on quasi-circular binaries. We determine the sensitivity of our search to high-mass (total mass M>70 Mâ) binaries covering eccentricities up to 0.3 at 15 Hz orbital frequency, and use this to compare model predictions to search results. Assuming all detections are indeed quasi-circular, for our fiducial population model, we place an upper limit for the merger rate density of high-mass binaries with eccentricities 0<eâ€0.3 at 0.33 Gpcâ3 yrâ1 at 90\% confidence level
Ultralight vector dark matter search using data from the KAGRA O3GK run
- Author
- Abac A. G.
- Abbott R.
- Abe H.
- Abouelfettouh I.
- Acernese F.
- Ackley Kendall
- Adamcewicz Christian
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Adya V. B.
- Affeldt C.
- Afif Ismail M.
- Agarwal Deepali
- Agathos Michalis
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Al-Shammari S.
- Albanesi S.
- Alberto Trani Alessandro
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Altin Paul
- Alvarez-Lopez Sofia
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Amra C.
- Anand S.
- Ananyeva A.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
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- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés-Carcasona Marc
- Anglin J.
- Anne Bizouard Marie
- Ansoldi S.
- Antelis Javier M.
- Antier Sarah
- Antoni Ramis Vidal Felip
- Antonietta Palaia Maria
- Antonio Font Roda Jose
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- Armato F.
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- Arogeti Megan
- Aronson Scott
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- de rossi camilla
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- Yin X.
- Yokoyama Jun'ichi
- Yokozawa T.
- Yoo Jooheon
- Yu Hang
- Yuzurihara Hirotaka
- ZadroĆŒny A.
- Zahoor Jan Aasim
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- Zerrad M.
- Zevin Michael
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- Zhao Yue
- Zhao Yuhang
- Zheng Yanyan
- Zhong Haowen
- Zhong S.
- Zhou R.
- Zhu Zong-Hong
- Zucker M. E.
- Zweizig John
- ĂrpĂĄd Gergely LĂĄszlĂł
- ć ćæŹœ
- æčćšéź
- éœäžž éèĄ
- Publication venue
- Publication date
- 01/03/2024
- Field of study
Among the various candidates for dark matter (DM), ultralight vector DM can be probed by laser interferometric gravitational wave detectors through the measurement of oscillating length changes in the arm cavities. In this context, KAGRA has a unique feature due to differing compositions of its mirrors, enhancing the signal of vector DM in the length change in the auxiliary channels. Here we present the result of a search for U(1)BâL gauge boson DM using the KAGRA data from auxiliary length channels during the first joint observation run together with GEO600. By applying our search pipeline, which takes into account the stochastic nature of ultralight DM, upper bounds on the coupling strength between the U(1)BâL gauge boson and ordinary matter are obtained for a range of DM masses. While our constraints are less stringent than those derived from previous experiments, this study demonstrates the applicability of our method to the lower-mass vector DM search, which is made difficult in this measurement by the short observation time compared to the auto-correlation time scale of DM
Search for gravitational-lensing signatures in the full third observing run of the LIGO-Virgo network
- Author
- Abbott R.
- Abe H.
- Acernese F.
- Ackley Kendall
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Adya V. B.
- Affeldt C.
- Agarwal D.
- Agathos Michalis
- Aguiar Odylio D.
- Aiello Lorenzo
- Ain A.
- Ajith Parameswaran
- Akutsu Tomotada
- Albanesi S.
- Alfaidi R. A.
- Allocca Annalisa
- Alléné C.
- Altin Paul
- Amato Alex
- Anand S.
- Ananyeva A.
- Anderson Stuart
- Anderson Warren G.
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés-Carcasona Marc
- Anne Bizouard Marie
- Ansoldi S.
- Antelis Javier M.
- Antier Sarah
- Antonio Font Roda Jose
- Apostolatos T.
- Appavuravther E. Z.
- Appert S.
- Apple S. K.
- Arai Koji
- Araya Akito
- Araya Melody
- Areeda Joseph
- Arif Shaikh Md
- Aritomi Naoki
- Arnaud Nicolas
- Arogeti M.
- Aronson S. M.
- ArĂšne M.
- Asada Hideki
- Ashton Gregory
- Aso Yoichi
- Assiduo M.
- Aston S. M.
- Astone Pia
- Aubin Florian
- Babak Stanislav
- Badaracco Francesca
- Badger C.
- Bae S.
- Bae Y.
- Bagnasco Stefano
- Bai Y.
- Baier J. G.
- Baird J.
- Bajpai Rishabh
- Baka T.
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- Ballardin G.
- Ballmer S. W.
- Baltus Grégory
- Banagiri Sharan
- Banerjee Biswajit
- Bankar Deepak
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- Weller Robert
- Wellmann F.
- Wen L.
- Wette Karl
- WeĂels P.
- Whelan John
- White D. D.
- Whiting Bernard F.
- Whittle Chris
- Wilk O. S.
- Wilken Dennis
- Williams C. E.
- Williams Daniel
- Williams Michael J.
- Williamson Andrew R.
- Willis Joshua
- Willke Benno
- Wipf C. C.
- Woan Graham
- Woehler J.
- Wofford Jared
- Wojtowicz I. A.
- Wong D.
- Wright M.
- Wu Chien-Ming
- Wu David S.
- Wu H.
- Wysocki Daniel
- Xiao Liting
- Yadav N.
- Yamada T.
- Yamamoto Hiroaki
- Yamamoto Kazuhiro
- Yamamoto Takahiro
- Yamashita K.
- Yamazaki R.
- Yang Fengwei
- Yang Kate Z.
- Yang Le
- Yang Y. -C.
- Yang Yang
- Yang Yi
- Yap M. J.
- Yeeles D. W.
- Yeh S. -W.
- Yelikar A. B.
- Yokoyama Jun'ichi
- Yokozawa T.
- Yoo Jooheon
- Yoshioka T.
- Yu Hang
- Yu Haocun
- Yuzurihara H.
- ZadroĆŒny A.
- Zahoor Jan Aasim
- Zanolin M.
- Zeidler Simon
- Zelenova T.
- Zendri J. -P.
- Zevin Michael
- Zhan M.
- Zhang H.
- Zhang Jue
- Zhang L.
- Zhang Rui
- Zhang T.
- Zhang Y.
- Zhao C.
- Zhao G.
- Zhao Yue
- Zhao Yuhang
- Zheng Yanyan
- Zhou R.
- Zhu Xingjiang
- Zhu Zong-Hong
- Zimmerman Aaron
- Zucker M. E.
- ĂrpĂĄd Gergely LĂĄszlĂł
- ć ćæŹœ
- æčćšéź
- çè°š
- éœäžž éèĄ
- Publication venue
- Publication date
- 01/04/2023
- Field of study
Gravitational lensing by massive objects along the line of sight to the source causes distortions of gravitational wave-signals; such distortions may reveal information about fundamental physics, cosmology and astrophysics. In this work, we have extended the search for lensing signatures to all binary black hole events from the third observing run of the LIGO--Virgo network. We search for repeated signals from strong lensing by 1) performing targeted searches for subthreshold signals, 2) calculating the degree of overlap amongst the intrinsic parameters and sky location of pairs of signals, 3) comparing the similarities of the spectrograms amongst pairs of signals, and 4) performing dual-signal Bayesian analysis that takes into account selection effects and astrophysical knowledge. We also search for distortions to the gravitational waveform caused by 1) frequency-independent phase shifts in strongly lensed images, and 2) frequency-dependent modulation of the amplitude and phase due to point masses. None of these searches yields significant evidence for lensing. Finally, we use the non-detection of gravitational-wave lensing to constrain the lensing rate based on the latest merger-rate estimates and the fraction of dark matter composed of compact objects
Proceedings of the Virtual 3rd UK Implementation Science Research Conference : Virtual conference. 16 and 17 July 2020.
