Forecasting Equity using LSTM Value-at-Risk Estimation

A deep learning hybrid approach (LSTM-VaR) is proposed for risk-based stock value prediction by comparing the relationship and temporal sequence of stock value data. By utilizing time in its predictions, the model can improve accuracy and reduce volatility in stock price projections. It can anticipate changes in stock market indices and develop a reliable strategy for projecting future costs while calculating normal fluctuations of indices

High frequency plant regeneration from shoot tip explants of Citrullus colocynthis (Linn.) Schrad. – An important medicinal herb

A high frequency and rapid regeneration protocol was developed from shoot tip explants of Citrullus colocynthis on Murashige and Skoog (MS) medium supplemented with N6-benzylamino-purine (BAP, 0.5 mg/l) and α-naphthalene acetic acid (NAA, 0.5 mg/l). Highest number of shoots (23.0 ± 0.567) was obtained on MS medium containing BAP (0.5 mg/l) and NAA (0.5 mg/l). The regenerated shoots were further elongated on same medium. In vitro shoots were excised from shoot clumps and transferred to rooting medium containing indole-3-butyric acid (IBA, 4.0 mg/l) with 0.2% activated charcoal. The rooted plants were hardened in polycups containing sterile soil and vermiculite and finally well established in the field; survival rate was 60%. This is the first report of direct in vitro plantlet regeneration in C. colocynthis from shoot tip explant.Key words: Citrullus colocynthis, regeneration, shoot tip

455 Length of stay for heart failure hospitalization in the eplerenone post‐acute myocardial infarction heart failure efficacy and survival study (EPHESUS)

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/106768/1/ehfs90327-x.pd

MR imaging of anterio cruciate ligament injuries

Background: Of all the ligaments of the knee joint the Anterior cruciate ligament (ACL) is the most commonly injured. It is an important pillar of the ligament stabilization of knee joint preventing anterior translation of Tibia over Fibula. Magnetic resonance imaging (MRI) is an excellent modality providing fine-resolution and multiplanar imaging without any radiation, for detection and evaluation of ACL injury with the associated injuries to other ligaments of the knee join. The purpose of the work was to study the role of MRI in classifying the ACL injuries.Methods: MRI Knee of 162 patients with ACL injuries was studied. All the MR imaging scans were performed on 1.5-T MR system (Siemens magnetom Essenza).Results: A total of 162 patients were studied in which majority of them i.e. 43 patients had interstitial sprain, 38 patients had complete tear, 33 patients had mucoid degeneration, 27 had partial tear and 14 had high grade partial tear, however 7 patients had normal ACL. There were associated injuries to the other ligaments of the knee joint along with ACL injury, medial meniscus tear being the most common and was seen in 39.50% followed by lateral meniscus tear in 9.87%, MCL tear in 6.79%, LCL tear in 1.85% and PCL tear in 2.46 %.Conclusions: MRI is a good modality for classifying ACL injury and evaluation of injuries to the associated ligaments

Prevalence of Dyskinesia and OFF by 30-Minute Intervals Through the Day and Assessment of Daily Episodes of Dyskinesia and OFF: Novel Analyses of Diary Data from Gocovri Pivotal Trials.

BACKGROUND: Parkinson\u27s disease (PD) patients using levodopa commonly develop dyskinesia and OFF episodes that reduce quality of life. OBJECTIVE: Evaluate prevalence of troublesome dyskinesia and OFF through the day, assessed by 30-minute intervals, as well as the mean number and duration of troublesome dyskinesia and OFF episodes, transitions between PD states, and effects of Gocovri® (amantadine) extended release capsules on these episodes. METHODS: Evaluate diary data from pooled Gocovri phase 3, placebo-controlled trials-analyzed for 17 hours following wake-up-at baseline and week 12. RESULTS: Diaries were evaluable for 162 patients. At baseline, 67% of patients woke up OFF, with prevalence decreasing to 13% at 2 hours and then remaining relatively steady at ∼12% (range, 6-17%) across half-hour intervals thereafter. Troublesome dyskinesia prevalence rose steadily from 5% to 24% over the first 2 hours, then fluctuated between 20% and 44% through the rest of the waking day. At baseline, patients experienced a mean of 3.0 daily episodes of troublesome dyskinesia (average duration 2.0 hours each), and 2.2 daily episodes of OFF (average duration 1.1 hour each). At week 12, Gocovri-treated patients showed greater reductions than placebo in troublesome dyskinesia and OFF episodes per day (treatment difference: -1.0 episodes and -0.4 episodes, respectively) and average episode duration (treatment difference: -0.6 hours and -0.3 hours, respectively). Mean duration of individual episodes of ON without troublesome dyskinesia (Good ON) increased by 5.0 hours for Gocovri, compared with 2.0 hours for placebo. Patients taking Gocovri experienced 2.2 fewer transitions between states than patients taking placebo. CONCLUSIONS: Troublesome dyskinesia and OFF occurred in the morning and throughout the waking day. Gocovri-treated patients experienced fewer, shorter episodes of both troublesome dyskinesia and OFF, thereby increasing the duration of continuous Good ON episodes and reducing the frequency of transitions between motor states

