A NOVEL HPTLC METHOD FOR SIMULTANEOUS DETERMINATION OF CO-ENZYME Q10 AND α-TOCOPHEROL IN BULK AND PHARMACEUTICAL FORMULATION

Objective: HPTLC Method for Simultaneous quantification of co-enzyme Q10 and α-tocopherol in bulk and capsule dosage form was developed and validated as per International Conference on Harmonization [(ICH) Q2 (R1)] guideline.Methods: The chromatograms were developed using a mobile phase of Toluene: ethyl acetate: chloroform (10:1:2 v/v/v) on Pre-coated silica 60F 254 plates and quantified by densitometric absorbance mode at 280 nm.Results: The Rf values were 0.77 and 0.87 for co-enzyme Q10 and α-tocopherol, respectively. The linearity of the method was found to be in the concentration range of 0.6µg-1.8 µg/band for α-tocopherol and 2 µg-6 µg/band for co-enzyme Q10. The limits of detection and quantification were 0.3154 and 0.9559 µg/band for α-tocopherol and 3.441 and 10.42 µg/band for co-enzyme Q10.Conclusion: Developed densitometric method was found to be robust, precise, accurate, and rapid and can be used to analyse fixed-dose capsule samples of co-enzyme Q10 and α-tocopherol

Formulation and Development of Spirulina (Athrospira plantasis) Loaded Chocolatesas Immunity Boosters

Adults, as well as children, have a great need for nutrients such as Calcium, Iron, Zinc, Protein, and Vitamin B12. Spirulina is very rich in protein, omega 3 and omega 6 oils, vitamin, and mineral, and its incorporation into chocolates will enrich their nutritional values. Spirulina satisfies the nutritional needs by providing all these nutrients, as well as all the essential amino acids. Spirulina is unique and 100% safe. In fact, Spirulina is the only natural food that contains GLA (gamma linoleic acid) an essential fatty acid that is found only in mother’s milk. This GLA plays a very vital in balancing the hormonal system in the body. So it is actually very good to give Spirulina to the children.Our Spirulina Chocolates were prepared by simple incorporation method by addition of 1gm Spirulina by dissolving in 10 ml NaCl as a solubility enhancer as well as to mask the taste and smell. This chocolate form is easier for every individual to chew and absorb. The chocolates were assessed for organoleptic properties, pH, blooming test, and hardness. This significant study revealed the efficacy of Spirulina Chocolate Formulation and it would definitely have a wide scope in the future as an immunity booster and in treatments of malnutrition in children as well. Further study is required to reveal the quantification of constituents present in Spirulina Chocolate formulation by in vivo and invitro studies

Local Industrialization Based Lucrative Farming Using Machine Learning Technique

In recent times, agriculture have gained lot of attention of researchers. More precisely, crop prediction is trending topic for research as it leads agri-business to success or failure. Crop prediction totally rest on climatic and chemical changes. In the past which crop to promote was elected by rancher. All the decisions related to its cultivation, fertilizing, harvesting and farm maintenance was taken by rancher himself with his experience. But as we can see because of constant fluctuations in atmospheric conditions coming to any conclusion have become very tough. Picking correct crop to grow at right times under right circumstances can help rancher to make more business. To achieve what we cannot do manually we have started building machine learning models for it nowadays. To predict the crop deciding which parameters to consider and whose impact will be more on final decision is also equally important. For this we use feature selection models. This will alter the underdone data into more precise one. Though there have been various techniques to resolve this problem better performance is still desirable. In this research we have provided more precise & optimum solution for crop prediction keeping Satara, Sangli, Kolhapur region of Maharashtra. Along with crop & composts to increase harvest we are offering industrialization around so rancher can trade the yield & earn more profit. The proposed solution is using machine learning algorithms like KNN, Random Forest, Naïve Bayes where Random Forest outperforms others so we are using it to build our final framework to predict crop

Resistive Switching Memory Properties of Electrodeposited Cu2O Thin Films

The Cu2O thin film was developed using an electrodeposition approach for resistive memory application. The impact of the deposition voltage (1V, 2V, 3V, and 4V) on resistive switching (RS)/memristive properties of Cu2O thin films was studied. The XRD spectrum reveals that deposited Cu2O has a cubic crystal structure. The bipolar RS in Al/Cu2O/FTO device was clearly observed during the current-voltage (I-V) measurement. The basic memristive properties were calculated from I-V data. The charge transport studies suggested that the SCLC mechanism was responsible for device conduction, and RS was due to filamentary effect. The result suggested that the electrodeposition technique is useful to fabricate a memristive device for various applications

Self-nano Emulsifying Formulations: An Encouraging Approach for Bioavailability Enhancement and Future Perspective

Currently lipid-based formulations are playing a vital and promising role in improving the oral bioavailability of poorly water-soluble drugs. Lipid based formulations mainly consist of a drug dissolved in lipids such as triglycerides, glycerides, oils and surface active agent. Self nanoemulsifying formulations (SNEF) are isotropic mixtures of lipids/oils, surfactants and co-surfactants. On mild agitation followed by dilution in aqueous media, such as GI fluids, SNEF can form fine oil-in-water (o/w) nanoemulsions. Present chapter summarizes different types of lipid formulations with special emphasis on SNEF, availability of dosage forms, different components with natural surfactants from medicinal plants, mechanism of SNEF, recent advancements in oral drug delivery, solid SNEDDS, patents on SNEF and future prospects. SNEF emerging as powerful technique to improve solubility and commercialization of solid SNEF is the future novel drug delivery to improve bioavailability of poorly water soluble drugs

ENHANCEMENT OF POLY PHASE INDUCTION MOTOR WORKING AS A ROTARY PHASE CONVERTER AND WELDING TRANSFORMER

In this paper, a model which is implemented on idea that, the Polyphase induction motor works as welding transformer and rotary phase converter on a single Polyphase Induction motor by redesigning of stator winding of that motor. In our proposed model, for obtaining these three functions the rotorremains as it is and we only changed the design of stator winding

Enhancement of Poly Phase Induction Motor Working as a Rotary Phase Converter and Welding Transformer

In this paper, a model which is implemented on idea that, the Polyphase induction motor works as welding transformer and rotary phase converter on a single Polyphase Induction motor by redesigning of stator winding of that motor. In our proposed model, for obtaining these three functions the rotorremains as it is and we only changed the design of stator winding