- Author
- Abroms Lorien
- Adriaanse MC
- Ahuja Shalini
- Ahuja Shalini
- Allaham Shereen
- Allan Louise
- Amato Michael
- Amiel Stephanie
- Amiel Stephanie
- Andleeb Humma
- ASPIRES study coinvestigators
- Bailey Maria
- Bakolis Ioannis
- Bakolis Ioannis
- Bakolis Ioannis
- Balayah Zuhur
- Barker Nicki
- Batura Neha
- Bawab Noura
- Bell Jack
- Belton Emma
- Benbow N
- Benbow Nanette
- Bergin Aislinn
- Best Stephani
- Bestwick Harry
- Bhatti Faheem
- Bidwell Posy
- Binagwaho Agnes
- Birgand Gabriel
- Birgand Gabriel
- Brady Sarah
- Braithwaite Jeffrey
- Brandt HE
- Bright Sophie
- Brima Nataliya
- Briscoe Simon
- Brooks Augustin
- Brooks Augustin
- Brown Sue
- Brown Tracey
- Bugnon Olivier
- Calnan Susan
- Campos Rosana Teresa Onocko
- Carey Eileen
- Carrieri Daniele
- Carter A
- Carter Andrea
- Chan Priscilla
- Charani Esmita
- Charnley Karen
- Coffey Alice
- Colbourn T
- Connelly M
- Corrado Ann Marie
- Corrado Ann Marie
- Coumoundouros Chelsea
- Dalal Hasnain
- Daoh K
- Davies Benjamin M
- Davies Justine
- Daw Paulina
- Deen B
- Doherty Patrick J
- Donnelly Patricia
- dos Santos Treichel Carlos Alberto
- Drown Laura
- Drysdale R
- Durham Rory
- Dwane Jackie
- Edwards Chanel
- El-Toukhy Sherine
- Elena Pallari
- Elmas Kai
- Elphick Heather
- Erwin Jo
- Ferraris Giulia
- Finch Tracy
- Flanagan Helen
- Flannery Caragh
- Franklin Sue
- Frisch Miriam F
- Gibney A
- Gibney Amber
- Gilmour Jenny
- Godwin Gregory
- Goodfellow Henry
- Goodhart Venetia
- Greaves Colin J
- Green James SA
- Grimshaw Jeremy
- Grodzinski Ben
- Gul Hossai
- Gurol-Urganci Ipek
- Hallett R
- Hanlon C
- Hanlon C
- Harrison Alexander
- Hayward Andrew
- Healey Andy
- Healey Andy
- Healey Andy
- Heller Simon
- Heller Simon
- Heys Michelle
- Hirschhorn Lisa R
- Hogden Emily
- Hogervorst S
- Holmes Alison
- Holmes Alison
- Hugtenburg JG
- Hull Louise
- Hull Louise
- Hurley M
- Hurley Mike
- Iliopoulou Katerina
- Irish Carol
- Irwin Sally
- Issa Sattu
- Ivers Noah
- Ivers Noah
- Jackson Mark
- Jeays-Ward Katherine
- Jones J
- Jopling Helena
- Jurczuk Magdalena
- Kamara TB
- Karim Yasmin Bou
- Kariyawasam Dulmini
- Kariyawasam Dulmini
- Keiser Brennan
- Keohane Aoife
- Khadjesari Zarnie
- Khadjesari Zarnie
- Khan Maaz
- Khan Sobia
- Khan Sobia
- Kolehmainen Niina
- Lakhanpaul Monica
- Laur Celia
- Leather Andrew
- Leather Andrew
- Leather Andrew
- Leather Andrew JM
- Lewis Caitlin
- Li Dennis H
- Li DH
- Llewellyn Clare
- Long Janet
- Macapagal K
- Madkins K
- Makusha T
- Manikam Logan
- Marques Iuri
- Martin Jennifer
- Mattick Karen
- McCarthy Avril
- McCluskey Jessica
- McDonagh Sinead TJ
- McHugh Sheena
- Medlinskiene Kristina
- Mendelson Marc
- Meskell Pauline
- Metherall Pete
- Mongrella Melissa
- Moore Julia E
- Moore Julia E
- Morrow April
- Moullin Joanna C
- Mowforth Oliver
- Murdoch J
- Murphy Carol-Anne
- Mustanski B
- Mustanski Brian
- MĂ„rtensson Erika
- Nathan Paul C
- Nkurunziza Dieudonné
- Ntawukuriryayo Jovial Thomas
- On behalf of AO Spine RECODE-DCM Consortia
- on behalf of co-investigators of ASPIRES
- OâDoherty Jane
- OâMeara Daly Eoin
- OâReilly Martina
- OâReilly Valerie
- Papoutsi Chrysanthi
- Partha-Sarathi Celine
- Payne Cathy
- Pearson Mark
- Peiffer-Smadja Nathan
- Peiffer-Smadja Nathan
- People with Diabetes Group
- People with Diabetes Group
- Perraudin Clémence
- Petty Duncan
- Peven Kimberly
- Pranav V
- Prince M
- Ramsey Alex
- Rapport Frances
- Read Heath
- Redmond Sean
- Remble Thomas
- Richardson Susan
- Richter L
- Ridout Alexandra
- Robotham Dan
- Rushton Alita
- Sam Betty
- Sandall Jane
- Sanderman Robbert
- Sevdalis N
- Sevdalis N
- Sevdalis Nick
- Sevdalis Nick
- Sevdalis Nick
- Sevdalis Nick
- Sevdalis Nick
- Sevdalis Nick
- Sevdalis Nick
- Sevdalis Nick
- Seward N
- Seward N
- Shah Nida
- Sheldon H
- Shennan Andrew
- Shuldiner Jennifer
- Sibley Fay
- Silverton Louise
- Singh Sanjeev
- Singh Sanjeev
- Slemming W
- Smith Emma
- Smith JD
- Smith JD
- Soukup Tayana
- Soukup Tayana
- Striling Katherine
- Sykes Michael
- Taylor Natalie
- Taylor Rod S
- Teh Jye Quan
- Thakar Ranee
- Thomson Richard
- To Wilson
- Tomlinson Justine
- Udoh Kelechi
- Van Der Meulen Jan
- van Dijk L
- van Zanten Jet Veldhuijzen
- VanderZanden Amy
- Venkatapuram S
- Vervloet M
- Villamar Juan
- von Essen Louise
- Webb-Martin Kelley
- White Michelle
- White Michelle C
- Willox Matt
- Wolstenholme Daniel
- Wong Geoff
- Woodford Joanne
- Wurie H
- Xyrichis Andreas
- Publication venue
- Implement Sci
- Publication date
- 17/07/2020
- Field of study
31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two
- Author
- Abassi Yama
- Abelin Jennifer G
- Abolhalaj Milad
- Abraham Tara S
- Adam Ammar
- Adams David
- Adams Homer
- Adams Sarah F
- Adamus Tomasz
- Addepalli Murali
- Addepalli Murali
- Adjei Alex A
- Agapova Larissa
- Agarwala Sanjiv
- Ager Casey
- Aggarwal Charu
- Agnello Giulia
- Agudo Judith
- Aguilar Ethan G
- Aguilera Todd
- Ahamadi Malidi
- Ahn Yong-Oon
- Ahrens Eric T
- Aizer Ayal
- Ajina Reham
- Akerley Wallace
- Al-Muftah Mariam
- Albershardt Tina C
- Albershardt Tina C
- Albrekt Ann-Sofie
- Alekar Shilpa
- Alemany Ramon
- Alemany Ramon
- Alexander Brian
- Allbritton Omaira
- Allen Clint T
- Alley Evan W
- Allison James
- Allison James
- Allison James
- Alston Tesha
- Alt JĂŒrgen
- Alters Susan
- Amatulli Michael
- Anand Snjezana
- Anand Snjezana
- Anand Snjezana
- Anderson Clark
- Anderson Mark
- Andersson Bengt
- Andre Pascale
- Andtbacka Robert H I
- Andtbacka Robert H I
- Angiuoli Sam
- Ansari Tameem
- Anthony Scott
- Antonarakis Emmanuel S
- Antonia Scott J
- Anwar Firoz
- Aquino-Michaels Keston
- Archer Jacob F
- Arina Ainhoa
- Armand Philippe
- Armenta Paul
- Armet Caroline M
- Arnoux Thomas
- Ascarateil Stephane
- Askmyr David
- Atkins Michael
- Atkins Michael B
- Atkinson Victoria
- Au Katrina
- Autio Karen A
- Awad Mark
- Bagarazzi Mark
- Bai Dina
- Baia Gilson
- Baird Jason
- Bajaj Anshika
- Balatoni Timea
- Balboni Tracy
- Balch Leslie
- Bang Andrew
- Bao Riyue
- Bao Yangyi
- Bao Yangyi
- Barakat David
- Barberi Theresa
- Barker Christopher A
- Barnea Eytan
- Barras David
- Bartkowiak Todd
