High temperature, short term tensile strength of C6000/PMR-15 composites

Tensile tests were conducted on 0 unidirectionally reinforced Celion 6000 graphite fibers in PMR-15 polyimide matrix. Tensile strengths for coupons subjected to short and long term uniform temperatures were obtained. Thick coupons, heated on one side to produce significant transient through thickness temperature gradients, were tested and compared to the strength of specimens with uniform temperature distributions. All coupons were radiantly heated and reached maximum test temperatures within 15 sec. Tensile loads were applied to the coupons after 15 sec of elevated temperature exposure. Loading rates were selected so that specimen failures occurred within a maximum of 45 sec after reaching the test temperature. Results indicate that significant tensile strength remains beyond the material post cure temperature

Complex permeability of soft magnetic ferrite polyester resin composites at frequencies above 1 MHz

Composite soft magnetic materials consist of magnetic particles in a non-magnetic matrix. The properties of such materials can be modelled using effective medium theory. Measurements have been made of the complex permeability of composites produced using ferrite powder and polyester resin. The success of various effective medium expressions in predicting the variation of complex permeability with composition has been assessed

Recurring Ocular Palsy.

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Emmonsia

29.1 Introduction 29.1.1 Classification, Morphology, and Biology 29.1.2 Clinical Features and Epidemiology 29.1.3 Diagnosis 29.2 Methods 29.2.1 Sample Preparation 29.2.2 Detection Procedures 29.2.2.1 Sequencing Analysis of ITS Regions 29.2.2.2 Panfungal PCR and Sequencing Analysis 29.2.2.3 Sequencing Analysis of LSU rRNA Gene 29.3 Conclusion Reference

GABA-B receptor function in healthy volunteers, a pharmacokinetic and pharmacodynamic study of two doses of baclofen compared to placebo

AIMS AND HYPOTHESIS To assess the subjective and objective effects of baclofen on brain function in healthy volunteers. BACKGROUND Recent evidence suggests baclofen, a γ-aminobutyric acid type B (GABA-B) receptor agonist, reduces alcohol consumption and craving and promotes abstinence in alcoholics. However, characterisation of the GABA-B receptor system in clinical addiction is limited, and it is unclear why some patients require, or tolerate, higher doses to treat alcoholism. This study assesses the effects of baclofen on brain function in healthy volunteers to inform future studies investigating the sensitivity of GABA-B receptors in alcohol addiction. METHODS Eight healthy male volunteers completed a double blind randomised 3-way cross over study, receiving oral placebo (vitamin C 100mg), 10mg and 60mg baclofen. Subjective and objective measurements were taken at baseline (before medication) and at +30mins, 1, 2, 3, 4 and 6 hours after dosing. Objective measures included blood plasma samples, heart rate and blood pressure. Subjective measures included; the Subjective High Assessment Questionnaire (SHAS), visual analogue scales for sleepy, relaxed, tense and alert and a motor coordination task (zig-zag task). Pharmacokinetic data was obtained using liquid chromatography mass-spectrometry (LC-MS) to measure plasma baclofen concentrations. RESULTS 60mg Baclofen showed changes in subjective measures peaking at 2 hours post dosing compared with placebo, including a significant increase (p<0.05) in total SHAS scores with individual items, including feeling ‘drunk or intoxicated’, effects of alcohol and ‘muddled or confused’ particular affected.. Systolic blood pressure was significantly increased (p<0.05) at the 2 hours post 60mg dose. For both 10mg and 60mg baclofen, peak plasma concentration was achieved 60 minutes post dose. Pharmacokinetic data will be presented. There were no significant changes in these measures between 10mg Baclofen and placebo. CONCLUSIONS The objective and subjective measures used in this study are able to differentiate between placebo and 60mg baclofen. These findings will inform further research investigating the sensitivity of GABA-B receptors in alcohol addiction

Infinite dimensional integrals beyond Monte Carlo methods: yet another approach to normalized infinite dimensional integrals

An approach to (normalized) infinite dimensional integrals, including normalized oscillatory integrals, through a sequence of evaluations in the spirit of the Monte Carlo method for probability measures is proposed. in this approach the normalization through the partition function is included in the definition. For suitable sequences of evaluations, the ("classical") expectation values of cylinder functions are recoveredComment: Submitted as a communication in the ICMSQUARE conference, september 201

Molecular Flexibility and Bend in Semi‐Rigid Liquid Crystals: Implications for the Heliconical Nematic Ground State

The NTB phase phases possess a local helical structure with a pitch length of a few nanometers and is typically exhibited by materials consisting of two rigid mesogenic units linked by a flexibile oligomethylene spacer of odd parity, giving a bent shape. We report the synthesis and characterisation of two novel dimeric liquid crystals, and perform a computational study on ten cyanobiphenyl dimers with varying linking groups, generating a large library of conformers for each compound; this allows us to present molecular bend angles as probability weighted averages of many conformers, rather than use a single conformer. We validate conformer libraries by comparison of interproton distances with those obtained from solution based 1D 1H NOESY NMR, finding good agreement between experiment and computational work. Conversely, we find that using any single conformer fails to reproduce experimental interproton distances. We find the use of a single conformer significantly overestimates the molecular bend angle while also ignoring flexibility; we show that the average bend angle and flexibility are both linked to the relative stability of the NTB phase