MR imaging of meniscal tears

Background: Menisci transmit the forces across the joint and cushion the mechanical loading of the joint. Thus, it is important to identify meniscal tear. A thorough understanding of normal meniscal anatomy and surrounding structure is critical for diagnosis. Magnetic resonance imaging is the current modality of choice providing fine resolution and multi-planar imaging for identifying the meniscal injuries and the various pattern of tear, helping to plan the subsequent management. The purpose of the work was to study the role of MRI in classifying the meniscal injuries.Methods: MRI Knee of 136 patients with meniscal injuries was studied. All the MR imaging scans were performed on 1.5-T MR system (Siemens magnetom Essenza).Results: A total of 136 patients were studied in which majority of the patient’s i.e.  90.44 % had medial meniscal tear while 18.38 % patients had lateral meniscal tear. Both medial and lateral meniscal tears were found in 8.82 % patients. Among the different types of tears, horizontal tear was the most common tear in both medial and lateral meniscus comprising 52.8 % and 52 % respectively. The tears being most common in the age group 41-50years. There were associated injuries to the other ligaments of the knee joint along with meniscal tear, ACL tear being the most common and was seen in 50% of patients.Conclusions: MRI is a good modality for classifying meniscal injury and evaluation of injuries to the associated ligaments. Secondary signs are good predictors of underlying meniscal tear in equivocal cases

Potential for the psychrophilic anaerobic treatment of swine manure using a sequencing batch reactor

. 1997. Potential for the psychrophilic anaerobic treatment of swine manure using a sequencing batch reactor. Can. Agric. Eng. 39:025-034. The feasibility of psychrophilic anaerobic digestion (PAD) in intermittently fed sequencing batch reactors (SBR) was investigated during the start-up run of an ongoing laboratory study. The start-up run results indicated that PAD in SBRs was efficient in stabilizing and deodorizing swine manure slurry. The digester effluents had little odour when compared to the raw manure. Total chemical oxygen demand (COD) was reduced by 58 to 73% and soluble COD (SCOD) by 85 to 96%. Methane production varied from 0.30 to 0.66 L CH4/g volatile solids added and methane concentration in the biogas ranged from 50 to 80%. The biog<ls production rate continued to increase even when concentrations of acetic acid and ammonia nitrogen were as high as 5500 mg/L and 3700 mg/L, respectively. Keywords: anaerobic digestion, swine manure, biogas, manure treatment, psychrophilic process, anaerobic treatment. Cet article presente les resultats preliminaires du projet d'etude sur la digestion anaerobie en condition psychrophile dans un bioreacteur it operation sequentielle. Les resultats experimentaux ont demontre que cette nouvelle technologie desodorise et stabilise Ie lisier de porco Le lisier traite est presque inodore comparativement au lisier de porc brut: La demande chimique en oxygene totale a ele reduite de 58 it 73%. La demande en oxygene chimique soluble a subit une forte diminution variant de 85 it 96%. La production de methane etait de 0.30 it 0.66 litre de CH4 par gramme de solides volatiles alimentes aux bio-reacteurs. La concentration du methane dans Ie biogaz variait entre 50 et 80%. Ce procede est tres stable, il n'est pas affecte par des concentrations elevees d'acide acetique (5500 mg/l) et ammoniac (3700 mg/l)

Household overcrowding and risk of SARS-CoV-2: analysis of the Virus Watch prospective community cohort study in England and Wales

Background: Household overcrowding is associated with increased risk of infectious diseases across contexts and countries. Limited data exist linking household overcrowding and risk of COVID-19. We used data collected from the Virus Watch cohort to examine the association between overcrowded households and SARS-CoV-2. // Methods: The Virus Watch study is a household community cohort of acute respiratory infections in England and Wales. We calculated overcrowding using the measure of persons per room for each household. We considered two primary outcomes: PCR-confirmed positive SARS-CoV-2 antigen tests and laboratory-confirmed SARS-CoV-2 antibodies. We used mixed-effects logistic regression models that accounted for household structure to estimate the association between household overcrowding and SARS-CoV-2 infection. // Results: 26,367 participants were included in our analyses. The proportion of participants with a positive SARS-CoV-2 PCR result was highest in the overcrowded group (9.0%; 99/1,100) and lowest in the under-occupied group (4.2%; 980/23,196). In a mixed-effects logistic regression model, we found strong evidence of an increased odds of a positive PCR SARS-CoV-2 antigen result (odds ratio 2.45; 95% CI:1.43–4.19; p-value=0.001) and increased odds of a positive SARS-CoV-2 antibody result in individuals living in overcrowded houses (3.32; 95% CI:1.54–7.15; p-value<0.001) compared with people living in under-occupied houses. // Conclusion: Public health interventions to prevent and stop the spread of SARS-CoV-2 should consider the risk of infection for people living in overcrowded households and pay greater attention to reducing household transmission