- Bartlett David
- Bartlett David
- Bartlett David
- Bartlett David
- Barton Sunjay M
- Barve Minal
- Bauer Todd
- Bauer Todd W
- Bauman Julie
- Baumgaertner Petra
- Bauml Joshua
- Beceren-Braun Figen
- Beck Kristen
- Becker Annette
- Beckers Johannes
- Beckett Michael A
- Bedognetti Davide
- Bedognetti Davide
- Bedognetti Davide
- Bell Bryan
- Bell Charles J M
- Bell Peter
- Beltran Pedro
- Bender Lewis H
- Bender Steven
- Bennett Mark K
- Benz Steven
- Bera Tapan
- Berglund Peter
- Berglund Peter
- Berkey Sara
- Bernatchez Chantale
- Berry John S
- Berzofsky Jay A
- Bhardwaj Nina
- Bian Zhen
- Bianco Alberto
- Biediger Ronald J
- Bifulco Carlo
- Bigley Alison
- Bingham Patrick
- Biniszkiewicz Detlev M
- Bischoff Helge
- Blake Zoe
- Blake Zoe
- Blakely Collin
- Blazar Bruce R
- Blogowski Wojciech
- Bloom Anja C
- Boehm Jesse
- Bokovanov Vladimir
- Bommareddy Praveen K
- Bommareddy Praveen K
- Bommareddy Praveen K
- Bommareddy Praveen K
- Booth Jamie
- Bornschlegl Svetlana
- Bose Nandita
- Bossenmaier Birgit
- Boughorbel Sabri
- Boyer Jean
- Bramante Simona
- Branstetter Daniel
- Brech Dorothee
- Brenin David
- Broaddus V. C
- Brockstedt Dirk G
- Brockstedt Dirk G
- Brody Joshua
- Bronson Roderick
- Brooks Alan
- Brooks Alan D
- Broucek Joseph
- Brown Alice
- Brown Brian
- Brown Brittany
- Brown Gail L
- Brown Sheila
- Bruce Jeffrey N
- Brunet Laura R
- Bruno Tullia C
- Bryan Jennifer
- Bryant Richard
- Buchbinder Elizabeth
- Bucsek Mark
- Budhu Sadna
- Budhu Sadna
- Budkowska Marta
- Bueno Raphael
- Buettner Florian
- Buettner Nico
- Bullock Kim
- Bullock Kim
- Burova Elena
- Burrill Joel
- Bussler Holm
- Butterfield Lisa H
- Butterfield Lisa H
- Byrne-Steele Miranda
- Cagney Daniel
- Calderon Hugo
- Callahan Margaret K
- Campesato Luis F
- Campogan Dwayne
- Cao Felicia
- Capasso Cristian
- Capasso Cristian
- Caplazi Patrick
- Cappuccini Federica
- Carcaboso Angel M
- Carlino Matteo S
- Carpi Sara
- Carrasco Ruben
- Carrera Diego A
- Carrero Rosa M S
- Carson Dennis A
- Castellini Laura
- Cathomas Richard
- Cauvin Annick
- Cauwenberghs Sandra
- Caux Christophe
- Cebon Jonathan S
- Ceccarelli Michele
- Celis Esteban
- Cerignoli Fabio
- Cerullo Vincenzo
- Cerullo Vincenzo
- Cervera-CarrascĂłn VĂctor
- Cesareni Gianni
- Cha John
- Cha John
- Cha John
- Champion Brian
- Chan Anissa S H
- Chan Chanty
- Chan Chanty
- Chan Ivan
- Chan Leo
- Chan Timothy A
- Chang Alfred E
- Chang Alfred E
- Chang Joe
- Chang Nancy N
- Chang Thomas
- Chanuc Fabien
- Chapelin Fanny
- Chaplin Jenny
- Chappel Scott C
- Charych Deborah H
- Charych Deborah H
- Chaudhuri Amitabha
- Chaussabel Damien
- Chen Ada
- Chen Ada
- Chen Gang
- Chen Jason
- Chen Jason
- Chen Xiaomu
- Chen Xin
- Chen Xiufen
- Chen Yu
- Chen Yu
- Chenchik Alex
- Chheda Zinal
- Chiang Eugene
- Chikina Maria
- Chittenden Thomas
- Chiu Hsiling
- Cho Charles
- Chongyung Fang
- Chou Margaret
- Choueiri Toni K
- Choy Carmen
- Clark Joseph I
- Clavijo Paul E
- Clifton Guy T
- Clynes Raphael
- Cobbold Mark
- Cobbold Mark
- Cobbold Mark
- Coder Brandon
- Coffman Robert L
- Cohen Cyrille
- Cohen Ezra E W
- Cohen Roger
- Colen Rivka
- Colevas A. D
- Collins Natalie
- Colrain Jillian
- Coltharp Carla
- Concha-Benavente Fernando
- Connolly Eileen P
- Conwell Darwin
- Conwell Darwin
- Corrales Leticia P
- Corrales Leticia P
- Coukos George
- Coukos George
- Coussens Lisa M
- Coussens Lisa M
- Craggs Graham
- Craig Andrew
- Crittenden Marka
- Cron Kyle R
- Cronstein Bruce N
- Crooks James
- Crosby Andrea
- Crosignani Stefano
- Crowder Robert
- Cruickshank Scott
- Csuka Orsolya
- Curbishley Stuart
- Curiel Tyler
- Curran Emily
- Curran Michael
- Curti Brendan
- Curti Brendan
- Da Costa Andre
- Dai Fu
- Dai Jie
- Dai Peihong
- Dalgleish Angus
- Dalvie Deepak
- Daniels Gregory A
- Daud Adil
- David Justin M
- Davies Bronwyn
- de Boisferon Marc H
- de Groot Patricia
- de Gruijl Tanja
- De Henau Olivier
- de Leon Laura
- De Maeseneire Coraline
- De Sanctis Francesco
- de Silva Suresh
- Deacon Donna
- Deacon Donna H
- DeBenedette Mark
- DeBenedette Mark
- Declerck Paul
- Decock Julie
- Decock Julie
- DeFalco Jeff
- Dela Cruz Filemon
- Delgoffe Greg
- Delgoffe Greg M
- Delgoffe Greg M
- Delgoffe Greg M
- Delogu Lucia
- Delorenzi Mauro
- Demaria Sandra
- Demaria Sandra
- Deng Liang
- Deng Weiwen
- Deng Wentao
- Denies Sofie
- Denis Caroline
- Desbien Anthony L
- deVries Michele
- Dhupkar Pooja
- Diab Adi
- Diab Adi
- Diab Adi
- Diaz Luis
- DiCostanzo AriCeli
- Diede Scott J
- Dietz Allan B
- Dillhoff Mary
- Dillon Patrick
- Dilworth Ryan
- Dimberg Anna
- Ding Yueyun
- Doberstein Stephen K
- Dobkin Julie
- Doener Fatma
- Dolegowska Barbara
- Doleschall Zoltan
- Doman Thompson
- Dominguez George
- Donahue Renee
- Donahue Renee
- Dorsey Frank C
- Dovedi Simon
- Downs-Canner Stephanie
- Drake Charles
- Drake Charles G
- Drake Charles G
- Driessens Gregory
- Driscoll Kyla
- Druker Brian J
- Dubensky Thomas W
- Dubensky Thomas W
- Dudimah Duafalia
- Duff Susan
- Dumontet Charles
- Dunai Cordelia
- Dunai Cordelia
- Dutcher Janice P
- Duttagupta Priyanka
- Duvvuri Uma
- Dyson Mike
- DâApuzzo Massimo
- Ebner Peggy
- Edwards Robert
- Edwards Robert P
- Edwards Robert P
- Eickhoff Jens
- Eisenhower Mary
- El Alaoui Meddy
- El Alaoui Said
- Eles Klara
- Ellies Lesley
- Elnaggar Omar
- Elvecrog James
- Emberley Ethan
- Emerling Daniel
- Eng Charis
- Engelhard Victor H
- English Jessie
- Enstrom Amanda
- Eremeev Artem
- Eriksson Emma
- Eriksson Emma
- Eriksson Emma
- Ertelt Kathleen
- Eswarappa Rajesh
- Evans Elizabeth
- Evans Kathy
- Facciabene Andrea
- Facciabene Andrea
- Facciabene Andrea
- Facciponte John
- Facciponte John
- Falchook Gerald
- Fantini Massimo
- Fantini Massimo
- Fantini Massimo
- Farkas Emil
- Farren Matthew
- Faustman Denise
- Faâak Faisal
- Faâak Faisal
- Femel Julia
- Feng JunLi
- Feng Yan
- Feng Zipei
- Feola Sara
- Fernandez Christian
- Fernando Ingrid
- Ferris Robert L
- Ferris Robert L
- Ferris Robert L
- Ferris Robert L
- Fesenkova Valentyna
- Field Jessica J
- Fisher Kerry
- Fisher Terry
- Fitzharris Bernie
- Flano Emilio
- Flechtner Jessica B
- Flies Dallas B
