Arithmetic Operations in Multi-Valued Logic

This paper presents arithmetic operations like addition, subtraction and multiplications in Modulo-4 arithmetic, and also addition, multiplication in Galois field, using multi-valued logic (MVL). Quaternary to binary and binary to quaternary converters are designed using down literal circuits. Negation in modular arithmetic is designed with only one gate. Logic design of each operation is achieved by reducing the terms using Karnaugh diagrams, keeping minimum number of gates and depth of net in to consideration. Quaternary multiplier circuit is proposed to achieve required optimization. Simulation result of each operation is shown separately using Hspice.Comment: 12 Pages, VLSICS Journal 201

Hepcidin secretion was not directly proportional to intracellular iron-loading in recombinant-TfR1 HepG2 cells: short communication

Hepcidin is the master regulator of systemic iron homeostasis and its dysregulation is observed in several chronic liver diseases. Unlike the extracellular iron-sensing mechanisms, the intracellular iron-sensing mechanisms in the hepatocytes that lead to hepcidin induction and secretion are incompletely understood. Here, we aimed to understand the direct role of intracellular iron-loading on hepcidin mRNA and peptide secretion using our previously characterised recombinant HepG2 cells that over-express the cell-surface iron-importer protein transferrin receptor-1. Gene expression of hepcidin (HAMP) was determined by real-time PCR. Intracellular iron levels and secreted hepcidin peptide levels were measured by ferrozine assay and immunoassay, respectively. These measurements were compared in the recombinant and wild-type HepG2 cells under basal conditions at 30 min, 2 h, 4 h and 24 h. Data showed that in the recombinant cells, intracellular iron content was higher than wild-type cells at 30 min (3.1-fold, p<0.01), 2 h (4.6-fold, p<0.01), 4 h (4.6-fold, p<0.01) and 24 h (1.9-fold, p<0.01). Hepcidin (HAMP) mRNA expression was higher than wild-type cells at 30 min (5.9-fold; p=0.05) and 24 h (6.1-fold; p<0.03), but at 4 h, the expression was lower than that in wild-type cells (p<0.05). However, hepcidin secretion levels in the recombinant cells were similar to those in wild-type cells at all time-points, except at 4 h, when the level was lower than wild-type cells (p<0.01). High intracellular iron in recombinant HepG2 cells did not proportionally increase hepcidin peptide secretion. This suggests a limited role of elevated intracellular iron in hepcidin secretio

Quantum Random Walks do not need a Coin Toss

Classical randomized algorithms use a coin toss instruction to explore different evolutionary branches of a problem. Quantum algorithms, on the other hand, can explore multiple evolutionary branches by mere superposition of states. Discrete quantum random walks, studied in the literature, have nonetheless used both superposition and a quantum coin toss instruction. This is not necessary, and a discrete quantum random walk without a quantum coin toss instruction is defined and analyzed here. Our construction eliminates quantum entanglement from the algorithm, and the results match those obtained with a quantum coin toss instruction.Comment: 6 pages, 4 figures, RevTeX (v2) Expanded to include relation to quantum walk with a coin. Connection with Dirac equation pointed out. Version to be published in Phys. Rev.

Search on a Hypercubic Lattice through a Quantum Random Walk: II. d=2

We investigate the spatial search problem on the two-dimensional square lattice, using the Dirac evolution operator discretised according to the staggered lattice fermion formalism. $d=2$ is the critical dimension for the spatial search problem, where infrared divergence of the evolution operator leads to logarithmic factors in the scaling behaviour. As a result, the construction used in our accompanying article \cite{dgt2search} provides an $O(\sqrt{N}\log N)$ algorithm, which is not optimal. The scaling behaviour can be improved to $O(\sqrt{N\log N})$ by cleverly controlling the massless Dirac evolution operator by an ancilla qubit, as proposed by Tulsi \cite{tulsi}. We reinterpret the ancilla control as introduction of an effective mass at the marked vertex, and optimise the proportionality constants of the scaling behaviour of the algorithm by numerically tuning the parameters.Comment: Revtex4, 5 pages (v2) Introduction and references expanded. Published versio

Type I seesaw mechanism for quasi degenerate neutrinos

We discuss symmetries and scenarios leading to quasi-degenerate neutrinos in type-I seesaw models. The existence of degeneracy in the present approach is not linked to any specific structure for the Dirac neutrino Yukawa coupling matrix $y_D$ and holds in general. Basic input is the application of the minimal flavour violation principle to the leptonic sector. Generalizing this principle, we assume that the structure of the right handed neutrino mass matrix is determined by $y_D$ and the charged lepton Yukawa coupling matrix $y_l$ in an effective theory invariant under specific groups ${\cal G}_F$ contained in the full symmetry group of the kinetic energy terms. ${\cal G}_F$ invariance also leads to specific structure for the departure from degeneracy. The neutrino mass matrix (with degenerate mass $m_0$) resulting after seesaw mechanism has a simple form ${\cal M}_\nu\approx m_0(I-p y_ly_l^T)$ in one particular scenario based on supersymmetry. This form is shown to lead to correct description of neutrino masses and mixing angles. The thermal leptogenesis after inclusion of flavour effects can account for the observed baryon asymmetry of the universe within the present scenario. Rates for lepton flavour violating processes can occur at observable levels in the supersymmetric version of the scenario.Comment: 14 pages; two figure

Size at maturity in the mud spiny lobster Panulirus polyphagus (Herbst, 1793)

The size at sexual maturity of the mud spiny lobster Panulirus polyphagus was estimated by assessing the sizes at which the animals become morphologically, physiologically and functionally mature, from samples collected from the wild along the Saurashtra coast. The size at physiological maturity was assessed from the condition of the gonad and its stage of development. The size at morphological maturity was assessed by following the development of external indices of maturity. Change in the length of the penile process in relation to the carapace length (CL) was also studied in males. Linear plots of the somatic lengths against the carapace lengths in size groups 50 mm CL were used to assess changes in growth patterns from juvenile phase to sub-adult and adult phases. Comparisons were also made between growth patterns of males and females. The size at functional or physical maturity was assessed from the frequency distribution of males and females with respect to specialised structures which ensure the mating and propagative capabilities of the animals, namely, decalcified windows on the ventral side, well developed setal brush on the dactylii of the fifth pair of walking legs and ovigerous condition in females and penile process in males. Observations made in the study indicated that the size at onset of sexual maturity can be traced to 51–55 mm CL for males and 51–60 mm CL for females. The critical maturation phase extends between 56 and 65 mm CL for males and between 66 and 75 mm CL for females