Determination of Ground Water Associated with Lignite Mining in Arid Climate,

Ground water and surface water create a range of problems in lignite mining utilizing surface mining methods. In order to create a safe and economic mining environment, it is essential to carry out mining after dewatering the rock mass surrounding the lignite mines by advance dewatering techniques. This paper briefly describes the ground water regimes including pressure gradients associated with various lignite deposits together with the practical examples of some important lignite deposits in the world. An effective method of controlling ground water in multi-aquifer environment in lignite deposits is to carry out rock mass dewatering using borehole pumps. This approach will help reducing the inflow rates of ground water to the mining excavation and also increase the effective strength of the overburden strata, thus, increasing the slope stability of the mining excavations. The main theme of this paper is to present a case history analysis of Thar lignite deposit in Sindh, Pakistan which has lignite reserves of some 193 billion tonnes. The paper presents a proposed method of dewatering the Thar prospect together with an assessment of the quality of aquifer water which can be used to improve the quality of life of people inhabiting in the Thar Desert area of Sindh, Pakistan. Water samples from three aquifers were collected from nine different locations and were analyzed in the laboratory for evaluating their physical and chemical characteristics. The test results indicated that the aquifer water can be classified as (sodium+ potassium) -chloride type water with a TDS range of 1000 to 20,000 mg/L. Consequently, this ground water is classified as brackish (saline water) requiring treatment before it can be utilised for domestic or industrial consumptions. It should be noted that this ground water does not contain heavy metals and toxic metals including arsenic, mercury and lead or cyanide. However, results indicate that groundwater from a few locations contained traces of silver (<4oppb) Owithozinc0<0.1ppm

Predictions of the mechanical properties of unidirectional fibre composites by supervised machine learning

We present an application of data analytics and supervised machine learning to allow accurate predictions of the macroscopic stiffness and yield strength of a unidirectional composite loaded in the transverse plane. Predictions are obtained from the analysis of an image of the material microstructure, as well as knowledge of the constitutive models for fibres and matrix, without performing physically-based calculations. The computational framework is based on evaluating the 2-point correlation function of the images of 1800 microstructures, followed by dimensionality reduction via principal component analysis. Finite element (FE) simulations are performed on 1800 corresponding statistical volume elements (SVEs) representing cylindrical fibres in a continuous matrix, loaded in the transverse plane. A supervised machine learning (ML) exercise is performed, employing a gradient-boosted tree regression model with 10-fold cross-validation strategy. The model obtained is able to accurately predict the homogenized properties of arbitrary microstructures

Characterizations of Ultrasonically Prepared Nanostructured ZnO powder and NH3 Sensing Performance of its Thick Film Sensor

AbstractIn the present investigation nanostructured ZnO powder was prepared using ultrasonic atomization method. An aqueous solution of Zn (NO3)2 *6H2O was atomised using ultrasonic atomizer. The prepared nanostructured ZnO powder was collected using a simple but novel trapping system. The powder was characterized using XRD, TEM, SEM and EDAX. Nanostructured thick-film sensors of this powder were prepared by using the simple screen printing technique. The gas sensing performance of this film was tested. The sensor was found to be most sensitive to NH3

Expansion of anti-AFP Th1 and Tc1 responses in hepatocellular carcinoma occur in different stages of disease

Copyright @ 2010 Cancer Research UK. This work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/.Background: α-Fetoprotein (AFP) is a tumour-associated antigen in hepatocellular carcinoma (HCC) and is a target for immunotherapy. However, there is little information on the pattern of CD4 (Th1) and CD8 (Tc1) T-cell response to AFP in patients with HCC and their association with the clinical characteristics of patients. Methods: We therefore analysed CD4 and CD8 T-cell responses to a panel of AFP-derived peptides in a total of 31 HCC patients and 14 controls, using an intracellular cytokine assay for IFN-γ. Results: Anti-AFP Tc1 responses were detected in 28.5% of controls, as well as in 25% of HCC patients with Okuda I (early tumour stage) and in 31.6% of HCC patients with stage II or III (late tumour stages). An anti-AFP Th1 response was detected only in HCC patients (58.3% with Okuda stage I tumours and 15.8% with Okuda stage II or III tumours). Anti-AFP Th1 response was mainly detected in HCC patients who had normal or mildly elevated serum AFP concentrations (P=0.00188), whereas there was no significant difference between serum AFP concentrations in these patients and the presence of an anti-AFP Tc1 response. A Th1 response was detected in 44% of HCC patients with a Child–Pugh A score (early stage of cirrhosis), whereas this was detected in only 15% with a B or C score (late-stage cirrhosis). In contrast, a Tc1 response was detected in 17% of HCC patients with a Child–Pugh A score and in 46% with a B or C score. Conclusion: These results suggest that anti-AFP Th1 responses are more likely to be present in patients who are in an early stage of disease (for both tumour stage and liver cirrhosis), whereas anti-AFP Tc1 responses are more likely to be present in patients with late-stage liver cirrhosis. Therefore, these data provide valuable information for the design of vaccination strategies against HCC.Association for International Cancer Research and Polkemmet Fund, London Clinic

Safety and immunogenicity of boosting BCG vaccinated subjects with BCG: comparison with boosting with a new TB vaccine, MVA85A.