- Flynn Patrick
- Fogler William
- Fong Lawrence
- Formenti Silvia C
- Formenti Silvia C
- Foster Cathie
- Foster Rosemary
- Fotin-Mleczek Mariola
- Fox Bernard
- Francica Brian
- Francis Julie-Ann
- Frangou Costa
- Franklin Marilyn
- Franklin Wilbur
- Frascaro Federica
- Fraser Kathryn
- Frederix Kim
- Freimark Bruce
- Freimark Bruce
- Freimark Bruce
- Frey Alan
- Fridman Leticia
- Friedman Alan
- Friedman David
- Fromm George
- FrĂŒh Martin
- Fu Yang-Xin
- Fu Yichun
- Fu Yichun
- Fuertes Marraco Silvia A
- Fugle Caroline W
- Fuhrmann Steven
- Fukaya Satoshi
- Fulton Noreen
- Fuoco Claudia
- Fusciello Manlio
- Fuseri Nicolas
- Gabitzsch Elizabeth
- Gabrail Nashat
- Gabrilovich Dmitry
- Gajewski Thomas
- Gajewski Thomas F
- Gajewski Thomas F
- Gajewski Thomas F
- Gajewski Thomas F
- Gajewski Thomas F
- Gajewski Thomas F
- Galeassi Nadejda
- Gamble Alicia
- Gamble Alicia
- Gameiro Sofia
- Gameiro Sofia R
- Gandhi Anita
- Gao Chan
- Gardai Shyra J
- Gardner Kellie
- Gartrell Robyn
- Gartrell Robyn
- Gartrell Robyn
- Gasmi Billel
- Gastineau Dennis A
- Gaughan Elizabeth
- Gauthier Audrey
- Gauthier Kelsey S
- Geissler Michael
- Gergel Ivan
- Geukens Nick
- Gfeller David
- Ghadially Hormas
- Ghamsari Lila
- Ghandi Leena
- Ghisoli Maurizio
- Giaccia Amato
- Gibney Geoffrey
- Giffin Louise
- Gillies Stephen D
- Giri Sanjeev
- Gladstone Douglas
- Glickman Laura H
- Gnad-Vogt Ulrike
- Godwin John
- Gomes Bruno
- Gong Jian
- Gong Jian
- Gonzales Rodney J M
- Gooding William
- Gooding William
- Goodman Reid
- Gopal Ajay
- Gordon Keith
- Gordon Nancy
- Gottschalk Stephen
- Gough Michael
- Gowda Nagaraj
- Goyal Sharad
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- Graves Edward
- Gray Michael
- Gray Michael
- Greasley Samantha
- Greenberg Norman
- Greiff Lennart
- Greiner John W
- Grenga Italia
- Grenga Italia
- Gressett Monica M
- Griesinger Frank
- Grigoryeva Olga
- Grigsby Iwen
- Grivas Petros
- Grogan Elizabeth W
- Grogan Jane
- Grose Mark
- Grose Mark
- Grose Mark
- Grosh William
- Gross Matt
- Gross Matt
- Grossenbacher Steven K
- Grossmann Kenneth
- Gruber Harry
- Gu Xuemin
- Guenther Garret
- Guerriero Jennifer
- Gugel Elena G
- Guiducci Cristina
- Guirado Elizabeth
- Gulley James L
- Gunatilaka Leslie A A
- Guo Jie
- Guo Zeng-qing
- Gupta Ravi
- Gupta Sachin
- Gupta Sumati
- Gustafson Michael P
- Gutierrez Andres A
- Guttridge Denis
- Guy Emily I
- Guzman Wilson
- Hagihara Katsunobu
- Hagner Patrick
- Hailemichael Yared
- Hailemichael Yared
- Haining W. N
- Hale Diane F
- Hall Gerald
- Hallmeyer Sigrun
- Hamdy Freddie
- Hammond Scott A
- Han Jian
- Han Yanyan
- Hank Jacquelyn A
- Hanks Brent A
- Hanson Bill
- Harari Paul M
- Harbell Michael
- Hardin Mark O
- Hardwick James
- Harrington Kevin
- Harris Jaryse
- Harris-Bookman Sarah
- Hart Philip
- Hasapidis Jeannette
- Hassan Raffit
- Havel Jonathan
- Havunen Riikka
- Havunen Riikka
- Hayashi Tomoko
- Haymaker Cara
- Haynes Heather
- Heinze Clinton
- Hellmann Matthew D
- Hellmann Matthew D
- Hellmann Matthew D
- Hellström Ann-Charlotte
- Helming Laura
- Hemmi Silvio
- Hemminki Akseli
- Hemminki Akseli
- Hemminki Otto
- Hendrickx Wouter
- Hendrickx Wouter
- Hendrickx Wouter
- Henrich Ian
- Heo Dae S
- Herbert Garth S
- Herbst Ronald
- Heron Dwight
- Herranz Mireia U
- Hess Kenneth R
- Heymach John
- Higuchi Tomoe
- Hilbe Wolfgang
- Hill Adrian
- Hill Andrew G
- Hill Jonathan A
- Hillringhaus Lars
- Hipp Madeleine
- Hirschhorhn-Cymerman Daniel
- Ho Po
- Hoch Ute
- Hoch Ute
- Hoch Ute
- Hodge James
- Hodge James
- Hodge James W
- Hodi F. S
- Hodi F. S
- Hodi F. S
- Hofmeister Robert
- Holland Pamela M
- Hollevoet Kevin
- Hollingsworth Robert E
- Hollingsworth Robert E
- Holmgaard Rikke
- Holtzhausen Alisha
- Honarmand Somayeh
- Hong Bang-Xing
- Hong David
- Hong Henoch S
- Hong Peter
- Horst Basil
- Horton Brendan
- Horvath Szabolcs
- Hotson Andrew
- Hou Jinlin
- Hou Xiaohong
- Hou Yafei
- Howell Alan
- Hu Yangyang
- Hu Yangyang
- Hu-Lieskovan Siwen
- Hua Hong
- Huang Fei
- Huang Jing
- Huang Shiang
- Huang Shiang
- Huang Tony
- Huang Yuanhiu
- Huang Yuanhiu
- Hudson Thomas E
- Huelsmann Erica
- Huffman Austin P
- Humeau Laurent
- Hunt Donald F
- Hunt Donald F
- Hurt Elaine
- Hurt Elaine
- Hurwitz Michael
- Hutchins Jeff
- Hutchins Jeff
- Hutchins Jeff
- Hwu Patrick
- Hwu Wen-Jen
- Hylander Bonnie
- Ibrahim Nageatte
- Illingworth Sam
- Infante Jeffrey
- Ioffe Ella
- Irmler Martin
- Irving Bryan A
- Irving Bryan A
- Izaki Daisuke
- Jablons David
- Jablonski Sandra
- Jackson Doreen O
- Jackson Natalie
- Jacobson Caron
- Jacques Judy
- Jaen Juan C
- Jaen Juan C
- Jahan Naznin
- Jahan Thierry
- Jaini Ritika
- Jaiswal Ashvin
- Jameson Michael B
- Jang Dadi
- Janku Filip
- Janne Pasi A
- Janssen Louise
- Jarblad-Leja Justyna
- Jeraj Robert
- Jessen Katti
- Jhawar Sachin
- Jhawar Sachin
- Jia Dan T
- Jin Ming
- Johnson Brian
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- Yadav Mahesh
- Yagiz Kader
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- Yan Jian
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- Yin Catherine
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- YlösmÀki Erkko
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- Young Gregory
- Young Kristina
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- Young Steve W
- Young Steve W
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- Zalevsky Jonathan
- Zalevsky Jonathan
- Zalevsky Jonathan
- Zalevsky Jonathan
- Zappasodi Roberta
- Zappasodi Roberta
- Zauderer Maurice
- Zeh Herbert
- Zelenetz Andrew D
- Zeng Weiping
- Zeng Xue
- Zha Yuanyuan
- Zhang Danhui
- Zhang Jing
- Zhang Ping
- Zhang Qifang
- Zhang Shannon S
- Zhang Theresa
- Zhang Winter
- Zhang Yanping
- Zhao Fei
- Zhao Leyna
- Zhao Xingli
- Zheng Lianxing
- Zheng Wenxin
- Zheng Xianxian
- Zheng Yi
- Zhong Hong
- Zhou Li
- Zhou Xiangjun
- Zippelius Alfred
- Zloza Andrew
- Zloza Andrew
- Zloza Andrew
- Zloza Andrew
- Zloza Andrew
- Zou Jun
- Zuba-Surma Ewa
- Zubkova Olga
- Zureikat Amer
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Background
The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd.
