Prescription pattern of cardiovascular drugs in intensive cardiac care unit patients in a tertiary care hospital

Background: Cardiovascular diseases (CVD) account for high morbidity and mortality all over the world. A study of prescription pattern ensures rational pharmacotherapy and assures quality medical care to the patients. The aim was to observe the prescribing pattern of cardiovascular drugs among the patients admitted to intensive cardiac care unit (ICCU).Methods: Prior permission from the Institutional Ethics Committee was obtained, and a prospective study of cardiovascular drugs was conducted on 100 consecutive patients admitted in ICCU of the Basaveshwar Teaching and General Hospital, Gulbarga. The duration of the study will be of 12 months from June 2012 to May 2013. The prescriptions of the patient who are treated during the course of the study will be audited prospectively using a specially designed form to record the required information. The data were statistically analyzed and presented as counts and percentages.Results: Majority of the patients were male (59%), and most of the patients belonged to age group of 51-60 years. Most common drug class was antianginal drugs with aspirin and clopidogrel being the mostly used combination drug. Most of the drugs were prescribed rationally.Conclusion: The present study concluded that most of the drugs were prescribed rationally according to current guidelines. In addition to prescribing drugs, patients should be educated about the risk factors of CVD and how they can be prevented

Exploration of Regional Agrowastes for the Production of Pectinase by Aspergillus niger

Svrha je ovog istraživanja procjena lokalno dostupnog poljoprivrednog otpada bogatog pektinom, i to korice limuna, stabljike sirka i glavice suncokreta, kao supstrata za proizvodnju pektinaze submerznim uzgojem plijesni Aspergillus niger DMF 27 i površinskim uzgojem plijesni A. niger DMF 45 na čvrstoj podlozi. Maksimalna količina endopektinaze (4,8 U/g) i egzopektinaze (17,2 U/g) dobivena je površinskim uzgojem na čvrstoj podlozi od glavica suncokreta, a nešto manje (endopektinaze 2,0 i egzopektinaze 10,2 U/g) na podlozi od korice limuna. Dodatkom izvora ugljika i dušika poljoprivrednom otpadu povećana je proizvodnja pektinaze, pri čemu je dodatak saharoze imao veći učinak od dodatka glukoze pri uzgoju na čvrstoj podlozi. Međutim, pri submerznom uzgoju dodatak glukoze povećao je prinos pektinaze. Amonijev sulfat kao izvor dušika povećao je proizvodnju pektinaze u oba postupka uzgoja.The aim of this study was to evaluate locally available pectin rich agrowastes, viz. lemon peel, sorghum stem and sunflower head, as substrates for the production of pectinase by Aspergillus niger DMF 27 and A. niger DMF 45 in submerged fermentation (SmF) and solid-state fermentation (SSF) systems, respectively. The maximum amount of endo- (4.8 U/g) and exopectinases (17.2 U/g) was obtained from sunflower head followed by lemon peel (endopectinase 2.0 and exopectinase 10.2 U/g) in solid-state system. The increased level in the production of pectinases was noticed when the agrowastes were supplemented with additional carbon and nitrogen sources, and supplementation of sucrose was more effective than glucose in SSF. But, glucose yielded more pectinases in SmF. Among the nitrogen sources, ammonium sulphate raised the production level of pectinases from all the substrates in both SmF and SSF systems

Comparative Evaluation of Air Quality Dispersion Models for Predicting Particulate Matter Concentrations at a Busy Traffic Roadway in Chennai City

Source: ICHE Conference Archive - https://mdi-de.baw.de/icheArchiv

Drug utilization study of antihypertensive drugs in hypertensive diabetic patients in a tertiary care hospital

Background: Diabetes along with hypertension is a very common ailment afflicting millions of people worldwide. The socio-economic stress caused by the morbidity and mortality associated with it is mind boggling. Hence, this study was undertaken to study the utilization of antihypertensive drugs in hypertensive diabetic patients.Methods: A prospective study was conducted on 100 hypertensive diabetic patients aged between 18 and 90 years of either gender attending Basaveshwar Teaching and General Hospital, Kalaburagi. The data collected were statistically analyzed and presented as counts and percentages.Results: In our study, we found that majority (63%) were male patients and majority belonged to 51-70 years age group. The majority of the patients were prescribed angiotensin converting enzyme inhibitors (ACEIs) alone (19%), followed by a combination of ACEIs and calcium channel blockers (9%). The generic prescribing was only 23%, and patient’s knowledge of correct dosage was 64%.Conclusion: In this study, it has been observed that the antihypertensives drugs were prescribed rationally, but the generic prescribing was only 23% which is inappropriate prescribing behavior. Hence, physicians should be educated to prescribe drugs in the generic name so that the cost of drugs is reduced

EFFECT OF CANNA INDICA L. EXTRACT AGAINST CAFFEINE-NICOTINE CO-ADMINISTRATION-INDUCED EXAGGERATION IN TYPE 2 DIABETIC RATS