OBJECTIVES: To investigate the safety and immunogenicity of a booster BCG vaccination delivered intradermally in healthy, BCG vaccinated subjects and to compare with a previous clinical trial where BCG vaccinated subjects were boosted with a new TB vaccine, MVA85A. DESIGN: Phase I open label observational trial, in the UK. Healthy, HIV-negative, BCG vaccinated adults were recruited and vaccinated with BCG. The primary outcome was safety; the secondary outcome was cellular immune responses to antigen 85, overlapping peptides of antigen 85A and tuberculin purified protein derivative (PPD) detected by ex vivo interferon-gamma (IFN-gamma) ELISpot assay and flow cytometry. RESULTS AND CONCLUSIONS: BCG revaccination (BCG-BCG) was well tolerated, and boosting of pre-existing PPD-specific T cell responses was observed. However, when these results were compared with data from a previous clinical trial, where BCG was boosted with MVA85A (BCG-MVA85A), MVA85A induced significantly higher levels (>2-fold) of antigen 85-specific CD4+ T cells (both antigen and peptide pool responses) than boosting with BCG, up to 52 weeks post-vaccination (p = 0.009). To identify antigen 85A-specific CD8+ T cells that were not detectable by ex vivo ELISpot and flow cytometry, dendritic cells (DC) were used to amplify CD8+ T cells from PBMC samples. We observed low, but detectable levels of antigen 85A-specific CD8+ T cells producing IFNgamma (1.5% of total CD8 population) in the BCG primed subjects after BCG boosting in 1 (20%) of 5 subjects. In contrast, in BCG-MVA85A vaccinated subjects, high levels of antigen 85A-specific CD8+ T cells (up to 14% total CD8 population) were observed after boosting with MVA85A, in 4 (50%) of 8 subjects evaluated. In conclusion, revaccination with BCG resulted in modest boosting of pre-existing immune responses to PPD and antigen 85, but vaccination with BCG-MVA85A induced a significantly higher response to antigen 85 and generated a higher frequency of antigen 85A-specific CD8+ T cells. TRIAL REGISTRATION: ClinicalTrials.gov NCT00654316 NCT00427830

Q-depict : Qatar determining emergency physician incidence of covid-positive testing

Publisher Copyright: © 2021 Hamad Medical Corporation. All rights reserved.Despite protective measures such as personal protective equipment (PPE) and a COVID airway management program (CAMP), some emergency physicians will inevitably test positive for COVID. We aim to develop a model predicting weekly numbers of emergency physician COVID converters to aid operations planning. The data were obtained from the electronic medical record (EMR) used throughout the national healthcare system. Hamad Medical Corporation's internal emergency medicine workforce data were used as a source of information on emergency physician COVID conversion and numbers of emergency physicians completing CAMP training. The study period included the spring and summer months of 2020 and started on March 7 and ran for 21 whole weeks through July 31. Data were extracted from the system's EMR database into a spreadsheet (Excel, Microsoft, Redmond, USA). The statistical software used for all analyses and plots was Stata (version 16.1 MP, StataCorp, College Station, USA). All data definitions were made a priori. A total of 35 of 250 emergency physicians (14.0%, 95% CI 9.9%-19.9%) converted to a positive real-time reverse transcriptase-polymerase chain reaction (PCR) during the study's 21-week period. Of these. only two were hospitalized for having respiratory-only disease, and none required respiratory support. Both were discharged within a week of admission. The weekly number of newly COVID-positive emergency physicians was zero and was seen in eight of 21 (38.1%) weeks. The peak weekly counts of six emergency physicians with new COVID-positive were seen in week 14. The mean weekly number of newly COVID-positive emergency physicians was 1.7 ^ 1.9, and the median was 1 (IQR, 0 to 3). This study demonstrates that in the State of Qatar's Emergency Department (ED) system, knowing only four parameters allows the reliable prediction of the number of emergency physicians likely to convert COVID PCR tests within the next week. The results also suggest that attention to the details of minimizing endotracheal intubation (ETI) risk can eliminate the expected finding of the association between ETI numbers and emergency physician COVID numbers.Peer reviewe

A computationally efficient approach for generating RVEs of various inclusion/fiber shapes

A computationally efficient method for generating virtual periodic representative volume element (RVE), capable of handling arbitrary inclusion shapes, is developed. A universal collision/overlap detection and repair method is proposed, where each inclusion shape is represented as a union of n-Spheres (UnS). A constrained optimization problem is formulated and solved to remove inclusion overlaps; a closed-form solution is derived for calculating the degree of inclusions overlap and its gradient vector with respect to inclusion position. RVE generation is illustrated with circular, spherical, four non-circular and four non-spherical inclusion shapes. Computational efficiency is demonstrated using an elaborate RVE generation time study. The generated RVEs are evaluated using various statistical metrics; results confirm the random distribution of inclusions. Effective properties of RVEs, representing unidirectional composites, are determined using homogenization with various fibre cross-section shapes; obtained mechanical properties have shown transverse isotropy