Methods
We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background.
Results
First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001).
Conclusions
In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival
Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19
- Author
- ?ivko Iris
- Abbass Hakam
- Abdeladim Lilia
- Abdelhady Hesham
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- Laffey John
- Laha Shondipon
- Lai Vivian
- Lambert Bridget
- Lamontagne Francois
- Lampro Lamprini
- Landais Michaël
- Landoni Giovanni
- Landsiedel-Mechenbier Elke
- Lang Eva
- Langridge Emma
- Latham Victoria
- Latino Reece
- Laudi Svenja
- Laugs Fabian
- Lavana Jayshree
- Laver Russell D.
- Law Daniel
- Lawler Patrick R.
- Le Basnier Elliot
- Le Guen LenaĂŻg
- Le Loup Guillaume
- Leaf David E.
- Lean Richard
- Leaver Susannah
- Leavis Helen
- Leblond Julie
- Leditschke Anne
- Lee Kelvin
- Lee Stephanie
- Lee Stephen
- Lefevre Montaine
- Leffelaar Evelien
- Lehalleur Adrien
- Lellouche Francois
- Lemaire-Brunel Delphine
- Lembo Rosalba
- Leparco CĂ©cile
- Leroyer Marie-Helene
- Lesona Eden
- Levett Chris
- Lewis Joanne
- Lewis Roger J.
- Lewis Sarah
- LewisProsser Lorraine
- Liao Angela
- Lim Rosario
- Limb James
- Lindergard Gabriella
- Linnett Vanessa
- Linstrum Kelsey M.
- Litton Ed
- Litton Edward
- Liu Theresa
- Lizotte Patricia
- Lock Stephen
- Lockett Teresa
- Logan Meg
- Lomme Kaatje
- Long Matilda
- Lopus Alyssa
- Lorenzi Elizabeth
- Lother Sylvain
- Lowe Benjamin
- Lowery Maryalyce
- Lowrey Julie
- Lucas Rachael
- Luis David
- Luitel Subekshya
- Luk Tracy
- Lunde Ragnar
- Luo Ji
- Lye Alison
- Lynch Ceri
- Lynch Daniella
- LĂłpez Maria
- LĂłpez Rafael
- Löbel Madlen
- MacKay Callum
- Mackay Euan
- Mackay Josephine
- MacKay Lynn
- Mackenzie Brittney
- Mackintosh Katherine
- MacLennan Sheila
- MacTavish Pamela
- Madani Yasser
- Madarbukus Daanyaal
- Maharajh Amitaa
- Maharjan Mili
- Maharjan Radhika
- Maharjan Sabi
- Maiden Matthew
- Mailman Jonathan
- Major Emmet
- Makanju Esther
- Makky Ahmed
- Makowski Arystarch
- Malakouti Salim
- Male Michelle
- Malfroy Sylvain
- Mali Sharmila
- Malissin Isabelle
- Malley Brian
- Maloney Carolyn
- Maloney Gracie
- Mandadapu Vineela
- Mani Ashwin
- Manley Rachel
- Manoharan Venika
- Maquigneau Natacha
- Marchesi Mattia
- Mariappa Vasanth
- Marin-Corral Judith
- Marin?ek Martin
- Marinoff Nicole
- Marion Beuzelin
- Markota Andrej
- Marmol Joy
- Marnai Remy
- Marriot Cheryl
- Marriott Yvonne
- Marroquin Oscar
- Marsden Tracy
- Marsh Emma
- Marshall John C.
- Marshall Lucy
- Marten Nicole
- Martin Elise
- Martin Emma
- Martin Jane
- Martin Laila
- Martin Timothy
- Martin-Lazarro Juan
- Martinez Maria
- Martucci Antonio
- Martynoga Robert
- Mary-Genetu Roman
- Mascherpa Glenda
- Masdeu-Eixarch Gaspar
- Maselli Astrid
- Mason Alexina
- Mason Brittany
- Masood Sobia
- Massar Brent
- Masse Marie-Helene
- Massey Natalie
- Masters Kristy
- Mataliotakis Michail
- Mathew Meghena
- Mathew Moncy
- Mathonnet Armelle
- Matimba-Mupaya Wadzanai
- Matsa Ramprasad
- Matthews Julie
- Maxime Virginie
- Mayak Katelyn
- Mayangao Irving
- Maynard Victoria
- Mayr Florian
- Mc-Kenzie Josette
- McAdams David
- McArthur Colin J.
- McAuley Daniel F.
- McAuley Julie
- McCallion Edmund
- McCarthy Aine
- McClintock Declan
- McConnochie Rachael
- McCracken Phoebe
- McCreary Erin
- McCreath Gordan
- McCullagh Iain
- McCullagh Liz
- McCulloch Corrienne
- McCullough James
- McDonald Bree
- McDyer John
- McEldrew Ben
- McEldrew Rebecca
- McEvoy Natalie
- McGain Forbes
- McGarry Karen
- McGhee Christopher
- McGlothlin Anna
- McGloughlin Steve
- McGlynn Deborah
- McGoldrick Clare
- McGuigan Peter
- McGuinness Shay P.
- McIntyre Joanne
- McIntyre Lauralyn
- McKee Madeleine
- McKenna Shirley
- McKenna Sonia
- Mckeon Laurie
- Mclaughlan Danielle
- McMaster Moyra
- McMillan Alexandra
- McMillan Catherine
- McMillan Helen
- McMorrow Liam
- McNamara Amanda
- McNamara Robert
- McNicholas Bairbre
- McQuilten Zoe
- McVerry Bryan J.
