Assesment of interprofessional training methodology in professional education as a potential tool to improve patient safety and quality of care

Study Objectives: Systematic current literature analysis: Does interprofessional training significantly improve the team communication? - Team member awareness (pre-and post-training survey scores) - Communication Does interprofessional training significantly improve healthcare safety? - Morbidity/mortality - Adverse events (nosocomial infections, serious safety events) - Hospital stay (in-patient setting)Trabajos libres ISTEC Salud y ACE.Ibero-American Science and Technology Education Consortium (ISTEC

Evidence-Based Approach and Standardization of Nutraceuticals

Evidence-based approach for the use and selection of nutraceuticals are presented as well as the need and challenges to creating a method for the standardization of these products. A systematic review was completed to analyze the impact of evidence-based and standardization of nutraceuticals. Evidence-based approach for nutraceuticals allow for the evaluation of these products. This process involves utilizing current and best evidence to provide individualized care for patients. Current Good Manufacturing Practices (cGMP) are regulations enforced by the FDA to ensure that drug manufacturing processes meet basic standards. Under these practices, design, monitoring, and control of manufacturing processes are regulated. These practices can track and provide tools to prevent contamination of products available to consumers. Using evidence-based approach for nutraceutical can provide healthcare providers and consumers with evidence that is patient specific, for a given intervention and desired outcome. The global market for nutraceuticals is growing and all manufacturers should comply with cGMP to ensure safe, quality products for consumers. The goal is to have all nutraceutical manufacturers worldwide embrace cGMP in order to provide consumers with safe, effective and high quality products

Advancing Professional Development through CPE in Public Health

The education division is a prominent part of the public health profession. It focuses on educating individuals and communities to promote health and prevent disease. The educators are drawn from a diverse range of disciplines and defined as professionally prepared individuals who serve in a variety of roles using appropriate educational strategies and methods to facilitate the development of policies, procedures, interventions, and systems conducive to the health of individuals.This unique volume in the Global Science Education Series describes some of the challenges faced by this profession in helping the audience to understand public health and solve health issues

Innovative approaches in Mexico and North East India health care system and their implications in other Ibero American countries

Objetives - Discuss and look at innovative ideas in Mexico and North east India to structure a better healthcare system for other Ibero American countries. - Overcome shortage of human resources for health and provide center for information systems in North east India and its implications. - Execute a more refined system in healthcare education.Trabajos libres ISTEC Salud y ACE.Ibero-American Science and Technology Education Consortium (ISTEC

Formulation of metformin-loaded alginate microspheres by ionotropic gelationaerosolization technique

Metformin hydrochloric acid (HCl)-loaded alginate microspheres prepared using aerosolization method were subsequently evaluated for their physico-chemical characteristics in terms of particle size, morphology, drug loading, entrapment efficiency, yield and in vitro release. A two factorial Design of Experiment (DoE) was used to study the influence of polymer alginate and cross-linker calcium chloride (CaCl2 ) concentrations on microparticle characteristics. The results indicated that all microspheres were spherical in shape, while their particle size was less than 5 µm, although this increased with the intensification of alginate and CaCl2 concentrations. Encapsulation efficiency, loading, and yield were all enhanced by increasing alginate concentration and, conversely, decreasing CaCl2 concentration. The highest encapsulation efficiency, loading, and yield were 40, 31, and 73%, respectively, produced by a formula containing 1.75% alginate and 3% CaCl2 . The drug release of Metformin-loaded microparticles in HCl pH 1.2 ranged from 22 to 28% during a two-hour period, while further drug release of PBS pH 7.4 increased from 67 to 95% over ten hours. The total amount of drug released during a 12-h period increased by reducing alginate concentration. Furthermore, a kinetic study of the dissolution data confirmed the prevalence of a diffusion-controlled mechanism or Higuchi pattern of drug release

Requirement Prediction for Toluene Detox with Foods Intake Rich in CYP2E1 Enzyme and Glycine to Prevent Nerve and Kidney Damage at Shoe Home Industry Workers in Romokalisari Surabaya

BACKGROUND: Toluene was an organic compound used in chemical and drug industries, the main source of toluene emissions from fires. To reduce and even eliminate toluene toxins in chemical component could be using detoxification by foods. AIM: This research aimed to calculate the intake of foods rich in CYP2E1 enzyme and glycine to improve toluene detoxification.METHODS: The type of research was a descriptive study. The subject of the study was 51 workers in Romokalisari Surabaya who had worked for more than or equal to 10 years. Variables were body weight, duration of working (years), working time per week (days), and working time per day (hours). The breathing rate, intake of non-carcinogen per respondent, can be calculated by variables before. Then, the effective dose of food rich in CYP2E1 enzyme and glycine will be obtained.RESULTS: Majority respondents had toluene concentrations below the threshold limit value (TLV). The highest effective dose of foods rich in CYP2E1 enzymes such as beef liver, beef brain, and salmon was 239.61 g, 745.45 g, and 203.3 g. Also, foods rich in glycines such as seaweed, tuna, and spinach were 432.98 mg, 934.41 mg, and 2070.71 mg. CONCLUSION: The level of adequacy of the CYP2E1 enzyme and glycine of each person was different and varied. The effective dose required by each respondent depending on weight, length of work, and concentration of benzene in the workplace. The greater the toluene concentration, the greater the needs for foods rich in CYP2E1 enzymes and glycine. Body weight can also be another factor in differences in individual intake. Weight, length of working, and toluene concentration can affect the intake of non-carcinogen in each which can affect the effective dose of foods