Objective: This study was designed to evaluate the protective effect of Canna indica L. extract against caffeine-nicotine administration-induced type 2 diabetes exaggeration in rats.Methods: A study was conducted for three weeks in four rat groups (n=6); viz.  type 2 diabetic control group, a caffeine-nicotine diabetic control group (20mg/kg, 0.4mg/kg, ip twice daily),  and Canna indica L. extract and caffeine-nicotine treatment group and  standard drug treated caffeine-nicotine diabetic group (Glibencamide, 5mg/kg, once daily). Type 2 diabetes was induced by two weeks high fatty diet and a single dose streptozotocin (50mg/kg, ip) on 1th day of the study in all groups. Blood and urine samples were collected every week for serum biochemical analysis.Results: Results of extract treatment and standard drug treatment were compared with untreated caffeine-nicotine co-administration group. Difference in each relevant serum parameter was analyzed through ANOVA and Dunett's t test. Extract treated caffeine-nicotine-diabetic group showed about 150-200mg/dL (p<0.001) reduction in the serum glucose than untreated caffeine-nicotine-diabetic control group. Extract treatment reduces serum glucose by 10-15 mg/dL than glibenclamide treatment with higher significance (p<0.001). Extract treatment showed better results than standard drug in liver and kidney function test and exhibited its better potential in controlling diabetic complications. Extract treatment increased HDL-C and reduced triglycerides, LDL-C, VLDL-C and TC much better and with higher significance than standard drug. Extract treatment reduced TC by at least 60-80mg/dL (p<0.01) in comparison to caffeine-nicotine-diabetic control group. Extract treatment reduced 10-15mg/dL of more total cholesterol than that of standard drug.Conclusion: Caffeine-nicotine co-administration-induced exaggeration of type 2 diabetes was better treated by CI extract than that of standard drug gibenclamide. Keywords: Type 2 diabetes, Streptozotocin, Caffeine, Nicotine, Diabetic complication, Ra

Study of maternal and fetal outcome in pregnancy beyond 40 weeks: a prospective observational study at a tertiary institute

Background: Prolonged pregnancy is one that exceeds 42 0/7weeks. Management of prolonged pregnancy is very challenging in modern obstetrics.Methods: It is prospective observational study in department of Obstetrics and Gynecology, Shri B.M Patil medical college and Research center, deemed to be University, Vijayapur, North karnataka. Study period was from January 2018 to January 2019.Results: Total of 186 pregnant women were included in the study. Results in terms of age, gravidity, gestational age, time of induction, mode of delivery, neonatal outcome and maternal complications.Conclusion: Pregnancies beyond 40 weeks require early detection, effective fetal monitoring and proper planning of labour. In pregnancies beyond 40 weeks, decision of induction should be taken cautiously as early induction leads to failure of induction and increased rates of lower (uterine) segment Caesarean section (LSCS), while delayed induction leads to increased fetal complications

Characterisation of general proteolytic, milk clotting and antifungal activity of Ficus carica latex during fruit ripening

The physiological role of fig latex is to protect the plant from pathogens. Latex is a rich source of proteases, predominantly ficin. Fig latex also contains collagenolytic protease and chitinolytic enzymes. Our aim was to investigate changes in protein composition, enzyme and antifungal activities of fig latex during fruit ripening. RESULTSComparison of latex samples in different time periods showed a uniform increase of protein concentration in chronological order. The content of collagenolytic protease did not differ significantly in the latex samples, while the content of ficin decreased. Ficin-specific activity towards casein was the highest at the beginning of fruit development (about 80 U mg(-1)). Specific milk clotting activity increased as well as the abundance of casein band in the clots. Specific chitinolytic activity at the beginning of flowering was 6.5 times higher than the activity in the period when fruits are ripe. Antifungal activity is the most extensive in spring. CONCLUSIONFicin forms with different casein specificities are present in different proportions during fruit ripening, which is of importance for applications in the dairy industry. The protection mechanism against insects and fungi, which relies on chitinolytic activity, is the most important in the early phases of flowering and is replaced with other strategies over time. (c) 2015 Society of Chemical IndustryThis is peer-reviewed version of the following article: Raskovic, B.; Lazic, J.; Polovic, N. Characterisation of General Proteolytic, Milk Clotting and Antifungal Activity of Ficus Carica Latex during Fruit Ripening. Journal of the Science of Food and Agriculture 2016, 96 (2), 576–582. [https://doi.org/10.1002/jsfa.7126]Supplementary material: [http://cherry.chem.bg.ac.rs/handle/123456789/3398

EEG Based Brain Computer Interfacing for Hand Assistant System Using Wavelet Transform

Robots have been of great use to mankind for several years. In situation where human body fails to operate as per the need robot’s functions in those situations quite efficiently. Electroencephalogram (EEG) controlled hand assistant makes use of EEG signals and Brain Computer Interface (BCI). EEG signals are obtained from the brain using Emotiv Insight headset, after which processing and features extraction of the signals is performed and then conditioning of signals is done as it is a low amplitude signal with additive noise. Signals processing is done on the analog signal by using wavelet transform. Wavelet transform will help to extract information from the analog signal. Then the signals are assigned with the signatures to perform the dedicated task Filtered signal is given to analog pins of Arduino Uno. With the help of inbuilt ADC available on Arduino Uno, Digital Data is also made available on the digital pins. Then through MATLAB access Arduino board. In near future if it gets similar kind of input it will understand exactly what operation to perform. Further the Robotic hand assistant can be operated as we want

Parametric Evaluation of Melting Practice on Induction Furnace to Improve Efficiency and System Productivity of CI and SGI Foundry- A Review

Abstract: We provide some recommendations for the productivity improvement. Due to non-availability of the proper instrumentation the effect of the ill practices cannot be precisely judged. If this is properly measured, the percentage of productivity improvement in steel melting Induction Furnace can be calculated. The review is carried out from the literature in the various journals and manuals. The aim of this paper is to study the overall performance of induction furnace and to suggest the method to improve melt rate with optimum use of electricity. This paper mainly put attention on induction furnace as these are main consumer of electricity in foundry. In case of induction furnace efficiency is sensitive to many controllable features lie in operational practices, coil height; charge mix, furnace utilization etc. So with the help of recommendation, it is easy to find out the ways to lower the specific energy consumption in this furnace. So, in this paper we are trying to develop certain relationship between input and output parameters to improve the Whole process