- McWilliam Stephen
- Medhurst Laura
- Medva Rebecca
- Meermeier Werner
- Megarbane Bruno
- Mehrtens Jan
- Mehta Reena
- Meijer Karina
- Menon David
- Mercier Emmanuelle
- Mercier Romain
- Merdji Hamid
- Meredith Megan
- Metherell Stella
- Meunier Juliette
- Mevavala Bhaumik
- Mew Louise
- Meyer Jason
- Mezher Chaouki
- Meziani Ferhat
- Mfuko Celina
- Mguni Nhlanhla
- Michael Angiy
- Michalak-Glinska Natalia
- Middledorp Saskia
- Miezitis Sydney
- Mikusek Justyna
- Mila de la Fuente Gema
- Miles Helen
- Millen Tina
- Miller Amanda
- Miller Jennene
- Miller Lorna
- Mills Gary
- Miln Rebecca
- Minnier Tami
- Mistry Deena
- Misztal Beata
- Mitchard Sarah
- Moakes Emma
- Moghbeli Kaveh
- Mohammed Amal
- Moine Pierre
- Mokhtar Nabih
- Monaghan Holly
- Monaghan Maree
- Monchi Mehran
- Moneger Guy
- Monnier Alexandra
- Monzon Angelica
- Moore Lorraine
- Moore Vanessa
- Moorhouse Louise
- Morel Guillaume
- Morgan Karen
- Morgan Matt
- Morgan Stacey
- Morpeth Susan
- Morris Anna
- Morris Jenny
- Morris Lucy
- Morris Sheila
- Morrison Lynette
- Mouncey Paul R.
- Mowery Brent
- Mrad Aymen
- Mtuwa Shelia
- Mukherjee Dipak
- Mulder John
- Mulier Jelle
- Mulla Suleman
- Mullan Dee
- Muller Grégoire
- Munt Sheila
- Murphy Aisling
- Murphy Lorna
- Murphy Peter
- Murphy Ryan
- Murphy Sheenagh
- Murray Andrew
- Murray Lauren
- Murray Lyle
- Murthy Srinivas
- Music Edvin
- Muteithia Margaret
- Muvindi Himasha
- Muzengi Natasha
- Muñoz-BermĂșdez Rosana
- Mwaura Esther
- Mwembani Tina
- Naeem Anas
- Naidu Brintha
- Naim Giulia
- Nair Priya
- Nakamuro Hiromi
- Nakazono Kenichi
- Nakhnoukh Cristina
- Nand Kiran
- Nandani Aarti
- Navarra Leanlove
- Nay Mai-Anh
- Nayyar Vineet
- Naz Mobeena
- Neal Matthew
- Nee Jens
- Neill Andy
- Nelli Apoorva
- Nemeth Christopher
- Nemeth-Roszpopa Karolina
- Netea Mihai
- Netherton Kimberley
- Neto Ary
- Newbould David
- Newlands Jessica
- Newman Julie
- Newman Tabitha
- Ng Anthony
- NG Christopher
- Nguyen Philippe
- Nguyen-Valat Thi-My-Hue
- Nichol Alistair D.
- Nicholier Tiphaine
- Nicholson Andrew
- Nicholson Anne
- Nicholson Sarah
- Nickoleit-Bitzenberger Daniela
- Nierhaus Axel
- Nikitas Nikitas
- Noble Harriet
- Noel-Hunter Monia
- Nolan Jerry
- Nordin Nazril
- North Julie
- Nortje Jurgens
- Nourse Mary
- Nown Angie
- Nygren Maria
- O Rourke Kate
- O'Connell Martin
- O'Kell Eleanor
- O'Neill Lorraine
- O'Neill Stephen
- O'Reilly Joanna
- O?Brien Julie
- O?Brien Neale
- O?Connor Aibhilin
- O?Connor Anne
- O?Connor Caroline
- O?Connor Stephanie
- O?Dwyer Michael
- O?Halloran Sinead
- O?Kane Cecilia
- O?Kane Sinéad
- O?Leary Ryan
- O?Malley Laura
- O?Neill Aisling
- O?Reilly Kevin
- Oakley Susan
- Oborska Aneta
- Occhipinti Giovanna
- Ochin Evelina
- Oczkowski Simon
- Ogg Bethan
- Ogungbenro Kayode
- Okubanjo Maryanne
- Okundaye Clementina
- Oliver Anne
- Oliver Martyn
- Omer Nimca
- Oncea Lynne
- Orford Neil
- Oritz-Ruiz de Gordoa Laura
- Orlikowska Izabela
- Orlikowski David
- Orr Katrina
- Osagie Rawlings
- Osborne Alexander
- Osborne Jason
- Osinga Margreet
- Ostermann Marlies
- Ottens Thomas
- Owen David R. J.
- Oza Deepali
- Padmakumar Anand
- Page Shannon
- Page Valerie
- Pakats Mari-Liis
- Pakou Glykeria
- Palermo Annamaria
- Paneru Hem
- Panjwani Ashok
- Panwar Rakshit
- Pappa Evita
- Paramasivam Elankumaran
- Parekh Dhruv
- Parikh Harshel G.
- Parke Rachael L.
- Parker Jane C.
- Parker Lorraine
- Parker Natasha
- Parmar Dinesh
- Parry-Billings Karen
- Parsons Penny
- Pasieka Bastian
- Patanwala Asad
- Patawala Asad
- Patch Sarah
- Patel Amit
- Patel Bijal
- Patel Brijesh
- Patel Kamal
- Paterson David
- Pathak Shreya
- Patil Sonal
- Patterson Lisa
- Paudel Pratibha
- Peake Sandra
- Pearson Harriet
- Pearson Karen
- Pech Yadira
- Pegler Suzannah
- Pellicano Susan
- Pemberton Abigail
- Pendlebury Jessica
- Pereira Rita
- Pereira Tiago Nuno Alfaro Lima
- Perez Jane
- Perri Reno
- Peters Anna
- Peters Cecilia
- Peters Marco
- Peters Sam
- Peters Svenja
- Petros Sirak
- PettilÀ Leena
- PettilÀ Ville
- Phalod Gunjan
- Philbin Jennifer
- Philip Annlin
- Philippe Rigaud
- Phillips Barbara
- Phillips Matt
- Phua Jason
- Phull Mandeep-Kaur
- Phuyal Aarti
- Pickering Charlotte
- Pickkers Peter
- Piercy Charlie
- Pietersma Mario
- Pillai Suresh
- Pinder Meredith
- Pinnell Jez
- Pinto Marta
- Pitts Sally
- Piva Simone
- Plantefeve Gaetan
- Platenkamp Ellen
- Plesnikova Yvonna
- Pletz Mathias
- Plummer Bethany
- Plummer Mark
- Pogreban Tatiana
- Pogson David
- Polfliet Margot
- Polgarova Petra
- Polley Grace
- Pollock Katrina M.