A Deep Insight Into CAR-T Cell Therapy in Non-Hodgkin Lymphoma: Application, Opportunities, and Future Directions

Non-Hodgkin’s lymphoma (NHL) is a cancer that starts in the lymphatic system. In NHL, the important part of the immune system, a type of white blood cells called lymphocytes become cancerous. NHL subtypes include marginal zone lymphoma, small lymphocytic lymphoma, follicular lymphoma (FL), and lymphoplasmacytic lymphoma. The disease can emerge in either aggressive or indolent form. 5-year survival duration after diagnosis is poor among patients with aggressive/relapsing form of NHL. Therefore, it is necessary to understand the molecular mechanisms of pathogenesis involved in NHL establishment and progression. In the next step, we can develop innovative therapies for NHL based on our knowledge in signaling pathways, surface antigens, and tumor milieu of NHL. In the recent few decades, several treatment solutions of NHL mainly based on targeted/directed therapies have been evaluated. These approaches include B-cell receptor (BCR) signaling inhibitors, immunomodulatory agents, monoclonal antibodies (mAbs), epigenetic modulators, Bcl-2 inhibitors, checkpoint inhibitors, and T-cell therapy. In recent years, methods based on T cell immunotherapy have been considered as a novel promising anti-cancer strategy in the treatment of various types of cancers, and particularly in blood cancers. These methods could significantly increase the capacity of the immune system to induce durable anti-cancer responses in patients with chemotherapy-resistant lymphoma. One of the promising therapy methods involved in the triumph of immunotherapy is the chimeric antigen receptor (CAR) T cells with dramatically improved killing activity against tumor cells. The CAR-T cell-based anti-cancer therapy targeting a pan–B-cell marker, CD19 is recently approved by the US Food and Drug Administration (FDA) for the treatment of chemotherapy-resistant B-cell NHL. In this review, we will discuss the structure, molecular mechanisms, results of clinical trials, and the toxicity of CAR-T cell-based therapies. Also, we will criticize the clinical aspects, the treatment considerations, and the challenges and possible drawbacks of the application of CAR-T cells in the treatment of NHL

High Precision Measurements of Interstellar Dispersion Measure with the upgraded GMRT

Pulsar radio emission undergoes dispersion due to the presence of free electrons in the interstellar medium (ISM). The dispersive delay in the arrival time of pulsar signal changes over time due to the varying ISM electron column density along the line of sight. Correcting for this delay accurately is crucial for the detection of nanohertz gravitational waves using Pulsar Timing Arrays. In this work, we present in-band and inter-band DM estimates of four pulsars observed with uGMRT over the timescale of a year using two different template alignment methods. The DMs obtained using both these methods show only subtle differences for PSR 1713+0747 and J1909$-$3744. A considerable offset is seen in the DM of PSR J1939+2134 and J2145$-$0750 between the two methods. This could be due to the presence of scattering in the former and profile evolution in the latter. We find that both methods are useful but could have a systematic offset between the DMs obtained. Irrespective of the template alignment methods followed, the precision on the DMs obtained is about $10^{-3}$ pc cm$^{-3}$ using only BAND3 and $10^{-4}$ pc cm$^{-3}$ after combining data from BAND3 and BAND5 of the uGMRT. In a particular result, we have detected a DM excess of about $5\times10^{-3}$ pc cm$^{-3}$ on 24 February 2019 for PSR J2145$-$0750. This excess appears to be due to the interaction region created by fast solar wind from a coronal hole and a coronal mass ejection (CME) observed from the Sun on that epoch. A detailed analysis of this interesting event is presented.Comment: 11 pages, 6 figures, 2 tables. Accepted by A&

Handbook of lung targeted drug delivery systems : Recent trends and clinical evidences

Handbook of Lung Targeted Drug Delivery Systems: Recent Trends and Clinical Evidences covers every aspect of the drug delivery to lungs, the physiology and pharmacology of the lung, modelling for lung delivery, drug devices focused on lung treatment, regulatory requirements, and recent trends in clinical applications. With the advent of nano sciences and significant development in the nano particulate drug delivery systems there has been a renewed interest in the lung as an absorption surface for various drugs. The emergence of the COVID-19 virus has brought lung and lung delivery systems into focus, this book covers new developments and research used to address the prevention and treatment of respiratory diseases. Written by well-known scientists with years of experience in the field this timely handbook is an excellent reference book for the scientists and industry professionals.Key Features: - Focuses particularly on the chemistry, clinical pharmacology, and biological developments in this field of research. - Presents comprehensive information on emerging nanotechnology applications in diagnosing and treating pulmonary diseases - Explores drug devices focused on lung treatment, regulatory requirements, and recent trends in clinical applications - Examines specific formulations targeted to pulmonary system