A comprehensive experimental characterization of the iPIX gamma imager

The results of more than 280 different experiments aimed at exploring the main features and performances of a newly developed gamma imager, called iPIX, are summarized in this paper. iPIX is designed to quickly localize radioactive sources while estimating the ambient dose equivalent rate at the measurement point. It integrates a 1 mm thick CdTe detector directly bump-bonded to a Timepix chip, a tungsten coded-aperture mask, and a mini RGB camera. It also represents a major technological breakthrough in terms of lightness, compactness, usability, response sensitivity, and angular resolution. As an example of its key strengths, an (241)Am source with a dose rate of only few nSv/h can be localized in less than one minute

Evaluation of the next generation gamma imager

Conference of 2013 3rd International Conference on Advancements in Nuclear Instrumentation, Measurement Methods and Their Applications, ANIMMA 2013 ; Conference Date: 23 June 2013 Through 27 June 2013; Conference Code:102802International audienceTowards the end of their life-cycle, nuclear facilities are generally associated with high levels of radiation exposure. The implementation of the ALARA principle requires limiting the radiation exposure of the operating people during the different tasks of maintenance, decontamination and decommissioning. CANBERRA's latest involvement in the provision of nuclear measurement solutions has led, in the framework of a technology transfer agreement with CEA LIST, to the development of a new generation gamma imager. The latter, which is designed for an accurate localization of radioactive hotspots, consists of a pixilated chip hybridized to a 1 mm thick CdTe substrate to record photon pulses and a coded mask aperture allowing for background noise subtraction by means of a procedure called mask/anti-mask, which greatly contributes to the reduced size and weight of the gamma imager as gamma shielding around the detector is less required. The spatial radioactivity map is automatically superimposed onto a pre-recorded photographic (visible) image of the scene of interest. In an effort to evaluate the performances of the new gamma imager, several experimental tests have been performed on a industrial prototype to investigate its detection response, including photon sensitivity and angular resolution, over a wide energy range (at least from 59 keV to 1330 keV). The impact of the background noise was also evaluated together with some future features like energy discrimination and parallax correction. This paper presents and discusses the main results obtained in the above experimental study. A comparison with Monte Carlo simulations using the MCNP code is provided as well

Nonadiabatic effects in electronic and nuclear dynamics

Due to their very nature, ultrafast phenomena are often accompanied by the occurrence of nonadiabatic effects. From a theoretical perspective, the treatment of nonadiabatic processes makes it necessary to go beyond the (quasi) static picture provided by the time-independent Schrödinger equation within the Born-Oppenheimer approximation and to find ways to tackle instead the full time-dependent electronic and nuclear quantum problem. In this review, we give an overview of different nonadiabatic processes that manifest themselves in electronic and nuclear dynamics ranging from the nonadiabatic phenomena taking place during tunnel ionization of atoms in strong laser fields to the radiationless relaxation through conical intersections and the nonadiabatic coupling of vibrational modes and discuss the computational approaches that have been developed to describe such phenomena. These methods range from the full solution of the combined nuclear-electronic quantum problem to a hierarchy of semiclassical approaches and even purely classical frameworks. The power of these simulation tools is illustrated by representative applications and the direct confrontation with experimental measurements performed in the National Centre of Competence for Molecular Ultrafast Science and Technology.ISSN:2329-777

Longitudinal study assessing the return of chloroquine susceptibility of Plasmodium falciparum in isolates from travellers returning from West and Central Africa, 2000-2011.

BACKGROUND: Chloroquine (CQ) was the main malaria therapy worldwide from the 1940s until the 1990s. Following the emergence of CQ-resistant Plasmodium falciparum, most African countries discontinued the use of CQ, and now promote artemisinin-based combination therapy as the first-line treatment. This change was generally initiated during the last decade in West and Central Africa. The aim of this study is to describe the changes in CQ susceptibility in this African region, using travellers returning from this region as a sentinel system. METHODS: The study was conducted by the Malaria National Reference Centre, France. The database collated the pfcrtK76T molecular marker for CQ susceptibility and the in vitro response to CQ of parasites from travellers' isolates returning from Senegal, Mali, Ivory Coast or Cameroon. As a proxy of drug pressure, data regarding CQ intake in febrile children were collated for the study period. Logistic regression models were used to detect trends in the proportions of CQ resistant isolates. RESULTS: A total of 2874 parasite isolates were genotyped between 2000-2011. The prevalence of the pfcrt76T mutant genotype significantly decreased for Senegal (from 78% to 47%), Ivory Coast (from 63% to 37%), Cameroon (from 90% to 59%) and remained stable for Mali. The geometric mean of the 50% inhibitory concentration (IC50) of CQ in vitro susceptibility and the proportion of resistant isolates (defining resistance as an IC50 value > 100 nM) significantly decreased for Senegal (from 86 nM (59%) to 39 nM (25%)), Mali (from 84 nM (50%) to 51 nM (31%)), Ivory Coast (from 75 nM (59%) to 29 nM (16%)) and Cameroon (from 181 nM (75%) to 51 nM (37%)). Both analyses (molecular and in vitro susceptibility) were performed for the 2004-2011 period, after the four countries had officially discontinued CQ and showed an accelerated decline of the resistant isolates for the four countries. Meanwhile, CQ use among children significantly deceased in this region (fixed effects slope = -0.3, p < 10-3). CONCLUSIONS: An increase in CQ susceptibility following official withdrawal of the drug was observed in travellers returning from West and Central African countries. The same trends were observed for molecular and in vitro analysis between 2004-2011 and they correlated to the decrease of the drug pressure