- Pomeroy Fiona
- Poojara Latesh
- Pooni Jagtar- Singh
- Porteous Rebecca
- Porter David
- Postlethwaite Kelly
- Postma Douwe
- Potter Alison
- Potter Sarah
- Poulter Amber-Louise
- Poupblanc SĂ©verine
- Pouplet Caroline
- Pourcine Franck
- Povoa Pedro
- Powell Elizabeth
- Prabakaran Rajalakshmi
- Pradel Gael
- Pratheema Ramachandran
- Prebeg Katharina
- Preijers Lieke
- Presneill Jeffrey
- Pridee Nicole
- Prinssen Anton
- Pritchard Kelly
- Proudfoot Nicola
- Prout Rachel
- Pugh Richard
- Purandare Laura
- Purnell Rebecca
- Purohit Dharam
- Purvis Sarah
- Puskarich Michael
- Putensen Daniel
- Puthucheary Zudin
- Puxty Kathryn
- PĂ©rez-TerĂĄn PurificaciĂłn
- PÔldots Liisi
- Qiu Shan
- Qiu Xinyi
- Quayle Rachael
- Quenot Jean Pierre
- Quinn Alison
- Quinn Kevin
- Qureshi Hafiz
- Raczek James
- Rad Laura
- Rademaker Emma
- Rahmani Hassene
- Rai Namrata
- Rai Sabi
- Raithatha Ajay
- Raj Ashok
- Ralston Maximillian
- Ramakrishnan N
- Ramali Mohamed
- Ramamurthi Balaji
- Ramanan Mahesh
- Ramos Angelo
- Ramos Lidia
- Randell Georgina
- Rangan Ritika
- Ranganathan Lakshmi
- Rao Deepak
- Rashan Aasiyah
- Rashan Sumayyah
- Ratcliffe Megan
- Ratnam Valli
- Ravry Celine
- Rawlins Sam
- Reay Michael
- Rebello Rashmi
- Reddy Amie
- Reddy Harsha
- Reed Catherine
- Rees Stephanie
- Reeve Brenda
- Regli Adrian
- Rehman Atique
- Reid Andrew
- Reid Liadain
- Reidy Bryan
- Reill Lorenz
- Reinhard Veronika
- Rengers Els
- Rennit Pille
- Reschreiter Henrik
- Reverté-Villarroya Silvia
- Revill Adam
- Rewa Oleksa
- Reyes Luis Felipe
- Reynolds Bob
- Reynolds Claire
- Reynolds Jessica
- Rhodes Jonathan
- Richards Carol
- Richards Suzanne
- Richards-Belle Alvin
- Richardson Aaron
- Richardson Angus
- Richecoeu Jack
- Riches Joanne
- Ricketts Dan
- Ricketts Daniel
- Riddell Phillip
- Riepe Ansgar
- Rietveld Ilse
- Rimmer Dominic
- Ripa Marco
- Rissen Reimer
- RistimÀki Sanna
- Ritzema Jenny
- Rivett Justine
- Rizzoni Damiano
- Roberts Belinda
- Roberts David
- Roberts Eilir
- Roberts Tracey
- Robertson Debra
- Robinson Matt
- Roche Lisa
- Roche-Campo Ferran
- Rochwerg Bram
- Rodden Natalie
- Rodriguez Marina
- RodrĂguez-GĂłmez Jorge
- Roebers Harald
- Roedl Kevin
- Rohde Gernot
- Rojo Roceld
- Romagnuolo Tina
- Roman Jaime
- Romberg Birgit
- Rook Clare
- Rooney Kevin
- Roovers Noortje
- Rosaroso Lace
- Rosborough Brian
- Rose Steve
- Rosenstein-Sisson Rachel
- Ross Elizabeth
- Rostron Anthony
- Roth Jason
- Rouge Patrick
- Roumen Rudy
- Rounds Charles
- Rovere-Querini Patrizia
- Rowan Kathryn M.
- Rowe-Leete Louise
- Rowland Matthew
- Roy Alistair
- Roynon-Reed Anna
- RueĂ-Paterno Giusi
- Ruiz Winningtom
- Runge Isabelle
- Ruselli Giovanna
- Russo Giada
- Ryalls Kim
- Ryan Donal
- Ryan Lucy
- Sabaretnam Suganya
- Sabelhaus Timo
- Sackrowitz Rachel
- Sadera Girendra
- Sadique Zia
- Sagnier Anne
- Saha Sian
- Saint Martin Marjorie
- Saito Hiroki
- Saiyed Salim
- Salahuddin Nawal
- Salberg Armorel
- Saleem Malik
- Salhi Sara
- Sall Jas
- Salmon Charlotte
- Salmon Karen
- Saluja Rupali
- Saluzzio Romina
- Salvati Stefano
- Sampson Julia
- Sanders Arnate
- Sanderson Amanda
- Sandhu Gyan
- Sanghavi Ritesh
- Santamaria John
- Santos Filipa
- Santos Marlene S.
- Sapsford David
- Sara Treena
- Saran Anita
- Sathe Sonia
- Sathianathan Kushaharan
- Sathianathan Prasannakumari
- Saull Michelle
- Saunders Christina T.
- Saunderson Paula
- Sauras-ColĂłn Esther
- Saxena Manoj
- Sayada Sarah
- Sayehli Cyrus
- Scanlan Jeremy
- Scano Riccardo
- Schaaf Bernhard
- Schlegel Christian
- Schmidhofer Mark
- Schneider Francis
- Schoenling Andrew
- Scholl Denise
- Schotsman Joost
- Schouten Jeroen
- Schueler Robert
- Schuster-Bruce Martin
- Schutgens Roger
- Schweikert Sacha
- Scott Kathryn
- Scott Zoe
- Scully Michael
- Seaman Rebecca
- Seidel Antje
- Seidu Fatima
- Seigne Patick
- Sekiwala Rose
- Sellers Katharine
- Selmi Carlo
- Sement Arnaud
- Senya Ho
- Seppelt Ian
- Sernicola Elisa
- Serri Karim
- Sevilla Chanthou
- Seymour Christopher W.
- Shah Faraaz
- Shahid Tasnin
- Shaikh Arif
- Shaikh Mohiuddin
- Shakya Roshni
- Shankar-Hari Manu
- Sharma Deepak
- Shaw David
- Shaw Deborah
- Shaw Joanne
- Shearer Audrey
- Sheath Ben
- Sheffield Jonathan
- Shehabi Yahya
- Shekar Kiran
- Shelton Sarah
- Sherwood Nick
- Shetty Varun
- Shields Fiona
- Shimabukuro-Vornhagen Alexander
- Shintani Ayumi
- Shirley Kim
- Shovelton Charmaine
- Shree Madhu
- Shrestha Namrata
- Shrestha Sabita
- Shrestha Tapaswi
- Shu Ki Lok Jennifer
- Shyamsundar Murali
- Siami Shidasp
- Sibin Sindhu
- Sicat Christine
- Siddiqui Atif
- Siddiqui Ayesha
- Sidéris Georgios
- Siewerski Chris
- Siika Wangari
- Sikondari Nyma
- Silversides Jon
- Sim Malcolm
- Simmonds Catherine
- Simons Koen
- Simpson Benjamin
- Simpson Joanna
- Simpson Scott
- Simpson Tom
- Sinclair Julie-Ann
- Singh Jayaprakash
- Singh Rajeev
- Singh Vanessa
- Singler Karen
- Singleton Jo
- Sinha Pratik
- Skinner Denise
- Skinner Tabitha
- Skorko Agnieszka
- Skrtich Aimee
- Slaughter Melanie
- Slieker Kitty
- Sligl Wendy
- Sloan Andrew
- Sloots-Cuppen Sonja
- Small Charlotte
- Smallshaw Karen
- Smallwood Andrew
- Smee Joanna
- Smit Albertine
- Smith Alex
- Smith Catherine
- Smith Eleanor
- Smith Emma
- Smith John
- Smith Judith
- Smith Julie
- Smith Kerry
- Smith Lucie
- Smith Matthew
- Smith Natalie
- Smith Oliver
- Smith Paul
- Smith Simon
- Smith Tim
- Smuts Sara
- Smyth Kirsty
- Smyth Michelle
- Smyth Naoise
- Soar Natalie
- Solesbury Amanda
- Somerville Alastair
- Song Rima
- Soukup Jens
- Southern David
- Southin Sara
- Spain Sandra
- Speight Holly
- Spencer Kayleigh
- Spencer Stephen
- Spencer Thomas
- Speyer Rebecca
- Spiers Catriona
- Spittle Nick
- Spivey Michael
- Spong Adam
- Sprinckmoller Stefan
- Squires Rebecca
- Stambaugh Martha
- Stammers Katie
- Stanciu Delia
- Stanley Timothy
- Stanworth Simon
- Stapleton Liana
- Starke Lisa
- Stavor Dara
- Stedman Roger
- Steffen Melanie
- Stephanie Gelinotte
- Stephens Deanna
- Stevenson Lesley
- Stewart Richard
- Stienstra Riejanne
- Stone Sarah
- Stowe Bethan
- Stratton Emma
- Stronach Lucy
- Suber Tomeka
- Sukuraman Anila
- Summerfield Anna
- Summers Charlotte
- Sundaram Radha
- Sundaran Dhinesh
- Sunkara Krishna
- Surti Zuhra
- Sutherland Helen
- Sutherland Sara-Beth
- Sutterlin Laetitia
- Sutton Joanne
- Sutu Mihaela
- Sven?ek Franc
- Svit?kar Nikolai
- Swabe Jacqueline
- Sweet Katie
- Sy Eric
- Szakmany Tamas
- Szawarski Piotr
- Tai Charlotte
- Tait Jennifer
- Talia Nadine
- Tallott Mandy
- Tamm Tina
- Tamme Kadri
- Taqdees Huda
- Tarr Esther
- Tate Margaret
- Tatham Kate
- Tavares Silvia
- Taylor Holly
- Taylor Melanie
- Taylor Sian
- Tee Ameila
- Templeton Maie
- Teo Hoon
- Terrill Lenae
- The Stephanie
- Thedinga Karen
- Thomas Amy
- Thomas Ashly
- Thomas Emma
- Thomas Helen
- Thomas Matt
- Thomas Vicky
- Thompson Patricia
- Thompson Taylor
- Thomson Nicola
- Thrush Jessica
- Thurairatnam Saranya
- Tierney Carey
- Tinmouth Alan
- Tirot Patrice
- Tlayjeh Haytham
- Toffalo Sue
- Tolppa Timo
- Tomasi Enrico
- Tomlinson Helen
- Tong Steve
- Tong Steven
- Tony Kiran
- Totzke Juliane
- Touma Omar
- Towns Miriam
- Trapani Tony
- Trask Kara
- Traverse Eleanor
- Trickey Jemma
- Trim Fiona
- Trimmer Ken
- Triulzi Darrell
- Troeman Darren
- Trues Estefania
- Truman Nicholas
- Tsakiridou Kyriaki
- Tsang Jennifer
- Tsinaslanidis Georgios
- Tuckwell Caroline
- Tully Redmond
- Tully Riona
- Tung Raymond
- Tupper-Carey Daryl
- Turgeon Alexis F.
- Turki Salah
- Turner Anne M.
- Turner Elizabeth
- Turner Keri
- Turner-Bone Ian
- Turns Margaret
- TV Bharath
- Udayanga Ishara
- Uddin Ruzena
- Udy Andrew
- Ullmann Hannah
- Umrani Zulfiqar
- Unsworth Adam
- Uriel Alison
- Ustianowski Andrew
- Uyeki Tim
- Vaara Suvi
- Vaduganathan Muthiah
- Vahtera Annukka
- Vale Cassandra
- Valentine Eliza
- Vamplew Luke
- van Amerongen Roosmarijn
- van Bentum-Puijk Wilma
- van Bree Sjoerd
- van de Veerdonk Frank L.
- van den Berg Lettie
- van den Oever Huub
- van der Eng Hetty
- Van Der Heyden Kymbalee
- van der Kraan-Donker Annemarie
- van Gulik Laura
- van Haren Frank
- Van Hecke Jolien
- van Kimmenade Roland
- van Nieuwkoop Kees
- van Zanten Arthur
- van Zuylen Tamara
- Van?t Hoff William
- Vandewoestyne Sophie
- Vanjak Christian
- Vanmali Piyush
- van Opdorp Marjolein
- van Vonderen Marit
- Vargas Jr. Jesus
- Varghese Siby
- Vautier Sarah
- Vazquez-Grande Gloria
- Veenith Tonny
- Veillard Marion
- Venkatesh Bala
- Verlander Mark
- Vermassen Joris
- Vermeiren Daisy
- Vermont - van der Staaij Janine
- Verrier Nathalie
- Vertue Mark
- Verula Jerik
- Victor Saji
- Viehman Alex
- Vieillard-Baron Antoine
- Vignesh C
- Villot Solenne
- VilĂĄ Clara
- Vincent Rachel
- Virdee Satwinder
- Visentin Elisa
- Visser Yorik
- Vita Tina
- Vivier Dominique
- Vodovar Dominique
- Voicu Sebastian
- Voigt Ingo
- Voiriot Guillaume
- Volkov Lev
- Voza Gennaro
- Vuylsteke Alain
- Wada Asako
- Waddington Natalia
- Wahl Nadine
- Waite Alicia
- Walden Andrew
- Walker Gena
- Walker Rachel
- Walker Susan
- Walsh Joanne
- Walsh Tim
- Walsham James
- Walton Catherine
- Wang Shu
- Ward Geraldine
- Ward Kathryn
- Ward Luke
- Warnapura Loku
- Warnock Majella
- Watchorn Olivia
- Waters Abby
- Waterson Sharon
- Watkins Claire
- Watpool Irene
- Watters Malcolm
- Watts Angela
- Waugh Victoria
- Webb Steve A.
- Weber Lisa
- Webster Denise
- Weerasinghe Thanuja
- Weismann Dirk
- Weiss Daniel
- Weissman Alexandra
- Wells Alan
- Wells Colin
- Wells Karen
- Welters Ingeborg
- West Lauren
- Westlake Samantha
- Wetherill Bill
- Wetzold Richard
- Whileman Amanda
- Whitbread Jennifer
- White Alison
- White Hayden
- White Ian
- White Katie
- Whitehead Christina
- Whitehouse Tony
- Wibrow Bradley
- Wigbers Jeanette
- Wijewardena Gayathri
- Wilby Elizabeth
- Wilcox Elizabeth
- Wilcox Louise
- Wild Helen
- Wild Laura
- Wilding Laura
- Wiles Matt
- Wiley Daisy
- Wilhelmsen Elva
- Wilkinson Dean
- Willams Felicity
- Williams Alexandra
- Williams Angharad
- Williams Anna
- Williams Erin
- Williams Gemma
- Williams Hannah
- Williams Karen
- Williams Marie
- Williams Patricia
- Williams Penny
- Williams Tony
- Williams Virginie
- Williamson Dawn
- Williamson James D
- Willis Joanna
- Willson Jayne
- Wilson Anna
- Wilson Craig
- Wilson Jean
- Wilson Maggie
- Winters James
- Winters Lauren
- Wise Matt
- Wisniewski Mary
- Wittekamp Bastiaan
- Wittenberg Wendy
- Wnuk Chris
- Woelke Amy
- Wong Jenny
- Wong Onyee
- Wood Erica
- Wood Hannah
- Wood Tracy
- Woods Jane
- Woods Lindsey
- Woodward Robert
- Woolett Melissa
- Worner Ruth
- Wren Jess
- Wren Lynn
- Wrey Brown Caroline
- Wright Chris
- Wright Kim
- Wunderley Renee
- Wyatt Rachel
- Wylie Katharine
- Xavier Kugan
- Yamagishi Yoshiaki
- Yamashita Chizuru
- Yang Yang
- Yarad Elizabeth
- Yates Bryan
- Yates David
- Yealy Donald
- Young Ian
- Young Meredith
- Young Paul
- Youngstein Taryn
- Yu Haili
- Yusuff Hakeem
- Zaharia Mihaela
- Zaidi Abbas
- Zaki Ahmed
- Zaman Mohsin
- Zarychanski Ryan
- Zdanavidiene Ausra
- Zhao Xiao
- Zinzoni Vanessa
- Zitter Letizia
- Zouita Louisa
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 11/04/2023
- Field of study
IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19.
Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19.
DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 nonâcritically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022).
INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (nâ=â257), ARB (nâ=â248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; nâ=â10), or no RAS inhibitor (control; nâ=â264) for up to 10 days.
MAIN OUTCOMES AND MEASURES The primary outcome was organ supportâfree days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes.
RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ supportâfree days among critically ill patients was 10 (â1 to 16) in the ACE inhibitor group (nâ=â231), 8 (â1 to 17) in the ARB group (nâ=â217), and 12 (0 to 17) in the control group (nâ=â231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ supportâfree days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively).
CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes.
TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570
Reading in the contect areas: an interactive approach for international students
- Publication venue
- New York: Longman
- Publication date
- 01/01/1990
- Field of study
xv, 104 p.; 22 cm
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